La digitalización y el crecimiento empresarial en el restaurante Mochica de Doña Fresia de Trujillo en el 2023

En el presente trabajo de investigación ha tenido como objetivo determinar la relación entre la digitalización y el crecimiento empresarial en el restaurante Mochica de Doña Fresia de Trujillo en el 2023. Para lo cual, se planteó un estudio cuantitativo, de tipo aplicada, con diseño no experimental transversal y correlacional, aplicado una muestra de 40 colaboradores del restaurante, la técnica de recolección de datos usada fue la encuesta y el instrumento fue el cuestionario. Los resultados de la relación de la variable digitalización frente a crecimiento externo en el crecimiento empresarial establecieron un Rho= 47,8%, en cuanto a la variable de digitalización frente a crecimiento interno en el crecimiento empresarial presento un Rho= 71,1%; así mismo la relación entre digitalización y gestión empresarial establecido que existe una correlación cuyo indicador un Rho= 77.3%. Se concluyo que la digitalización se relaciona positivamente con el crecimiento empresarial en el restaurante Mochica de Doña Fresia de Trujillo, puesto que los colaboradores indican que se deben adaptar a los constantes cambios digitales y de esta manera obtener beneficios para el crecimiento empresarial del restaurante

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Modeling pulp fiber suspension rheology

Rheological properties of pulp suspensions play a very important role in the industry, mainly due to the consumption of energy for transporting pulp among the different parts of the paper mill. In this work, we determined the rheology of long- and short-fiber bleached kraft pulp suspensions by using a new rotational viscometer especially designed for their analysis. The experimental rheograms were adjusted to the Herschel-Bulkley model. We established the dependence of the rheological parameters on temperature, fiber length, and pulp consistency, to evaluate the relative influence of these factors and the corresponding interactions in the rheological parameters. In addition, we defined a mathematical model that enables the estimation of rheological parameters as a function of the different input factors. We validated this model with some preliminary experimental data. Application: The knowledge of pulp suspensions rheology is of utmost importance for the optimum design and operation of the majority of unit operations in the pulp and paper industry; accordingly, this study intends to clarify the rheological behaviour of pulp fiber suspensions, by modeling it as a function of consistency, temperature and fiber lengt

Proyecto de innovación docente para la autoevaluación y mejora de la metodología docente usando encuestas personalizadas en Moodle.

La metodología docente usada durante el desarrollo de las asignaturas es un aspecto importante que tienen en cuenta los alumnos a la hora de evaluar dichas asignaturas. Además, la incorporación de las nuevas tecnologías al apoyo de la docencia presencial hace que las metodologías docentes tradicionales (clases magistrales y exámenes) se queden obsoletas y sean menos atractivas. Es por tanto necesario, que al final del curso nos preguntemos cómo se ha desarrollado la asignatura y qué les ha parecido a los alumnos. Uno de los principales métodos para recopilar esta información son las encuestas, siempre que se mantenga el anonimato de los resultados (no se sepa quién ha contestado qué). En este artículo, presentamos el resultado de un proyecto innovación docente que perseguía autoevaluar la metodología docente de cualquier asignatura (de acuerdo a las necesidades de cada profesor) a través de encuestas anónimas personalizadas. Para conseguirlo en el proyecto se desarrolló un módulo de Moodle que permite crear este tipo de encuestas y, además, se elaboró, una batería de preguntas que pudieran usarse para evaluar dichas metodologías

Study of Antispasmodic and Antidiarrheal Activities of Tagetes lucida (Mexican Tarragon) in Experimental Models and Its Mechanism of Action

Tagetes lucida has been used in traditional medicine as a remedy to alleviate several gastrointestinal disorders that provoke stomachaches, abdominal cramps, and diarrhea. However, there is not enough scientific evidence that supports these effects. Therefore, the purpose of this study was to evaluate antispasmodic and antidiarrheal activities of aqueous extract of T. lucida (AqExt-TL) as well as its mechanism of action in experimental models. Antispasmodic activity and the mechanism of action of AqExt-TL were assessed on segments of the guinea pig ileum precontracted with KCl, acetylcholine (ACh), or electrical field stimulation (EFS). Furthermore, the antispasmodic effect of two coumarins (umbelliferone and herniarin) previously identified in this species was evaluated. Antidiarrheal activity of AqExt-TL was determined using the charcoal meal test in mice. AqExt-TL showed antispasmodic activity in segments of the guinea pig ileum precontracted with KCl (83.7 ± 1.9%) and ACh (77.2 ± 5.3%) at the maximal concentration; however, practically, it did not alter the contractions induced by EFS (10.1 ± 2.2%). Antispasmodic activity of AqExt-TL was not significantly altered by hexamethonium (a ganglionic blocker) or L-NAME (an inhibitor of nitric oxide synthase). However, this extract decreased the maximal contractile response to calcium (82.7 ± 8.5%), serotonin (68.1 ± 8.5%), and histamine (63.9 ± 5.9%) in their concentration-response curves. Umbelliferone and herniarin also induced an antispasmodic effect on tissues precontracted with KCl. In addition, low doses of AqExt-TL reduced to 50% the distance traveled by charcoal meal in the gastrointestinal transit model in mice as loperamide, an antidiarrheal agent, did. These results provided evidence of the antispasmodic and antidiarrheal activity of T. lucida, which supports its use in the folk medicine in relieving symptoms in some gastrointestinal disorders. In the antispasmodic effect, the blockade of histaminergic and serotoninergic pathway as well as the calcium channels seems to be involved. Finally, umbelliferone and herniarin could be partially responsible for the antispasmodic activity induced by T. lucida

V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

International audienceThe signaling pathway of G protein-coupled receptors is strongly linked to their trafficking profile. Little is known about the molecular mechanisms involved in the vasopressin receptor V1b subtype (V1b R) trafficking and its impact on receptor signaling and regulation. For this purpose, we investigated the role of β-arrestins in receptor desensitization, internalization and recycling and attempted to dissect the V1b R-mediated MAP kinase pathway. Using MEF cells Knocked-out for β-arrestins 1 and 2, we demonstrated that both β-arrestins 1 and 2 play a fundamental role in internalization and recycling of V1b R with a rapid and transient V1b R-β-arrestin interaction in contrast to a slow and long-lasting β-arrestin recruitment of the V2 vasopressin receptor subtype (V2 R). Using V1b R-V2 R chimeras and V1b R C-terminus truncations, we demonstrated the critical role of the V1b R C-terminus in its interaction with β-arrestins thereby regulating the receptor internalization and recycling kinetics in a phosphorylation-independent manner. In parallel, V1b R MAP kinase activation was dependent on arrestins and Src-kinase but independent on G proteins. Interestingly, Src interacted with hV1b R at basal state and dissociated when receptor internalization occurred. Altogether, our data describe for the first time the trafficking profile and MAP kinase pathway of V1b R involving both arrestins and Src kinase family

Do bilinguals show neural differences with monolinguals when processing their native language?

International audienceThe present research used fMRI to measure brain activity in passive listening and picture-naming tasks with a group of early high proficient Spanish–Catalan bilinguals, in which Spanish was dominant, and a group of Spanish monolinguals. Both tasks were conducted in Spanish and the effect of cognateness was studied. The behavioural results showed slow naming responses in bilinguals. The fMRI results revealed that bilinguals and monolinguals differed only during the picture naming task. Unlike previous results, obtained mainly with L2, monolinguals displayed more activity in receptive language areas and less activity in the posterior cingulate cortex and right STG in the picture-naming task than bilinguals. As far as we know, this is the first study to investigate the neural basis of L1 processing in bilinguals and monolinguals by performing the task in the same language and in a monolingual context. The results indicate more efficient use of language networks in monolinguals because bilinguals utilised a more distributed network, which may imply subtle processing disadvantage

Evidence of circadian biological rhythm alterations in glaucoma patients

Univ Sao Paulo, Dept Expt Psychol, Sao Paulo, BrazilPrevent Senior, Ophthalmol Ctr, Sao Paulo, BrazilUniv Murcia, Coll Biol, Dept Physiol, Chronobiol Lab, Murcia, SpainUniv Fed Sao Paulo, Oftalm Inst Visao EP, Sao Paulo, BrazilUniv Fed Sao Paulo, Oftalm Inst Visao EP, Sao Paulo, BrazilWeb of Scienc