Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Coaching documental: un nuevo paradigma para la profesión

We try to explain a new challenge for the profession of librarian. The challenge is give a name to be understood by small and medium enterprises, it is speaking their language. This type of organization can not afford a librarian or an information manager full time so you should train staff so they can meet their needs and organizational information. We define the tools and skills that are accorded to people who want to dedicate this occupational field. Is a translation of user training in the field of libraries, applied to the business world

Creación de un directorio sobre fotografía en España

Se establecen unas pautas y reflexiones sobre lo que debe ser un directorio sobre colecciones de fotografía en España. Además se presenta una breve exposición sobre los distintos poseedores de fondos fotográficos y de los distintos soportes en los que se presenta la fotografíaGato Gutiérrez, ÁM. (2012). Creación de un directorio sobre fotografía en España. http://hdl.handle.net/10251/17679.Archivo delegad

Coaching documental: un nuevo paradigma para la profesión

We try to explain a new challenge for the profession of librarian. The challenge is give a name to be understood by small and medium enterprises, it is speaking their language. This type of organization can not afford a librarian or an information manager full time so you should train staff so they can meet their needs and organizational information. We define the tools and skills that are accorded to people who want to dedicate this occupational field. Is a translation of user training in the field of libraries, applied to the business world.Esta ponencia resume y presenta un nuevo reto para la profesión del documentalista. Este reto consiste en hacerse un nombre dentro la gestión de la documentación en las pequeñas y medianas empresas, hablando su mismo lenguaje. Este tipo de organización no se puede permitir tener un documentalista o gestor de información a tiempo completo por eso se debe formar al personal para que puedan cubrir sus necesidades informativas y organizacionales. Se pretende definir las herramientas y habilidades que debe tener toda persona que se quiera dedicar a esta rama profesional. Es una traslación de la formación de usuarios dentro del ámbito de las bibliotecas, aplicada al mundo de la empresa

Colecciones de fotografía en España. Propuesta del directorio de fotografía en España (DeFOTO)

Description of a new repository of photography collections in Spain and how will be it constructed