New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P <5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.Peer reviewe

Construction of compact step down voltage converter in terms of EMC

At the present there is a wide variety of step down converters on market. Due to differences in converter’s prices, parameters and principles of function, it is not that easy to choose a proper one suitable for a concrete application. Moreover, really strict standards are applied in order to achieve high EMC compatibility between different devices. This article tries to show the possibilities of a really low-end DC/DC converter controller AOZ 1284. The set of measurements according to the set specifications and standard EN 61000-6-3 are presented together. Moreover, measures needed to comply to limits of the standard are shown along with it's results

The possibilities of using Bluetooth to control the lift platform used for people with reduced mobility

The paper presents the design of a control unit and an application for Android OS, which will use the Bluetooth transmission to control vertical lifting devices for people with reduced mobility. The theoretical part consists of the description of the Android Studio development environment, the description of data transfer using Bluetooth, and the estimation of the reduction in platform production costs and the competitiveness of these products on the global market. From the theoretical part there is a practical part, which deals with the development of a new control unit for lifting equipment ZP5, using mobile application and introducing these technologies into the production process. The practical part also describes the effect of these adjustments on increasing the production and sale of vertical staircase platforms with a view to use for other products for people with reduced mobility

Intensity of EMF generated by electronic safety system devices

As the importance of wireless networks based on radio frequencies increases in time, a space for discussion on harmfulness of the electromagnetic radiation has occurred. On the one hand there are studies showing that a direct influence of non-ionizing electromagnetic waves on the human organism was not confirmed until a certain intensity has been reached. On the other hand, critical voices appear, warning that even low intensities of non-ionizing electromagnetic fields are harmful to the human body, if it is exposed to the radiation for a prolonged time. The authors of this paper have no ambition to resolve this dispute. However, they provide data on the intensity of the electromagnetic fields generated by several components of electronic security system that are operating on the basis of the wireless network. The data have been gained in a specialized workplace and will allow the reader to imagine how intensive the radio signals generated by the battery-operated devices are compared to the current hygienic and technical limits

Remote controlled gate controller using a GSM network and Arduino platform

Most remote controllers for entrance gates operate on free frequencies 433 or 868 MHz. However, this technology limits the user comfort, as it is usually not common that bi-directional communication is established. A higher comfort of controlling the entrance gates can be achieved by employing the GSM network for transmission of commands and messages between the gate controller and the user. In this case, only a conventional GSM cellular phone is needed to control the gate. A description of such a controller based on the GSM module and Arduino controller is provided in this paper

RFID reader immunity test against electrostatic discharge

This paper provides a description of an immunity test against the electrostatic discharge according to the standard EN 61000-4-2 that was applied to an RFID reader. The RFID reader was primarily developed for access systems, employing the on-board recognition of the RFID tags. The results obtained by the test are described hereby as well as the discussion on the security of this solution. The results of this experiment are beneficial for the developers of RFID devices, as these devices are endangered by the electrostatic discharge brought by their users. The hereby described results also shown a security hole in a simple access system based on the RFID technology. Details can be found in the paper

Self-organizing migrating algorithm with clustering-aided migration

This paper proposes a novel migration strategy for Self-organizing Migrating Algorithm (SOMA), which combines advantages of the explorative All-To-Random migration with new exploitation focused All-To-Cluster-Leaders strategy. The main goal of this novel innovation to SOMA is to deliver competitive results, not only on the latest CEC 2020 benchmark set on a single objective bound-constrained numerical optimization. The proposed algorithm variant was titled SOMA-CL, and it has manifested notable potential in such demanding challenges. The results of the proposed algorithm were compared and tested for statistical significance against two other SOMA variants. © 2020 ACM