1,063 research outputs found
Muons tomography applied to geosciences and volcanology
Imaging the inner part of large geological targets is an important issue in
geosciences with various applications. Dif- ferent approaches already exist
(e.g. gravimetry, electrical tomography) that give access to a wide range of
informations but with identified limitations or drawbacks (e.g. intrinsic
ambiguity of the inverse problem, time consuming deployment of sensors over
large distances). Here we present an alternative and complementary tomography
method based on the measurement of the cosmic muons flux attenuation through
the geological structures. We detail the basics of this muon tomography with a
special emphasis on the photo-active detectors.Comment: Invited talk at the 6th conference on New Developments In
Photodetection (NDIP'11), Lyon-France, July 4-8, 2011; Nuclear Instruments
and Methods in Physics Research Section A, 201
Acquired factor V inhibitor in a context of sepsis and disseminated intravascular coagulation
International audienc
Effect on Adherence to Nicotine Replacement Therapy of Informing Smokers Their Dose Is Determined by Their Genotype: A Randomised Controlled Trial
BACKGROUND: The behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA. METHODS AND FINDINGS: We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, participants were informed that their doses of oral NRT were based either on their mu-opioid receptor (OPRM1) genotype, or their nicotine dependence questionnaire score (phenotype). The proportion of prescribed NRT consumed in the first 28 days following quitting was not significantly different between groups: (68.5% of prescribed NRT consumed in genotype vs 63.6%, phenotype group, difference = 5.0%, 95% CI -0.9,10.8, p = 0.098). Motivation to make another quit attempt among those (n = 331) not abstinent at six months was not significantly different between groups (p = 0.23). Abstinence at 28 days was not different between groups (p = 0.67); at six months was greater in genotype than phenotype group (13.7% vs 7.9%, difference = 5.8%, 95% CI 1.0,10.7, p = 0.018). CONCLUSIONS: Informing smokers their oral dose of NRT was tailored to genotype not phenotype had a small, statistically non-significant effect on 28-day adherence to NRT. Among those still smoking at six months, there was no evidence that saying NRT was tailored to genotype adversely affected motivation to make another quit attempt. Higher abstinence rate at six months in the genotype arm requires investigation. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN14352545.</p
Speeding up Simplification of Polygonal Curves using Nested Approximations
We develop a multiresolution approach to the problem of polygonal curve
approximation. We show theoretically and experimentally that, if the
simplification algorithm A used between any two successive levels of resolution
satisfies some conditions, the multiresolution algorithm MR will have a
complexity lower than the complexity of A. In particular, we show that if A has
a O(N2/K) complexity (the complexity of a reduced search dynamic solution
approach), where N and K are respectively the initial and the final number of
segments, the complexity of MR is in O(N).We experimentally compare the
outcomes of MR with those of the optimal "full search" dynamic programming
solution and of classical merge and split approaches. The experimental
evaluations confirm the theoretical derivations and show that the proposed
approach evaluated on 2D coastal maps either shows a lower complexity or
provides polygonal approximations closer to the initial curves.Comment: 12 pages + figure
Introducing genetic testing for cardiovascular disease in primary care: a qualitative study
Background: While primary care systematically offers conventional cardiovascular risk assessment, genetic tests for coronary heart disease (CHD) are increasingly commercially available to patients. It is unclear how individuals may respond to these new sources of risk information.
Aim: To explore how patients who have had a recent conventional cardiovascular risk assessment, perceive additional information from genetic testing for CHD.
Design and setting: Qualitative interview study in 12 practices in Nottinghamshire from both urban and rural settings.
Method: Interviews were conducted with 29 adults, who consented to genetic testing after having had a conventional cardiovascular risk assessment.
Results: Individuals’ principal motivation for genetic testing was their family history of CHD and a desire to convey the results to their children. After testing, however, there was limited recall of genetic test results and scepticism about the value of informing their children. Participants dealt with conflicting findings from the genetic test, family history, and conventional assessment by either focusing on genetic risk or environmental lifestyle factors. In some participants, genetic test results appeared to reinforce healthy behaviour but others were falsely reassured, despite having an ‘above-average’ conventional cardiovascular risk score.
Conclusion: Although genetic testing was acceptable, participants were unclear how to interpret genetic risk results. To facilitate healthy behaviour, health professionals should explore patients’ understanding of genetic test results in light of their family history and conventional risk assessment
Physical micro-environment interventions for healthier eating in the workplace: protocol for a stepped wedge randomised controlled pilot trial
Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial
On five commercial cattle rearing sites across Europe, a total of 802 young cattle at high risk of developing bovine respiratory disease (BRD) associated with the bacterial pathogens Mannheimia haemolytica or Pasteurella multocida and/or Mycoplasma bovis were enrolled into a multicentre, controlled field trial. Half were treated with a single dose of gamithromycin at 6 mg/kg bodyweight by subcutaneous injection and half received an injection of a saline placebo as the control. All animals were observed daily for 14 days for signs of BRD as defined by set criteria. The proportion of metaphylactic preventive treatment successes, defined as animals surviving to day 14 without signs of BRD, in the gamithromycin-treated group (86 per cent) was significantly (P=0.0012) higher than in the saline-treated controls (61 per cent). Morbidity among the treated animals was reduced by 64 per cent compared with the controls
Un système de synthèse et d'annotation automatique à partir de données capturées pour l'animation faciale expressive en LSF
National audienceCe papier présente le fonctionnement d'un système visant à créer automatiquement des corpus d'animations faciales annotées pour la Langue des Signes Française (LSF) à partir de données issues de capture du mouvement (MoCap). L'animation produite est basée \emph{blendshapes}. Les coefficients associés à ce modèle sont calculés à partir des données capturées puis utilisés par le module de reconnaissance afin d'annoter automatiquement ces animations
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