Multimodality in VR: A survey

Virtual reality (VR) is rapidly growing, with the potential to change the way we create and consume content. In VR, users integrate multimodal sensory information they receive, to create a unified perception of the virtual world. In this survey, we review the body of work addressing multimodality in VR, and its role and benefits in user experience, together with different applications that leverage multimodality in many disciplines. These works thus encompass several fields of research, and demonstrate that multimodality plays a fundamental role in VR; enhancing the experience, improving overall performance, and yielding unprecedented abilities in skill and knowledge transfer

Fijación de precios en el mercado farmacéutico : Un análisis descriptivo en tiempos de pandemia

La propagación del virus SARS-CoV-2, la consecuente pandemia de COVID-19 y las medidas de confinamiento y distanciamiento social implementadas como respuesta a este fenómeno durante los primeros meses del año 2020 han dado lugar una serie de efectos económicos (OCDE, 2020) y financieros (De Vito y Gómez, 2020) en todos los rincones del planeta.Aún no se conoce con precisión en qué consisten dichos efectos, pero es probable que muchos de ellos se develen con el transcurso del tiempo.Fil: Meller, Leandro Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; ArgentinaFil: Gutierrez, Emiliano Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Económicas y Sociales del Sur. Universidad Nacional del Sur. Departamento de Economía. Instituto de Investigaciones Económicas y Sociales del Sur; ArgentinaFil: Domínguez, Diego Leandro. Universidad Nacional del Sur. Departamento de Ciencias de la Administración; Argentin

Systematic evaluation of cryptic freshwater snails from central Chile, including the enigmatic Littoridina santiagensis (Gastropoda, Truncatelloidea)

In 1944, Walter Biese described Littoridina santiagensis (Cochliopidae) from Estero Dehesa based exclusively on external shell features and a second allopatric population in Yeso Spring three years later. Different samplings carried out since 2011 in the type locality have only provided specimens of the morphologically similar invasive mudsnail Potamopyrgus antipodarum (Tateidae) raising doubts about the identity of the species. The recent finding of two snail morphotypes in Yeso Spring, a thick shelled form congruent with type specimens of L. santiagensis and a slender one morphologically associable to P. antipodarum, allowed comparative studies, including the taxonomic analysis of additional populations with similar shell morphology occurring in central Chile. A DNA barcoding (COI) approach identified the slender form from Yeso Spring in Maipo Basin and a second population from the contiguous Rapel Basin indeed as the invasive P. antipodarum, however, L. santiagensis was recovered among species of Potamolithus (Tateidae) justifying the binomem Potamolithus santiagensis as a new combination. Besides recognition of other three populations as belonging to Potamolithus, the molecular analysis also suggests trans-Andean dispersal of this group of snails in the Southern Cone of South America.Fil: Collado, Gonzalo A.. Universidad del Bio Bio; ChileFil: Aguayo, Karina P.. Universidad del Bio Bio; ChileFil: Cazzaniga, Néstor Jorge. Universidad Nacional del Sur; ArgentinaFil: Gutierrez Gregoric, Diego Eduardo. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Invertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: de Lucia, Micaela. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Invertebrados; ArgentinaFil: Haase, Martin. University of Greifswald; Alemani

Earth system data cubes unravel global multivariate dynamics

Understanding Earth system dynamics in light of ongoing human intervention and dependency remains a major scientific challenge. The unprecedented availability of data streams describing different facets of the Earth now offers fundamentally new avenues to address this quest. However, several practical hurdles, especially the lack of data interoperability, limit the joint potential of these data streams. Today, many initiatives within and beyond the Earth system sciences are exploring new approaches to overcome these hurdles and meet the growing interdisciplinary need for data-intensive research; using data cubes is one promising avenue. Here, we introduce the concept of Earth system data cubes and how to operate on them in a formal way. The idea is that treating multiple data dimensions, such as spatial, temporal, variable, frequency, and other grids alike, allows effective application of user-defined functions to co-interpret Earth observations and/or model-data integration. An implementation of this concept combines analysis-ready data cubes with a suitable analytic interface. In three case studies, we demonstrate how the concept and its implementation facilitate the execution of complex workflows for research across multiple variables, and spatial and temporal scales: (1) summary statistics for ecosystem and climate dynamics; (2) intrinsic dimensionality analysis on multiple timescales; and (3) model-data integration. We discuss the emerging perspectives for investigating global interacting and coupled phenomena in observed or simulated data. In particular, we see many emerging perspectives of this approach for interpreting large-scale model ensembles. The latest developments in machine learning, causal inference, and model-data integration can be seamlessly implemented in the proposed framework, supporting rapid progress in data-intensive research across disciplinary boundaries. © 2020 Institute of Electrical and Electronics Engineers Inc.. All rights reserved

Estudio de prefactibilidad para la elaboración de una aplicación Web buscador de cupos en colegios de la ciudad de Bogotá.

Actualmente, existen aproximadamente unos ocho millones de alumnos en el país, según cifras entregadas por el Ministerio de Educación Nacional, los cuales se encuentran distribuidos tanto en colegios privados como en colegios públicos (En el caso de Bogotá conocidos comúnmente como Colegios Distritales). Los padres de cada niño buscan un colegio que sea académicamente eficiente, que quede cerca de su lugar de domicilio y que garantice la calidad en la educación. Hoy en día es posible realizar cualquier tipo de trámite desde la comodidad del hogar, como pagar servicios, hacer transferencias, giros, reservaciones de hotel e incluso comprar tiquetes aéreos o terrestres. Es aquí donde queremos llegar, e implementar un sistema que permita filtrar cada uno de los colegios por región (o Distrito), categoría (Público o Privado), Calidad (Ranking ICFES) o precios, de tal manera que desde la comodidad del hogar se pueda realizar separación de cupo o matrícula desde un ordenador o desde un celular

Earth system data cubes unravel global multivariate dynamics

Understanding Earth system dynamics in light of ongoing human intervention and dependency remains a major scientific challenge. The unprecedented availability of data streams describing different facets of the Earth now offers fundamentally new avenues to address this quest. However, several practical hurdles, especially the lack of data interoperability, limit the joint potential of these data streams. Today, many initiatives within and beyond the Earth system sciences are exploring new approaches to overcome these hurdles and meet the growing interdisciplinary need for data-intensive research; using data cubes is one promising avenue. Here, we introduce the concept of Earth system data cubes and how to operate on them in a formal way. The idea is that treating multiple data dimensions, such as spatial, temporal, variable, frequency, and other grids alike, allows effective application of user-defined functions to co-interpret Earth observations and/or model-data integration. An implementation of this concept combines analysis-ready data cubes with a suitable analytic interface. In three case studies, we demonstrate how the concept and its implementation facilitate the execution of complex workflows for research across multiple variables, and spatial and temporal scales: (1) summary statistics for ecosystem and climate dynamics; (2) intrinsic dimensionality analysis on multiple timescales; and (3) model-data integration. We discuss the emerging perspectives for investigating global interacting and coupled phenomena in observed or simulated data. In particular, we see many emerging perspectives of this approach for interpreting large-scale model ensembles. The latest developments in machine learning, causal inference, and model-data integration can be seamlessly implemented in the proposed framework, supporting rapid progress in data-intensive research across disciplinary boundaries. © 2020 Institute of Electrical and Electronics Engineers Inc.. All rights reserved

Estudio de prefactibilidad para la elaboración de una aplicación Web buscador de cupos en colegios de la ciudad de Bogotá.

Actualmente, existen aproximadamente unos ocho millones de alumnos en el país, según cifras entregadas por el Ministerio de Educación Nacional, los cuales se encuentran distribuidos tanto en colegios privados como en colegios públicos (En el caso de Bogotá conocidos comúnmente como Colegios Distritales). Los padres de cada niño buscan un colegio que sea académicamente eficiente, que quede cerca de su lugar de domicilio y que garantice la calidad en la educación. Hoy en día es posible realizar cualquier tipo de trámite desde la comodidad del hogar, como pagar servicios, hacer transferencias, giros, reservaciones de hotel e incluso comprar tiquetes aéreos o terrestres. Es aquí donde queremos llegar, e implementar un sistema que permita filtrar cada uno de los colegios por región (o Distrito), categoría (Público o Privado), Calidad (Ranking ICFES) o precios, de tal manera que desde la comodidad del hogar se pueda realizar separación de cupo o matrícula desde un ordenador o desde un celular

Galectin-1 prevents pathological vascular remodeling in atherosclerosis and abdominal aortic aneurysm

Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside-binding protein, as a therapeutic target for atherosclerosis and AAA. Mice lacking Gal-1 (Lgals1 −/− ) developed severe atherosclerosis induced by pAAV/D377Y-mPCSK9 adenovirus and displayed higher lipid levels and lower expression of contractile markers of vascular smooth muscle cells (VSMCs) in plaques than wild-type mice. Proteomic analysis of Lgals1 −/− aortas showed changes in markers of VSMC phenotypic switch and altered composition of mitochondrial proteins. Mechanistically, Gal-1 silencing resulted in increased foam cell formation and mitochondrial dysfunction in VSMCs, while treatment with recombinant Gal-1 (rGal-1) prevented these effects. Furthermore, rGal-1 treatment attenuated atherosclerosis and elastase-induced AAA, leading to higher contractile VSMCs in aortic tissues. Gal-1 expression decreased in human atheroma and AAA compared to control tissue. Thus, Gal-1-driven circuits emerge as potential therapeutic strategies in atherosclerosis and AAA. Galectin-1 plays an essential role in prevention of atherosclerosis and abdominal aortic aneurysm