Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health.

Animal models have shown that chronic stress increases cortisol, which contributes to overeating of highly palatable food, increased abdominal fat and lower cortisol reactivity. Few studies in humans have simultaneously examined these trajectories. We examined premenopausal women, either mothers of children with a diagnosis of an autism spectrum disorder (n = 92) or mothers of neurotypical children (n = 91). At baseline and 2-years, we assessed hair cortisol, metabolic health, and reward-based eating. We compared groups cross-sectionally and prospectively, accounting for BMI change. Caregivers, relative to controls, had lower cumulative hair cortisol at each time point, with no decreases over time. Caregivers also had stable levels of poor metabolic functioning and greater reward-based eating across both time points, and evidenced increased abdominal fat prospectively (all ps ≤.05), independent of change in BMI. This pattern of findings suggest that individuals under chronic stress, such as caregivers, would benefit from tailored interventions focusing on better regulation of stress and eating in tandem to prevent early onset of metabolic disease, regardless of weight status

Birefringence and transmission of an antireflection-coated sulfur-free cadmium selenide Wollaston prism at 30 K

We present a determination of the change with temperature and wavelength of the degree of birefringence of a cold (similar to 30K) Wollaston prism constructed from antireflection (AR)-coated sulfur-free cadmium selenide (CdSe). We compare the normalized birefringence for the material to that estimated by the Sellmeier-4 formula and to previously published measurements of a warm sample of sulfur-free CdSe. Finally, we measure the transmission as a function of wavelength

Correction: Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health.

[This corrects the article DOI: 10.1371/journal.pone.0216541.]

The Effects of Resistance Exercise Training on Quality of Life and Muscle Strength in Patients Undergoing Cancer Treatment: A Systematic Review

BACKGROUND: Breast cancer and prostate cancer are two of the most common cancers seen in females and males respectively worldwide. Treatments such as chemotherapy, radiation, and androgen deprivation therapy are essential to combat cancerous cells. However, the lasting side effects of these lifesaving treatments can impact an individual’s quality of life and muscle strength without appropriate intervention. While exercise has been shown to be beneficial for patients with cancer, there is limited understanding of the effects of resistance training when performed concurrently with medical interventions. PURPOSE: The purpose of this systematic review was to evaluate the impact of resistance training on quality of life and muscle strength in patients with breast and prostate cancer undergoing cancer treatment. METHODS: An academic search was conducted beginning August of 2020 and ending January 2021. The databases searched consisted of PubMed, EBSCO, Academic Search Ultimate, CINAHL, and Medline. This search yielded 18 randomized controlled trials, 11 pertaining to breast cancer and 7 pertaining to prostate cancer. RESULTS: All articles utilized a myriad of outcome measures to see changes in QoL and muscle strength. Studies evaluated resulted in either a positive short term or no improvement during the period of active intervention. However, some studies did note a lack of long-term significant differences in outcome measures between the intervention and control groups. Review of the literature did not reveal patient attrition was due to adverse effects of the intervention. CONCLUSION: Resistance training can be a safe and effective intervention to improve quality and life and muscle strength in patients undergoing cancer treatment. Current studies demonstrate the need for physical therapists to be included in the interdisciplinary approach from the moment of a cancer diagnosis.https://digitalcommons.misericordia.edu/research_posters2021/1044/thumbnail.jp

On the difference of torus geometry between hidden and non-hidden broad line active galactic nuclei

We present results from the fitting of infrared (IR) spectral energy distributions of 21 active galactic nuclei (AGN) with clumpy torus models. We compiled high spatial resolution ($\sim 0.3$--$0.7$ arcsec) mid-IR $N$-band spectroscopy, $Q$-band imaging and nuclear near- and mid-IR photometry from the literature. Combining these nuclear near- and mid-IR observations, far-IR photometry and clumpy torus models, enables us to put constraints on the torus properties and geometry. We divide the sample into three types according to the broad line region (BLR) properties; type-1s, type-2s with scattered or hidden broad line region (HBLR) previously observed, and type-2s without any published HBLR signature (NHBLR). Comparing the torus model parameters gives us the first quantitative torus geometrical view for each subgroup. We find that NHBLR AGN have smaller torus opening angles and larger covering factors than those of HBLR AGN. This suggests that the chance to observe scattered (polarized) flux from the BLR in NHBLR could be reduced by the dual effects of (a) less scattering medium due to the reduced scattering volume given the small torus opening angle and (b) the increased torus obscuration between the observer and the scattering region. These effects give a reasonable explanation for the lack of observed HBLR in some type-2 AGN.Comment: 13 pages, 5 figures, accepted for publication in Ap

Interviewer: 'Are women and girls ever responsible for the domestic violence they encounter?' Student: 'No, well, unless they did something really, really bad …'

Research shows the ‘gendered nature’ of domestic violence, with Women’s Aid (a UK-based charity) estimating that 1 in 4 women are affected (2014). This paper reports on a project - funded by Comic Relief, completed by Nottinghamshire Domestic Violence Forum (now known as Equation) and evaluated by Nottingham Trent University. The project adopts a Whole School Approach in seeking to prevent domestic violence. Students at three secondary schools attended between one and five blocks of work, and special events. There is evidence of positive developments - with young people showing understanding of domestic violence as well as the margins between healthy and unhealthy relationships. However, not all students could reply ‘never’ to the question of ‘are women and girls to blame for the domestic violence they experience?’, remarking that if the woman had done something ‘really, really bad’ then violence might be justified. We argue that young people’s uncertainties need to be situated within the gender-unequal socio-contexts of contemporary society, and further call for a WSA to domestic violence prevention to be a compulsory part of the UK national curriculum

The social value of a QALY : raising the bar or barring the raise?

Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England, there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether QALYs gained by different beneficiaries of health care should be weighted equally. The Social Value of a QALY (SVQ) project, reported in this paper, was commissioned to address these two questions. The results of SVQ were released during a time of considerable debate about the NICE threshold, and authors with differing perspectives have drawn on the SVQ results to support their cases. As these discussions continue, and given the selective use of results by those involved, it is important, therefore, not only to present a summary overview of SVQ, but also for those who conducted the research to contribute to the debate as to its implications for NICE. Discussion: The issue of the threshold was addressed in two ways: first, by combining, via a set of models, the current UK Value of a Prevented Fatality (used in transport policy) with data on fatality age, life expectancy and age-related quality of life; and, second, via a survey designed to test the feasibility of combining respondents’ answers to willingness to pay and health state utility questions to arrive at values of a QALY. Modelling resulted in values of £10,000-£70,000 per QALY. Via survey research, most methods of aggregating the data resulted in values of a QALY of £18,000-£40,000, although others resulted in implausibly high values. An additional survey, addressing the issue of weighting QALYs, used two methods, one indicating that QALYs should not be weighted and the other that greater weight could be given to QALYs gained by some groups. Summary: Although we conducted only a feasibility study and a modelling exercise, neither present compelling evidence for moving the NICE threshold up or down. Some preliminary evidence would indicate it could be moved up for some types of QALY and down for others. While many members of the public appear to be open to the possibility of using somewhat different QALY weights for different groups of beneficiaries, we do not yet have any secure evidence base for introducing such a system

Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds

In macrolecithal species, cryopreservation of the oocyte and zygote is not possible due to the large size and quantity of lipid deposited within the egg. For birds, this signifies that cryopreserving and regenerating a species from frozen cellular material are currently technically unfeasible. Diploid primordial germ cells (PGCs) are a potential means to freeze down the entire genome and reconstitute an avian species from frozen material. Here, we examine the use of genetically engineered (GE) sterile female layer chicken as surrogate hosts for the transplantation of cryopreserved avian PGCs from rare heritage breeds of chicken. We first amplified PGC numbers in culture before cryopreservation and subsequent transplantation into host GE embryos. We found that all hatched offspring from the chimera GE hens were derived from the donor rare heritage breed broiler PGCs, and using cryopreserved semen, we were able to produce pure offspring. Measurement of the mutation rate of PGCs in culture revealed that 2.7 × 10-10 de novo single-nucleotide variants (SNVs) were generated per cell division, which is comparable with other stem cell lineages. We also found that endogenous avian leukosis virus (ALV) retroviral insertions were not mobilized during in vitro propagation. Taken together, these results show that mutation rates are no higher than normal stem cells, essential if we are to conserve avian breeds. Thus, GE sterile avian surrogate hosts provide a viable platform to conserve and regenerate avian species using cryopreserved PGCs

A close look at the dwarf AGN of NGC 4395 : optical and near-IR integral field spectroscopy

Intermediate-mass black holes (103–105 M⊙) in the centre of dwarf galaxies are believed to be analogous to growing active galactic nuclei (AGNs) in the early Universe. Their characterization can provide insight about the early galaxies. We present optical and near-infrared integral field spectroscopy of the inner ∼50 pc of the dwarf galaxy NGC 4395, known to harbour an AGN. NGC 4395 is an ideal candidate to investigate the nature of dwarf AGN, as it is nearby (d ≈ 4.4 Mpc) enough to allow a close look at its nucleus. The optical data were obtained with the Gemini GMOS-IFU covering the 4500 –7300 Å spectral range at a spatial resolution of 10 pc. The J and K-band spectra were obtained with the Gemini NIFS at spatial resolutions of ∼5 pc. The gas kinematics show a compact, rotation disc component with a projected velocity amplitude of 25 kms−1. We estimate a mass of 7.7 × 105 M⊙ inside a radius of 10 pc. From the Hα broad-line component, we estimate the AGN bolometric luminosity as Lbol=(9.9±1.4)×1040 erg s−1 and a mass MBH=(2.5+1.0−0.8)×105 M⊙ for the central black hole. The mean surface mass densities for the ionized and molecular gas are in the ranges (1–2) M⊙ pc−2 and (1–4) × 10−3 M⊙ pc−2 and the average ratio between ionized and hot molecular gas masses is ∼500. The emission-line flux distributions reveal an elongated structure at 24 pc west of the nucleus, which is blueshifted relative to the systemic velocity of the galaxy by ≈30 kms−1. We speculate that this structure is originated by the accretion of a gas-rich small satellite or by a low-metallicity cosmic clou