Nanomechanical effects in an Andreev quantum dot

We consider a quantum dot with mechanical degrees of freedom which is coupled to superconducting electrodes. A Josephson current is generated by applying a phase difference. In the absence of coupling to vibrations, this setup was previously proposed as a detector of magnetic flux and we wish here to address the effect of the phonon coupling to this detection scheme. We compute the charge on the quantum dot and determine its dependence on the phase difference in the presence of phonon coupling and Coulomb interaction. This allows to identify regions in parameter space with the highest charge to phase sensitivity, which are relevant for flux detection. Further insight about the interplay of such couplings and subsequent entanglement properties between electron and phonon degrees of freedom are gained by computing the von Neuman entropy.Comment: 9 pages, 7 figures; minor corretion

The identification of histidine ligands to cytochrome a in cytochrome c oxidase

A histidine auxotroph of Saccharomyces cerevisiae has been used to metabolically incorporate [1,3-15N2] histidine into yeast cytochrome c oxidase. Electron nuclear double resonance (ENDOR) spectroscopy of cytochrome a in the [15N]histidine-substituted enzyme reveals an ENDOR signal which can be assigned to hyperfine coupling of a histidine 15N with the low-spin heme, thereby unambiguously identifying histidine as an axial ligand to this cytochrome. Comparison of this result with similar ENDOR data obtained on two 15N-substituted bisimidazole model compounds, metmyoglobin-[15N]imidazole and bis[15N]imidazole tetraphenyl porphyrin, provides strong evidence for bisimidazole coordination in cytochrome a

Accidental Father-to-Son HIV-1 Transmission During the Seroconversion Period

A 4-year-old child born to an HIV-1 seronegative mother was diagnosed with HIV-1, the main risk factor being transmission from the child's father who was seroconverting at the time of the child's birth. In the context of a forensic investigation, we aimed to identify the source of infection of the child and date of the transmission event. Samples were collected from the father and child at two time points about 4 years after the child's birth. Partial segments of three HIV-1 genes (gag, pol, and env) were sequenced and maximum likelihood (ML) and Bayesian methods were used to determine direction and estimate date of transmission. Neutralizing antibodies were determined using a single cycle assay. Bayesian trees displayed a paraphyletic-monophyletic topology in all three genomic regions, with the father's host label at the root, which is consistent with father-to-son transmission. ML trees found similar topologies in gag and pol and a monophyletic-monophyletic topology in env. Analysis of the time of the most recent common ancestor of each HIV-1 gene population indicated that the child was infected shortly after the father. Consistent with the infection history, both father and son developed broad and potent HIV-specific neutralizing antibody responses. In conclusion, the direction of transmission implicated the father as the source of transmission. Transmission occurred during the seroconversion period when the father was unaware of the infection and was likely accidental. This case shows how genetic, phylogenetic, and serological data can contribute for the forensic investigation of HIV transmission.info:eu-repo/semantics/publishedVersio

Plastid redox state and sugars: Interactive regulators of nuclear-encoded photosynthetic gene expression

Feedback regulation of photosynthesis by carbon metabolites has long been recognized, but the underlying cellular mechanisms that control this process remain unclear. By using an Arabidopsis cell culture, we show that a block in photosynthetic electron flux prevents the increase in transcript levels of chlorophyll a/b-binding protein and the small subunit of Rubisco that typically occurs when intracellular sugar levels are depleted. In contrast, the expression of the nitrate reductase gene, which is induced by sugars, is not affected. These findings were confirmed in planta by using Arabidopsis carrying the firefly luciferase reporter gene fused to the plastocyanin and chlorophyll a/b-binding protein 2 gene promoters. Transcription from both promoters increases on carbohydrate depletion. Blocking photosynthetic electron transport with 3-(3',4'-dichlorophenyl)-1,1'-dimethylurea prevents this increase in transcription. We conclude that plastid-derived redox signaling can override the sugar-regulated expression of nuclear-encoded photosynthetic genes. In the sugar-response mutant, sucrose uncoupled 6 (sun6), plastocyanin-firefly luciferase transcription actually increases in response to exogenous sucrose rather than decreasing as in the wild type. Interestingly, plastid-derived redox signals do not influence this defective pattern of sugar-regulated gene expression in the sun6 mutant. A model, which invokes a positive inducer originating from the photosynthetic electron transport chain, is proposed to explain the nature of the plastid-derived signal

Role of functionally dominant species in varying environmental regimes: evidence for the performance-enhancing effect of biodiversity

Background Theory suggests that biodiversity can act as a buffer against disturbances and environmental variability via two major mechanisms: Firstly, a stabilising effect by decreasing the temporal variance in ecosystem functioning due to compensatory processes; and secondly, a performance enhancing effect by raising the level of community response through the selection of better performing species. Empirical evidence for the stabilizing effect of biodiversity is readily available, whereas experimental confirmation of the performance-enhancing effect of biodiversity is sparse. Results Here, we test the effect of different environmental regimes (constant versus fluctuating temperature) on bacterial biodiversity-ecosystem functioning relations. We show that positive effects of species richness on ecosystem functioning are enhanced by stronger temperature fluctuations due to the increased performance of individual species. Conclusions Our results provide evidence for the performance enhancing effect and suggest that selection towards functionally dominant species is likely to benefit the maintenance of ecosystem functioning under more variable conditions

Supersoft Supersymmetry is Super-Safe

We show that supersymmetric models with a large Dirac gluino mass can evade much of the jets plus missing energy searches at LHC. Dirac gaugino masses arise from "supersoft" operators that lead to finite one-loop suppressed contributions to the scalar masses. A little hierarchy between the Dirac gluino mass 5 - 10 times heavier than the squark masses is automatic and technically natural, in stark contrast to supersymmetric models with Majorana gaugino masses. At the LHC, colored sparticle production is suppressed not only by the absence of gluino pair (or associated) production, but also because several of the largest squark pair production channels are suppressed or absent. We recast the null results from the present jets plus missing energy searches at LHC for supersymmetry onto a supersoft supersymmetric simplified model (SSSM). Assuming a massless LSP, we find the strongest bounds are: 748 GeV from a 2j + MET search at ATLAS (4.7 fb^{-1}), and 684 GeV from a combined jets plus missing energy search using $\alpha_T$ at CMS (1.1 fb^{-1}). In the absence of a future observation, we estimate the bounds on the squark masses to improve only modestly with increased luminosity. We also briefly consider the further weakening in the bounds as the LSP mass is increased.Comment: 13 pages, 8 figure

Influence of spin filtering and spin mixing on the subgap structure of I-V characteristics in superconducting quantum point contact

The effect of spin filtering and spin mixing on the dc electric current for voltage biased magnetic quantum point contact with superconducting leads is theoretically studied. The I-V characteristics are calculated for the whole range of spin filtering and spin mixing parameters. It is found that with increasing of spin filtering the subharmonic step structure of the dc electric current, typical for low-transparency junction and junction without considerable spin filtering qualitatively changes. In the lower voltage region and for small enough spin mixing the peak structure arises. When spin mixing increases the peak subgap structure evolves to the step structure. The voltages where subharmonic gap features are located are found to be sensitive to the value of spin filtering. The positions of peaks and steps are calculated analytically and the evolution of the subgap structure from well-known tunnel limit to the large spin filtering case is explained in terms of multiple Andreev reflection (MAR) processes. In particular, it is found that for large spin filtering the subgap feature at $eV_k$ arises from $2k^{\rm th}$ and $(2k\pm 1)^{\rm th}$ order MAR processes, while in the tunnel limit the step at $eV_n$ is known to result from $n^{\rm th}$ order MAR process.Comment: 9 pages, 3 figure

Stretching single polysaccharide molecules using AFM: A potential method for the investigation of the intermolecular uronate distribution of alginate?

Illustrative examples of the way in which the molecular force-extension behaviour of polysaccharides is governed by the nature of the linkage between their constituent pyranose rings are presented for a series of standard homopolymers. These results agree with previously proposed general hypotheses regarding the possibility of generating force-induced conformational transitions, and with the predictions of a model in which the inter-conversion of pyranose conformers is assumed to be an equilibrium process on the timescale of the molecular stretching. Subsequently, we investigate the potential of the technique in the characterisation of co-polymeric polysaccharides in which the nature of the glycan linkages is different between the two distinct residue types. Specifically, we explore the possibility that the ratio of mannuronic acid (M) to guluronic acid (G) in alginate chains will be reflected in their single molecule stretching behaviour, owing to their contrasting equatorial and axial linkages. Furthermore, as the technique described interrogates the sample one polymer at a time we outline the promise of, and the obstacles to, obtaining a new level of characterisation using this methodology where differences observed in the single molecule stretching curves obtained from single alginate samples reflectsomething of the real intermolecular distribution of the M / G ratio

A one-channel conductor in an ohmic environment: mapping to a TLL and full counting statistics

It is shown that a one-channel mesoscopic conductor in an ohmic environment can be mapped to the problem of a backscattering impurity in a Tomonaga-Luttinger liquid (TLL). This allows to determine non perturbatively the effect of the environment on $I-V$ curves, and to find an exact relationship between dynamic Coulomb blockade and shot noise. We investigate critically how this relationship compares to recent proposals in the literature. The full counting statistics is determined at zero temperature.Comment: 5 pages, 2 figures, shortened version for publication in Phys. Rev. Let

Detection of finite frequency current moments with a dissipative resonant circuit

We consider the measurement of higher current moments with a dissipative resonant circuit, which is coupled inductively to a mesoscopic device in the coherent regime. Information about the higher current moments is coded in the histograms of the charge on the capacitor plates of the resonant circuit. Dissipation is included via the Caldeira-Leggett model, and it is essential to include it in order for the charge fluctuations (or the measured noise) to remain finite. We identify which combination of current correlators enter the measurement of the third moment. The latter remains stable for zero damping. Results are illustrated briefly for a quantum point contact