A ontologia na ciência da informação

Este artigo apresenta o uso do termo ontologia, a partir de levantamento da freqüência deste em artigos de periódicos indexados na Base LISA. Procurou-se identificar a evolução do volume de publicações em diversos idiomas, desde a primeira vez em que o termo foi utilizado, em 1977, até março de 2006; a relação do termo com outros temas e a identificação dos pesquisadores com maior contribuição acadêmica na área. Os dados encontrados sugerem que deve ser realizado um estudo qualitativo, como a análise de conteúdo dos resumos ou textos completos para estabelecer uma análise mais aprofundada do escopo em que a ontologia se vê inserida hoje no campo da Ciência da Informação. Abstract This paper presents ontology term using thorough of frequency reseraching of it, at articles of indexed journals at LISA database. The objective was identify publications quantity increasing at various languages, since the first time where the term was used, at 1977, until March 2006 and the researchers identification with great academic contribution at this area. The founded data suggest that it must be developed a qualitative study, like the complete analysis of content of the abstracts or texts to establish a scope deeper analysis where Ontology is inserted today at Information Science area

Predictors of In-Hospital Mortality after Recovered Out-of-Hospital Cardiac Arrest in Patients with Proven Significant Coronary Artery Disease: A Retrospective Study

Introduction: Recovered Out-of-Hospital Cardiac Arrest (rOHCA) population is heterogenous. Few studies focused on outcomes in the rOHCA subgroup with proven significant coronary artery disease (SigCAD). We aimed to characterize this subgroup and study the determinants of in-hospital mortality. Methods: Retrospective study of consecutive rOHCA patients submitted to coronary angiography. Only patients with SigCAD were included. Results: 60 patients were studied, 85% were male, mean age was 62.6 ± 12.1 years. In-hospital mortality rate was 43.3%. Patients with diabetes and history of stroke were less likely to survive. Significant univariate predictors of in-hospital mortality were further analysed separately, according to whether they were present at hospital admission or developed during hospital evolution. At hospital admission, initial non-shockable rhythm, low-flow time>12min, pH4.75mmol/L were the most relevant predictors and therefore included in a score tested by Kaplan-Meyer. Patients who had 0/4 criteria had 100% chance of survival till hospital discharge, 1/4 had 77%, 2/4 had 50%, 3/4 had 25%. Patients with all 4 criteria had 0% survival. During in-hospital evolution, a pH2mmol/L at 24h, anoxic brain injury and persistent hemodynamic instability proved significant. Patients who had 0/4 of these in-hospital criteria had 100% chance of survival till hospital discharge, 1/4 had 94%, 2/4 had 47%, 3/4 had 25%. Patients with all 4 criteria had 0% survival. Contrarily, CAD severity and ventricular dysfunction didn't significantly correlate to the outcome. Conclusion: Classic prehospital variables retain their value in predicting mortality in the specific group of OHCA with SigCAD. In-hospital evolution variables proved to add value in mortality prediction. Combining these simple variables in risk scores might help refining prognostic prediction in these patients's subset.info:eu-repo/semantics/publishedVersio

Exposição ocupacional ao SARSCov2 e uso de EPI nos cuidados de saúde: narrativa da construção de um recurso formativo

info:eu-repo/semantics/publishedVersio

GAMMA RADIATION AS A METHOD FOR STERILIZATION OF ALL-IN-ONE ADMIXTURES BAGS FOR CLINICAL USE: A STUDY OF STABILITY

Objective: The aim of this work was to evaluate the stability of all-in-one (AIO) admixtures exposed to gamma irradiation sterilization.Methods: The samples were divided into four groups with 10 bags each: a) Group I: control samples (bags without sterilization or inoculation with microorganisms); b) Group II: bags sterilized by gamma irradiation; c) Group III: bags inoculated and then irradiated and, d) Group IV: bags only inoculated. The following studies were performed: macroscopic analysis of admixtures; physicochemical stability; degree of lipoperoxidation (LPO), and microbiological tests.Results: Gamma irradiation sterilization was 100% effective, since no irradiated sample showed growth of microorganisms. All groups exhibited similar particle size distribution, but a longer storage time led to a smaller percentage of large particles. In general, irradiated samples showed reduced LPO.Conclusion: Gamma irradiation sterilization of these admixtures can be extended to clinical practice, as it results in physicochemically stable admixtures

Plasmatic miR-210, miR-221 and miR-1233 profile:Potential liquid biopsies candidates for renal cell carcinoma

Renal cell carcinoma (RCC) represents a challenge for clinicians since the nonexistence of screening and monitoring tests contributes to the fact that one-third of patients are diagnosed with metastatic disease and 20-40% of the remaining patients will also develop metastasis. Modern medicine is now trying to establish circulating biomolecules as the gold standard of biomarkers. Among the molecules that can be released from tumor cells we can find microRNAs. The aim of this study was to evaluate the applicability of cancer-related miR-210, miR-218, miR-221 and miR-1233 as prognostic biomarkers for RCC. Patients with higher levels of miR-210, miR-221 and miR-1233 presented a higher risk of specific death by RCC and a lower cancer-specific survival. The addition of miR-210, miR-221 and miR-1233 plasma levels information improved the capacity to predict death by cancer in 8, 4% when compared to the current variables used by clinicians. We also verified that hypoxia stimulates the release of miR-210 and miR-1233 from HKC-8, RCC-FG2 and 786-O cell lines. These results support the addition of circulating microRNAs as prognostic biomarkers for RCC

Gestão de cuidado na segurança do paciente grave: revisão integrativa

Introduction: Care management in the ICU is carried out by the nurse, who must organize her team to provide assistance to critical patients in all their therapeutic complexity, using technology, science and humanization. Objective: To evaluate care management in critically ill patient safety. Methodology: Integrative literature review research, guided by the following steps: construction of the research question; delimitation of inclusion and exclusion criteria; choice of databases; search and selection of studies; analysis and presentation of results. Results and Discussion: 1,500 studies were identified, after applying the language inclusion criteria, remaining 50 studies, and then reading the titles, in which 1,450 articles were excluded, as they were not related to the objective of this article. The summaries of the 50 articles selected based on the analysis of the titles were read. 10 articles were included in the work. Conclusion: Therefore, we can conclude the objective of the work was concluded by identifying that occurrences of errors and adverse events within the ICU, for the most part, are the responsibility of the nursing team due to the direct and constant provision of patient care and are linked to medications, failure in communication between the nursing team, lack of training and professional overload, in addition to carrying out procedures.Introdução: A gestão do cuidado na UTI é feita pela enfermeira, na qual deve organizar sua equipe para prestar assistência ao paciente crítico em toda sua complexidade terapêutica, utilizando tecnologia, ciência e humanização. Objetivo: Avaliar a gestão do cuidado na segurança do paciente grave. Metodologia: Pesquisa de revisão integrativa da literatura, guiada pelas seguintes etapas: construção da questão de pesquisa; delimitação dos critérios de inclusão e exclusão; escolha das bases de dados; busca e seleção dos estudos; análise e exposição dos resultados.  Resultados e Discussão: Foram identificados 1.500 estudos, depois da aplicação do critério de inclusão do idioma, permanecendo os 50 estudos, e em seguida a leitura dos títulos, nos quais foram excluídos 1.450 artigos, por não estarem relacionados ao objetivo deste artigo. Houve a leitura dos resumos dos 50 artigos selecionados a partir da análise dos títulos. Foram incluídos 10 artigos no trabalho. Conclusão: Sendo assim, podemos concluir o objetivo do trabalho foi concluído identificando que ocorrências de erros e eventos adversos dentro da UTI, em sua maioria, são de competência são de competência da equipe de enfermagem devido à realização direta e constante dos cuidados ao paciente e estão ligadas a medicamentos, falha na comunicação da equipe de enfermagem, falta de capacitação e sobrecarga do profissional, além de realização de procedimentos

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression

Blood flow shapes vascular networks by orchestrating endothelial cell behavior and function. How endothelial cells read and interpret flow-derived signals is poorly understood. Here, we show that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress. Inducible genetic deletion of the essential cilia component intraflagellar transport protein 88 (IFT88) in endothelial cells caused premature and random vessel regression without affecting proliferation, cell cycle progression, or apoptosis. IFT88 mutant cells lacking primary cilia displayed reduced polarization against blood flow, selectively at low and intermediate flow levels, and have a stronger migratory behavior. Molecularly, we identify that primary cilia endow endothelial cells with strongly enhanced sensitivity to bone morphogenic protein 9 (BMP9), selectively under low flow. We propose that BMP9 signaling cooperates with the primary cilia at low flow to keep immature vessels open before high shear stress-mediated remodeling

Epidemiology of Psoriasis in Portugal: A Population-Based Study

Introduction: Psoriasis is a common, chronic, and inflammatory skin disorder with a high personal, social and economic burden and important implications for healthcare systems. The aim of this study was to provide an epidemiological characterization of individuals with psoriasis in Portugal. Material and Methods: A large observational, cross-sectional, nationwide, population-based survey study developed by the Portuguese Psoriasis Group of the Portuguese Society of Dermatology and Venereology (GPP-SPDV). A structured questionnaire was designed and applied by experienced interviewers to a random, representative sample of Portuguese individuals with psoriasis and/or psoriatic arthritis. Patients were considered to have psoriasis if they replied positively to one of the following questions: “Does any physician have ever diagnosed you with psoriasis?” or “Do you have a skin disorder characterized by scaling, reddish skin lesions located in the elbows/knees/scalp?”. Results: A total of 6381 individuals were interviewed, of which 283 met the criteria for psoriasis, corresponding to a prevalence rate of 4.4% (95% CI 3.95 – 4.98). Out of the participants that met psoriasis criteria, 24% had suggestive signs/symptoms but did not have a clinical diagnosis established and were not being monitored by a physician. Although more than 70% of participants had active disease (scaling, erythema, or pruritus) and one third had joint symptoms, only 12% were on systemic treatment. Fifty percent of participants with psoriasis (n = 139) had relevant comorbidities (most frequently depression/anxiety and cardiometabolic diseases). Sixteen percent of participants with psoriasis (n = 46) reported that psoriasis interfered with their daily activities (median impact of 5 in a 0 – 10 scale) and 12% mentioned the disease had an impact in their sexual life (median impact of 5 in a 0 – 10 scale). Conclusion: The results of this study suggest that the prevalence rate of psoriasis is likely to be high in Portugal, and several gaps exist at different levels of healthcare delivery to these patients, from diagnosis to treatment. This study provides important data for the future planning of interventions targeting the improvement of psoriasis care in Portugal