Modulación de la entropía del electroencefalograma en esquizofrenia y trastorno bipolar

Para que se lleve a cabo un acto cognitivo es necesaria la correcta integración y coordinación entre las diferentes regiones cerebrales y sus respectivas redes neuronales. El electroencefalograma permite el estudio de todas estas conexiones cerebrales, así como sus cambios en el tiempo durante la realización de una tarea. Uno de los parámetros de mayor interés en este análisis, es la modulación de la entropía, que refleja los cambios que se producen en términos de regularidad y coordinación del trazado electroencefalográfico. El objetivo principal de este Trabajo de Fin de Grado es continuar ampliando el conocimiento acerca de los sustratos cerebrales de las psicosis, su representación a nivel electroencefalográfico y su relación con la clínica de los pacientes. Asimismo, busca replicar y reforzar los hallazgos obtenidos en estudios anteriores con muestras diferentes y compararlos con los registros en pacientes con Trastorno Bipolar para encontrar diferencias y similitudes entre ambos síndromes.Grado en Medicin

Analysis of timber as sustainable material for construction

Comunicació presentada a IN-TECH 2014 International Conference on Innovative Technologies (Leiria, Portugal 10-13, september 2014).Facing the climate change scenario, professionals and technicians of civil engineering and architecture are searching for ecological solutions and construction methods that would allow for higher energy-efficiency and then reduce environmental impacts. Timber represents one of the best choices for energy-efficient construction, since it also functions as a material with good thermal transmittance properties if compared to other construction materials. This work analyses the possibilities and benefits that wood offers for the construction industry, in terms of sustainability. On the one hand, the sustainable forest management system contributes to ensure the quality and well-management in the exploitation of the forest in order to produce timber and other sub-products such as cork, paper and tree resins. In relation to this, the construction industry has an important role to increase the level of sustainable products by demanding certified timber. On the other hand, due to its Life Cycle Assessment (LCA), timber has the lower energy consumption compared to other building materials, as well as the CO2 stored and saved contributes to mitigate climate change. The LCA stages for the production of timber, the potential of saving carbon emissions and its comparison with other building products are presented. Concerning energy efficiency, once timber is implemented in a building taking part of the structure or as cladding material, it provides a high insulation decreasing the thermal transmittance of the walls, roofs, floors and windows. Its versatility as construction material also enables obtaining innovative solutions which can be implemented in buildings, as it is presented in this study. The optimum energy performance and low carbon emissions of timber make from this product a suitable and sustainable material to be highly considered for the construction industry

Noves aportacions a l'arbre genealògic de la família Montcada, senyors de la Baronia d'Aitona

Montcada’s family had in Middle Ages the Baronia d’Aitona in the land known as Baix Segre, in Lleida. His properties included the villages of Serós, Aitona, Mequinensa, Faió, Vallobar and Maials. This part of the family, who lived in Lleida, is really unknown. Documents from the Arxiu Ducal de Medinaceli a Catalunya have shown new members of this part of the family unknown since now. This new information has allowed to complete the genealogical trees of the Montcada’s family in Lleida.Montcada’s family had in Middle Ages the Baronia d’Aitona in the land known as Baix Segre, in Lleida. His properties included the villages of Serós, Aitona, Mequinensa, Faió, Vallobar and Maials. This part of the family, who lived in Lleida, is really unknown. Documents from the Arxiu Ducal de Medinaceli a Catalunya have shown new members of this part of the family unknown since now. This new information has allowed to complete the genealogical trees of the Montcada’s family in Lleida

Determination of dimethyl selenide and dimethyl sulphide compounds causing off-flavours in bottled mineral waters

Sales of bottled drinking water have shown a large growth during the last two decades due to the general belief that this kind of water is healthier, its flavour is better and its consumption risk is lower than that of tap water. Due to the previous points, consumers are more demanding with bottled mineral water, especially when dealing with its organoleptic properties, like taste and odour. This work studies the compounds that can generate obnoxious smells, and that consumers have described like swampy, rotten eggs, sulphurous, cooked vegetable or cabbage. Closed loop stripping analysis (CLSA) has been used as a pre-concentration method for the analysis of off-flavour compounds in water followed by identification and quantification by means of GC-MS. Several bottled water with the aforementioned smells showed the presence of volatile dimethyl selenides and dimethyl sulphides, whose concentrations ranged, respectively, from 4 to 20 ng/L and from 1 to 63 ng/L. The low odour threshold concentrations (OTCs) of both organic selenide and sulphide derivatives prove that several objectionable odours in bottled waters arise from them. Microbial loads inherent to water sources, along with some critical conditions in water processing, could contribute to the formation of these compounds. There are few studies about volatile organic compounds in bottled drinking water and, at the best of our knowledge, this is the first study reporting the presence of dimethyl selenides and dimethyl sulphides causing odour problems in bottled watersPostprint (published version

Effect of storage on the nitro blue tetrazolium reduction test in dog blood samples

Altres ajuts: acords transformatius de la UABIntroduction: The nitro blue tetrazolium (NBT) reduction test (NBTT) has been used for measuring the metabolic activity of phagocytes of mammals. Activated neutrophils transform NBT into formazan in the cytoplasm. The NBTT can detect the activation of neutrophils in peripheral blood and is used to assess neutrophil function in dogs. However, the NBTT is not used frequently in the clinical setting, as samples should be processed after blood collection. Objective: The aim of this study was to evaluate the effect of storage on NBTT in dog blood samples. Materials and Methods: Residual EDTA blood samples from 22 dogs were included of different ages, breeds, and sex. The buffy coat layer was separated from the blood and incubated with 0.1% NBT. The NBTT was performed at 0, 24, 48, and 72 h after the collection of blood. Blood samples were stored at 4°C until the tests were performed. Blood smears were evaluated by light microscopy, and the NBT reduction rate was reported, which represents the percentage of activated neutrophils. The NBT reduction rate was calculated after counting 300 neutrophils in each slide. Results: The means of NBTT in dog blood samples at 0, 24, 48, and 72 h were 8.3%, 8.5%, 8.7%, and 7.8%, respectively. No significant differences were observed between time points. Conclusions: This study showed that the NBTT can be performed up to 72 h after the collection of canine blood if correctly refrigerated at 4°C. This finding supports the performance of the NBTT in the clinical setting

Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line

In human cervical carcinomas papillomavirus DNA is frequently integrated in the cell genome. We have cloned the integration site of human papillomavirus-18 DNA in human chromosome region 12q13-15 present in the SW756 cervical carcinoma cell line. Viral DNA is broken from nucleotides 2643 to 3418 in the E1 and E2 open reading frames, resulting in a deletion of 775 bases of viral DNA. Cloning and sequence analysis of the rearranged and germline alleles shows that there is no homology between the target cellular and viral DNA, suggesting it is a nonhomologous recombination. The target cellular region is called papillomavirus associated locus 2 (PAL2). The 5'- and 3'-flanking probes derived from the hybrid viral-cellular clone detect completely different germline restriction fragments in DNA from cells with normal chromosome 12. There is no overlap between the restriction maps of the target germline clones obtained with 5'- and 3'-flanking probes. Probes from these germline clones beyond the breakpoint position do not detect any DNA rearrangement in SW756 cells DNA. These data prove that there is a deletion of cellular DNA as consequence of the integration, with an estimated minimum size of 14 kilobases. Both cellular flanking probes are outside the amplicon of this chromosome region identified in the OSA and RMS13 sarcoma cell lines, comprising SAS-CHOP-CDK4-MDM2 genes and where translocation breakpoints are located in liposarcomas. The integration at 12q13-15 might have been selected by its contribution to the tumor phenotype.This work was supported in part by grants from Comisio ́n Inter-ministerial de Ciencia y Tecnologı ́a (SAF94/059), Fundacio ́n Ramo ́nAreces, and Fondo de Investigaciones Sanitarias (FIS95/413). The costsof publication of this article were defrayed in part by the payment ofpage charges. This article must therefore be hereby marked “advertise-ment” in accordance with 18 U.S.C. Section 1734 solely to indicate thisfact.S

Peptidomics as a tool for quality control in dry-cured ham processing

Spanish dry-cured ham is a high quality product whose economic value is mainly given by its curing time. An intense proteolysis takes place throughout the dry-cured processing, which results in the generation of a high amount of peptides and free amino acids responsible for the final quality of dry-cured hams. In this work, a peptidomics approach has been used to study the evolution of peptides throughout the ham dry-curing process, identifying and quantifying the generated peptides in order to define potential quality biomarkers. For this purpose, dry-cured ham extracts at different processing times (0, 2, 3.5, 5, 6.5 and 9 months) were fractionated by size-exclusion chromatography and analysed by nanoliquid chromatography coupled to tandem mass spectrometry. Differences obtained in the relative quantification of peptides by using a label-free methodology were useful to establish differences between processing times, being peptides generated by the degradation of myosin light chain 1 protein mainly responsible for the observed differences during the last stages of curing. In particular, APAPAPAPPKEEKI and PAPAPAPAPAPAPAPPKE, exclusively identified at 9 months of curing, would be potential markers to control the time of curing and thus the final quality of dry-cured hams.The FPI Scholarship BES-2011-046096 from MINECO (Spain) to M.G. and Grants AGL2013-47169-R from MINECO and FEDER funds are acknowledged. The research also received funding from the European Union Seventh Framework Programme FP7-PEOPLE-2013-CIG under Grant Agreement 614281 (HIGHVALFOOD). The JAEDOC-CSIC postdoctoral contract to L.M. co-funded by the European Social Fund is also acknowledged.Peer reviewe

El castell palau de Seròs, residència senyorial de la família Montcada

A la primera meitat del segle XVI la família Montcada, senyors d'Aitona, van promoure la construcció d'un gran palau a Seròs per establir-hi la seva residència. El Palau va ser construït amb la voluntat de disposar d'una residència senyorial condicionada, atenent a les necessitats del moment, situada a la plana del Segre, en els dominis de la família, tot substituint l'antic castell d'Aitona, molt afectat per les vicissituds històriques. Ës d'un edifici de planta rectangular, de línies senzilles que no descuida els aspectes ornamentals i els detalls característics de l'arquitectura siscentista. Diversos són els motius que determinaren l'establiment dels Montcada a la vila de Seròs, on van crear una nova capital dels seus dominis senyorial

Self-consumption for energy communities in Spain: a regional analysis under the new legal framework

European climate polices acknowledge the role that energy communities can play in the energy transition. Self-consumption installations shared among those living in the same building are a good example of such energy communities. In this work, we perform a regional analysis of optimal self-consumption installations under the new legal framework recently passed in Spain. Results show that the optimal sizing of the installation leads to economic savings for self-consumers in all the territory, for both options with and without remuneration for energy surplus. A sensitivity analysis on technology costs revealed that batteries still require noticeably cost reductions to be cost-effective in a behind the meter self-consumption environment. In addition, solar compensation mechanisms make batteries less attractive in a scenario of low PV costs, since feeding PV surplus into the grid, yet less efficient, becomes more cost-effective. An improvement for the current energy surplus remuneration policy was proposed and analysed. It consists in the inclusion of the economic value of the avoided power losses in the remuneration.Comment: Submitted version. 23 pages, 8 figure

Behaviour of texture-modified meats using proteolytic enzymes during gastrointestinal digestion simulating elderly alterations

[EN] This study aimed to apply different proteolytic enzymes (bromelain, papain, and flavourzyme) to develop texture-modified meats suitable for people with chewing or swallowing problems. The samples were categorised at level 6 (soft and bite-sized food) of the dysphagia diet, characterised in terms of physicochemical and textural parameters, and evaluated for their behaviour during gastrointestinal digestion simulating elderly alterations. In general, the enzyme-treated samples had lower moisture content, weight, and diameter of the piece of meat, and presented colour differences compared to the control samples. Textural analyses did not show significant differences in terms of hardness and cohesiveness for the texture-modified meats, while flavourzyme-treated samples presented less elasticity. Instrumental mastication assay showed the breakdown of samples' structure mainly during the first mastication cycles, with flavourzyme-treated samples presenting slightly higher consistency. The protein digestibility of the meats greatly increased after simulated gastrointestinal digestion, but a decrease in proteolysis for the control and papain-treated samples in the altered gastric model and an increase for flavourzyme-treated samples in the altered both gastric and intestinal model were shown compared to standard conditions. These results allow integrating knowledge to design foods that better meet the requirements of dysphagics or elderly people.M.G. gratefully thanks the Postdoctoral grant (PAID-10-19) from the Universitat Politecnica de Valencia. Authors acknowledge Vicerrectorado de Investigacion de la Universitat Politecnica de Valencia (PAID-11-22) for the financial support. Funding for open access charge: CRUE-Universitat Politecnica de ValenciaGallego, M.; Grau Meló, R.; Talens Oliag, P. (2023). Behaviour of texture-modified meats using proteolytic enzymes during gastrointestinal digestion simulating elderly alterations. Meat Science. 206. https://doi.org/10.1016/j.meatsci.2023.10934120