110 research outputs found

    Mapping autism risk loci using genetic linkage and chromosomal rearrangements.

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    International audienceAutism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size relative to other studies of ASDs by using Affymetrix 10K SNP arrays and 1,181 [corrected] families with at least two affected individuals, performing the largest linkage scan to date while also analyzing copy number variation in these families. Linkage and copy number variation analyses implicate chromosome 11p12-p13 and neurexins, respectively, among other candidate loci. Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs

    Study of the doubly charmed tetraquark T+cc

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    Quantum chromodynamics, the theory of the strong force, describes interactions of coloured quarks and gluons and the formation of hadronic matter. Conventional hadronic matter consists of baryons and mesons made of three quarks and quark-antiquark pairs, respectively. Particles with an alternative quark content are known as exotic states. Here a study is reported of an exotic narrow state in the D0D0π+ mass spectrum just below the D*+D0 mass threshold produced in proton-proton collisions collected with the LHCb detector at the Large Hadron Collider. The state is consistent with the ground isoscalar T+cc tetraquark with a quark content of ccu⎯⎯⎯d⎯⎯⎯ and spin-parity quantum numbers JP = 1+. Study of the DD mass spectra disfavours interpretation of the resonance as the isovector state. The decay structure via intermediate off-shell D*+ mesons is consistent with the observed D0π+ mass distribution. To analyse the mass of the resonance and its coupling to the D*D system, a dedicated model is developed under the assumption of an isoscalar axial-vector T+cc state decaying to the D*D channel. Using this model, resonance parameters including the pole position, scattering length, effective range and compositeness are determined to reveal important information about the nature of the T+cc state. In addition, an unexpected dependence of the production rate on track multiplicity is observed

    Education and ICT-based self-regulation in learning: Theory, design and implementation

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    The tragedy of American diplomacy? Rethinking the Marshall Plan

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    Two British scholars reassess what they view as the decisive episode in the early Cold War, the Marshall Plan. Far from seeing the Plan as a mere act of generosity by the United States, they argue that it was an integral part of an increasingly aggressive U.S. posture toward the Soviet Union. The Soviet Union was still seeking a cooperative relationship with the United States, but the U.S. decision to establish a European Recovery Program (ERP) without a sincere intention of including the Soviet Union posed a threat to Soviet security interests. Josif Stalin wanted to prevent the United States from luring the East European countries away from the Soviet Union's sphere of influence and into the Western sphere. Although Stalin was reluctant to abandon his bid for close cooperation with the West, the Marshall Plan left him with little choice. As the ERP progressed, Stalin drastically tightened his hold over Eastern Europe and imposed Soviet-style systems on the countries in the region. The Marshall Plan thus had the "tragic" effect of creating a long-term divide in Europe that consigned tens of millions of people to life under tyranny

    Is the Supreme Court Sometimes Irrelevant?: Race and the Southern Criminal Justice System in the World War II Era

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