The Impact of Crowdfunding and its Ability to facilitate the Liability of Newness: A Case Study on New Ventures within the Product Design Industry

Crowdfunding is often considered as a financial source to close the early stage financial gap of new ventures. However, there is little research on its impact regarding other liabilities new ventures face. The aim of this study is to find evidence on how crowdfunding can provide new ventures with additional value apart from financial resources. For this purpose, the concept of liability of newness is used as a framework to understand the specific impact of crowdfunding in different areas. This article uses a qualitative approach with three new ventures within the product design industry that used the crowdfunding platform Kickstarter. The findings showed that new ventures in this particular kind of industry use crowdfunding only as a marketing and sales channel rather than as a financial resource. It turned out that crowdfunding especially helps to facilitate external liabilities that are visible to the crowd, whereas internal liabilities that are not visible to the crowd are not affected

Rediscovery of Gastrotheca chrysosticta Laurent, 1976 (Anura: Hemiphractidae) in Baritú National Park, Salta, Argentina

We report the rediscovery of the Marsupial Frog Gastrotheca chrysosticta, 25 years after the last record of this species in Baritú National Park, Salta Province, Argentina.Fil: Akmentins, Mauricio Sebastián. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Boullhesen, Martin. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Bardavid, Sofia. Universidad Nacional de Jujuy. Instituto de Ecorregiones Andinas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Ecorregiones Andinas; ArgentinaFil: Espinoza, CJ. Administración de Parques Nacionales; ArgentinaFil: Falke, Fernando. Administración de Parques Nacionales; Argentin

Dealing with Uncertainties in Asteroid Deflection Demonstration Missions: NEOTwIST

Deflection missions to near-Earth asteroids will encounter non-negligible uncertainties in the physical and orbital parameters of the target object. In order to reliably assess future impact threat mitigation operations such uncertainties have to be quantified and incorporated into the mission design. The implementation of deflection demonstration missions offers the great opportunity to test our current understanding of deflection relevant uncertainties and their consequences, e.g., regarding kinetic impacts on asteroid surfaces. In this contribution, we discuss the role of uncertainties in the NEOTwIST asteroid deflection demonstration concept, a low-cost kinetic impactor design elaborated in the framework of the NEOShield project. The aim of NEOTwIST is to change the spin state of a known and well characterized near-Earth object, in this case the asteroid (25143) Itokawa. Fast events such as the production of the impact crater and ejecta are studied via cube-sat chasers and a flyby vehicle. Long term changes, for instance, in the asteroid's spin and orbit, can be assessed using ground based observations. We find that such a mission can indeed provide valuable constraints on mitigation relevant parameters. Furthermore, the here proposed kinetic impact scenarios can be implemented within the next two decades without threatening Earth's safety.Comment: Accepted for publication in the proceedings of the IAUS 318 - Asteroids: New Observations, New Models, held at the IAU General Assembly in Honolulu, Hawaii, USA 201

Long range transport of ultra cold atoms in a far-detuned 1D optical lattice

We present a novel method to transport ultra cold atoms in a focused optical lattice over macroscopic distances of many Rayleigh ranges. With this method ultra cold atoms were transported over 5 cm in 250 ms without significant atom loss or heating. By translating the interference pattern together with the beam geometry the trap parameters are maintained over the full transport range. Thus, the presented method is well suited for tightly focused optical lattices that have sufficient trap depth only close to the focus. Tight focusing is usually required for far-detuned optical traps or traps that require high laser intensity for other reasons. The transport time is short and thus compatible with the operation of an optical lattice clock in which atoms are probed in a well designed environment spatially separated from the preparation and detection region.Comment: 14 pages, 6 figure

Fluctuations of inspired concentrations of nitric oxide and nitrogen dioxide during mechanical ventilation

BACKGROUND: Nitric oxide (NO) is a very reactive agent with potentially toxic oxidation products such as nitrogen dioxide (NO(2)). Therefore, during NO inhalation a constant inspired concentration and accurate measurement of NO and NO(2) concentrations are essential. The objective of this study was to test the NO concentrations at various positions along the inspiratory limb of the breathing circuit using a recently developed system to administer NO in phase with inspiratory flow during mechanical ventilation (Servo 300 NO-A, Siemens, Sweden). Furthermore, we tested whether an active heating system would interfere with inspired NO concentrations. RESULTS: A sharp decline in the NO concentration was found between the respirator's inspiratory outlet and more distal points along the inspiratory limb of the circuit. This finding was most evident when an active heating system was mounted between those points. CONCLUSIONS: The concentrations of NO and NO(2) should be measured as near to the patient as possible, as significant fluctuations of these concentrations might be found along the inspiratory limb of the respiratory circuit especially when an active heating system is used

TlpC, a novel chemotaxis protein in Rhodobacter sphaeroides , localizes to a discrete region in the cytoplasm

TlpC is encoded in the second chemotaxis operon of Rhodobacter sphaeroides . This protein shows some homology to membrane-spanning chemoreceptors of many bacterial species but, unlike these, is essential for R. sphaeroides chemotaxis to all compounds tested. Genomic replacement of tlpC with a C-terminal gfp fusion demonstrated that TlpC localized to a discrete cluster within the cytoplasm. Immunogold electron microscopy also showed that TlpC localized to a cytoplasmic electron-dense region. Correct TlpC–GFP localization depended on the downstream signalling proteins, CheW 3 , CheW 4 and CheA 2 , and was tightly linked to cell division. Newly divided cells contained a single cluster but, as the cell cycle progressed, a second cluster appeared close to the initial cluster. As elongation continued, these clusters moved apart so that, on septation, each daughter cell contained a single TlpC cluster. The data presented suggest that TlpC is either a cytoplasmic chemoreceptor responding to or integrating global signals of metabolic state or a novel and essential component of the chemotaxis signalling pathway. These data also suggest that clustering is essential for signalling and that a mechanism may exist for targeting and localizing proteins within the bacterial cytoplasm.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75441/1/j.1365-2958.2002.03252.x.pd

Waterfall Formation at a Desert River-Reservoir Delta Isolates Endangered Fishes

Unforeseen interactions of dams and declining water availability have formed new obstacles to recovering endemic and endangered big-river fishes. During a recent trend of drying climate and declining reservoir water levels in the southwestern United States, a large waterfall has formed on two separate occasions (1989-1995 & 2001-present) in the transition zone between the San Juan River and Lake Powell reservoir because of deposited sediments. Because recovery plans for two large-bodied endangered fish species, razorback sucker (Xyrauchen texanus) and Colorado pikeminnow (Ptychocheilus lucius), include annual stockings in the San Juan River, this waterfall potentially blocks upstream movement of individuals that moved downstream from the river into the reservoir. To quantify the temporal variation in abundance of endangered fishes aggregating downstream of the waterfall and determine population demographics, we remotely monitored and sampled in spring 2015, 2016, and 2017 when these fish were thought to move upstream to spawn. Additionally, we used an open population model applied to tagged fish detected in 2017 to estimate population sizes. Colorado pike minnow were so infrequently encountered (\u3c 30 individuals) that population estimates were not performed. Razorback sucker captures from sampling (335) and detections from remote monitoring (943) showed high abundance across all three years. The razorback sucker population estimate for 2017 alone was 755 individuals and, relative to recent population estimates ranging from ~2000 to ~4000 individuals, suggests a substantial population exists seasonally downstream of this barrier. Barriers to fish movement in rivers above reservoirs are not unique, thus the formation of this waterfall exemplifies how water development and hydrology can interact to cause unforeseen changes to a riverscape

Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study

The Μ, Δ, and Κ opioid receptors are the three main types of opioid receptors round in the central nervous system (CNS) and periphery. These receptors and the peptides with which they interact are important in a number of physiological functions, including analgesia, respiration, and hormonal regulation. This study examines the expression of Μ, Δ, and Κ receptor mRNAs in the rat brain and spinal cord using in situ hybridization techniques. Tissue sections were hybridized with 35 S-labeled cRNA probes to the rat Μ (744–1, 064 b), Δ (304–1,287 b), and Κ (1,351–2,124 b) receptors. Each mRNA demonstrates a distinct anatomical distribution that corresponds well to known receptor binding distributions. Cells expressing Μ receptor mRNA are localized in such regions as the olfactory bulb, caudate-putamen, nucleus accumbens, lateral and medial septum, diagonal band of Broca, bed nucleus of the stria terminalis, most thalamic nuclei, hippocampus, amygdala, medial preoptic area, superior and inferior colliculi, central gray, dorsal and median raphe, raphe magnus, locus coeruleus, parabrachial nucleus, pontine and medullary reticular nuclei, nucleus ambiguus, nucleus of the solitary tract, nucleus gracilis and cuneatus, dorsal motor nucleus of vagus, spinal cord, and dorsal root ganglia. Cellular localization of Δ receptor mRNA varied from Μ or Κ, with expression in such regions as the olfactory bulb, allo- and neocortex, caudate-putamen, nucleus accumbens, olfactory tubercle, ventromedial hypothalamus, hippocampus, amygdala, red nucleus, pontine nuclei, reticulotegmental nucleus, motor and spinal trigeminal, linear nucleus of the medulla, lateral reticular nucleus, spinal cord, and dorsal root ganglia. Cells expressing, Κ receptor mRNA demonstrate a third pattern of expression, with cells localized in regions such as the claustrum, endopiriform nucleus, nucleus accumbens, olfactory tubercle, medial preoptic area, bed nucleus of the stria terminalis, amygdala, most hypothalamic nuclei, median eminence, infundibulum, substantia nigra, ventral tegmental area, raphe nuclei, paratrigeminal and spinal trigeminal, nucleus of the solitary tract, spinal cord, and dorsal root ganglia. These findings are discussed in relation to the physiologica functions associated with the opioid receptors.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50064/1/903500307_ftp.pd