587 research outputs found

    Extroverted financialization: how US finance shapes European banking

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    The managerial contradictions of extroverted financialization: the rise and fall of Deutsche Bank

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    Bestimmung der EigenstabilitÀt von enoralen Zirkondioxid-Implantaten

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    Den deutlichen biologischen Vorteilen von ZrO2-Implantaten steht eine möglicherweise geringere StabilitĂ€t im Interfacebereich gegenĂŒber. Es sollte daher die mechanische StabilitĂ€t zweiteiliger vollkeramischer ZrO2-Implantate geprĂŒft und mit der von Ti-Implantaten verglichen werden. Durch das technisch ausgereifte und in der Zahnheilkunde bereits erprobte Rotationsschwinger-Verfahren (DIN 1331-2) wurden verschiedene Typen von ZrO2-Implantaten (geteilte Formen mit verschiedenen Interface-Levels, zementierte und verschraubte Abutments mit ZrO2- und Titanschrauben, einteilige Kontroll-Implantate) pseudorealistischen Belastungen von 15 und 50 Ncm im life time-Modus ausgesetzt. Vor, wĂ€hrend und nach den Stresstests wurden die Lockerung der Verbindungsschraube, das Kipp- und Drehspiel sowie die Bruchfestigkeit im Verbundbereich zwischen Fixtur und Abutment bestimmt. Frakturen im Interface-Bereich traten bei 15 Ncm-Belastung in 3 %, bei 50 Ncm in 26 % der FĂ€lle auf. Als besonders bruchanfĂ€llig erwiesen sich Implantate mit zementiertem Abutment sowie sog. Bone Level-Implantate mit ZrO2-Schrauben. Die Lösedrehmomente (Restdrehmomente) betrugen fĂŒr Titan-Schrauben 64 % und fĂŒr solche aus ZrO2 nur noch 36 % des initialen Anzugsdrehmoments. Das höchste Drehspiel im Verbundbereich (+2,5°) wurde bei Bone Level-Implantaten mit ZrO2-Schrauben beobachtet. Das Kippspiel aller Implantate blieb wĂ€hrend der Tests weitgehend unabhĂ€ngig vom Material und einer Zementierung der Fixierungsschrauben relativ stabil. Die höchste mechanische StabilitĂ€t des Verbundbereichs wurde unter BerĂŒcksichtigung aller Testkriterien bei sog. Tissue Level-Implantaten, die mit Titan-Schrauben befestigt waren, beobachtet. Durch das Rotationsschwinger-Verfahren kann eine langjĂ€hrige Belastung von Implantaten innerhalb kurzer Zeit simuliert werden. Im Vergleich zu Ti-Implantaten zeigten dabei ZrO2-Implantate weitgehend bessere Ergebnisse bezĂŒglich Bruchfestigkeit, AbnĂŒtzungs- und Lockerungseffekten im Bereich des Verbunds zwischen Fixtur und Abutment

    High environmental ozone levels lead to enhanced allergenicity of Birch pollen

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    BACKGROUND: Evidence is compelling for a positive correlation between climate change, urbanisation and prevalence of allergic sensitisation and diseases. The reason for this association is not clear to date. Some data point to a pro-allergenic effect of anthropogenic factors on susceptible individuals. OBJECTIVES: To evaluate the impact of urbanisation and climate change on pollen allergenicity. METHODS: Catkins were sampled from birch trees from different sites across the greater area of Munich, pollen were isolated and an urbanisation index, NO(2) and ozone exposure were determined. To estimate pollen allergenicity, allergen content and pollen-associated lipid mediators were measured in aqueous pollen extracts. Immune stimulatory and modulatory capacity of pollen was assessed by neutrophil migration assays and the potential of pollen to inhibit dendritic cell interleukin-12 response. In vivo allergenicity was assessed by skin prick tests. RESULTS: The study revealed ozone as a prominent environmental factor influencing the allergenicity of birch pollen. Enhanced allergenicity, as assessed in skin prick tests, was mirrored by enhanced allergen content. Beyond that, ozone induced changes in lipid composition and chemotactic and immune modulatory potential of the pollen. Higher ozone-exposed pollen was characterised by less immune modulatory but higher immune stimulatory potential. CONCLUSION: It is likely that future climate change along with increasing urbanisation will lead to rising ozone concentrations in the next decades. Our study indicates that ozone is a crucial factor leading to clinically relevant enhanced allergenicity of birch pollen. Thus, with increasing temperatures and increasing ozone levels, also symptoms of pollen allergic patients may increase further

    Kolloquium Forschende Frauen 2016 und 2017: BeitrÀge Bamberger Nachwuchswissenschaftlerinnen

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    Die Buchreihe „Forschende Frauen in Bamberg“ begleitet das gleichnamige Forschungskolloquium der Frauenbeauftragten der Otto-Friedrich-UniversitĂ€t Bamberg. Der neunte Band unserer Reihe umfasst als Besonderheit sowohl das Kolloquium 2016 als auch 2017. AnlĂ€sslich des von uns fĂŒr 2016 ausgerufenen „Genderjahres“ haben alle in diesem Buch veröffentlichten BeitrĂ€ge eine Gemeinsamkeit: Untersucht werden Fragestellungen, die sich mit Genderthemen befassen, beziehungsweise Geschlechterunterschiede aufzeigen oder Frauen in den Fokus nehmen

    Ancient DNA of the pygmy marmoset type specimen Cebuella pygmaea (Spix, 1823) resolves a taxonomic conundrum

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    The pygmy marmoset, the smallest of the anthropoid primates, has a broad distribution in Western Amazonia. Recent studies using molecular and morphological data have identified two distinct species separated by the Napo and SolimÔes-Amazonas rivers. However, reconciling this new biological evidence with current taxonomy, i.e., two subspecies, Cebuella pygmaea pygmaea (Spix, 1823) and Cebuella pygmaea niveiventris (Lönnberg, 1940), was problematic given the uncertainty as to whether Spix's pygmy marmoset (Cebuella pygmaea pygmaea) was collected north or south of the Napo and SolimÔes-Amazonas rivers, making it unclear to which of the two newly revealed species the name pygmaea would apply. Here, we present the first molecular data from Spix's type specimen of Cebuella pygmaea, as well as novel mitochondrial genomes from modern pygmy marmosets sampled near the type locality (Tabatinga) on both sides of the river. With these data, we can confirm the correct names of the two species identified, i.e., C. pygmaea for animals north of the Napo and SolimÔes-Amazonas rivers and C. niveiventris for animals south of these two rivers. Phylogenetic analyses of the novel genetic data placed into the context of cytochrome b gene sequences from across the range of pygmy marmosets further led us to reevaluate the geographical distribution for the two Cebuella species. We dated the split of these two species to 2.54 million years ago. We discuss additional, more recent, subdivisions within each lineage, as well as potential contact zones between the two species in the headwaters of these rivers

    Comparison of dental topography of marmosets and tamarins (Callitrichidae) to other platyrrhine primates using a novel freeware pipeline

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    Dental topographic metrics (DTMs), which quantify different aspects of the shape of teeth, are powerful tools for studying dietary adaptation and evolution in mammals. Current DTM protocols usually rely on proprietary software, which may be unavailable to researchers for reasons of cost. We address this issue in the context of a DTM analysis of the primate clade Platyrrhini (“New World monkeys”) by: 1) presenting a large comparative sample of scanned second lower molars (m2s) of callitrichids (marmosets and tamarins), previously underrepresented in publicly available datasets; and 2) giving full details of an entirely freeware pipeline for DTM analysis and its validation. We also present an updated dietary classification scheme for extant platyrrhines, based on cluster analysis of dietary data extracted from 98 primary studies. Our freeware pipeline performs equally well in dietary classification accuracy of an existing sample of platyrrhine m2s (excluding callitrichids) as a published protocol that uses proprietary software when multiple DTMs are combined. Individual DTMs, however, sometimes showed very different results in classification accuracies between protocols, most likely due to differences in smoothing functions. The addition of callitrichids resulted in high classification accuracy in predicting diet with combined DTMs, although accuracy was considerably higher when molar size was included (90%) than excluded (73%). We conclude that our new freeware DTM pipeline is capable of accurately predicting diet in platyrrhines based on tooth shape and size, and so is suitable for inferring probable diet of taxa for which direct dietary information is unavailable, such as fossil species
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