Effect of air pollution and racism on ethnic differences in respiratory health among adolescents living in an urban environment

Recent studies suggest that stress can amplify the harm of air pollution. We examined whether experience of racism and exposure to particulate matter with an aerodynamic diameter of less than 2.5 µm and 10 µm (PM2.5 and PM10) had a synergistic influence on ethnic differences in asthma and lung function across adolescence. Analyses using multilevel models showed lower forced expiratory volume (FEV1), forced vital capacity (FVC) and lower rates of asthma among some ethnic minorities compared to Whites, but higher exposure to PM2.5, PM10 and racism. Racism appeared to amplify the relationship between asthma and air pollution for all ethnic groups, but did not explain ethnic differences in respiratory health

AutoSyP: A Low-Cost, Low-Power Syringe Pump for Use in Low-Resource Settings

This article describes the design and evaluation of AutoSyP, a low-cost, low-power syringe pump intended to deliver intravenous (IV) infusions in low-resource hospitals. A constant-force spring within the device provides mechanical energy to depress the syringe plunger. As a result, the device can run on rechargeable battery power for 66 hours, a critical feature for low-resource settings where the power grid may be unreliable. The device is designed to be used with 5- to 60-mL syringes and can deliver fluids at flow rates ranging from 3 to 60 mL/hour. The cost of goods to build one AutoSyP device is approximately $500. AutoSyP was tested in a laboratory setting and in a pilot clinical study. Laboratory accuracy was within 4% of the programmed flow rate. The device was used to deliver fluid to 10 healthy adult volunteers and 30 infants requiring IV fluid therapy at Queen Elizabeth Central Hospital in Blantyre, Malawi. The device delivered fluid with an average mean flow rate error of −2.3% ± 1.9% for flow rates ranging from 3 to 60 mL/hour. AutoSyP has the potential to improve the accuracy and safety of IV fluid delivery in low-resource settings

The effect of a concept mapping Intervention on shared cognition and adaptive team performance over time

Research has demonstrated the value of team adaptation for organizational teams. However, empirical work on interventions that teams can take to increase adaptive team performance is scarce. In response, this study proposes a concept mapping intervention as a way to increase teams’ ability to adapt following a task change. Particularly, this study examines the effect of a concept mapping intervention on team transition adaptation (the drop in performance after a change) and reacquisition adaptation (the slope of performance after the change) via its effect on task mental models and transactive memory systems. We conducted a longitudinal experimental study of 44 three-person teams working on an emergency management simulation. Findings suggest that the concept mapping intervention promotes reacquisition adaptation, task mental models, and transactive memory systems. Results also suggest that task mental models mediate the effect of the concept mapping intervention on reacquisition adaptation. A post hoc analysis suggests that the concept mapping intervention is only effective if it leads to high task mental model accuracy. Our study presents concept mapping as a practical intervention to promote shared cognition and reacquisition adaptation.Fundação para a Ciência e Tecnologia - FCTinfo:eu-repo/semantics/acceptedVersio

Language And Functionality Of Post-stroke Adults: Evaluation Based On International Classification Of Functioning, Disability And Health (icf)

O Acidente Vascular Encefálico é um importante problema de Saúde Pública, com alto índice de mortes e sequelas, tais como alterações de linguagem. As mudanças conceituais da saúde, ao longo do tempo, levaram à incorporação de aspectos funcionais e sociais como propõe a Organização Mundial de Saúde na Classificação Internacional de Funcionalidade, Incapacidade e Saúde. O objetivo foi avaliar e classificar aspectos de linguagem, funcionalidade e participação de pessoas pós-Acidente Vascular Encefálico com base conceitual da Classificação Internacional de Funcionalidade, Incapacidade e Saúde e caracterizar o perfil sociodemográfico dos participantes. Método A coleta de dados ocorreu pela aplicação de instrumento clínico para avaliação de linguagem, participação e funcionalidade em cinquenta indivíduos, com base na Classificação Internacional de Funcionalidade, Incapacidade e Saúde. Resultados A idade variou de 32 a 88 anos, sendo a maioria do gênero masculino. Em relação a funções do corpo, os participantes referiram maior dificuldade em funções da memória; nos aspectos de atividade e participação, verificou-se maior dificuldade em recreação e lazer; e nos fatores ambientais, os profissionais de saúde foram indicados como facilitadores para a maioria dos participantes. Conclusão Os resultados mostram o impacto das dificuldades de linguagem na vida das pessoas pós-Acidente Vascular Encefálico e reafirmam a aplicabilidade da Classificação Internacional de Funcionalidade, Incapacidade e Saúde como importante instrumento complementar à avaliação de linguagem, funcionalidade e participação numa abordagem integral e humanizada, em prol do aprimoramento da assistência à saúde no atendimento ambulatorial desse grupo.29

Proliferative and Transcriptional Identity of Distinct Classes of Neural Precursors in the Mammalian Olfactory Epithelium

Neural precursors in the developing olfactory epithelium (OE) give rise to three major neuronal classes – olfactory receptor (ORNs), vomeronasal (VRNs) and gonadotropin releasing hormone (GnRH) neurons. Nevertheless, the molecular and proliferative identities of these precursors are largely unknown. We characterized two precursor classes in the olfactory epithelium (OE) shortly after it becomes a distinct tissue at midgestation in the mouse: slowly dividing self-renewing precursors that express Meis1/2 at high levels, and rapidly dividing neurogenic precursors that express high levels of Sox2 and Ascl1. Precursors expressing high levels of Meis genes primarily reside in the lateral OE, whereas precursors expressing high levels of Sox2 and Ascl1 primarily reside in the medial OE. Fgf8 maintains these expression signatures and proliferative identities. Using electroporation in the wild-type embryonic OE in vitro as well as Fgf8, Sox2 and Ascl1 mutant mice in vivo, we found that Sox2 dose and Meis1 – independent of Pbx co-factors – regulate Ascl1 expression and the transition from lateral to medial precursor state. Thus, we have identified proliferative characteristics and a dose-dependent transcriptional network that define distinct OE precursors: medial precursors that are most probably transit amplifying neurogenic progenitors for ORNs, VRNs and GnRH neurons, and lateral precursors that include multi-potent self-renewing OE neural stem cells.Molecular and Cellular Biolog

Racism, ethnic density and psychological well-being through adolescence: evidence from the Determinants of Adolescent Social well-being and Health longitudinal study

Objective. To investigate the effect of racism, own-group ethnic density, diversity and deprivation on adolescent trajectories in psychological well-being

Youth drug use in Barbados and England: correlates with online peer influences

This study examined the relationship between susceptibility to drug-related online peer influence on Facebook and offline alcohol, tobacco, and marijuana use among emerging adults (18-24 years) enrolled at the university level in Barbados and England. A cross-national comparative, explanatory sequential mixed-methods design was employed with samples of students of African-Caribbean descent and European descent in Barbados and England, respectively. Quantitative data were collected using surveys from 241 students in Barbados and 186 in England. Qualitative focus groups were conducted with 23 Barbadian students and 16 English students. Spearman’s rank-order correlations were conducted to analyze quantitative data and a three-tiered categorization system was used to analyze the qualitative data. Significant positive relationships between students’ susceptibility to online peer influence (SOPI) and alcohol, tobacco, and marijuana use were found. Six qualitative themes emerged representing cross-national similarities, while three themes emerged highlighting some differences between the two contexts. We propose that the relationship between SOPI and offline drug use may be mediated by the interrelated factors of emerging-adult developmental characteristics and the online and offline social environments. We represent these findings diagrammatically to convey that developmental and environmental factors together can provide a holistic understanding of the interplay between online interactions and offline risk behaviors

Improving adult behavioural weight management services for diverse UK Black Caribbean and Black African ethnic groups: a qualitative study of insights from potential service users and service providers.

BACKGROUND: A significantly higher proportion of UK Black ethnic adults live with overweight or obesity, compared to their White British counterparts. The role of obesity in excess infection rates and mortality from COVID-19 has increased the need to understand if weight management interventions are appropriate and effective for Black ethnic groups. There is a paucity of existing research on weight management services in Black populations, and whether anticipated or experienced institutional and interpersonal racism in the healthcare and more widely affects engagement in these services. Understanding the lived experience of target populations and views of service providers delivering programmes is essential for timely service improvement. METHODS: A qualitative study using semi-structured interviews was conducted in June-October 2021 among 18 Black African and Black Caribbean men and women interested in losing weight and 10 weight management service providers. RESULTS: The results highlighted a positive view of life in the United Kingdom (UK), whether born in the UK or born abroad, but one which was marred by racism. Weight gain was attributed by participants to unhealthy behaviours and the environment, with improving appearance and preventing ill health key motivators for weight loss. Participants relied on self-help to address their overweight, with the role of primary care in weight management contested as a source of support. Anticipated or previously experienced racism in the health care system and more widely, accounted for some of the lack of engagement with services. Participants and service providers agreed on the lack of relevance of existing services to Black populations, including limited culturally tailored resources. Community based, ethnically matched, and flexibly delivered weight management services were suggested as ideal, and could form the basis of a set of recommendations for research and practice. CONCLUSION: Cultural tailoring of existing services and new programmes, and cultural competency training are needed. These actions are required within systemic changes, such as interventions to address discrimination. Our qualitative insights form the basis for advancing further work and research to improve existing services to address the weight-related inequality faced by UK Black ethnic groups

Trends in suicide among migrants in England and Wales 1979–2003

Objective. Trends in suicide death rates among migrants to England and Wales 1979–2003 were examined

Clusters of microRNAs emerge by new hairpins in existing transcripts

Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare. However, microRNAs are frequently clustered in the genomes of animals, and these clusters are often transcribed as a single unit. The evolution of microRNA clusters has been the subject of much speculation, and a selective advantage of clusters of functionally related microRNAs is often proposed. However, the origin of microRNA clusters has not been so far explored. Here, we study the evolution of microRNA clusters in Drosophila melanogaster. We observed that the majority of microRNA clusters arose by the de novo formation of new microRNA-like hairpins in existing microRNA transcripts. Some clusters also emerged by tandem duplication of a single microRNA. Comparative genomics show that these clusters are unlikely to split or undergo rearrangements. We did not find any instances of clusters appearing by rearrangement of pre-existing microRNA genes. We propose a model for microRNA cluster evolution in which selection over one of the microRNAs in the cluster interferes with the evolution of the other linked microRNAs. Our analysis suggests that the study of microRNAs and small RNAs must consider linkage associations