A new spherically symmetric general relativistic hydrodynamical code

In this paper we present a full general relativistic one-dimensional hydro-code which incorporates a modern high-resolution shock-capturing algorithm, with an approximate Riemann solver, for the correct modelling of formation and propagation of strong shocks. The efficiency of this code in treating strong shocks is demonstrated by some numerical experiments. The interest of this technique in several astrophysical scenarios is discussed.Comment: 27 pages, 26 figures, accepted Ap

Numerical 3+1 general relativistic magnetohydrodynamics: a local characteristic approach

We present a general procedure to solve numerically the general relativistic magnetohydrodynamics (GRMHD) equations within the framework of the 3+1 formalism. The work reported here extends our previous investigation in general relativistic hydrodynamics (Banyuls et al. 1997) where magnetic fields were not considered. The GRMHD equations are written in conservative form to exploit their hyperbolic character in the solution procedure. All theoretical ingredients necessary to build up high-resolution shock-capturing schemes based on the solution of local Riemann problems (i.e. Godunov-type schemes) are described. In particular, we use a renormalized set of regular eigenvectors of the flux Jacobians of the relativistic magnetohydrodynamics equations. In addition, the paper describes a procedure based on the equivalence principle of general relativity that allows the use of Riemann solvers designed for special relativistic magnetohydrodynamics in GRMHD. Our formulation and numerical methodology are assessed by performing various test simulations recently considered by different authors. These include magnetized shock tubes, spherical accretion onto a Schwarzschild black hole, equatorial accretion onto a Kerr black hole, and magnetized thick accretion disks around a black hole prone to the magnetorotational instability.Comment: 18 pages, 8 figures, submitted to Ap

Predictors of high-quality cord blood units

BACKGROUNDAnalysis of umbilical cord blood (UCB) transplants shows a correlation between engraftment and total number of infused cells. Thus, it is worth evaluating what maternal and neonatal characteristics and collection techniques may affect the quality of UCB units. STUDY DESIGN AND METHODSA cross-sectional study was performed with 7897 donors sequentially selected in three health care institutions in Brazil from October 2004 to March 2012, in which both quantitative and qualitative approaches were applied. All donors were considered suitable for cord blood collection. RESULTSThe maternal and neonatal characteristics and techniques of collection that influenced the total number of nucleated cells (TNCsp<0.001) were type of delivery, newborn weight and sex, and institution of UCB collection. The TNC count was associated with gestational age (p=0.008), type of delivery (p<0.001), newborn sex (p<0.001), newborn weight (p<0.001), and UCB collection technique (p=0.003). Center B presented the largest number of nucleated cells in its results (p<0.001), followed by Center A (p=0.001). Other characteristics, such as maternal age, were analyzed but were not relevant for the nucleated cell number. CONCLUSIONThis study provides elements for a model that allows an efficient selection of UCB donors, prioritizing candidates who have a better chance to lead to an optimized use of cord blood cells units.Univ Fed Sao Paulo UNIFESP, Escola Paulista Enfermagem, Sao Paulo, BrazilInst Nacl Cardiol, Rio De Janeiro, BrazilInst Israelita Ensino & Pesquisa Albert Einstein, Sao Paulo, BrazilHosp Israelita Albert Einstein, Dept Hemoterapia, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Escola Paulista Enfermagem, Sao Paulo, BrazilWeb of Scienc

Investigating particle acceleration in Protostellar Jets: The triple radio continuum source in serpens

While most protostellar jets present free-free emission at radio wavelengths, synchrotron emission has also been proposed to be present in a handful of these objects. The presence of nonthermal emission has been inferred by negative spectral indices at centimeter wavelengths. In one case (the HH 80-81 jet arising from a massive protostar), its synchrotron nature was confirmed by the detection of linearly polarized radio emission. One of the main consequences of these results is that synchrotron emission implies the presence of relativistic particles among the nonrelativistic material of these jets. Therefore, an acceleration mechanism should be taking place. The most probable scenario is that particles are accelerated when the jets strongly impact against the dense envelope surrounding the protostar. Here we present an analysis of radio observations obtained with the Very Large Array of the triple radio source in the Serpens star-forming region. This object is known to be a radio jet arising from an intermediate-mass protostar. It is also one of the first protostellar jets where the presence of nonthermal emission was proposed. We analyze the dynamics of the jet and the nature of the emission and discuss these issues in the context of the physical parameters of the jet and the particle acceleration phenomenon.Fil: Rodríguez Kamenetzky, Adriana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Carrasco Gonzalez, Carlos Eugenio. Universidad Nacional Autónoma de México; MéxicoFil: Araudo, Anabella Teresa. University of Oxford. Department of Physics; Reino Unido. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Torrelles, Jose M.. Universidad de Barcelona; EspañaFil: Anglada, Guillem. Instituto de Astrofisica Andalucia; EspañaFil: Marti, Josep. Universidad de Jaén; EspañaFil: Luis Felipe Rodriguez. Universidad Nacional Autónoma de México; MéxicoFil: Valotto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; Argentin

On the performance of multi-GPU-based expert systems for acoustic localization involving massive microphone array

Sound source localization is an important topic in expert systems involving microphone arrays, such as automatic camera steering systems, human-machine interaction, video gaming or audio surveillance. The Steered Response Power with Phase Transform (SRP-PHAT) algorithm is a well-known approach for sound source localization due to its robust performance in noisy and reverberant environments. This algorithm analyzes the sound power captured by an acoustic beamformer on a defined spatial grid, estimating the source location as the point that maximizes the output power. Since localization accuracy can be improved by using high-resolution spatial grids and a high number of microphones, accurate acoustic localization systems require high computational power. Graphics Processing Units (GPUs) are highly parallel programmable co-processors that provide massive computation when the needed operations are properly parallelized. Emerging GPUs offer multiple parallelism levels; however, properly managing their computational resources becomes a very challenging task. In fact, management issues become even more difficult when multiple GPUs are involved, adding one more level of parallelism. In this paper, the performance of an acoustic source localization system using distributed microphones is analyzed over a massive multichannel processing framework in a multi-GPU system. The paper evaluates and points out the influence that the number of microphones and the available computational resources have in the overall system performance. Several acoustic environments are considered to show the impact that noise and reverberation have in the localization accuracy and how the use of massive microphone systems combined with parallelized GPU algorithms can help to mitigate substantially adverse acoustic effects. In this context, the proposed implementation is able to work in real time with high-resolution spatial grids and using up to 48 microphones. These results confirm the advantages of suitable GPU architectures in the development of real-time massive acoustic signal processing systems.This work has been partially funded by the Spanish Ministerio de Economia y Competitividad (TEC2009-13741, TEC2012-38142-C04-01, and TEC2012-37945-C02-02), Generalitat Valenciana PROMETEO 2009/2013, and Universitat Politecnica de Valencia through Programa de Apoyo a la Investigacion y Desarrollo (PAID-05-11 and PAID-05-12).Belloch Rodríguez, JA.; Gonzalez, A.; Vidal Maciá, AM.; Cobos Serrano, M. (2015). On the performance of multi-GPU-based expert systems for acoustic localization involving massive microphone array. Expert Systems with Applications. 42(13):5607-5620. https://doi.org/10.1016/j.eswa.2015.02.056S56075620421

Differential scanning calorimetry and elasticity of textured, heat set and mechanical strained polylactide multifilaments

Industrially textured PLA multifilaments were heat set under different conditions at 110 ºC for 1 min and subjected to one cycle of deformation up to 20%. Thermal transitions of the original textured, heat set and cyclic strained filaments were measured using differential scanning calorimetry from 25 to 250 ºC. Cyclic deformation induces an endo-exo transition at peak temperatures between 55 - 60 ºC that is not observed in the original textured and heat set multifilaments. There is another endo-exo transition with peak temperatures between 67 and 72 ºC in all filaments, the intensity of which varies according to texturing conditions, heat setting and cycle strain. Texturing conditions, heat setting and cyclic strain play a role in thermal transitions, the strain at breaking and elastic properties of the filaments. The crystallinity and magnitude of the endo-exo thermal events detected by DSC are related to the strain at breaking and elasticity of polylactide textured multifilamentsPostprint (published version

WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion

Melanoma is a highly aggressive tumour that can metastasize very early in disease progression. Notably, melanoma can disseminate using amoeboid invasive strategies. We show here that high Myosin II activity, high levels of ki-67 and high tumour-initiating abilities are characteristic of invasive amoeboid melanoma cells. Mechanistically, we find that WNT11-FZD7-DAAM1 activates Rho-ROCK1/2-Myosin II and plays a crucial role in regulating tumour-initiating potential, local invasion and distant metastasis formation. Importantly, amoeboid melanoma cells express both proliferative and invasive gene signatures. As such, invasive fronts of human and mouse melanomas are enriched in amoeboid cells that are also ki-67 positive. This pattern is further enhanced in metastatic lesions. We propose eradication of amoeboid melanoma cells after surgical removal as a therapeutic strategy. Amoeboid cells are associated with melanoma invasive capacity. Here, the authors show that the WNT11-FZD7-DAAM1 pathway regulates tumour-initiating potential, invasion and metastasis lead by amoeboid cells in the invasive front of melanoma tumours