Developing an Instrument to Observe and Evaluate Assessment System Maturity

Maturity models fill the need for a measure of overall growth in how outcomes assessment is defined and how feedback informs improvement to meet internal and external expectations at individual institutions of higher education. An exploratory qualitative study was conducted to develop an instrument, the Assessment System Maturity Matrix (ASMM), to observe and evaluate outcomes assessment system maturity. Research procedures included conducting a literature review and comparing business, software, and limited education maturity models; administering self-reported questionnaires to higher education outcomes assessment professionals; and piloting the instrument. Data collection results provided the ideal criteria for the ASMM design and content and led to ASMM development and refinement. Some deviation from the established maturity order sequence of plan, build, implement, and evaluate was noted. The ASMM can enable diverse institutions of higher education to focus on current assessment practice maturity efficiently to determine subsequent actions to improve outcomes assessment performance. Further research is required to explore the awareness and development of outcomes assessment system maturity awareness among the various types of institutions within the higher education community

CLAD: A Complex and Long Activities Dataset with Rich Crowdsourced Annotations

This paper introduces a novel activity dataset which exhibits real-life and diverse scenarios of complex, temporally-extended human activities and actions. The dataset presents a set of videos of actors performing everyday activities in a natural and unscripted manner. The dataset was recorded using a static Kinect 2 sensor which is commonly used on many robotic platforms. The dataset comprises of RGB-D images, point cloud data, automatically generated skeleton tracks in addition to crowdsourced annotations. Furthermore, we also describe the methodology used to acquire annotations through crowdsourcing. Finally some activity recognition benchmarks are presented using current state-of-the-art techniques. We believe that this dataset is particularly suitable as a testbed for activity recognition research but it can also be applicable for other common tasks in robotics/computer vision research such as object detection and human skeleton tracking

CFHTLenS: A Weak Lensing Shear Analysis of the 3D-Matched-Filter Galaxy Clusters

We present the cluster mass-richness scaling relation calibrated by a weak lensing analysis of >18000 galaxy cluster candidates in the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS). Detected using the 3D-Matched-Filter cluster-finder of Milkeraitis et al., these cluster candidates span a wide range of masses, from the small group scale up to $\sim10^{15} M_{\odot}$, and redshifts 0.2 $\lesssim z\lesssim$ 0.9. The total significance of the stacked shear measurement amounts to 54$\sigma$. We compare cluster masses determined using weak lensing shear and magnification, finding the measurements in individual richness bins to yield 1$\sigma$ compatibility, but with magnification estimates biased low. This first direct mass comparison yields important insights for improving the systematics handling of future lensing magnification work. In addition, we confirm analyses that suggest cluster miscentring has an important effect on the observed 3D-MF halo profiles, and we quantify this by fitting for projected cluster centroid offsets, which are typically $\sim$ 0.4 arcmin. We bin the cluster candidates as a function of redshift, finding similar cluster masses and richness across the full range up to $z \sim$ 0.9. We measure the 3D-MF mass-richness scaling relation $M_{200} = M_0 (N_{200} / 20)^\beta$. We find a normalization $M_0 \sim (2.7^{+0.5}_{-0.4}) \times 10^{13} M_{\odot}$, and a logarithmic slope of $\beta \sim 1.4 \pm 0.1$, both of which are in 1$\sigma$ agreement with results from the magnification analysis. We find no evidence for a redshift-dependence of the normalization. The CFHTLenS 3D-MF cluster catalogue is now available at cfhtlens.org.Comment: 3D-MF cluster catalog is NOW AVAILABLE at cfhtlens.org. Magnification-shear mass comparison in Figure 10. 19 pages, 10 figures. Accepted to MNRA

Genetic mixed stock analysis of an interceptory Atlantic salmonfishery in the Northwest Atlantic

Interceptory fisheries represent an ongoing threat to migratory fish stocks particularly when managed in the absence of stock specific catch and exploitation information. Atlantic salmon from the southern portion of the North American range may be subject to exploitation in the commercial and recreational salmon fisheries occurring in the French territorial waters surrounding St. Pierre and Miquelon off southern Newfoundland. We evaluated stock composition of Atlantic salmon harvested in the St. Pierreand Miquelon Atlantic salmon fishery using genetic mixture analysis and individual assignment with a microsatellite baseline (15 loci, 12,409 individuals, 12 regional groups) encompassing the species western Atlantic range. Individual salmon were sampled from the St. Pierre and Miquelon fishery over four years (2004, 2011, 2013, and 2014). Biological characteristics indicate significant variation among years in the size and age distribution. Nonetheless, estimates of stock composition of the samples showed consistent dominance of three regions (i.e., Southern Gulf of St. Lawrence, Gaspe Peninsula, and New-foundland). Together salmon from these regions accounted for more than 70% of annual harvest over the decade examined. Comparison of individual assignments and biological characteristics revealed a trend of declining fresh water age with latitude of assigned region. Moreover, locally harvested Newfoundland salmon were ten times more likely to be small or one sea winter individuals whereas Quebec and Gaspe Peninsula salmon were two-three times more likely to be harvested as large or two sea winter salmon.Estimates of region specific catch were highest for salmon from the southern Gulf of St. Lawrence region ranging from 242 to 887 individuals annually. This work illustrates how genetic analysis of interceptory marine fisheries can directly inform assessment and management efforts in highly migratory marines pecies

Multimodal magnetic resonance neuroimaging measures characteristic of early cART-treated pediatric HIV: A feature selection approach

Children with perinatally acquired HIV (CPHIV) have poor cognitive outcomes despite early combination antiretroviral therapy (cART). While CPHIV-related brain alterations can be investigated separately using proton magnetic resonance spectroscopy

Mutational signature dynamics indicate SARS-CoV-2's evolutionary capacity is driven by host antiviral molecules

The COVID-19 pandemic has been characterised by sequential variant-specific waves shaped by viral, individual human and population factors. SARS-CoV-2 variants are defined by their unique combinations of mutations and there has been a clear adaptation to more efficient human infection since the emergence of this new human coronavirus in late 2019. Here, we use machine learning models to identify shared signatures, i.e., common underlying mutational processes and link these to the subset of mutations that define the variants of concern (VOCs). First, we examined the global SARS-CoV-2 genomes and associated metadata to determine how viral properties and public health measures have influenced the magnitude of waves, as measured by the number of infection cases, in different geographic locations using regression models. This analysis showed that, as expected, both public health measures and virus properties were associated with the waves of regional SARS-CoV-2 reported infection numbers and this impact varies geographically. We attribute this to intrinsic differences such as vaccine coverage, testing and sequencing capacity and the effectiveness of government stringency. To assess underlying evolutionary change, we used non-negative matrix factorisation and observed three distinct mutational signatures, unique in their substitution patterns and exposures from the SARS-CoV-2 genomes. Signatures 1, 2 and 3 were biased to C→T, T→C/A→G and G→T point mutations. We hypothesise assignments of these mutational signatures to the host antiviral molecules APOBEC, ADAR and ROS respectively. We observe a shift amidst the pandemic in relative mutational signature activity from predominantly Signature 1 changes to an increasingly high proportion of changes consistent with Signature 2. This could represent changes in how the virus and the host immune response interact and indicates how SARS-CoV-2 may continue to generate variation in the future. Linkage of the detected mutational signatures to the VOC-defining amino acids substitutions indicates the majority of SARS-CoV-2's evolutionary capacity is likely to be associated with the action of host antiviral molecules rather than virus replication errors

CFHTLenS: a weak lensing shear analysis of the 3D-Matched-Filter galaxy clusters

We present the cluster mass-richness scaling relation calibrated by a weak lensing analysis of ≳ 18000 galaxy cluster candidates in the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS). Detected using the 3D-Matched-Filter (MF) cluster-finder of Milkeraitis etal., these cluster candidates span a wide range of masses, from the small group scale up to∼1015 M⊙, and redshifts 0.2≲z≲0.9. The total significance of the stacked shear measurement amounts to 54σ. We compare cluster masses determined using weak lensing shear and magnification, finding the measurements in individual richness bins to yield 1σ compatibility, but with magnification estimates biased low. This first direct mass comparison yields important insights for improving the systematics handling of future lensing magnification work. In addition, we confirm analyses that suggest cluster miscentring has an important effect on the observed 3D-MF halo profiles, and we quantify this by fitting for projected cluster centroid offsets, which are typically∼0.4arcmin. We bin the cluster candidates as a function of redshift, finding similar cluster masses and richness across the full range up to z∼0.9. We measure the 3D-MF mass-richness scaling relation M200=M0(N200/20)β. We find a normalization $M_0 \sim (2.7^{+0.5}_{-0.4}) \times 10^{13} \,\mathrm{M}_{{\odot }}$, and a logarithmic slope of β∼1.4±0.1, both of which are in 1σ agreement with results from the magnification analysis. We find no evidence for a redshift dependence of the normalization. The CFHTLenS 3D-MF cluster catalogue is now available at cfhtlens.or

Perinatal HIV infection or exposure is associated with low N-acetylaspartate and glutamate in basal ganglia at age 9 but not 7 years

CITATION: Robertson, F. C., et al. 2018. Perinatal HIV infection or exposure is associated with low N-acetylaspartate and glutamate in basal ganglia at age 9 but not 7 years. Frontiers in Human Neuroscience, 12:145, doi:10.3389/fnhum.2018.00145.The original publication is available at https://www.frontiersin.orgENGLISH ABSTRACT: Abnormalities of the basal ganglia are frequently seen in HIV-infected (HIV+) children despite antiretroviral treatment (ART) initiation during childhood. Assessment of metabolites associated with neuronal integrity or with glial proliferation can present a sensitive description of metabolic events underlying basal ganglia structural changes. We used magnetic resonance spectroscopy to examine differences in creatine, choline, N-acetylaspartate (NAA), glutamate, and myo-inositol between HIV+ children and HIV-unexposed controls, as well as between HIV-exposed uninfected (HEU) children and HIV-unexposed controls at age 7 and at age 9. No differences in metabolites relative to the HIV-unexposed control group were found at age 7. However, at 9 years, both HIV+ and HEU had lower NAA and glutamate than unexposed control children. HEU children also had lower creatine and choline than control children. At age 7, lower CD4/CD8 ratio at enrollment was associated with lower choline levels. At age 9 lower CD4/CD8 at enrollment was associated with lower myo-inositol. Low NAA and glutamate at age 9, but not 7, suggest that basal ganglia neurons may be particularly affected by perinatal HIV/ART and that neuronal damage may be ongoing despite early ART and viral suppression. Reduced basal ganglia metabolite levels in HEU children suggest an effect of HIV exposure on childhood brain development that merits further investigation using neuroimaging and neurocognitive testing.https://www.frontiersin.org/articles/10.3389/fnhum.2018.00145/fullPublisher's versio

First Sample of Hα\alpha+[O III] λ\lambda5007 Line Emitters at z>6z > 6 through JWST/NIRCam Slitless Spectroscopy: Physical Properties and Line Luminosity Functions

We present a sample of four emission-line galaxies at $z=6.11-6.35$ that were serendipitously discovered using the commissioning data for the JWST/NIRCam wide-field slitless spectroscopy (WFSS) mode. One of them (at $z=6.11$) has been reported previously while the others are new discoveries. These sources are selected by the secure detections of both [O III] $\lambda$5007 and H$\alpha$ lines with other fainter lines tentatively detected in some cases (e.g., [O II] $\lambda$3727, [O III] $\lambda$4959 and [N II] $\lambda$6583). In the [O III]/H$\beta$ - [N II]/H$\alpha$ Baldwin-Phillips-Terlevich diagram, these galaxies occupy the same parameter space as that of $z\sim2$ star-forming galaxies, indicating that they have been enriched rapidly to sub-solar metallicities ($\sim$0.6 $Z_{\odot}$), similar to galaxies with comparable stellar masses at much lower redshifts. The detection of strong H$\alpha$ lines suggests a higher ionizing photon production efficiency within galaxies in the early Universe. We find brightening of the [O III] $\lambda$5007 line luminosity function (LF) from $z=3$ to 6, and no or weak redshift evolution of the H$\alpha$ line LF from $z=2$ to 6. Both LFs are under-predicted at $z\sim6$ by a factor of $\sim$10 in certain cosmological simulations. This further indicates a global Ly$\alpha$ photon escape fraction of 5-7% at $z\sim6$, much lower than previous estimates through the comparison of the UV-derived star-formation rate density and Ly$\alpha$ luminosity density. Our sample recovers $88^{+164}_{-57}$% of $z=6.0-6.6$ galaxies in the survey volume with stellar masses greater than $5\times10^8$ $M_{\odot}$, suggesting the ubiquity of strong H$\alpha$ and [O III] line emitters in the Epoch of Reionization, which will be further uncovered in the era of JWST.Comment: 25 pages, 11 figures, submitted to Ap

Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome

<p>Abstract</p> <p>Background</p> <p>Autogenous Iliac Crest Bone Graft (ICBG) has been the "gold standard" for spinal fusion. However, bone graft harvest may lead to complications, such as chronic pain, numbness, and poor cosmesis. The long-term impact of these complications on patient function and well-being has not been established but is critical in determining the value of expensive bone graft substitutes such as recombinant bone morphogenic protein. We thus aimed to investigate the long-term complications of ICBG. Our second aim was to evaluate the psychometric properties of a new measure of ICBG morbidity that would be useful for appropriately gauging spinal surgery outcomes.</p> <p>Methods</p> <p>Prospective study of patients undergoing spinal fusion surgery with autologous ICBG. The SF-36v2, Oswestry Disability Index, and a new 14-item follow-up questionnaire addressing persistent pain, functional limitation, and cosmesis were administered with an 83% response rate. Multiple regression analyses examined the independent effect of ICBG complications on physical and mental health and disability.</p> <p>Results</p> <p>The study population included 170 patients with a mean age of 51.1 years (SD = 12.2) and balanced gender (48% male). Lumbar fusion patients predominated (lumbar = 148; cervical n = 22). At 3.5 years mean follow-up, 5% of patients reported being bothered by harvest site scar appearance, 24% reported harvest site numbness, and 13% reported the numbness as bothersome. Harvest site pain resulted in difficulty with household chores (19%), recreational activity (18%), walking (16%), sexual activity (16%), work activity (10%), and irritation from clothing (9%). Multivariate regression analyses revealed that persistent ICBG complications 3.5 years post-surgery were associated with significantly worse disability and showed a trend association with worse physical health, after adjusting for age, workers' compensation status, surgical site pain, and arm or leg pain. There was no association between ICBG complications and mental health in the multivariate model.</p> <p>Conclusion</p> <p>Chronic ICBG harvest site pain and discomfort is reported by a significant percentage of patients undergoing this procedure more than three years following surgery, and these complications are associated with worse patient-reported disability. Future studies should consider employing a control group that does not include autologous bone graft harvest, e.g., a group utilizing rhBMP, to determine whether eliminating harvest-site morbidity does indeed lead to observable improvement in clinical outcome sufficient to justify the increased cost of bone graft substitutes.</p