A beam search approach to solve the convex irregular bin packing problem with guillotine cuts

This paper presents a two dimensional convex irregular bin packing problem with guillotine cuts. The problem combines the challenges of tackling the complexity of packing irregular pieces, guaranteeing guillotine cuts that are not always orthogonal to the edges of the bin, and allocating pieces to bins that are not necessarily of the same size. This problem is known as a two-dimensional multi bin size bin packing problem with convex irregular pieces and guillotine cuts. Since pieces are separated by means of guillotine cuts, our study is restricted to convex pieces.A beam search algorithm is described, which is successfully applied to both the multi and single bin size instances. The algorithm is competitive with the results reported in the literature for the single bin size problem and provides the first results for the multi bin size problem

Sheep as an experimental model: individual housing allowing visual, auditory, olfactory and tactile contact is not an obstacle for studies involving hormonal interrelationships

Thirty-two ewes were used to determine whether individual housing, allowing contact with neighbours, induces a stress response. Ewes were housed in individual pens designed to allow the ewes to see, hear, smell and touch adjacent animals, and were distributed into four groups (n=8/group): ewes with subcutaneous implants containing melatonin and oestradiol (M+E), melatonin (M), oestradiol (E) and non-implanted control ewes (C). Heart rate, stress indicators (plasma cortisol, glucose, lactate and creatine kinase (CK) concentrations) and luteinizing hormone (LH) concentrations were measured hourly and compared with the resting values (before and after pen housing). Heart rate increased significantly during the introduction into the pen (P<0.001) in all groups, in comparison with the resting values. No significant differences between groups were observed for cortisol concentrations, with the exception of the M group, which showed the highest response (P<0.001) when ewes were introduced into the pens. Lactate, CK and glucose changes in comparison with the resting values were similar between groups. LH concentrations during pen housing decreased significantly in all groups in comparison with resting values. In conclusion, individual confinement of sheep allowing visual, auditory, olfactory and tactile contact with their neighbouring animals was not an obstacle for investigating particular hormonal interrelationships with multiple sampling procedures. However further investigations are required to determine if this conclusion applies to other hormone systems in sheep

An Entangled Model for Sustainability Indicators.

Nowadays the challenge for humanity is to find pathways towards sustainable development. Decision makers require a set of sustainability indicators to know if the sustainability strategies are following those pathways. There are more than one hundred sustainability indicators but they differ on their relative importance according to the size of the locality and change on time. The resources needed to follow these sustainability indicators are scarce and in some instances finite, especially in smaller regions. Therefore strategies to select set of these indicators are useful for decision makers responsible for monitoring sustainability. In this paper we propose a model for the identification and selection of a set of sustainability indicators that adequately represents human systems. In developing this model, we applied evolutionary dynamics in a space where sustainability indicators are fundamental entities interconnected by an interaction matrix. we used a fixed interaction that simulates the current context for the city of Cuernavaca, México as an example. We were able to identify and define relevant sets indicators for the system by using the Pareto principle. In this case we identified a set of sixteen sustainability indicators with more than 80% of the total strength. This set presents resilience to perturbations. For the Tangled Nature framework we provided a manner of treating different contexts (i.e., cities, counties, states, regions, countries, continents or the whole planet), dealing with small dimensions. This model provides decision makers with a valuable tool to select sustainability indicators set for towns, cities, regions, countries, continents or the entire planet according to a coevolutionary framework. The social legitimacy can arise from the fact that each individual indicator must be selected from those that are most important for the subject community

Estado del Arte en Cambio Climático, Agricultura y Seguridad Alimentaria en El Salvador

El Salvador es uno de los países con mayor vulnerabilidad ante los efectos del cambio climático en América Central; es por esto que el Ministerio de Agricultura y Ganadería (MAG) en colaboración con el Programa de Investigación de CGIAR en Cambio Climático, Agricultura y Seguridad Alimentaria (CCAFS) en América Latina y con apoyo del Consejo Agropecuario Centroamericano (CAC) presentan el “Estado del Arte en Cambio Climático, Agricultura y Seguridad Alimentaria en El Salvador”, así como el marco gubernamental y actores involucrados en torno a esta temática. En el documento se evidencia que a nivel nacional se realizan diferentes iniciativas para enfrentar los efectos del cambio climático en el sector agropecuario, que se han agravado debido al deterioro ambiental del territorio nacional, así como por la alta vulnerabilidad ante eventos climáticos extremos y el nivel de pobreza de las comunidades. Estas iniciativas promueven el desarrollo integral de los productores de cultivos de subsistencia y comerciales, mediante un abordaje transversal de los temas de cambio climático y seguridad alimentaria con la intervención de actores tanto del sector público como privado, y con un marco de políticas e instrumentos que fomentan las acciones colaborativas a nivel regional y nacional hacia el desarrollo sostenible. Sin embargo es necesario fomentar y fortalecer las investigaciones a nivel nacional, así como las capacidades de los productores para adaptarse a los efectos del cambio climático

A Semantic Web methodological framework to evaluate the support of integrity in thesaurus tools

12 p.With the Semantic Web, thesauri recover a relevant role supporting semantic searches and other added-value services. Thesaurus standards define what constructs a thesaurus can have and the integrity rules it must comply with. Thesaurus editors can be helped in their work if thesaurus tools offer them support for integrity, warning when integrity rules are violated and/or helping them to correct these mistakes. The most recent thesaurus standard is ISO 25964, which supersedes ISO 2788, evolving towards concept-based thesauri, better aligned with the Semantic Web approach than the term-based thesauri of ISO 2788. However, the W3C recommendation for KOS (Knowledge Organization System) representation in the semantic web context is SKOS, which is in fact prior to ISO 25964. This paper focuses on thesaurus integrity and the evolution from ISO 2788 to ISO 25964. Its effect on integrity issues is analyzed. A methodological proposal for evaluating integrity support in thesaurus tools, arising from the results of this work, is presented. Its target audience is professionals in charge of thesaurus edition. Besides being adapted to the most recent thesaurus standard, ISO 25964, it also includes the comparison of ISO standards with SKOS. The paper is completed with the presentation of the results of applying it to three thesaurus tools

Analytical model for predicting the buckling load of continuous welded rail tracks

The use of continuous welded rail (CWR) track has solved many of the problems associated with tread surface discontinuities that occur in jointed tracks. However, due to the longitudinal expansion of the rails in CWR tracks being highly constrained, the generated compressive stresses in the rails can cause track buckling in the horizontal plane. Track buckling is a complex phenomenon, in which many factors are involved and around which there is much uncertainty. The objective of this paper is to present an analytical model that can be used to calculate the buckling load of a CWR track. This model accounts for the contributions of base, crib and shoulder ballast and includes the effect of vertical loading on each of these components. Moreover, a parametric study based on this model is developed, in order to understand how and the extent to which the considered factors affect track stability. The results of the study indicate that the characteristics of the existing misalignments in the track are the critical parameters involved in the phenomenon. In addition, maintenance operations that affect the ballast, such as tamping or surfacing, and the dimensions and material of the track sleepers are also important factors.Navarro Martinez, JI.; Villalba Sanchis, I.; Martínez Fernández, P.; Insa Franco, R. (2015). Analytical model for predicting the buckling load of continuous welded rail tracks. Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit. 229(5):542-552. doi:10.1177/0954409713518039S5425522295Kerr, A. D. (1978). Analysis of thermal track buckling in the lateral plane. Acta Mechanica, 30(1-2), 17-50. doi:10.1007/bf01177436Grissom, G. T., & Kerr, A. D. (2006). Analysis of lateral track buckling using new frame-type equations. International Journal of Mechanical Sciences, 48(1), 21-32. doi:10.1016/j.ijmecsci.2005.09.006Le Pen, L. M., & Powrie, W. (2011). Contribution of Base, Crib, and Shoulder Ballast to the Lateral Sliding Resistance of Railway Track: A Geotechnical Perspective. Proceedings of the Institution of Mechanical Engineers, Part F: Journal of Rail and Rapid Transit, 225(2), 113-128. doi:10.1177/095440971039709

Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9

In adaptive immunity, CLEC-2+ dendritic cells (DCs) contact fibroblastic reticular cells (FRCs) inhibiting podoplanin-dependent actomyosin contractility, permitting FRC spreading and lymph node expansion. The molecular mechanisms controlling lymph node remodelling are incompletely understood. We asked how podoplanin is regulated on FRCs in the early phase of lymph node expansion, and which other proteins are required for the FRC response to DCs. We find that podoplanin and its partner proteins CD44 and CD9 are differentially expressed by specific lymph node stromal populations in vivo, and their expression in FRCs is coregulated by CLEC-2 (encoded by CLEC1B). Both CD44 and CD9 suppress podoplanin-dependent contractility. We find that beyond contractility, podoplanin is required for FRC polarity and alignment. Independently of podoplanin, CD44 and CD9 affect FRC–FRC interactions. Furthermore, our data show that remodelling of the FRC cytoskeleton in response to DCs is a two-step process requiring podoplanin partner proteins CD44 and CD9. Firstly, CLEC-2 and podoplanin binding inhibits FRC contractility, and, secondly, FRCs form protrusions and spread, which requires both CD44 and CD9. Together, we show a multi-faceted FRC response to DCs, which requires CD44 and CD9 in addition to podoplanin

Pollutant dispersion in a developing valley cold-air pool

Pollutants are trapped and accumulate within cold-air pools, thereby affecting air quality. A numerical model is used to quantify the role of cold-air-pooling processes in the dispersion of air pollution in a developing cold-air pool within an alpine valley under decoupled stable conditions. Results indicate that the negatively buoyant downslope flows transport and mix pollutants into the valley to depths that depend on the temperature deficit of the flow and the ambient temperature structure inside the valley. Along the slopes, pollutants are generally entrained above the cold-air pool and detrained within the cold-air pool, largely above the ground-based inversion layer. The ability of the cold-air pool to dilute pollutants is quantified. The analysis shows that the downslope flows fill the valley with air from above, which is then largely trapped within the cold-air pool, and that dilution depends on where the pollutants are emitted with respect to the positions of the top of the ground-based inversion layer and cold-air pool, and on the slope wind speeds. Over the lower part of the slopes, the cold-air-pool-averaged concentrations are proportional to the slope wind speeds where the pollutants are emitted, and diminish as the cold-air pool deepens. Pollutants emitted within the ground-based inversion layer are largely trapped there. Pollutants emitted farther up the slopes detrain within the cold-air pool above the ground-based inversion layer, although some fraction, increasing with distance from the top of the slopes, penetrates into the ground-based inversion layer.Peer reviewe