2,019 research outputs found
Ecosystem size-induced environmental fluctuations affect the temporal dynamics of community assembly mechanisms
Understanding processes that determine community membership and abundance is important for many fields from theoretical community ecology to conservation. However, spatial community studies are often conducted only at a single timepoint despite the known influence of temporal variability on community assembly processes. Here we used a spatiotemporal study to determine how environmental fluctuation differences induced by mesocosm volumes (larger volumes were more stable) influence assembly processes of aquatic bacterial metacommunities along a press disturbance gradient. By combining path analysis and network approaches, we found mesocosm size categories had distinct relative influences of assembly process and environmental factors that determined spatiotemporal bacterial community composition, including dispersal and species sorting by conductivity. These processes depended on, but were not affected proportionately by, mesocosm size. Low fluctuation, large mesocosms primarily developed through the interplay of species sorting that became more important over time and transient priority effects as evidenced by more time-delayed associations. High fluctuation, small mesocosms had regular disruptions to species sorting and greater importance of ecological drift and dispersal limitation indicated by lower richness and higher taxa replacement. Together, these results emphasize that environmental fluctuations influence ecosystems over time and its impacts are modified by biotic properties intrinsic to ecosystem size
Stones, Bones and Homes: An Examination of Regionality in the Iron Age Settlements and Landscape of West Wales
West Wales in the Iron Age contained a diverse range of settlement types, from hill-forts to unenclosed farmsteads, with the dominant type of settlement the enclosed farmstead. However, a recent review of information available for the British Iron Age identified a relative lack of systematised information for Wales and consequently there is a pressing need to re-examine the settlement record for this area, as the belief in a single Iron Age "culture" gives way to recognition of regional difference in material cultures, social institutions and life-ways. This thesis examines the settlements and landscape of West Wales in an attempt to contribute to our understanding of this region in the Iron Age. In order to make a regionally synthesised investigation of the social, I conducted a survey of excavation and survey information for Iron Age settlements in West Wales. Analysis centred on examining the spatial patterning of settlements by considering the morphology, distribution, placement and structure of settlements, their place in the landscape and regional trends in the structuring of space and artefacts. The investigation was contextualised within the wider body of material for the Iron Age in Britain. The use of landscape theory as an interpretive framework in examining the spatial patterning of the material culture in the Iron Age proved an effective method for interpreting domestic settlements within the lived landscape. Social and cosmological relations within settlements and within the referential structuring of a landscape, particularly with respect to pre-existing monuments, were suggested by the analysis. By comparing these trends in the structuring of settlements within the landscape to settlements elsewhere in Britain, a distinct and regional culture for the Iron Age of West Wales was identified
Breakdown of a conservation law in incommensurate systems
We show that invariance properties of the Lagrangian of an incommensurate
system, as described by the Frenkel Kontorova model, imply the existence of a
generalized angular momentum which is an integral of motion if the system
remains floating. The behavior of this quantity can therefore monitor the
character of the system as floating (when it is conserved) or locked (when it
is not). We find that, during the dynamics, the non-linear couplings of our
model cause parametric phonon excitations which lead to the appearance of
Umklapp terms and to a sudden deviation of the generalized momentum from a
constant value, signalling a dynamical transition from a floating to a pinned
state. We point out that this transition is related but does not coincide with
the onset of sliding friction which can take place when the system is still
floating.Comment: 7 pages, 6 figures, typed with RevTex, submitted to Phys. Rev. E
Replaced 27-03-2001: changes to text, minor revision of figure
Building Protein Domain Based Composite Biobricks for Mammalian Expression Systems
The purpose of this RFC is to describe a method that allows the design of protein domain based parts, starting with gene centered information and translate these informations into BBF RFC 25 compatible part. The method is designed to be used in mammalian expression systems
Captopril reduces cardiac inflammatory markers in spontaneously hypertensive rats by inactivation of NF-kB
<p>Abstract</p> <p>Background</p> <p>Captopril is an angiotensin-converting enzyme (ACE) inhibitor widely used in the treatment of arterial hypertension and cardiovascular diseases. Our objective was to study whether captopril is able to attenuate the cardiac inflammatory process associated with arterial hypertension.</p> <p>Methods</p> <p>Left ventricle mRNA expression and plasma levels of pro-inflammatory (interleukin-1β (IL-1β) and IL-6) and anti-inflammatory (IL-10) cytokines, were measured in spontaneously hypertensive rats (SHR) and their control normotensive, Wistar-Kyoto (WKY) rats, with or without a 12-week treatment with captopril (80 mg/Kg/day; n = six animals per group). To understand the mechanisms involved in the effect of captopril, mRNA expression of ACE, angiotensin II type I receptor (AT1R) and p22phox (a subunit of NADPH oxidase), as well as NF-κB activation and expression, were measured in the left ventricle of these animals.</p> <p>Results</p> <p>In SHR, the observed increases in blood pressures, heart rate, left ventricle relative weight, plasma levels and cardiac mRNA expression of IL-1β and IL-6, as well as the reductions in the plasma levels and in the cardiac mRNA expression of IL-10, were reversed after the treatment with captopril. Moreover, the mRNA expressions of ACE, AT1R and p22phox, which were enhanced in the left ventricle of SHR, were reduced to normal values after captopril treatment. Finally, SHR presented an elevated cardiac mRNA expression and activation of the transcription nuclear factor, NF-κB, accompanied by a reduced expression of its inhibitor, IκB; captopril administration corrected the observed changes in all these parameters.</p> <p>Conclusion</p> <p>These findings show that captopril decreases the inflammation process in the left ventricle of hypertensive rats and suggest that NF-κB-driven inflammatory reactivity might be responsible for this effect through an inactivation of NF-κB-dependent pro-inflammatory factors.</p
Measuring and Analyzing Effects of HEMP Simulation on Synthetic Power Grids
There is significant uncertainty about the potential effects of a
high-altitude electromagnetic pulse (HEMP) detonation on the bulk electric
system. This study attempts to account for such uncertainty, in using
Monte-Carlo methods to account for speculated range of effect of HEMP
contingency. Through task parallelism and asynchronous processing techniques
implemented throughout simulation, this study measure the effects of 700
large-scale HEMP simulations on a 7173 bus synthetic power grid. Analysis
explores how contingency severity varies, depending on initial contingency
parameters. Severity indices were captured throughout simulation to measure and
quantify the cascading nature of an HEMP event. Further development of HEMP
simulation modeling is explored as well, which could augment forecasts of
potential contingency events as well.Comment: 6 pages. 13 figure
Titan Science with the James Webb Space Telescope (JWST)
The James Webb Space Telescope (JWST), scheduled for launch in 2018, is the
successor to the Hubble Space Telescope (HST) but with a significantly larger
aperture (6.5 m) and advanced instrumentation focusing on infrared science
(0.6-28.0 m ). In this paper we examine the potential for scientific
investigation of Titan using JWST, primarily with three of the four
instruments: NIRSpec, NIRCam and MIRI, noting that science with NIRISS will be
complementary. Five core scientific themes are identified: (i) surface (ii)
tropospheric clouds (iii) tropospheric gases (iv) stratospheric composition and
(v) stratospheric hazes. We discuss each theme in depth, including the
scientific purpose, capabilities and limitations of the instrument suite, and
suggested observing schemes. We pay particular attention to saturation, which
is a problem for all three instruments, but may be alleviated for NIRCam
through use of selecting small sub-arrays of the detectors - sufficient to
encompass Titan, but with significantly faster read-out times. We find that
JWST has very significant potential for advancing Titan science, with a
spectral resolution exceeding the Cassini instrument suite at near-infrared
wavelengths, and a spatial resolution exceeding HST at the same wavelengths. In
particular, JWST will be valuable for time-domain monitoring of Titan, given a
five to ten year expected lifetime for the observatory, for example monitoring
the seasonal appearance of clouds. JWST observations in the post-Cassini period
will complement those of other large facilities such as HST, ALMA, SOFIA and
next-generation ground-based telescopes (TMT, GMT, EELT).Comment: 50 pages, including 22 figures and 2 table
Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations
Background: Haptoglobin (Hp) α-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties. Hp1-1 genotype results in the production of small dimeric, Hp2-1 linear, and Hp2-2 cyclic polymeric haptoglobin molecules. We investigated the haptoglobin polymorphism in patients with celiac disease and its possible association to the presenting symptoms.
Methods: We studied 712 unrelated, biopsy-proven Hungarian celiac patients (357 children, 355 adults; severe malabsorption 32.9%, minor gastrointestinal symptoms 22.8%, iron deficiency anemia 9.4%, dermatitis herpetiformis 15.6%, silent disease 7.2%, other 12.1%) and 384 healthy subjects. We determined haptoglobin phenotypes by gel electrophoresis and assigned corresponding genotypes.
Results: Hp2-1 was associated with a significant risk for celiac disease (P = 0.0006, odds ratio [OR] 1.54, 95% CI 1.20–1.98; prevalence 56.9% in patients vs 46.1% in controls). It was also overrepresented among patients with mild symptoms (69.2%) or silent disease (72.5%). Hp2-2 was less frequent in patients than in controls (P = 0.0023), but patients having this phenotype were at an increased risk for severe malabsorption (OR 2.21, 95% CI 1.60–3.07) and accounted for 45.3% of all malabsorption cases. Celiac and dermatitis herpetiformis patients showed similar haptoglobin phenotype distributions.
Conclusions: The haptoglobin polymorphism is associated with susceptibility to celiac disease and its clinical presentations. The predominant genotype in the celiac population was Hp2-1, but Hp2-2 predisposed to a more severe clinical course. The phenotype-dependent effect of haptoglobin may result from the molecule’s structural and functional properties
Atomic Scale Sliding and Rolling of Carbon Nanotubes
A carbon nanotube is an ideal object for understanding the atomic scale
aspects of interface interaction and friction. Using molecular statics and
dynamics methods different types of motion of nanotubes on a graphite surface
are investigated. We found that each nanotube has unique equilibrium
orientations with sharp potential energy minima. This leads to atomic scale
locking of the nanotube.
The effective contact area and the total interaction energy scale with the
square root of the radius. Sliding and rolling of nanotubes have different
characters. The potential energy barriers for sliding nanotubes are higher than
that for perfect rolling. When the nanotube is pushed, we observe a combination
of atomic scale spinning and sliding motion. The result is rolling with the
friction force comparable to sliding.Comment: 4 pages (two column) 6 figures - one ep
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