3,002 research outputs found

    Acute-Onset Central Serous Retinopathy After Immunization with COVID-19 mRNA Vaccine

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    Purpose We report the case of a 33-year-old male who presented with unilateral central serous retinopathy three days after the injection of a COVID-19 vaccine. Observations A 33-year-old healthy Hispanic male referred to the ophthalmology service due to blurry vision and metamorphopsia in the right eye without any flashes, floaters, eye redness or pain. The patient reported that 69 hours prior to presentation he received the first dose of the Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine. He denied any past ocular history or pertinent medical history. He does not take any medicines and denies stressful factors in his life. The clinical examination and imaging tests were consistent with central serous retinopathy that resolved in three months. Conclusions and importance This is the first report of an ocular complication potentially associated with a COVID-19 vaccination. Our case contributes information of a side effect potentially related to this new vaccine

    Raman threshold for nth-order cascade Raman amplification

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    We study theoretically and experimentally Raman threshold for 1, 2, ... , n orders Stokes in a free running configuration. Using alternative way to solve the differential coupled equations that describe the stimulate Raman scattering, we find simple mathematical expressions that allow calculating the necessary pumping power to obtain Raman threshold for nth-order Stokes and the maximum output power available in each Stokes. The theoretical calculations coincide with the results obtained experimentally

    Planetary nebulae abundances and stellar evolution II

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    Context: In recent years mid- and far infrared spectra of planetary nebulae have been analysed and lead to more accurate abundances. It may be expected that these better abundances lead to a better understanding of the evolution of these objects. Aims: The observed abundances in planetary nebulae are compared to those predicted by the models of Karakas (2003) in order to predict the progenitor masses of the various PNe used. The morphology of the PNe is included in the comparison. Since the central stars play an important role in the evolution, it is expected that this comparison will yield additional information about them. Methods: First the nitrogen/oxygen ratio is discussed with relation to the helium/hydrogen ratio. The progenitor mass for each PNe can be found by a comparison with the models of Karakas. Then the present luminosity of the central stars is determined in two ways: first by computing the central star effective temperature and radius, and second by computing the nebular luminosity from the hydrogen and helium lines. This luminosity is also a function of the initial mass so that these two values of initial mass can be compared. Results: Six of the seven bipolar nebulae can be identified as descendants of high mass stars (4Msun - 6Msun) while the seventh is ambiguous. Most of the elliptical PNe have central stars which descend from low initial mass stars, although there are a few caveats which are discussed. There is no observational evidence for a higher mass for central stars which have a high carbon/oxygen ratio. The evidence provided by the abundance comparison with the models of Karakas is consistent with the HR diagram to which it is compared. In the course of this discussion it is shown how `optically thin' nebulae can be separated from those which are 'optically thick'.Comment: 12 pages, 4 tables, 4 figures. Accepted for publication in A&

    Novel use of plga microspheres to create an animal model of glaucoma with progressive neuroretinal degeneration

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    Progressive degeneration of neuroretinal tissue with maintained elevated intraocular pressure (IOP) to simulate chronic glaucoma was produced by intracameral injections of poly (lactic-co-glycolic) acid (PLGA) microspheres (Ms) in rat eyes. The right eye of 39 rats received different sizes of PLGA-Ms (2 ”L suspension; 10% w/v): 14 with 38–20 ”m Ms (Ms38/20 model) and 25 with 20–10 ”m particles (Ms20/10 model). This novel glaucoma animal model was compared to the episcleral vein sclerosis (EPI) model (25 eyes). Injections were performed at baseline, two, four and six weeks. Clinical signs, IOP, retina and optic nerve thicknesses (using in vivo optical coherence tomography; OCT), and histological studies were performed. An IOP increment was observed in all three groups, however, the values obtained from the PLGA-Ms injection resulted lower with a better preservation of the ocular surface. In fact, the injection of Ms20/10 created a gentler, more progressive, and more sustained increase in IOP. This IOP alteration was correlated with a significant decrease in most OCT parameters and in histological ganglion-cell count for the three conditions throughout the eight-week follow-up. In all cases, progressive degeneration of the retina, retinal ganglion cells and optic nerve, simulating chronic glaucoma, was detected by OCT and corroborated by histological study. Results showed an alternative glaucoma model to the well-known episcleral vein model, which was simpler to perform, more reproducible and easier to monitor in vivo

    Monitoring new long-lasting intravitreal formulation for glaucoma with vitreous images using optical coherence tomography

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    Intravitreal injection is the gold standard therapeutic option for posterior segment patholo-gies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF

    Scholar-activists in an expanding European food sovereignty movement

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    This article analyzes the roles, relations, and positions of scholar-activists in the European food sovereignty movement. In doing so, we document, make visible and question the political dimensions of researchers' participation in the movement. We argue that scholar-activists are part of the movement, but are distinct from the affected constituencies, put in place to ensure adequate representation of key movement actors. This is because scholar-activists lack a collective identity, have no processes to formulate collective demands, and no mechanisms for inter-researcher and researchers-movement communication. We reflect on whether and how scholar-activists could organize, and discuss possible pathways for a more cohesive and stronger researcher engagement in the movement.</p

    Bounds on charged higgs boson in the 2HDM type III from Tevatron

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    We consider the Two Higgs Doublet Model (2HDM) of type III which leads to Flavour Changing Neutral Currents (FCNC) at tree level. In the framework of this model we can use an appropriate form of the Yukawa Lagrangian that makes the type II model limit of the general type III couplings apparent. This way is useful in order to compare with the experimental data which is model dependent. The analytical expressions of the partial width Γ(t→H+b)\Gamma (t \to H^+ b) are derived and we compare with the data available at this energy range. We examine the limits on the new parameters λij\lambda_{ij} from the validness of perturbation theory.Comment: 14 pages, 4 figures, Universidad Nacional de Colombia. typos correcte
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