Velocity Level Approximation of Pressure Field Contact Patches

Pressure Field Contact (PFC) was recently introduced as a method for detailed modeling of contact interface regions at rates much faster than elasticity-theory models, while at the same time predicting essential trends and capturing rich contact behavior. The PFC model was designed to work in conjunction with error-controlled integration at the acceleration level. Therefore a vast majority of existent multibody codes using solvers at the velocity level cannot incorporate PFC in its original form. In this work we introduce a discrete in time approximation of PFC making it suitable for use with existent velocity-level time steppers and enabling execution at real-time rates. We evaluate the accuracy and performance gains of our approach and demonstrate its effectiveness in simulating relevant manipulation tasks. The method is available in open source as part of Drake's Hydroelastic Contact model.Comment: 8 pages, 10 figures. Supplementary video can be found at https://youtu.be/AdCnTyqqQP

Visual Voices Participant Recruitment Flyer

Participant recruitment flyer for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents. This project was designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.https://dune.une.edu/minigrant_visvoice/1001/thumbnail.jp

Visual Voices Project Pre-Post Survey

Participant pre-/post-project survey for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents. This project was designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.https://dune.une.edu/minigrant_visvoice/1004/thumbnail.jp

Grant Application: Visual Voices, An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents

IPEC Mini-grant application for funding of UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents. This project was designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.https://dune.une.edu/minigrant_visvoice/1000/thumbnail.jp

Visual Voices Approved Consent Form

Approved project consent form for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents, designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers. This form documents the scope of the project and participants\u27 role therein.https://dune.une.edu/minigrant_visvoice/1003/thumbnail.jp

Detectors and Focal Plane Modules for Weather Satellites

Weather satellite instruments require detectors with a variety of wavelengths ranging from the visible to VLWIR. One of the remote sensing applications is the geostationary GOES-ABI imager covering wavelengths from the 450 to 490 nm band through the 13.0 to 13.6 micron band. There are a total of 16 spectral bands covered. The Cross-track infrared Sounder (CrIS) is a Polar Orbiting interferometric sensor that measures earth radiances at high spectral resolution, using the data to provide pressure, temperature and moisture profiles of the atmosphere. The pressure, temperature and moisture sounding data are used in weather prediction models that track storms, predict levels of precipitation etc. The CrIS instrument contains SWIR (lamba(sub c) approximately 5 micron at 98K), MWIR (lambda(sub c) approximately 9 micron at 98K) and LWIRs (lamba(sub c) approximately 15.5 micron at 81K) bands in three Focal Plane Array Assemblies (FPAAs). GOES-ABI contains three focal plane modules (FPMs), (i) a visible-near infrared module consisting of three visible and three near infrared channels, (ii) a MWIR module comprised of five channels from 3.9 micron to 8.6 micron and (iii) a 9.6 micron to 13.3 micron, five-channel LWIR module. The VNIR FPM operates at 205 K, and the MWIR and LWIR FPMs operate at 60 K. Each spectral channel has a redundant array built into a single detector chip. Switching is thus permitted from the primary selected array in each channel to the redundant array, given any degradation in performance of the primary array during the course of the mission. Silicon p-i-n detectors are used for the 0.47 micron to 0.86 micron channels. The thirteen channels above 1 micron are fabricated in various compositions of Hg1-xCdxTe, and in this particular case using two different detector architectures. The 1.38 micron to 9.61 micron channels are all fabricated in Hg1-xCdxTe grown by Liquid Phase Epitaxy (LPE) using the HDVIP detector architecture. Molecular beam epitaxy (MBE)-grown Hg1-xCdxTe material are used for the LWIR 10.35 micron to 13.3 micron channels fabricated in Double layer planar heterostructure (DLPH) detectors. This is the same architecture used for the CrIS detectors CrIS detectors are 850 micron diameter detectors with each FPAA consisting of nine photovoltaic detectors arranged in a 3 x 3 pattern. Each detector has an accompanying cold preamplifier. SWIR and MWIR FPAAs operate at 98 K and the LWIR FPAA at 81 K, permitting the use of passive radiators to cool the detectors. D* requirements at peak wavelength are 5.0E+10 Jones for LWIR, 9.3E+10 Jones for MWIR and 3.0E+11 Jones for SWIR. All FPAAs exceeded the D* requirements. Measured mean values for the nine photodiodes in each of the LWIR, MWIR and SWIR FPAAs are D* = 5.3 x 10(exp 10) cm-Hz(exp 1/2)/W at 14.0 micron, 1.0 x 10(exp 11) cm-Hz(exp 1/2)/W at 8.0 micron and 3.1 x 10(exp 11) cm-Hz(exp 1/2)/W at 4.64 micron

Visual Voices Weekly Session Scripts

Eleven weekly session scripts for UNE student project Visual Voices: An Arts-Based Assessment Of The Perceived Identity Of Aging Maine Residents. This project was designed to investigate the topics of perception, identity, and aging. Between February and May 2015, over the course of twelve sessions, the UNE team met with six female residents of the Park Danforth senior living community in Portland to have conversations and create art about how the residents perceive themselves in contrast to how they feel perceived by important people in their lives, such as friends, family, and healthcare providers.https://dune.une.edu/minigrant_visvoice/1002/thumbnail.jp

Detectors and Focal Plane Modules for Weather Instruments

Weather satellite instruments require detectors with a variety of wavelengths ranging from the visible to VLWIR. The Cross-track infrared Sounder (CrIS) is a Polar Orbiting interferometric sensor that measures earth radiances at high spectral resolution, using the data to provide pressure, temperature and moisture profiles of the atmosphere. The pressure, temperature and moisture sounding data are used in weather prediction models that track storms, predict levels of precipitation etc. The CrIS instrument contains SWIR (lambda(sub c) (is) approximately 5 micrometers at 98 K), MWIR (lambda(sub c) (is) approximately 9 micrometers at 98 K) and LWIRs (lambda(sub c) (is) approximately 15.4 m at 81 K) bands in three Focal Plane Array Assemblies (FPAAs). CrIS detectors are 850 micrometers diameter detectors with each FPAA consisting of nine photovoltaic detectors arranged in a 3 x 3 pattern. Molecular beam epitaxy (MBE)-grown Hg1-xCdxTe material are used for the detectors fabricated in a modified Double Layer Planar Heterostructure (DLPH) architecture. Each detector has an accompanying cold preamplifier. SWIR and MWIR FPAAs operate at 98 K and the LWIR FPAA at 81 K, permitting the use of passive radiators to cool the detectors. D* requirements at peak 14.01 micrometers wavelength are greater than 5.0E+10 Jones for LWIR, greater than 7.5E+10 Jones at 8.26 micrometers for MWIR and greater than 3.0E+11 Jones at peak 4.64 micrometers wavelength for SWIR. All FPAAs exceeded the D* requirements. Measured mean values for the nine photodiodes in each of the LWIR, MWIR and SWIR FPAAs are D* = 5.3 x 10(exp 10) cm-Hz1/2/W at 14.0 micrometers, 9.6 x 10(exp 10) cm-Hz1/2/W at 8.0 micrometers and 3.4 x 10(exp 11) cm-Hz1/2/W at 4.64 micrometers

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature

Evaluation of Cellular Mechanisms Involved in Recombinant Antibody Expression in Transiently Transfected Chinese Hamster Ovary Cells

Transient recombinant antibody production in Chinese hamster ovary (CHO) cells is often used to screen large panels of candidates for potential therapeutic use. However, a significant proportion of antibodies express at a level too low for adequate in vitro characterization. This study compares the pathways, including the unfolded protein response (UPR), involved in the transient expression of both low and high expressing antibody clones. Twenty historically low expressing antibodies from two different hybridoma campaigns were re-evaluated for antibody productivity using transient co-transfection of heavy and light chain plasmids in CHO 3E7 cells. Five antibodies had significantly improved antibody production while one antibody had moderately improved antibody production when expressed in CHO 3E7 cells compared to their respective historical data. Seven individual antibody chains were affected at the transcriptional level with minimal or no detectable levels of mRNA. These seven chains were used in different combinations for ten of the antibodies screened. For those ten antibodies, the lack of detectable mRNA, determined by Northern blot analysis, correlated with low levels of intracellular and secreted antibody. The low levels of mRNA could potentially be caused by enhanced degradation due to the physical characteristics of these sequences (Cooper, G. M., 2000). One variant had low levels of light chain mRNA but had secreted titers of antibody similar to its corresponding control and was the only antibody that possessed these features. The remaining four variants had adequate levels of mRNA and intracellular antibody, determined by Western blot analysis, but minimal amounts of secreted antibody, potentially implicating UPR induction. Antibodies 5L+19H (low expression) and 5L+6H (high expression) along with mock and untransfected cells were analyzed for UPR gene regulation using the Affimetrix CHO Gene array. Several observations were made. First, the transfection process alone had the most impact on differential gene expression affecting 1146 genes out of 29,700 genes assayed. Second, the UPR related gene CHOP was noted to be upregulated for both antibody transfections compared to mock, and HERPUD1 was shown to be upregulated for the low expressing antibody compared to mock. This suggests UPR induction had begun for both experimental transfections, however, the specific pathway or pathways that have been activated cannot be determined with the limited number of genes that were found to be upregulated. Additionally, when the two experimental transfections were compared to each other we found no significant difference in differential gene expression of UPR related genes. This implies that 72 hours post-transfection, the level of UPR induction was similar for an antibody that has low levels of secretion and one that has high levels of secretion. Finally, four key UPR associated genes were found to be downregulated in mock transfected cells compared to untransfected cells, (CHOP, GADD34, ERDJ4 and XBP1)