Association between sleep-disordered breathing and breast cancer aggressiveness

Background Sleep-disordered breathing (SDB) has been associated with cancer aggressiveness, but studies focused on specific tumors are lacking. In this pilot study we investigated whether SDB is associated with breast cancer (BC) aggressiveness. Methods 83 consecutive women <65 years diagnosed with primary BC underwent a home respiratory polygraphy. Markers of SDB severity included the apnea-hypopnea index (AHI) and the 4% oxygen desaturation index (ODI4). The Ki67 proliferation index, lack of hormone receptors (HR-), Nottingham Histological Grade (NHG), and tumor stage were used as markers of BC aggressiveness. The association between SDB and molecular subtypes of BC was also assessed. Results The mean (SD) age was 48.8 (8.8) years and body mass index was 27.4 (5.4) Kg/m2. 42 women (50.6%) were post-menopausal. The median (IQR) AHI was 5.1 (2–9.4), and ODI4 was 1.5 (0.5–5.8). The median (IQR) AHI did not differ between the groups with Ki67>28% and Ki6728% and Ki67<29% (51.2% vs 52.3%, p = 0.90), HR- and HR+ (58.3% vs 49.1%, p = 0.47), NHG categories (p = 0.89), different tumor stages (p = 0.71), or molecular subtypes (p = 0.73). These results did not change when the ODI4 was used instead of the AHI. Conclusion Our results do not support an association between the presence or severity of SDB and BC aggressiveness.Asociación de Neumología y Cirugía Torácica del Sur (NEUMOSUR) 1/201

Gestión documental en un grupo de investigación biomédica

In order to systematize the processes and improve the quality of the activities of a biomedical research group, a research, development and innovation (RDI) management system based on the Spanish norm UNE 166002:2006 has been designed and implemented. We describe the experience and results obtained during the selection and adaptation of the OpenKM document management system platform as a useful means for research group management. The usefulness of this type of platform for this purpose is demonstrated, which could be exported to other research groups

Semen Modulates the Expression of NGF, ABHD2, VCAN, and CTEN in the Reproductive Tract of Female Rabbits

Semen changes the gene expression in endometrial and oviductal tissues modulating important processes for reproduction. We tested the hypothesis that mating and/or sperm-free seminal plasma deposition in the reproductive tract affect the expression of genes associated with sperm-lining epithelium interactions, ovulation, and pre-implantation effects (nerve growth factor, NGF; α/β hydrolase domain-containing protein 2, ABHD2; C-terminal tensin-like protein, CTEN or TNS4; and versican, VCAN) in the period 10-72 h post-mating. In Experiment 1, does (n = 9) were treated with gonadotropin-releasing hormone (GnRH) (control), GnRH-stimulated, and vaginally infused with sperm-free seminal plasma (SP-AI), or GnRH-stimulated and naturally mated (NM). In Experiment 2, does (n = 15) were GnRH-stimulated and naturally mated. Samples were retrieved from the internal reproductive tracts (cervix-to-infundibulum) 20 h post-treatment (Experiment 1) or sequentially collected at 10, 24, 36, 68, or 72 h post-mating (Experiment 2, 3 does/period). All samples were processed for gene expression analysis by quantitative PCR. Data showed an upregulation of endometrial CTEN and NGF by NM, but not by SP-AI. The findings suggest that the NGF gene affects the reproductive tract of the doe during ovulation and beyond, influencing the maternal environment during early embryonic development

Semen Modulates the Expression of NGF, ABHD2, VCAN, and CTEN in the Reproductive Tract of Female Rabbits

Semen changes the gene expression in endometrial and oviductal tissues modulating important processes for reproduction. We tested the hypothesis that mating and/or sperm-free seminal plasma deposition in the reproductive tract affect the expression of genes associated with sperm-lining epithelium interactions, ovulation, and pre-implantation effects (nerve growth factor, NGF; α/β hydrolase domain-containing protein 2, ABHD2; C-terminal tensin-like protein, CTEN or TNS4; and versican, VCAN) in the period 10-72 h post-mating. In Experiment 1, does (n = 9) were treated with gonadotropin-releasing hormone (GnRH) (control), GnRH-stimulated, and vaginally infused with sperm-free seminal plasma (SP-AI), or GnRH-stimulated and naturally mated (NM). In Experiment 2, does (n = 15) were GnRH-stimulated and naturally mated. Samples were retrieved from the internal reproductive tracts (cervix-to-infundibulum) 20 h post-treatment (Experiment 1) or sequentially collected at 10, 24, 36, 68, or 72 h post-mating (Experiment 2, 3 does/period). All samples were processed for gene expression analysis by quantitative PCR. Data showed an upregulation of endometrial CTEN and NGF by NM, but not by SP-AI. The findings suggest that the NGF gene affects the reproductive tract of the doe during ovulation and beyond, influencing the maternal environment during early embryonic development

Semen Modulates the Expression of NGF, ABHD2, VCAN, and CTEN in the Reproductive Tract of Female Rabbits

Semen changes the gene expression in endometrial and oviductal tissues modulating important processes for reproduction. We tested the hypothesis that mating and/or sperm-free seminal plasma deposition in the reproductive tract affect the expression of genes associated with sperm-lining epithelium interactions, ovulation, and pre-implantation effects (nerve growth factor, NGF; α/β hydrolase domain-containing protein 2, ABHD2; C-terminal tensin-like protein, CTEN or TNS4; and versican, VCAN) in the period 10-72 h post-mating. In Experiment 1, does (n = 9) were treated with gonadotropin-releasing hormone (GnRH) (control), GnRH-stimulated, and vaginally infused with sperm-free seminal plasma (SP-AI), or GnRH-stimulated and naturally mated (NM). In Experiment 2, does (n = 15) were GnRH-stimulated and naturally mated. Samples were retrieved from the internal reproductive tracts (cervix-to-infundibulum) 20 h post-treatment (Experiment 1) or sequentially collected at 10, 24, 36, 68, or 72 h post-mating (Experiment 2, 3 does/period). All samples were processed for gene expression analysis by quantitative PCR. Data showed an upregulation of endometrial CTEN and NGF by NM, but not by SP-AI. The findings suggest that the NGF gene affects the reproductive tract of the doe during ovulation and beyond, influencing the maternal environment during early embryonic development

Diseño e implementación de Software para el programa de fortalecimiento de la Calidad Educativa para reducir errores contables en la coordinación del área de Ingenierías de la Universidad Autónoma de Zacatecas

The purpose of this research is to design and implement software which is used by the educational quality strengthening program. And this is able to reduce accounting errors in the Coordination of the Engineering Area of the Universidad Autonoma de Zacatecas Francisco García Salinas. The Software allows to improve the processes of validation of purchases, payments and quality management in both materials, services and academic infrastructure, and simultaneously issue both academic and financial reports, and thus have a better internal control in accounting movements that Requires the area. With the implementation The Software will determine with high precision the academic, fiscal and accounting movements required by the Engineering Department of the UAZ, to effectively transparent Federal Projects.El propósito de esta investigación es diseñar e implementar un software el cual sea utilizado por el programa de fortalecimiento de la calidad educativa.&nbsp; Y este sea capaz de reducir errores contables en la Coordinación del Área de Ingenierías de la Universidad Autónoma de Zacatecas Francisco García Salinas. El Software permite mejorar los procesos de validación de compras, pagos y gestión de la calidad tanto en materiales, servicios e infraestructura académica, y de manera simultánea emita reportes tanto académicos como financieros, y de esta manera tener un mejor control interno en movimientos contables del área. Con la implementación del Software se determinará con alta precisión los movimientos académicos, fiscales y contables que requiere el Área de Ingenierías de la UAZ, para transparentar de forma eficaz los Proyectos Federales

Diseño de un sistema informático para el seguimiento presupuestal en la unidad académica de Ingeniería Eléctrica de la Universidad Autónoma de Zacatecas

Public institutions in Mexico by regulation must develop a short-term management instrument Annual Work Plan, a set of activities and budget that each area or department has to exercise is described, this planning has to be followed up to comply to the goals and objectives. The main benefits that will be obtained are the following: to have a global panorama that allows decisions to be made to meet the short and long term objectives, relate activities to a budget that allows to visualize the cost of each activity, prioritize activities based on a budget, direct the activity towards customer satisfaction. Within the Academic Unit of Electrical Engineering, it prepares its Annual Work Program in the rudimentary way in EXCEL, hence the need to design and implement a computer system that allows the development of the annual planning of activities.Las instituciones públicas en México por normatividad deben elaborar un instrumento de gestión a corto plazo Plan de Trabajo Anual, se describe un conjunto de actividades y presupuesto que tiene que ejercer cada área o departamento, está planeación se tiene que dar un seguimiento para dar un cumplimento a las metas y objetivos. Los beneficios principales que se obtendrán son los siguientes: tener un panorama global que permite tomar decisiones para el cumplimiento de los objetivos a corto y largo plazo, relacionar actividades con un presupuesto que permita visualizar el costo de cada actividad, priorizar actividades en función de un presupuesto, dirigir la actividad hacia la satisfacción del cliente. Dentro de la Unidad Académica de Ingeniería Eléctrica de la Universidad Autónoma de Zacatecas elabora su Programa de Trabajo Anual de la forma rudimentaria en EXCEL de ahí la necesidad de diseñar e implementar un sistema informático que permita la elaboración de la planeación anual de las actividades

Improved thermal management in HKUST-1 composites upon graphite flakes incorporation: Hydrogen adsorption properties

HKUST-1-based composites have been synthesized through the incorporation of synthetic graphite flakes in the MOF synthesis media. The presence of flakes gives rise to high quality HKUST-1 crystals, combining different morphologies (octahedral-shape crystals, cauliflower-shape crystals and truncated pyramids). The incorporation of graphite in the composites improves the structural stability of the embedded nanocrystals upon a conforming step at 377 kg/cm2 (0.5 tons), with limited structural damage (below 10% BET surface area reduction as compared to the 40% observed for pure HKUST-1). Furthermore, composites exhibit a significant improvement in thermal management, associated with the excellent thermal and electrical properties of the graphite microdomains incorporated. The improved stability of the composites is also reflected in the adsorption performance for hydrogen at atmospheric pressure and cryogenic temperatures, with a significant preservation of the adsorption properties (gravimetric capacity, <15% decrease vs powders) in the monoliths containing graphite. The best adsorption performance is achieved with sample HKUST-1@10GF, in monolithic form, with a volumetric excess uptake at 0.1 MPa and −195 °C close to 18.7 g/L. This value is among the best described in the literature for monolithic MOFs under similar adsorption conditions.Authors would like to acknowledge financial support from Ministerio de Ciencia e Innovación (Project PID2019-108453GB-C21), Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana (project CIPROM/2021/022) and European Union: Horizon Europe (project MOST-H2; Grant agreement no. 101058547). M. R.-C. and M. M. thank the project PID2019-104379RB-C22 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe” for financial support. Authors would like to thank Imerys Graphite & Carbon Ltd. (Dr. Raffaele Gilardi) for the supply of the graphite flakes

Hybrid organometallo-silica catalysts for sustainable visible-light promoted olefin isomerization

The use of visible light as a clean and affordable reagent has turned photocatalysis into a green and powerful tool in synthetic chemistry. However, most of these photocatalytic processes are carried out under homogeneous conditions, which requires expensive catalysts that are difficult to recover and recycle. One way to overcome this problem is to incorporate the visible-active species into porous solid matrices. However, integrating these active species into the matrix to achieve a stable and active heterogeneous photocatalyst is not easy, and has usually been done by post-synthetic strategies. Herein, we describe the use of the highly emissive cyclometalated complex [Ir(dfppy)2(dasipy)]PF6 as a building block for the in-situ synthesis of four different silica-based heterogeneous photocatalysts, and a related post-synthetic grafted material. These highly stable materials have been assessed in the energy transfer photo-isomerization reaction of trans- to cis-stilbene under blue light and mild conditions; showing not only high isomerization yields (ca. 80 %), but also easy recovery and excellent recyclability (up to 100 % after 7 cycles).This work was supported by the Spanish MCIN/AIE/10.13039/501100011033, the ‘‘ERDF A way of making Europe’’, the ‘‘European Union’’ (projects PID2019-109742GB-I00 and PID2021-128761OB-C21), Gobierno de la Rioja (Project FORTALECE 2021/01) and Generalitat Valenciana (Regional Project AICO/2021/037 - Conselleria d’Innovació, Universitats, Ciència i Societat Digital)

¿Ha sido estable el crecimiento en América Latina?

In this paper, we characterize economic growth among a sample of Latin American countries by means of two panel stationarity tests: those of Carrion-i-Silvestre et al. (2005) and Hadri and Rao (2008). The latter has a number of advantages compared to the first, in that it allows us to control (i) non-observed heterogeneity, both in its form and dates of possible structural breaks in the tendency function; (ii) the cross-section dependency among the units with panel bootstrap methods; and (iii) serial correlation in the errors. Our results show that economic growth in most Latin American countries has slowed significantly following structural breaks. The main implication of this finding is the inability of countries to recover from negative impacts and thus return to the original path of balanced growth.En este trabajo caracterizamos el crecimiento económico de una muestra de países de América Latina mediante dos pruebas de estacionariedad en panel la de Carrion-i-Silvestre et al. (2005) y la de Hadri y Rao (2008), esta última tiene algunas ventajas con respecto a la primera ya que permite controlar: (i) la heterogeneidad no observada tanto en su forma como en la fecha de los posibles quiebres estructurales en la función de tendencia, (ii) la dependencia de sección cruzada entre las unidades con métodos de bootstrapping de panel, y (iii) la correlación serial en los errores. Los resultados evidencian que la mayoría de los países de América Latina presentan notables desaceleraciones en su crecimiento económico en los periodos posteriores a las rupturas estructurales cuya principal implicación es la incapacidad de recuperarse de los impactos negativos y por ende, de regresar a la senda de crecimiento equilibrado inicial.