Amin Maalouf : a literatura como mediação entre Oriente e Ocidente

Preocupado com as fricções do mundo contemporâneo que, motivadas por essencialismos segregacionistas, esfacelam comunidades e fazem perigar a paz e o equilíbrio mundiais, Amin Maalouf, autor libanês radicado em França, tem vindo a assumir-se como um construtor de pontes de entendimento entre os mundos árabe e ocidental. A sua condição de escritor desterritorializado, fronteiriço e minoritário, educado na confluência da cultura árabe e ocidental, legitima o seu estatuto de mediador empenhado, que se tem vindo a distribuir sobretudo pelo terreno da ficção e o de ensaio. O presente trabalho observa a forma como, na generalidade da sua ficção, centrada no Médio Oriente, Literatura e História se aliam na configuração de quadros históricos de convivência, através de uma mitificação positiva da História e de estratégias de reconfiguração identitária

A educação como contraponto das políticas neoliberais de fratura social

Este artigo apresenta as estratégias históricas do modelo econômico neoliberal e as arbitrariedades políticas instituídas nesse tipo de economia que gera graves consequências contra a classe trabalhadora brasileira e amplia as desigualdades sociais. Ao problematizar essas questões, foi necessário analisar e discutir demandas referentes às políticas neoliberais e suas arbitrárias imposições ao trabalhador. A partir desse fundamento, percebemos que é preciso assumir o risco de compreender a história como fundamento e enfrentamento das mazelas provocadas pelo presente sistema neoliberal que é um grande impositor das desigualdades sociais e constituidor de direitos que preservam a acumulação de capital da classe dominante.Palavras-chave: Neoliberalismo. Classe trabalhadora. Educação.Education as Counterpoint for Neoliberals Politics for Social FractureAbstract This article features the historical strategies of the neoliberal economic model and the political arbitrariness instituted in this type of economy, which generates serious consequences against a Brazilian labor class and wide social inequalities. Therefore, those questions are analyzed and discussed based on neoliberal policies against the workman. From this foundation, we perceive that it is necessary to take on or to understand the history as a foundation and confrontation of bad ones caused by the present neoliberal system that is a great diffuser of social inequalities and constituent of directs that preserve the riches of the dominant classKeywords: Neoliberalism. Class worker. Education.La Educación como Contrapunto de las Políticas Neoliberales de Fractura SocialResumenEste artículo presenta las estrategias históricas del modelo económico neoliberal y las arbitrariedades políticas instituidas en dicha economía, que genera graves consecuencias contra la clase trabajadora brasileña y amplía las desigualdades sociales. Al problematizar esas cuestiones, fue necesario analizar y discutir demandas referentes a las políticas neoliberales y sus arbitrarias imposiciones al trabajador. Con base en ello, percibimos que es necesario asumir el riesgo de comprender la historia como fundamento y enfrentamiento de los daños provocados por el presente sistema neoliberal que es un gran impositor de las desigualdades sociales y constituidor de derechos que preservan la acumulación de capital de la clase dominante,Palabras clave: Neoliberalismo. Clase trabajador. Educacion

A FEMINIZAÇÃO NO CAMPO DA EDUCAÇÃO BRASILEIRA

Resumo: Este texto apresenta uma análise histórica acerca da feminização no contexto da docência e as contradições no processo de inserção da mulher na profissão docente. Destaca que esse trabalho deve ser efetivamente valorizado em todos os aspectos necessários, uma vez que melhores condições de trabalho, remuneração adequada a função executada e o reconhecimento social são fatores fundamentais para que esse campo não seja segregado pela divisão sexual instituída ao longo da história. Portanto, é necessário explicitar esses contextos históricos, visando fomentar a conscientização e superação dessa condição de desigualdade, sobretudo, fortalecer as discussões ligadas ao contexto da profissão docente. Palavras-chave: Feminização. Docência. Educação

USE OF AMPHOTERICIN B IN THE SIMULTANEOUS TREATMENT OF CHROMOBLASTOMYCOSIS AND AMERICAN TEGUMENTARY LEISHMANIASIS: A CASE REPORT

ABSTRACT Chromoblastomycosis (CMB) is a polymorphic fungal disease that usually affects the lower limbs and manifests as verrucous nodules or plaques that may ulcerate. American Tegumentary Leishmaniasis (ATL) is an infectious parasitic disease caused by digenetic protozoa of the genus Leishmania sp. which affects the skin and/or mucous membranes of man and various species of wild and domestic animals. Both are part of the World Health Organization (WHO) neglected tropical diseases portfolio, mostly affecting economically vulnerable populations without adequate sanitation and in close contact with infectious vectors. We present the report of a 59-year-old male patient, referred to the Hospital Geral Público de Palmas (HGPP) in December 2017, carrying a positive result from a direct parasitological detection test for Leishmania sp., in addition to multiple previously biopsied lesions caused by CMB. It was observed that the patient had an important improvement of the CMB lesions with the use of amphotericin B in combination with itraconazole, thus demonstrating the role that the former can play in the therapy of this fungal disease.   Keywords: Chromoblastomycosis; American Tegumentary leishmaniasis; Amphotericin B. RESUMO A cromoblastomicose (CBM) é uma doença fúngica polimórfica, que acomete normalmente os membros inferiores e que se manifesta como nódulos ou placas verrucosas que podem ulcerar. A leishmaniose tegumentar (LT) é uma doença infectoparasitária causada por protozoários digenéticos do gênero Leishmania sp. que acomete a pele e/ou mucosas do homem e de várias espécies de animais silvestres e domésticos. Ambas fazem parte do portfólio de doenças negligenciadas da Organização Mundial da Saúde (OMS), afetando em sua maioria pessoas economicamente vulneráveis, sem saneamento adequado e em contato próximo com vetores infecciosos. Apresentamos neste trabalho o relato de um paciente, masculino, 59 anos, encaminhado ao Hospital Geral Público de Palmas (HGPP) em dezembro de 2017, portando exame parasitológico direto positivo para Leishmania sp., além de múltiplas lesões causadas por CBM previamente biopsiadas. Foi observado que o paciente teve importante melhora das lesões de CBM com uso da anfotericina B em associação ao itraconazol, demonstrando o papel que essa droga pode exercer na terapêutica desta doença fúngica. Palavras-chave: Cromoblastomicose; Leishmaniose Tegumentar; Anfotericina B

Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines

Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties

E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients

Approximately 30% of all hereditary diffuse gastric cancer (HDGC) families carry CDH1 germline mutations. The other two thirds remain genetically unexplained and are probably caused by alterations in other genes. Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gastric cancer for CDH1 germline mutations. In probands negative for CDH1 mutations, we screened genes involved in hereditary cancer syndromes in which gastric cancer may be one of the component tumours, namely p53 (Li-Fraumeni Syndrome) and hMLH1 and hMSH2 (HNPCC). We also screened in these patients for mutations in Caspase-10, a gene inactivated in sporadic gastric cancer, and SMAD4, a gene whose inactivation in mice is associated with signet-ring cell carcinoma of the stomach. One of the families fulfilling the HDGC criteria harboured a CDH1 germline mutation, and one of the families with incomplete criteria harboured a p53 germline mutation. No mutations were identified in hMLH1 and hMSH2, and only sequence variants were found in SMAD4 and Caspase-10. The present work reports for the first time CDH1 germline mutations in Portuguese gastric cancer families, and highlights the need for p53 mutation screening in families lacking CDH1 germline mutations, in a country with one of the highest incidences of gastric cancer in the world. No evidence was found for a role of germline mutations in SMAD4 and Caspase-10 in families lacking CDH1 mutations.http://www.sciencedirect.com/science/article/B6T68-4CP0YVH-5/1/0b2a789fc5dbe341d589aa4cee90b9e

BRSMG Realce: Common bean cultivar with striped grains for the state of Minas Gerais

The common bean cultivar “BRSMG Realce”, recommended for the state of Minas Gerais, has high yield potential and resistance to powdery mildew, bacterial wilt and to anthracnose pathotypes 65, 73, 77, 81, 91, 475 and 479. The plants and pods are high, resulting in lower loss during mechanical harves

Accuracy of faecal calprotectin and neutrophil Gelatinase B-associated Lipocalin in evaluating subclinical inflammation in UlceRaTIVE colitis-the ACERTIVE study

Background and Aims: Mucosal healing and histological remission are different targets for patients with ulcerative colitis, but both rely on an invasive endoscopic procedure. This study aimed to assess faecal calprotectin and neutrophil gelatinase B-associated lipocalin as biomarkers for disease activity in asymptomatic ulcerative colitis patients. Methods: This was a multicentric cross-sectional study including 371 patients, who were classified according to their endoscopic and histological scores. These results were evaluated alongside the faecal levels of both biomarkers. Results: Macroscopic lesions [i.e. endoscopic Mayo score >= 1] were present in 28% of the patients, and 9% had active disease according to fht Ulcerative Colitis Endoscopic Index of Severity. Moreover, 21% presented with histological inflammation according to the Geboes index, whereas 15% and 5% presented with focal and diffuse basal plasmacytosis, respectively. The faecal levels of calprotectin and neutrophil gelatinase B-associated lipocalin were statistically higher for patients with endoscopic lesions and histological activity. A receiver operating characteristic-based analysis revealed that both biomarkers were able to indicate mucosal healing and histological remission with an acceptable probability, and cut-off levels of 150-250 mu g/g for faecal calprotectin and 12 mu g/g for neutrophil gelatinase B-associated lipocalin were proposed. Conclusions: Faecal calprotectin and neutrophil gelatinase B-associated lipocalin levels are a valuable addition for assessment of disease activity in asymptomatic ulcerative colitis patients. Biological levels of the analysed biomarkers below the proposed thresholds can rule out the presence of macroscopic and microscopic lesions with a probability of 75-93%. However, caution should be applied whenever interpreting positive results, as these biomarkers present consistently low positive predictive values.Portuguese IBD Group [GEDII - Grupo de Estudo da Doenca Inflamatcria Intestinal]info:eu-repo/semantics/publishedVersio