406 research outputs found
Disordered Filaments Mediate the Fibrillogenesis of Type I Collagen in Solution
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How simple can a model of an empty viral capsid be? Charge distributions in viral capsids
We investigate and quantify salient features of the charge distributions on
viral capsids. Our analysis combines the experimentally determined capsid
geometry with simple models for ionization of amino acids, thus yielding the
detailed description of spatial distribution for positive and negative charge
across the capsid wall. The obtained data is processed in order to extract the
mean radii of distributions, surface charge densities and dipole moment
densities. The results are evaluated and examined in light of previously
proposed models of capsid charge distributions, which are shown to have to some
extent limited value when applied to real viruses.Comment: 10 pages, 10 figures; accepted for publication in Journal of
Biological Physic
The T2K Side Muon Range Detector
The T2K experiment is a long baseline neutrino oscillation experiment aiming
to observe the appearance of {\nu} e in a {\nu}{\mu} beam. The {\nu}{\mu} beam
is produced at the Japan Proton Accelerator Research Complex (J-PARC), observed
with the 295 km distant Super- Kamiokande Detector and monitored by a suite of
near detectors at 280m from the proton target. The near detectors include a
magnetized off-axis detector (ND280) which measures the un-oscillated neutrino
flux and neutrino cross sections. The present paper describes the outermost
component of ND280 which is a side muon range detector (SMRD) composed of
scintillation counters with embedded wavelength shifting fibers and Multi-Pixel
Photon Counter read-out. The components, performance and response of the SMRD
are presented.Comment: 13 pages, 19 figures v2: fixed several typos; fixed reference
Scintillator counters with WLS fiber/MPPC readout for the side muon range detector (SMRD)of the T2K experiment
The T2K neutrino experiment at J-PARC uses a set of near detectors to measure
the properties of an unoscillated neutrino beam and neutrino interaction
cross-sections. One of the sub-detectors of the near-detector complex, the side
muon range detector (SMRD), is described in the paper. The detector is designed
to help measure the neutrino energy spectrum, to identify background and to
calibrate the other detectors. The active elements of the SMRD consist of 0.7
cm thick extruded scintillator slabs inserted into air gaps of the UA1 magnet
yokes. The readout of each scintillator slab is provided through a single WLS
fiber embedded into a serpentine shaped groove. Two Hamamatsu multi-pixel
avalanche photodiodes (MPPC's) are coupled to both ends of the WLS fiber. This
design allows us to achieve a high MIP detection efficiency of greater than
99%. A light yield of 25-50 p.e./MIP, a time resolution of about 1 ns and a
spatial resolution along the slab better than 10 cm were obtained for the SMRD
counters.Comment: 7 pages, 4 figures; talk at TIPP09, March 12-17, Tsukuba, Japan; to
be published in the conference proceeding
Interaction patterns of methoprene-tolerant and germ cell-expressed Drosophila JH receptors suggest significant differences in their functioning
Methoprene-tolerant (Met) and germ cell-expressed (Gce) proteins were shown to be juvenile hormone (JH) receptors of Drosophila melanogaster with partially redundant functions. We raised the question of where the functional differentiation of paralogs comes from. Therefore, we tested Met and Gce interaction patterns with selected partners. In this study, we showed the ability of Gce and its C-terminus (GceC) to interact with 14-3-3 in the absence of JH. In contrast, Met or Met C-terminus (MetC) interactions with 14-3-3 were not observed. We also performed a detailed structural analysis of Met/Gce interactions with the nuclear receptor fushi tarazu factor-1 (Ftz-F1) ligand-binding domain. We showed that GceC comprising an Ftz-F1-binding site and full-length protein interacts with Ftz-F1. In contrast to Gce, only MetC (not full-length Met) can interact with Ftz-F1 in the absence of JH. We propose that the described differences result from the distinct tertiary structure and accessibility of binding sites in the full-length Met/Gce. Moreover, we hypothesize that each interacting partner can force disordered MetC and GceC to change the structure in a partner-specific manner. The observed interactions seem to determine the subcellular localization of Met/Gce by forcing their translocation between the nucleus and the cytoplasm, which may affect the activity of the proteins. The presented differences between Met and Gce can be crucial for their functional differentiation during D. melanogaster development and indicate Gce as a more universal and more active paralog. It is consistent with the theory indicating gce as an ancestor gene
First Measurement of Chiral Dynamics in \pi^- \gamma -> \pi^- \pi^- \pi^+
The COMPASS collaboration at CERN has investigated the \pi^- \gamma -> \pi^-
\pi^- \pi^+ reaction at center-of-momentum energy below five pion masses,
sqrt(s) < 5 m(\pi), embedded in the Primakoff reaction of 190 GeV pions
impinging on a lead target. Exchange of quasi-real photons is selected by
isolating the sharp Coulomb peak observed at smallest momentum transfers, t' <
0.001 (GeV/c)^2. Using partial-wave analysis techniques, the scattering
intensity of Coulomb production described in terms of chiral dynamics and its
dependence on the 3\pi-invariant mass m(3\pi) = sqrt(s) were extracted. The
absolute cross section was determined in seven bins of with an
overall precision of 20%. At leading order, the result is found to be in good
agreement with the prediction of chiral perturbation theory over the whole
energy range investigated.Comment: 10 pages, 5 figure
Measurement of the Collins and Sivers asymmetries on transversely polarised protons
The Collins and Sivers asymmetries for charged hadrons produced in deeply
inelastic scattering on transversely polarised protons have been extracted from
the data collected in 2007 with the CERN SPS muon beam tuned at 160 GeV/c. At
large values of the Bjorken x variable non-zero Collins asymmetries are
observed both for positive and negative hadrons while the Sivers asymmetry for
positive hadrons is slightly positive over almost all the measured x range.
These results nicely support the present theoretical interpretation of these
asymmetries, in terms of leading-twist quark distribution and fragmentation
functions.Comment: 9 Pages, 5 figure
The Spin-dependent Structure Function of the Proton g_1^p and a Test of the Bjorken Sum Rule
The inclusive double-spin asymmetry, A_1^p, has been measured at COMPASS in
deepinelastic polarised muon scattering off a large polarised NH3 target. The
data, collected in the year 2007, cover the range Q2 > 1 (GeV/c)^2, 0.004 < x <
0.7 and improve the statistical precision of g_1^p(x) by a factor of two in the
region x < 0.02. The new proton asymmetries are combined with those previously
published for the deuteron to extract the non-singlet spin-dependent structure
function g_1^NS(x,Q2). The isovector quark density, Delta_q_3(x,Q2), is
evaluated from a NLO QCD fit of g_1^NS. The first moment of Delta_q3 is in good
agreement with the value predicted by the Bjorken sum rule and corresponds to a
ratio of the axial and vector coupling constants g_A/g_V =
1.28+-0.07(stat)+-0.10(syst).Comment: 12 pages, 5 figure
Resonance Production and S-wave in at 190 GeV/c
The COMPASS collaboration has collected the currently largest data set on
diffractively produced final states using a negative pion
beam of 190 GeV/c momentum impinging on a stationary proton target. This data
set allows for a systematic partial-wave analysis in 100 bins of three-pion
mass, GeV/c , and in 11 bins of the reduced
four-momentum transfer squared, (GeV/c) . This
two-dimensional analysis offers sensitivity to genuine one-step resonance
production, i.e. the production of a state followed by its decay, as well as to
more complex dynamical effects in nonresonant production. In this paper,
we present detailed studies on selected partial waves with , , , , and . In these waves, we observe
the well-known ground-state mesons as well as a new narrow axial-vector meson
decaying into . In addition, we present the results
of a novel method to extract the amplitude of the subsystem with
in various partial waves from the
data. Evidence is found for correlation of the and
appearing as intermediate isobars in the decay of the known
and .Comment: 96 page
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