Thalassorama: Marketing Extension and Outreach in Sinaloa, Mexico: A Preliminary Analysis of Preferences for Oysters

Marketing, oyster preferences, Mexico, Agribusiness, Agricultural and Food Policy, Consumer/Household Economics, Crop Production/Industries, International Development, International Relations/Trade, Research Methods/ Statistical Methods, Teaching/Communication/Extension/Profession, M30, M39,

Antismoking campaigns’ perception and gender differences: a comparison among EEG Indices

Human factors’ aim is to understand and evaluate the interactions between people and tasks, technologies, and environment. Among human factors, it is possible then to include the subjective reaction to external stimuli, due to individual’s characteristics and states of mind. These processes are also involved in the perception of antismoking public service announcements (PSAs), the main tool for governments to contrast the first cause of preventable deaths in the world: tobacco addiction. In the light of that, in the present article, it has been investigated through the comparison of different electroencephalographic (EEG) indices a typical item known to be able of influencing PSA perception, that is gender. In order to investigate the neurophysiological underpinnings of such different perception, we tested two PSAs: one with a female character and one with a male character. Furthermore, the experimental sample was divided into men and women, as well as smokers and nonsmokers. The employed EEG indices were the mental engagement (ME: the ratio between beta activity and the sum of alpha and theta activity); the approach/withdrawal (AW: the frontal alpha asymmetry in the alpha band); and the frontal theta activity and the spectral asymmetry index (SASI: the ratio between beta minus theta and beta plus theta). Results suggested that the ME and the AW presented an opposite trend, with smokers showing higher ME and lower AW than nonsmokers. The ME and the frontal theta also evidenced a statistically significant interaction between the kind of the PSA and the gender of the observers; specifically, women showed higher ME and frontal theta activity for the male character PSA. This study then supports the usefulness of the ME and frontal theta for purposes of PSAs targeting on the basis of gender issues and of the ME and the AW and for purposes of PSAs targeting on the basis of smoking habits

Multi-scale analysis of lung computed tomography images

A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung CAD system, a segmentation algorithm for lung internal region identification, a multi-scale dot-enhancement filter for nodule candidate selection and a multi-scale neural technique for false positive finding reduction, are described. The results obtained on a dataset of low-dose and thin-slice CT scans are shown in terms of free response receiver operating characteristic (FROC) curves and discussed.Comment: 18 pages, 12 low-resolution figure

Impacto del cambio climático sobre la distribución de Prosopis Hassleri y P.alba en la región chaqueña

El algarrobo, principalmente Prosopis alba y P. hassleri son las especies nativas de mayor uso para madera de aserrío en nuestro país, registrándose en los últimos años un aumento constante en la tasa de consumo. Dado que la totalidad de la madera de algarrobo consumida proviene de bosques nativos, la explotación del recurso es insostenible no sólo desde el punto de vista ambiental sino también económico. A esta situación crítica se le agregan además problemáticas que están afectando a los bosques a escala global como es la expansión de la frontera agrícola sobre áreas de bosque nativo, forestación con especies exóticas de crecimiento rápido, y la interacción de estos factores con el cambio climático actual. En este trabajo indagamos sobre el posible impacto del cambio climático sobre la distribución de P. hassleri (Algarrobo paraguayo) y de tres morfotipos de P. alba (santiagueño, chaqueño y chaqueño sur) en el norte de Argentina, para proveer información útil en la planificación de estrategias de conservación y manejo de los recursos genéticos nativos. Para ello, se utilizaron modelos predictivos de nicho que permitieron estimar la distribución potencial de ambas especies bajo un escenario actual y de cambio climático futuro. De esta manera se pudieron establecer áreas de alto y bajo impacto, y nuevas áreas adecuadas para la persistencia de las respectivas especies. Se utilizaron datos georreferenciados de 30-77 individuos de poblaciones naturales de cada una de las especies y morfotipos, y los 19 parámetros bioclimáticos disponibles en la base de datos mundial WorldClim. Los análisis de modelado de nicho actual y futuro se realizaron mediante el algoritmo de máxima entropía implementado en el programa Maxent; posteriormente los modelados resultantes fueron procesados en el programa DIVA-GIS. Los resultados indican que todas las especies/morfotipos tienden a desplazar su área de distribución hacia el sur, excepto el morfotipo P. alba chaqueño sur que se expandiría hacia el norte. Prosopis hassleri sería la especie que perdería la mayor proporción de superficie de su distribución actual. Sin embargo, en un escenario futuro surgirían áreas favorables para su persistencia cuya superficie duplicaría la distribución actual. Contrariamente, el morfotipo santiagueño de P. alba conservaría casi la totalidad de su área de distribución actual, y es la que menos ampliaría su rango de distribución en un escenario futuro. A partir de los resultados obtenidos se sugieren estrategias de manejo y conservación para estas especies, a través de la identificación y protección de refugios climáticos y del establecimiento de corredores biológicos que favorezcan la dispersión natural de las especies hacia nuevas áreas adecuadas. (Nuestro agradecimiento al Proyecto Específico INTA PNFOR044341 y al Banco Nacional de Germoplasma de Prosopis, FCA-UNC, por facilitar la información básica para este trabajo).Fil: Venier, Maria Paula. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cosacov Martinez, Andrea. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: López Lauenstein, D.. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias; ArgentinaFil: Vega, C.. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias; ArgentinaFil: Verga, A.. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigaciones Agropecuarias; Argentin

Switching from a protease inhibitor-based regimen to a dolutegravir-based regimen : a randomized clinical trial to determine the effect on peripheral blood and ileum biopsies from antiretroviral therapy-suppressed human immunodeficiency virus-infected individuals

Background: Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted protease inhibitor (PI/r)-based therapy to dolutegravir (DTG)-based therapy. Methods: Impact of Integrase-inhibitor DOlutegravir On the viral Reservoir (INDOOR) is a phase 4 open-label clinical trial that randomly included 42 HIV type 1-infected individuals on effective cART: 20 who switched from PI/r-based to DTG-based cART (switch group), and 22 who remained in PI/r-based regimens (control group). We analyzed blood and ileum biopsies to quantify episomal, total, and integrated HIV DNA, cell-associated HIV RNA, residual plasma viremia, T-cell subsets, cell activation, and inflammation markers. Results: There were no related adverse events or treatment discontinuations due to drug intolerance. The HIV reservoir was consistently larger in ileal than in peripheral CD4(+) T cells in both groups (P <.01). Residual viremia in plasma decreased in the switch group (P =.03). However, we did not observe significant longitudinal changes in low-level viral replication, total and integrated HIV reservoir, HIV transcription, T-cell maturation subsets, immunoactivation markers, inflammatory soluble proteins, or cellular markers of latently infected cells. Conclusions: The INDOOR study is the first evaluation of changes in HIV reservoir size in ileum biopsies and in peripheral blood in individuals switched from PI/r- to DTG-based cART. Although this switch was safe and well tolerated, it had no impact on a large array of immunological and inflammatory markers or on HIV reservoir markers in peripheral or in ileal CD4(+) T cells

Sensitivity of bile acid transport by organic anion-transporting polypeptides to intracellular pH

AbstractWe investigated the influence of intracellular pH (pHi) on [14C]-glycocholate (GC) uptake by human hepatoblastoma HepG2 cells that express sodium-independent (mainly OATP-A and OATP-8), but not sodium-dependent, GC transporters. Replacement of extracellular sodium by choline (Chol) stimulated GC uptake but did not affect GC efflux from loaded cells. Amiloride or NaCl replacement by tetraethylammonium chloride (TeACl) or sucrose also increased GC uptake. All stimulating circumstances decreased pHi. By contrast, adding to the medium ammonium or imidazole, which increased pHi, had no effect on GC uptake. In Chinese hamster ovary (CHO) cells expressing rat Oatp1, acidification of pHi had the opposite effect on GC uptake, that is, this was reduced. Changes in extracellular pH (pHo) between 7.40 and 7.00 had no effect on GC uptake at pHi 7.30 or 7.45 when pHo<pHi. However, GC uptake was inhibited at pHo 7.40 and 7.80 when pHo>pHi. Inhibition was not proportional to the pHo−pHi difference. Intracellular acidification decreased Vmax, but had no effect on Km. In sum, sodium-independent GC transport can be affected by intracellular acidification, possibly due both to modifications in the driving forces and to the particular response to protonation of carrier proteins involved in this process

New cytogenetic prognostic markers in breast cancer

Abstract BACKGROUND: The aim of this study was to identify chromosomal imbalances in a series of invasive ductal carcinomas. In order to characterize the prognostic value of the chromosomal aberrations, we determined the association between genetic changes, overall survival, recurrences and some well-known prognostic and diagnostic parameters. MATERIAL AND METHODS: We included in this study 70 ductal invasive carcinomas diagnosed at the Hospital of Navarra during 1991-1994. We used the Comparative Genomic Hybridization Technique (CGH) for the molecular cytogenetic analysis of formalin-fixed, paraffin embedded specimens. RESULTS: We obtained successful results in 57 out of 70 cases (81.4%). The most frequent recurring findings were DNA gains on 8q, 17q, 1q, 20q, 11q and 6q and losses on 16q, Xp, Xq, 13q, 11q and 8p. In the survival study, gains on 1q and 11q13 were more frequent in patients with recurrence (41.3% vs. 18.5% and 50% vs. 23.7%). Loss of 16q appears as a prognostic factor of good outcome because of its association with good pathological prognostic features: 100% of tumors with this aberration showed overexpression of Bcl-2, and 75% of them were node negative. Besides, 46.7% of the positive cases for the expression of estrogen receptors also showed this imbalance. CONCLUSIONS: The CGH is a useful technique for the study of paraffin embedded tumors. Our results confirm that the cytogenetic aberrations of tumors could be considered as prognostic factors contributing to a better knowledge of tumor outcome