PV reconfiguration systems: A technical and economic study

Dynamical electrical array reconfiguration strategies for grid-connected PV systems have been proposed as solution to improve energy production due to the mismatch effect of PV plants during partial shading conditions. Strategies are based on the use of dynamic connections between PV panels given by the employment of switches that allow for each panel the series, parallel or exclusion connections, physically changing the electrical connections between the related PV modules, consequentially modifying the layout of the plant. Usually the cost of the dynamic matrix is not taken into account. This novel work evaluates the economic advantages obtained by the use of reconfiguration strategies in PV systems, by taking into consideration the price of energy due to incentives in different European and non-European countries and correlates it with the employment of two types of reconfigurators, with different internal structures. For each of the incentives proposed by the different Countries, the main strength and weakness points of the possible investment are highlighted and critically analyzed. From this analysis, it can be stated that the adoption of reconfiguration systems, in certain cases, can be a very convenient solution

Urothelial bladder carcinoma metastasizing to the eye: a systematic review and case report

The eye is a rare site for disseminated malignancies; nevertheless, several tumors may metastasize to ocular structures. Few cases of urothelial and bladder cancer with eye involvement have been described in the literature thus far. The rarity of metastatic ocular localization implies an accurate differential diagnosis among the possible primary tumor sites. However, a specific diagnostic algorithm is not currently available, nor a defined therapeutic approach. Eye metastases are associated with advanced disease and poor prognosis. Physicians should be made aware of the possibility of eye involvement in patients with a past medical history of urothelial bladder cancer associated with ocular symptoms. The present case reports discusses the first documented case, to the best of our knowledge, of an urothelial bladder cancer metastasizing to the retro bulbar region that infiltrates the lacrimal gland. Furthermore, the report provides a systematic qualitative review of the current literature on eye metastases from urothelial bladder cancer using the Preferred Reporting Items for Systematic Reviews and Meta Analyses

Digital interaction: where are we going?

In the framework of the AVI 2018 Conference, the interuniversity center ECONA has organized a thematic workshop on "Digital Interaction: where are we going?". Six contributions from the ECONA members investigate different perspectives around this thematic

The risk of late or advanced presentation of HIV infected patients is still high, associated factors evolve but impact on overall mortality is vanishing over calendar years: Results from the Italian MASTER Cohort

BACKGROUND: We aimed at evaluating frequency and factors associated with late presentation and advanced HIV disease and excess risk of death due to these conditions from 1985 to 2013 among naïve HIV infected patients enrolled in the Italian MASTER Cohort. METHODS: All antiretroviral naive adults with available CD4+ T cell count after diagnosis of HIV infection were included. Multivariable logistic regression analysis investigated factors associated either with late presentation or advanced HIV disease. Probabilities of survival were estimated both at year-1 and at year-5 according to the Kaplan-Meier method. Flexible parametric models were used to evaluate changes in risk of death overtime according to late presentation and advanced HIV disease. The analyses were stratified for calendar periods. RESULTS: 19,391 patients were included (54 % were late presenters and 37.6 % were advanced presenters). At multivariable analysis, the following factors were positively associated with late presentation: male gender (OR = 1.29), older age (≥55 years vs. <25 years; OR = 7.45), migration (OR = 1.54), and heterosexual risk factor for HIV acquisition (OR = 1.52) or IDU (OR = 1.27) compared to homosexual risk. Survival rates at year-5 increased steadily and reached 92.1 % for late presenters vs. 97.4 % for non-late presenters enrolled in the period 2004-2009. Using flexible parametric models we found a sustained reduction of hazard ratios over time for any cause deaths between late and non-late presenters over time. Similar results were found for advanced HIV disease. CONCLUSION: Screening polices need to be urgently implemented, particularly in most-at-risk categories for late presentation, such as migrants, older patients and those with heterosexual intercourse or IDU as risk factors for HIV acquisition. Although in recent years the impact of late presentation on survival decreased, about 10 % of patients diagnosed in more recent years remains at increased risk of death over a long-term follow-up

Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study

Abstract PURPOSE: To assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules. METHODS: Patients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4-5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a 653 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity, negative (NPV), and positive predictive value (PPV) were described. Multiple correspondence analysis (MCA) and logistic regression were applied. RESULTS: Cancer was found in 433/902 (48%) patients. Considering TIR4-5 only as positive cytology, specificity, and PPV were high (94 and 91%) but sensitivity and NPV were low (61 and 72%); conversely, including TIR3 among positive, sensitivity and NPV were higher (88 and 82%) while specificity and PPV decreased (52 and 63%). Ultrasonographic size 653\u2009cm was independently associated with benignity among TIR2 cases (OR of malignancy 0.37, 95% CI 0.18-0.78). In TIR3 cases the hard consistency of small nodules was associated with malignity (OR: 3.51, 95% CI 1.84-6.70, p\u2009<\u20090.001), while size alone, irrespective of consistency, was not diagnostically informative. No other significant association was found in TIR2 and TIR3. CONCLUSIONS: The combination of cytology with clinical and ultrasonographic parameters may improve diagnostic definition of palpable thyroid nodules. However, the need for innovative diagnostic tools is still high

A Catalog of Coding Sequence Variations in Salivary Proteins' Genes Occurring during Recent Human Evolution

Saliva houses over 2000 proteins and peptides with poorly clarified functions, including proline-rich proteins, statherin, P-B peptides, histatins, cystatins, and amylases. Their genes are poorly conserved across related species, reflecting an evolutionary adaptation. We searched the nucleotide substitutions fixed in these salivary proteins’ gene loci in modern humans compared with ancient hominins. We mapped 3472 sequence variants/nucleotide substitutions in coding, noncoding, and 5′-3′ untranslated regions. Despite most of the detected variations being within noncoding regions, the frequency of coding variations was far higher than the general rate found throughout the genome. Among the various missense substitutions, specific substitutions detected in PRB1 and PRB2 genes were responsible for the introduction/abrogation of consensus sequences recognized by convertase enzymes that cleave the protein precursors. Overall, these changes that occurred during the recent human evolution might have generated novel functional features and/or different expression ratios among the various components of the salivary proteome. This may have influenced the homeostasis of the oral cavity environment, possibly conditioning the eating habits of modern humans. However, fixed nucleotide changes in modern humans represented only 7.3% of all the substitutions reported in this study, and no signs of evolutionary pressure or adaptative introgression from archaic hominins were found on the tested genes

Proposals (33–34) to conserve the name Poo-Astragalion and to conserve the name Poo-Astragaletum sesamei with a conserved type, and requests (5–7) for a binding decision on the name-giving taxa in the same names and the inversion of the name Poo-Astragaletum sesamei

The alliance name Poo-Astragalion has been widely used by Iberian phytosociologists for nearly fifty years to indicate a type of sheep pastures thriving on base-rich substrates. This alliance is currently classified in the order Poetalia bulbosae and class Poetea bulbosae. However, the revision of its original diagnosis highlights that this alliance name must be considered as an alternative name to the largely disused name Medicagini-Brachypodion distachyi. In order to stabilize the nomenclature, we propose the conservation of the traditionally used name Poo-Astragalion. On the other hand, the type association of the alliance (Poo-Astragaletum sesamei) turns out to be a superfluous name for another association neglected in the syntaxonomical literature, the Astragalo scorpioidis-Medicaginetum truncatulae. Hence, with the same objective of stabilizing the nomenclature, we propose the designation of a conserved neotype for the Poo-Astragaletum sesamei and the conservation of this name against the earlier heterotypic synonym in case of union of both associations. At the same time, we propose to complete the two names Poo-Astragalion and Poo-Astragaletum sesamei by selecting Poa bulbosa and Astragalus sesameus as the name-giving taxa, and to invert the name Poo-Astragaletum in accordance with its neotype (Astragalo sesamei-Poetum bulbosae). (33) Poo-Astragalion Rivas Goday et Ladero 1970: 165–169, nom. cons. propos. Typus: Poo-Astragaletum sesamei Rivas-Goday et Ladero 1970: 166–170 (holotypus). (≡) Medicagini-Brachypodion distachyi Rivas-Goday et Rivas-Martínez in Rivas Goday et Ladero 1970: 165–166 (alternative name) [original form: "Medicago-Brachypodion"] (34) Poo-Astragaletum sesamei Rivas-Goday et Ladero 1970: 166–170, nom. cons. et typus cons. propos. [original forms: "Poo-Astragaletum", "Poeto-Astragaletum sesamei"] Typus cons. propos.: neotypus hoc loco (see below). (=) Astragalo scorpioidis-Medicaginetum truncatulae Rivas Goday et Borja 1959 nom. corr. [original form: Astragalo scorpioidis-Medicaginetum tribuloidis nom. inept. (Rivas Goday and Borja 1959: 475, table 2)] Taxonomic reference: Euro+Med (2023). Syntaxonomic reference: Mucina et al. (2016). Abbreviations: EVC = EuroVegChecklist (Mucina et al. 2016); ICPN = 4th edition of the International Code of Phytosociological Nomenclature (Theurillat et al. 2021)

La valorizzazione del <<capitale umano>>.

La crisi che ha colpito tutte le aree del Paese non ha risparmiato il Mezzogiorno le cui difficoltà rischiano di risultare aggravate dalla crisi internazionale