Localization of fermions in different domain wall models

Localization of fermions is studied in different gravitational domain wall models. These are generalizations of the brane-world models considered by Randall and Sundrum, but which also allow gravitational localization. Therefore, they might be considered as possible realistic scenarios for phenomenology.Comment: RevTeX, 6 pages, 10 figure

Marketing interno y su relación con el aprendizaje organizacional en el C.E.P. La Salle del distrito de Breña 2012

La presente investigación tiene como propósito describir como el marketing interno se relaciona con el aprendizaje organizacional en una muestra de 77 docentes del C.E.P. La Salle del Distrito de Breña 2012. Se utilizó un diseño descriptivo correlacional, y se les aplicó dos instrumentos de evaluación: el Cuestionario de Marketing Interno de María Bohnenberger y el Inventario de Aprendizaje Organizacional de Miguel Rodríguez y Juana Trujillo. Estos instrumentos fueron sometidos a los análisis respectivos que determinaron que las pruebas son válidas y confiables. Los resultados indican que existen correlaciones significativas y positivas entre el marketing interno y el aprendizaje organizacional (r = 0.78). Así mismo se encontró que todas las dimensiones del marketing interno se encuentran relacionadas con el aprendizaje organizacional y sus respectivas dimensiones

Investigating the land‑to‑sea transition in carnivorans from the evolution of sacrum morphology in pinnipeds

The form and function of the sacrum are of great relevance to understand the evolution of locomotion in tetrapods because it is a key piece of the vertebrate skeleton. The sacrum connects the caudal and presacral regions of the vertebral column and the hindlimbs through the pelvis. Here, we investigate sacrum shape evolution in pinnipeds (Carnivora: Pinnipedia) in relation to terrestrial mammalian carnivorans (fissipeds), and we include crown and stem taxa to quantify the morphological changes they experience in relation to the aquatic environment they inhabit. We use 3D geometric morphometric methods to explore the morphological variability and disparity of the sacrum in a set of terrestrial and aquatic carnivoran species. Our results show that the morphology of the sacrum of each pinniped family is remarkably different and that these differences may be related to the aquatic mode of locomotion (pectoral or pelvic oscillation), the use of hindlimbs to support body weight on land (otariids in contrast with phocids), and the presence or absence of a functional tail. In addition, disparity-through-time analyses indicate that the sacrum of pinnipeds is less constrained than that of fissipeds, which suggests a gravitational origin of such constraints in fissipeds. In conclusion, our results give further support to the important role played by this skeletal structure in the locomotory adaptations of mammals.Funding for open access publishing: Universidad Málaga/CBUA. This work has been funded by the Spanish Ministry of Science and Universities (Grant # PID2019-111185GB-I00) and Junta de Andalucía (Grant # P18-FR-3193). Support for laser scanning the specimen of Puijila darwini was provided by the Canadian Museum of Nature. Funding for open access charge: Universidad de Málaga / CBU

SWI/SNF Complex Alterations in Tumors with Rhabdoid Features: Novel Therapeutic Approaches and Opportunities for Adoptive Cell Therapy

The SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex is one of the most remarkably altered epigenetic regulators in cancer. Pathogenic mutations in genes encoding SWI/SNF-related proteins have been recently described in many solid tumors, including rare and aggressive malignancies with rhabdoid features with no standard therapies in advanced or metastatic settings. In recent years, clinical trials with targeted drugs aimed at restoring its function have shown discouraging results. However, preclinical data have found an association between these epigenetic alterations and response to immune therapy. Thus, the rationale for immunotherapy strategies in SWI/SNF complex alteration-related tumors is strong. Here, we review the SWI/SNF complex and how its dysfunction drives the oncogenesis of rhabdoid tumors and the proposed strategies to revert this alteration and promising novel therapeutic approaches, including immune checkpoint inhibition and adoptive cell therapy

Competencias digitales y buenas prácticas de enseñanza en docentes del sur de Perú

Digital tools and the quality of teaching practices have gained significant relevance in the digital age, however, the effective integration of ICT in the educational environment represents a fundamental challenge for teachers and institutions. Objective: To verify the way in which digital competencies influence good teaching practices in Systems Engineering teachers at the Private University of Tacna – 2021. Method: A correlational descriptive design was adopted that included 33 teachers and questionnaires developed by the authors were applied, resulting in descriptive and inferential analyses. Results: The value obtained from Rho was equal to 0.569 with a value of p = 0.001, indicating a positive correlation. A correlation between digital skills and good teaching practices was demonstrated. Regarding the levels of digital skills, it was found that the regular level predominated in aspects such as knowledge of technologies, pedagogy, management and professional development, as well as in attitudes and sociocultural aspects, with percentages above 50%. Conclusion: The relevance of continuously promoting digital skills for teachers and fostering positive attitudes towards technology in the educational field was highlighted. These competencies are a crucial factor in enriching and energizing teachers' teaching practices, adapting them to the demands of an increasingly digitalized educational environment.   Las herramientas digitales y la calidad de las prácticas de enseñanza han cobrado una relevancia significativa en la era digital, no obstante, la integración efectiva de las TIC en el entorno educativo representa un desafío fundamental para los docentes y las instituciones. Objetivo: Comprobar la manera en qué las competencias digitales influyen sobre las buenas prácticas de enseñanza en los docentes de Ingeniería en Sistemas de la Universidad Privada de Tacna – 2021. Método: Se adoptó un diseño descriptivo correlacional que incluyó a 33 docentes y se aplicaron cuestionarios elaborados por los autores, derivando en análisis descriptivos e inferenciales. Resultados: El valor obtenido de Rho fue igual a 0,569 con un valor de p = 0,001, indicó una correlación positiva. Se demostró una correlación entre las competencias digitales y las buenas prácticas de enseñanza. En cuanto a los niveles de competencias digitales, se encontró que predominaba el nivel regular en aspectos como el conocimiento de tecnologías, pedagogía, gestión y desarrollo profesional, así como en las actitudes y aspectos socioculturales, con porcentajes superiores al 50%. Conclusión: se resaltó la relevancia de promover de manera continua las competencias digitales para los docentes y fomentar actitudes positivas hacia la tecnología en el ámbito educativo. Estas competencias son un factor crucial para enriquecer y dinamizar las prácticas de enseñanza de los docentes, adaptándolas a las demandas de un entorno educativo cada vez más digitalizado. &nbsp

The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal and seeding capacity of cancer stem cells (CSC). Here, we tested the ability of the clinically proven inhibitor of the lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) to target SOX2-driven CSC in breast cancer. Iadademstat blocked CSC-driven mammosphere formation in breast cancer cell lines that are dependent on SOX2 expression to maintain their CSC phenotype. Iadademstat prevented the activation of an LSD1-targeted stemness-specific SOX2 enhancer in CSC-enriched 3-dimensional spheroids. Using high-throughput transcriptional data available from the METABRIC dataset, high expression of SOX2 was significantly more common in luminal-B and HER2-enriched subtypes according to PAM50 classifier and in IntClust1 (high proliferating luminal-B) and IntClust 5 (luminal-B and HER2-amplified) according to integrative clustering. Iadademstat significantly reduced mammospheres formation by CSC-like cells from a multidrug-resistant luminal-B breast cancer patient-derived xenograft but not of those from a treatment-naive luminal-A patient. Iadademstat reduced the expression of SOX2 in luminal-B but not in luminal-A mammospheres, likely indicating a selective targeting of SOX2-driven CSC. The therapeutic relevance of targeting SOX2-driven breast CSC suggests the potential clinical use of iadademstat as an epigenetic therapy in luminal-B and HER2-positive subtypes

Empirical mode decomposition-based filter applied to multifocal electroretinograms in multiple sclerosis diagnosis

As multiple sclerosis (MS) usually affects the visual pathway, visual electrophysiological tests can be used to diagnose it. The objective of this paper is to research methods for processing multifocal electroretinogram (mfERG) recordings to improve the capacity to diagnose MS. MfERG recordings from 15 early-stage MS patients without a history of optic neuritis and from 6 control subjects were examined. A normative database was built from the control subject signals. The mfERG recordings were filtered using empirical mode decomposition (EMD). The correlation with the signals in a normative database was used as the classification feature. Using EMD-based filtering and performance correlation, the mean area under the curve (AUC) value was 0.90. The greatest discriminant capacity was obtained in ring 4 and in the inferior nasal quadrant (AUC values of 0.96 and 0.94, respectively). Our results suggest that the combination of filtering mfERG recordings using EMD and calculating the correlation with a normative database would make mfERG waveform analysis applicable to assessment of multiple sclerosis in early-stage patients

A decade of GRB follow-up by BOOTES in Spain (2003-2013)

This article covers ten years of GRB follow-ups by the Spanish BOOTES stations: 71 follow-ups providing 23 detections. Follow-ups by BOOTES-1B from 2005 to 2008 were given in the previous article, and are here reviewed, updated, and include additional detection data points as the former article merely stated their existence. The all-sky cameras CASSANDRA have not yet detected any GRB optical afterglows, but limits are reported where available

Fragility Curves for Thin-Walled Cold-Formed Steel Wall Frames Affected by Ground Settlements Due to Land Subsidence

Land subsidence phenomenon due to ground water withdrawal is a current problem in many places around the world, particularly in the shallows of Mexico. This causes ground differential settlements that affect structures, mainly dwellings and buildings based on reinforced concrete and masonry. Eventually, these structural materials do not exhibit an adequate performance beyond a certain level of angular distortion. This work presents the results about a study regarding the performance of thin-walled cold-formed steel wall frames with different sheathing systems affected by angular distortions simulating ground differential settlements due to land subsidence. The wall frames are composed by vertical (studs) and horizontal elements (tracks), with different sheathing systems: polystyrene, OSB, gypsum and calcium silicate. By means of experimental testing of wall frames subjected to monotonic lateral loads, the rotational stiffness was obtained for the wall frames with polystyrene. Likewise the rotational stiffness of the other wall frame systems was calculated based on the data provided by other author’s publications. On the other hand, by means of numerical simulation, all the wall frame systems were modeled in structural analysis software, calibrating them based on the rotational stiffness. Also, the moment-rotation curves were calculated for the studs and tracks based on the direct strength method. A non-linear static pull down analysis was performed producing several degrees of angular distortion simulating ground settlements for all the wall frames sheathing systems. With the data acquired fragility curves were calculated according three levels of damage for the wall frames with different sheathing system