FORGE enabling FIRE facilities for the eLearning community

International audienceMany engineering students at third-level institutions across the world will not have the advantage of using real-world experimentation equipment, as the infrastructure and resources required for this activity are too expensive. This paper explains how the FORGE (Forging Online Education through FIRE) FP7 project transforms Future Internet Research and Experimentation (FIRE) testbed facilities into educational resources for the eLearning community. This is achieved by providing a framework for remote experimentation that supports easy access and control to testbed infrastructure for students and educators. Moreover, we identify a list of recommendations to support development of eLearning courses that access these facilities and highlight some of the challenges encountered by FORGE

Index selection in terminal sires improves early lamb growth

The use of terminal sires (TS) for crossbreeding is integral to the UK sheep industry where approximately 71% of market lambs are sired by TS rams. Early growth of these crossbred lambs affects profitability. The objectives of this study were i) to evaluate the effectiveness of index selection among TS on BW and ADG of their crossbred offspring; and ii) to compare the efficacy of that selection within TS breeds. The most widely used TS breeds in the United Kingdom are Charollais, Suffolk, and Texel. These participated in sire referencing schemes in which they were evaluated on a lean growth index designed to increase carcass lean weight at a given age. From 1999 to 2002, approximately 15 high and 15 low lean growth index rams per breed (93 in total, differing in index on average by 4.6 SD) were selected from within their sire referencing schemes and mated to Welsh and Scottish Mule ewes. Their crossbred offspring were reared commercially on 3 experimental farms in England, Scotland, and Wales. A total of 6,515 lambs were born between 2000 and 2003. Lambs were weighed at birth (BWT), 5 wk (5WT), and 10 wk (10WT), and their ADG from birth to 10 wk was calculated. Lambs sired by high index rams were on average, across breeds, heavier at all ages (P \u3c 0.01) with 0.07 ± 0.03, 0.3 ± 0.1, and 0.4 ± 0.1 kg greater BWT, 5WT, and 10WT, respectively. Their ADG was 5.1 ± 1.9 g/d greater than low-index-sired lambs (P \u3c 0.01). Suffolk-sired lambs were on average heavier at all ages, with greater ADG, whereas Charollais-sired lambs were lightest with smallest ADG. Overall, there was no significant interaction between sire index and sire breed (P \u3e 0.10). Within Suffolk-sired lambs, there was little difference between high and low index sires for the traits studied (P \u3e 0.3). High and low index Charollais-sired lambs differed in BWT (0.09 ± 0.04 kg) and 5WT (0.3 ± 0.1 kg), and Texel-sired lambs differed in 5WT (0.5 ± 0.1 kg), 10WT (0.9 ± 0.2 kg), and ADG (10.2 ± 3.3 g/d; P \u3c 0.01). Lambs from Scottish Mule dams were heavier, with greater ADG, than lambs born to Welsh Mules (P \u3c 0.01). Lambs reared in Scotland were heavier at all ages (P \u3c 0.01). The results suggest that using index selection in TS can improve the growth of their commercial offspring reared on grass

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma.

While liposarcoma is the second most common soft tissue malignant tumor, the molecular pathogenesis in this malignancy is poorly understood. Our goal was therefore to expand the understanding of molecular mechanisms that drive liposarcoma and identify therapeutically-susceptible genetic alterations. We studied a cohort of high-grade liposarcomas and benign lipomas across multiple disease sites, as well as two liposarcoma cell lines, using multiplexed mutational analysis. Nucleic acids extracted from diagnostic patient tissue were simultaneously interrogated for 150 common mutations across 15 essential cancer genes using a clinically-validated platform for cancer genotyping. Western blot analysis was implemented to detect activation of downstream pathways. Liposarcoma cell lines were used to determine the effects of PI3K targeted drug treatment with or without chemotherapy. We identified mutations in the PIK3CA gene in 4 of 18 human liposarcoma patients (22%). No PIK3CA mutations were identified in benign lipomas. Western blot analysis confirmed downstream activation of AKT in both PIK3CA mutant and non-mutant liposarcoma samples. PI-103, a dual PI3K/mTOR inhibitor, effectively inhibited the activation of the PI3K/AKT in liposarcoma cell lines and induced apoptosis. Importantly, combination with PI-103 treatment strongly synergized the growth-inhibitory effects of the chemotherapy drugs doxorubicin and cisplatin in liposarcoma cells. Taken together, these findings suggest that activation of the PI3K/AKT pathway is an important cancer mechanism in liposarcoma. Targeting the PI3K/AKT/pathway with small molecule inhibitors in combination with chemotherapy could be exploited as a novel strategy in the treatment of liposarcoma

Resolving the age bimodality of galaxy stellar populations on kpc scales

Galaxies in the local Universe are known to follow bimodal distributions in the global stellar populations properties. We analyze the distribution of the local average stellar-population ages of 654,053 sub-galactic regions resolved on ~1-kpc scales in a volume-corrected sample of 394 galaxies, drawn from the CALIFA-DR3 integral-field-spectroscopy survey and complemented by SDSS imaging. We find a bimodal local-age distribution, with an old and a young peak primarily due to regions in early-type galaxies and star-forming regions of spirals, respectively. Within spiral galaxies, the older ages of bulges and inter-arm regions relative to spiral arms support an internal age bimodality. Although regions of higher stellar-mass surface-density, mu*, are typically older, mu* alone does not determine the stellar population age and a bimodal distribution is found at any fixed mu*. We identify an "old ridge" of regions of age ~9 Gyr, independent of mu*, and a "young sequence" of regions with age increasing with mu* from 1-1.5 Gyr to 4-5 Gyr. We interpret the former as regions containing only old stars, and the latter as regions where the relative contamination of old stellar populations by young stars decreases as mu* increases. The reason why this bimodal age distribution is not inconsistent with the unimodal shape of the cosmic-averaged star-formation history is that i) the dominating contribution by young stars biases the age low with respect to the average epoch of star formation, and ii) the use of a single average age per region is unable to represent the full time-extent of the star-formation history of "young-sequence" regions.Comment: 17 pages, 11 figures, MNRAS accepte

Near-Infrared and Star-forming properties of Local Luminous Infrared Galaxies

We use HST NICMOS continuum and Pa-alpha observations to study the near-infrared and star-formation properties of a representative sample of 30 local (d ~ 35-75Mpc) luminous infrared galaxies (LIRGs, infrared 8-1000um luminosities of L_IR=11-11.9[Lsun]). The data provide spatial resolutions of 25-50pc and cover the central ~3.3-7.1kpc regions of these galaxies. About half of the LIRGs show compact (~1-2kpc) Pa-alpha emission with a high surface brightness in the form of nuclear emission, rings, and mini-spirals. The rest of the sample show Pa-alpha emission along the disk and the spiral arms extending over scales of 3-7kpc and larger. About half of the sample contains HII regions with H-alpha luminosities significantly higher than those observed in normal galaxies. There is a linear empirical relationship between the mid-IR 24um and hydrogen recombination (extinction-corrected Pa-alpha) luminosity for these LIRGs, and the HII regions in the central part of M51. This relation holds over more than four decades in luminosity suggesting that the mid-IR emission is a good tracer of the star formation rate (SFR). Analogous to the widely used relation between the SFR and total IR luminosity of Kennicutt (1998), we derive an empirical calibration of the SFR in terms of the monochromatic 24um luminosity that can be used for luminous, dusty galaxies.Comment: Accepted for publication in ApJ. Contact first author for high qualitity version of figure

A New Empirical Model for the Structural Analysis of Early-type Galaxies and a Critical Review of the Nuker Model

The Nuker law was designed to match the inner few (~3-10) arcseconds of predominantly nearby (< 30 Mpc) early-type galaxy light-profiles; it was never intended to describe an entire profile. The Sersic model, on the other hand, was developed to fit the entire profile; however, due to the presence of partially depleted galaxy cores, the Sersic model cannot always describe the very inner region. We have therefore developed a new empirical model consisting of an inner power-law, a transition region, and an outer Sersic model to connect the inner and outer structure of elliptical galaxies. Moreover, the stability of the Nuker model parameters are investigated. Surprisingly, none are found to be stable quantities; all are shown to vary systematically with a profile's fitted radial extent, and often by more than 100%. Considering elliptical galaxies spanning a range of 7.5 magnitudes, the central stellar density of the underlying host galaxy is observed to increase with galaxy luminosity until the onset of core formation, detected only in the brightest elliptical galaxies. We suggest that the so-called ``power-law'' galaxies may actually be described by the Sersic model over their entire radial range

Consumer credit information systems: A critical review of the literature. Too little attention paid by lawyers?

This paper reviews the existing literature on consumer credit reporting, the most extensively used instrument to overcome information asymmetry and adverse selection problems in credit markets. Despite the copious literature in economics and some research in regulatory policy, the legal community has paid almost no attention to the legal framework of consumer credit information systems, especially within the context of the European Union. Studies on the topic, however, seem particularly relevant in view of the establishment of a single market for consumer credit. This article ultimately calls for further legal research to address consumer protection concerns and inform future legislation

Effect of gallium and vanadium in NiMoV/Al2O3-Ga2O3 catalysts on indole hydrodenitrogenation

The effect of Ga as support modifier and V as second promoter on the NiMoV/Al2O3-Ga2O3 catalyst varying the synthesis method (SG: sol–gel synthesis vs I: impregnation synthesis) was studied. The catalysts were characterized by elemental analysis, textural properties, XRD, XPS, 27Al NMR, Raman, EDX elemental mapping and HRTEM. The chemical analyses by XRF showed coincidence between experimental and theoretical values according to stoichiometric values proposed to Mo/Ni = 6 and (V + Ni)/(V + Ni + Mo) = 0.35. The sol–gel synthesis method increased the surface area by incorporation of Ga3+ ions into the Al2O3 forming Ga–O–Al bonding; whereas the impregnation synthesis leads to decrease by blocking of alumina pores, as follows NiMoV/Al2O3-Ga2O3(I) < NiMoV/Al2O3-Ga2O3(SG) < Al2O3-Ga2O3(I) < NiMo/Al2O3 < Al2O3-Ga2O3(SG) < Al2O3. The values of BJH mesopores mean size between 6.13 and 7.68 nm. XRD and XPS confirmed a bulk structure typical of (NH4)4[NiMo6O24H6]·5H2O and the presence at the surface of Mo4+, Mo6+, NixSy, NiMoS, Ni2+, Ga3+ and V5+ species, respectively. Raman showed that the sol–gel synthesis method reduces the interactions Ni-Mo sulfide-support and improvement the sulfidation degree NiMoV/Al2O3-Ga2O3(SG) as showed sulfur analysis CHONS. The largest proportion of AlO4 content using the impregnation method to add Ga was verified by 27Al solid-state MAS NMR. The EDS elemental mapping confirmed that Ni, Mo, Al, Ga, V and S are well-distributed on support. The HRTEM analysis shows that the length and stacking distribution of MoS2 crystallites varied from 5.67 to 6.01 nm and 2.46 to 2.74 when using the sol–gel and impregnation synthesis method, respectively. The catalytic results revealed that the synthesis method induced the presence of gallium on the surface influencing the dispersion V5+ species, whose effect could have some relation with strength and density of acid sites that in turn influence the dispersion of the MoS2 phase, which correlates well with the indole HDN activities. The activities as indole HDN pseudo-first-order rate constants’ values (kHDN) from 0.29 to 2.78 mol/(m2·h): NiMoV/Al2O3 < NiMoV/Al2O3-Ga2O3(I) < NiMo/Al2O3 < NiMoV/Al2O3-Ga2O3(SG). Nevertheless, the nature of the active site can be related with reaction pathways, that is, NiMoV/Al2O3-Ga2O3(SG) and NiMoV/Al2O3-Ga2O3(I) catalysts produce ECH through HIND, while NiMoV/Al2O3 and NiMo/Al2O3 produce EB by hydrogenolysis of HIND to OEA. In the regard, the Ga and V act as structural promoters in the NiMo catalysts, allowing the largest generation of NiMoS M-edge-like and BRIM sites for HDN