Metamorphic Domain-Specific Languages: A Journey Into the Shapes of a Language

External or internal domain-specific languages (DSLs) or (fluent) APIs? Whoever you are -- a developer or a user of a DSL -- you usually have to choose your side; you should not! What about metamorphic DSLs that change their shape according to your needs? We report on our 4-years journey of providing the "right" support (in the domain of feature modeling), leading us to develop an external DSL, different shapes of an internal API, and maintain all these languages. A key insight is that there is no one-size-fits-all solution or no clear superiority of a solution compared to another. On the contrary, we found that it does make sense to continue the maintenance of an external and internal DSL. The vision that we foresee for the future of software languages is their ability to be self-adaptable to the most appropriate shape (including the corresponding integrated development environment) according to a particular usage or task. We call metamorphic DSL such a language, able to change from one shape to another shape

Pesticide resistance in Plutella xylostella (Lepidoptera: Plutellidae) populations from Togo and Benin

Published online: 17 August 2016The diamondback moth, Plutella xylostella (L.) is the major insect pest of cabbage crops in Togo and Benin. For control, farmers very often resort to spraying chemical insecticides at high dosages with frequent applications. Bioassays were carried out on three populations of P. xylostella, two from Togo (Kara and Dapaong) and one from Benin (Cotonou), to assess their level of susceptibility to currently used insecticides. A reference strain of P. xylostella from Matuu in Kenya was used as a control. In the laboratory, three insecticide representatives of different chemical families (deltamethrin, chlorpyrifos ethyl and spinosad) were assayed against third instar larvae of P. xylostella. Results revealed that P. xylostella populations from Dapaong, Kara and Cotonou were more resistant to deltamethrin (13 to 59-fold at LC50 level, 149 to 1772-fold at LC90 level) and chlorpyrifos ethyl (5 to 15-fold at LC50 level, 9 to 885-fold at LC90 level) than the reference strain. Spinosad was more toxic to P. xylostella populations than the other insecticides with LC50 and LC90 values less than 1 μg/ml and 15 μg/ml, respectively. However, the population from Cotonou appeared significantly more resistant to spinosad compared to the reference strain. These results are discussed in the light of developing an integrated pest management strategy for reducing the selection pressure of spinosad

Quantum algorithm for the Boolean hidden shift problem

The hidden shift problem is a natural place to look for new separations between classical and quantum models of computation. One advantage of this problem is its flexibility, since it can be defined for a whole range of functions and a whole range of underlying groups. In a way, this distinguishes it from the hidden subgroup problem where more stringent requirements about the existence of a periodic subgroup have to be made. And yet, the hidden shift problem proves to be rich enough to capture interesting features of problems of algebraic, geometric, and combinatorial flavor. We present a quantum algorithm to identify the hidden shift for any Boolean function. Using Fourier analysis for Boolean functions we relate the time and query complexity of the algorithm to an intrinsic property of the function, namely its minimum influence. We show that for randomly chosen functions the time complexity of the algorithm is polynomial. Based on this we show an average case exponential separation between classical and quantum time complexity. A perhaps interesting aspect of this work is that, while the extremal case of the Boolean hidden shift problem over so-called bent functions can be reduced to a hidden subgroup problem over an abelian group, the more general case studied here does not seem to allow such a reduction.Comment: 10 pages, 1 figur

A genetic management toolkit: hormonal and behavioural research towards the development of artificial insemination technology in the African wild dog (Lycaon pictus)

African wild dogs have a complex pack structure with separate male and female dominance hierarchies in which reproduction is typically exclusive to the alpha male and female. Current efforts to maintain genetic diversity involve translocation of live animals in captivity, a process that involves the combination of male and female single-sex groups to form a new social pack. Due to their complex social structure, such introductions are difficult: regularly leading to aggression and injuries to the animals. Moreover, this may not result in breeding among genetically valuable individuals if they do not become dominant. To overcome these translocation-associated problems of intra-pack aggression our team has studied a number of facets of basic reproduction as well as stress and behavioural management in African wild dogs with the goal of developing strategies for semen cryopreservation and artificial insemination as a key to the introduction of new genes into existing stable packs (Van den Berghe et al. 2012, Anim Reprod Sci 133, 1-9). We began by establishing detailed reproductive and adrenal hormone profiles from multiple females in several reproductive states in both captive and free-ranging populations. Faecal samples from captive females in four European institutions and from wild males and females in South Africa were analysed for oestradiol, progestagens, testosterone and glucocorticoids. Captive data demonstrated that female wild dogs have reproductive characteristics similar to other canids, such as spontaneous ovulation and obligate pseudopregnancy. Almost all adult females became pseudopregnant, implying that the mechanism of reproductive suppression in this sex is likely to be behavioural rather than physiological. This was supported by data from free-ranging populations. Adrenal activity in captive and free-ranging animals was measured by faecal cortisol metabolites. Captive females had higher concentrations than free-ranging females. Glucocorticoid concentrations were more variable in captive individuals, whereas in both wild males and females, they were highest during gestation and denning. Adrenal activity in males, but not females, was also affected by age, with the highest glucocorticoid concentrations measured in yearlings. We have also investigated the use of dog appeasing pheromone (DAP) collars to down-regulate aggression associated with the formation of new packs in captivity. Our initial findings indicate that DAP may reduce baseline stress levels in females and, when applied during regrouping of same-sex individuals, results in a relative reduction in observed levels of aggression. Building on these findings, work is underway to develop a semen bank and artificial insemination techniques. Although reproductive suppression in females is likely to be behavioural, the effect of dominance on male fertility is still unresolved. We have begun investigating the relationship between hierarchy and sperm quality across the seasons. This will guide our development of a robust semen collection and freezing protocol that will permit the establishment of a high-quality semen bank. We are also progressing with non-invasive techniques to predict ovulation for timed artificial insemination of females. These techniques must first be established in captivity before our ultimate goal to implement them as tools for genetic meta-population management in semi-captive and free-ranging populations

Monitoring stress in captive and free-ranging African wild dogs (Lycaon pictus) using faecal glucocorticoid metabolites

An understanding of stress physiology is important for species management because high levels of stress can hamper reproduction and affect an individual’s ability to cope with threats to their survival, such as disease and human–wildlife conflict. A commonly used indicator of stress, faecal concentrations of cortisol metabolites (FCM), can be used to assess the impact of social, biological and environmental factors. Measurements of FCM are particularly valuable for endangered species that are logistically challenging to study and where non-invasive techniques are preferred. As the second most endangered canid in Africa, the African wild dog (Lycaon pictus) has been the focus of considerable conservation research, yet there is still little understanding of factors associated with stress, in either captive or free-ranging populations. The present study therefore aimed to determine whether stress levels differ between captive and freeranging populations, and to detect social, biological and environmental factors that are stressful in these populations. Faecal samples were collected from 20 captive and 62 free-ranging animals. Within freeranging populations, the sexes differed significantly, but there was no effect of social status, age or breeding period for either sex. Captive females had higher FCM concentrations than free-ranging females. In captive populations, FCM concentrations differed among zoos and with reproductive status in females, but were not related to age class or group-housing structure. In conclusion, FCM is a useful indicator of stress and should be considered an integrative aspect of management, for both in situ and ex situ African wild dog populations.Australian Postgraduate Award and funding provided by the School of Animal Biology (University of Western Australia) and the Institute for Breeding Rare and Endangered African Mammals (IBREAM).http://www.elsevier.com/locate/ygcen2017-01-31hb201

Natural and anthropogenic lead in sediments of the Rotorua lakes, New Zealand

Global atmospheric sources of lead have increased more than 100-fold over the past century as a result of deforestation, coal combustion, ore smelting and leaded petroleum. Lead compounds generally accumulate in depositional areas across the globe where, due to low solubility and relative freedom from microbial degradation, the history of their inputs is preserved. In lakes there is rapid deposition and often little bioturbation of lead, resulting in an excellent depositional history of changes in both natural and anthropogenic sources. The objective of this study was to use sediments from a regionally bounded set of lakes to provide an indication of the rates of environmental inputs of lead whilst taking into account differences of trophic state and lead exposure between lakes. Intact sediment gravity cores were collected from 13 Rotorua lakes in North Island of New Zealand between March 2006 and January 2007. Cores penetrated sediments to a depth of 16–30 cm and contained volcanic tephra from the 1886 AD Tarawera eruption. The upper depth of the Tarawera tephra enabled prescription of a date for the associated depth in the core (120 years). Each core showed a sub-surface peak in lead concentration above the Tarawera tephra which was contemporaneous with the peak use of lead alkyl as a petroleum additive in New Zealand. An 8 m piston core was taken in the largest of the lakes, Lake Rotorua, in March 2007. The lake is antipodal to the pre-industrial sources of atmospheric lead but still shows increasing lead concentrations from <2 up to 3.5 μg g−1 between the Whakatane eruption (5530 ± 60 cal. yr BP) and the Tarawera eruption. Peaks in lead concentration in Lake Rotorua are associated with volcanic tephras, but are small compared with those arising from recent anthropogenic-derived lead deposition. Our results show that diagenetic processes associated with iron, manganese and sulfate oxidation-reduction, and sulfide precipitation, act to smooth distributions of lead from anthropogenic sources in the lake sediments. The extent of this smoothing can be related to changes in sulfate availability and reduction in sulfide driven by differences in trophic status amongst the lakes. Greatest lead mobilisation occurs in mesotrophic lakes during seasonal anoxia as iron and manganese are released to the porewater, allowing upward migration of lead towards the sediment–water interface. This lead mobilisation can only occur if sulfides are not present. The sub-surface peak in lead concentrations in lake sediments ascribed to lead alkyl in petroleum persists despite the diagenetic processes acting to disperse lead within the sediments and into the overlying water

Non-destructive, dynamic detectors for Bose-Einstein condensates

We propose and analyze a series of non-destructive, dynamic detectors for Bose-Einstein condensates based on photo-detectors operating at the shot noise limit. These detectors are compatible with real time feedback to the condensate. The signal to noise ratio of different detection schemes are compared subject to the constraint of minimal heating due to photon absorption and spontaneous emission. This constraint leads to different optimal operating points for interference-based schemes. We find the somewhat counter-intuitive result that without the presence of a cavity, interferometry causes as much destruction as absorption for optically thin clouds. For optically thick clouds, cavity-free interferometry is superior to absorption, but it still cannot be made arbitrarily non-destructive . We propose a cavity-based measurement of atomic density which can in principle be made arbitrarily non-destructive for a given signal to noise ratio

Representation of the Community Earth System Model (CESM1) CAM4-chem within the Chemistry-Climate Model Initiative (CCMI)

The Community Earth System Model (CESM1) CAM4-chem has been used to perform the Chemistry Climate Model Initiative (CCMI) reference and sensitivity simulations. In this model, the Community Atmospheric Model version 4 (CAM4) is fully coupled to tropospheric and stratospheric chemistry. Details and specifics of each configuration, including new developments and improvements are described. CESM1 CAM4-chem is a low-top model that reaches up to approximately 40km and uses a horizontal resolution of 1.9° latitude and 2.5° longitude. For the specified dynamics experiments, the model is nudged to Modern-Era Retrospective Analysis for Research and Applications (MERRA) reanalysis. We summarize the performance of the three reference simulations suggested by CCMI, with a focus on the last 15 years of the simulation when most observations are available. Comparisons with selected data sets are employed to demonstrate the general performance of the model. We highlight new data sets that are suited for multi-model evaluation studies. Most important improvements of the model are the treatment of stratospheric aerosols and the corresponding adjustments for radiation and optics, the updated chemistry scheme including improved polar chemistry and stratospheric dynamics and improved dry deposition rates. These updates lead to a very good representation of tropospheric ozone within 20% of values from available observations for most regions. In particular, the trend and magnitude of surface ozone is much improved compared to earlier versions of the model. Furthermore, stratospheric column ozone of the Southern Hemisphere in winter and spring is reasonably well represented. All experiments still underestimate CO most significantly in Northern Hemisphere spring and show a significant underestimation of hydrocarbons based on surface observations

Back to the future: using ancient Bere barley landraces for a sustainable future

Societal Impact Statement Bere is an ancient barley (Hordeum vulgare L.) that was once widely grown in northern Britain, where its ability to grow on poor soils and under challenging climatic conditions made it a valuable staple. By the end of the 20th century, Bere had largely been replaced by higher-yielding modern varieties and only survived in cultivation on a few Scottish islands. This article reviews the recent revival of Bere, driven by its use in high-value food and drink products and multidisciplinary research into its genetics, valuable sustainability traits and potential for developing resilient barley varieties. Summary In Britain, modern cereal varieties have mostly replaced landraces. A remarkable exception occurs on several Scottish islands where Bere, an ancient 6-row barley (Hordeum vulgare L.), is grown as a monocrop or in mixtures. In the Outer Hebrides, the mixture is grown for animal feed, and cultivating it with traditional practices is integral to the conservation of Machair, an important coastal dune ecosystem. In Orkney, Bere is grown as a monocrop, and in situ conservation has recently been strengthened by improved agronomy and new markets for grain to produce unique foods and beverages from beremeal (flour) and malt. In parallel, a recently assembled collection of British and North European barley landraces has allowed the genotypic and phenotypic characterisation of Bere and several associated multidisciplinary studies. Genotyping demonstrated Bere's unique identity compared with most other barleys in the collection, indicating an earlier introduction to Scotland than the Norse settlement (c. 9th century AD) suggested previously. Valuable traits found in some Bere accessions include disease resistance, an early heading date (reflecting a short period from sowing to harvest), the ability to grow on marginal, high pH soils deficient in manganese and tolerance to salinity stress. These traits would have been important in the past for grain production under the region's challenging soil and Atlantic-maritime climatic conditions. We discuss these results within the context of Bere as a genetic, heritage and commercial resource and as a future source of sustainability traits for barley improvement