Accumulation and thermalization of cold atoms in a finite-depth magnetic trap

We experimentally and theoretically study the continuous accumulation of cold atoms from a magneto-optical trap (MOT) into a finite depth trap, consisting in a magnetic quadrupole trap dressed by a radiofrequency (RF) field. Chromium atoms (52 isotope) in a MOT are continuously optically pumped by the MOT lasers to metastable dark states. In presence of a RF field, the temperature of the metastable atoms that remain magnetically trapped can be as low as 25 microK, with a density of 10^17 atoms.m-3, resulting in an increase of the phase-space density, still limited to 7.10^-6 by inelastic collisions. To investigate the thermalization issues in the truncated trap, we measure the free evaporation rate in the RF-truncated magnetic trap, and deduce the average elastic cross section for atoms in the 5D4 metastable states, equal to 7.0 10^-16m2.Comment: 9 pages, 10 Figure

Thermo-Economic Modelling and Process Integration of CO2-Mitigation Options on Oil and Gas Platforms

The offshore extraction of oil and gas is an energy-intensive process associated with large CO2 and CH4 emissions to the atmosphere and chemicals to the sea. The taxation of these emissions has encouraged the development of more energy-efficient and environmental-friendly solutions, of which three are assessed in this paper. The integration of steam bottoming cycles on the gas turbines or of low-temperature power cycles on the export gas compression can result either in an additional power output, or in a greater export of natural gas. Another possibility is to implement a CO2-capture unit, which allows recovering CO2 that can be used for enhanced oil recovery. In this paper, a North Sea platform is considered as case study, and the site-scale retrofit integration of these three options is analysed, considering thermodynamic, economic and environmental performance indicators. The results illustrate the benefits of valorising the waste heat recovered from the exhaust gases, as the total CO2-emissions can be reduced by more than 15 %. Exploiting low-temperature heat seems feasible, although more challenging in retrofit situations. Integrating CO2-capture appears promising with a CO2-avoidance cost between 23 and 29 /tCO2 for the chosen economic assumptions

Structural studies provide new insights into the role of lysine acetylation on substrate recognition by CARM1 and inform the design of potent peptidomimetic inhibitors

Microbial Biotechnolog

New proposal for production of bioactive compounds by supercritical technology integrated to a sugarcane biorefinery

The construction of a supercritical fluid extraction (SFE) plant inside or in close proximity to a sugarcane biorefinery producing first and second generation ethanol demonstrated to be very promising, increasing the economic potential of the SFE process in up to 57 %, since the SFE plant could use directly the ethanol, CO2, heat, and electricity already available, with lower prices. In this study, Brazilian ginseng roots were used as model bioactive compounds source and first the statistical influence of the extraction conditions including pressure (10-20 MPa), temperature (323-363 K), and CO2/ethanol proportion ratio (90:10, 50:50, and 0:100 %, w/w) on the beta-ecdysone content in the extracts was experimentally evaluated and compared with literature results. SFE process evaluated experimentally at the present study showed higher selective extraction for beta-ecdysone from Brazilian ginseng roots, providing an extract with up to 2.16 times higher beta-ecdysone than the results obtained in previous studies. Thermal integration of the SFE process diminished energy requirements of the process, resulting in a reduction of cold utility requirement of 87 % and a final electricity demand of 7.5 kWh/g of beta-ecdysone in the extract. In a situation in which the Brazilian ginseng roots price was increased to 4.71 USD/g, only the SFE integrated with the biorefinery solution would be economically feasible. Finally, the selling of the ginseng roots leftover could be an interesting answer to increase the economical attractiveness of the integrated SFE process to the biorefinery

Coupling effects in the elastic scattering of 6^{6}He on 12^{12}C

To study the effect of the weak binding energy on the interaction potential between a light exotic nucleus and a target, elastic scattering of 6He at 38.3 MeV/nucleon on a 12C target was measured at Grand Accélérateur National d'Ions Lourds (GANIL). The 6He beam was produced by fragmentation. The detection of the scattered particles was performed by the GANIL spectrometer. The energy resolution was good enough to separate elastic from inelastic scattering contributions. The measured elastic data have been analyzed within the optical model, with the real part of the optical potential calculated in the double-folding model using a realistic density-dependent nucleon-nucleon interaction and the imaginary part taken in the conventional Woods-Saxon (WS) form. A failure of the "bare" real folded potential to reproduce the measured angular distribution over the whole angular range suggests quite a strong coupling of the higher-order breakup channels to the elastic channel. To estimate the strength of the breakup effects, a complex surface potential with a repulsive real part (designed to simulate the polarization effects caused by the projectile breakup) was added to the real folded and imaginary WS potentials. A realistic estimate of the polarization potential caused by the breakup of the weakly bound 6He was made based on a parallel study of 6He+12C and 6Li+12C optical potentials at about the same energies

A SUCCESSFUL COLLABORATION BETWEEN ADULT AND PEDIATRIC INTENSIVISTS: VENO-VENOUS EXTRACORPOREAL MEMBRANE OXYGENATION FOR A PEDIATRIC PATIENT WITH LIFE-THREATENING TRACHEAL OBSTRUCTION

peer reviewe

Measurement and Interpretation of Fermion-Pair Production at LEP energies above the Z Resonance

This paper presents DELPHI measurements and interpretations of cross-sections, forward-backward asymmetries, and angular distributions, for the e+e- -> ffbar process for centre-of-mass energies above the Z resonance, from sqrt(s) ~ 130 - 207 GeV at the LEP collider. The measurements are consistent with the predictions of the Standard Model and are used to study a variety of models including the S-Matrix ansatz for e+e- -> ffbar scattering and several models which include physics beyond the Standard Model: the exchange of Z' bosons, contact interactions between fermions, the exchange of gravitons in large extra dimensions and the exchange of sneutrino in R-parity violating supersymmetry.Comment: 79 pages, 16 figures, Accepted by Eur. Phys. J.

Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers

Although several synthetic or xenobiotic nucleic acids (XNAs) have been shown to be viable genetic materials in vitro, major hurdles remain for their in vivo applications, particularly orthogonality. The availability of XNAs that do not interact with natural nucleic acids and are not affected by natural DNA processing enzymes, as well as specialized XNA processing enzymes that do not interact with natural nucleic acids, is essential. Here, we report 3′–2′ phosphonomethyl-threosyl nucleic acid (tPhoNA) as a novel XNA genetic material and a prime candidate for in vivo XNA applications. We established routes for the chemical synthesis of phosphonate nucleic acids and phosphorylated monomeric building blocks, and we demonstrated that DNA duplexes were destabilized upon replacement with tPhoNA. We engineered a novel tPhoNA synthetase enzyme and, with a previously reported XNA reverse transcriptase, demonstrated that tPhoNA is a viable genetic material (with an aggregate error rate of approximately 17 × 10–3 per base) compatible with the isolation of functional XNAs. In vivo experiments to test tPhoNA orthogonality showed that the E. coli cellular machinery had only very limited potential to access genetic information in tPhoNA. Our work is the first report of a synthetic genetic material modified in both sugar and phosphate backbone moieties and represents a significant advance in biorthogonality toward the introduction of XNA systems in vivo

A Determination of the Centre-of-Mass Energy at LEP2 using Radiative 2-fermion Events

Using e+e- -> mu+mu-(gamma) and e+e- -> qqbar(gamma) events radiative to the Z pole, DELPHI has determined the centre-of-mass energy, sqrt{s}, using energy and momentum constraint methods. The results are expressed as deviations from the nominal LEP centre-of-mass energy, measured using other techniques. The results are found to be compatible with the LEP Energy Working Group estimates for a combination of the 1997 to 2000 data sets.Comment: 20 pages, 6 figures, Accepted by Eur. Phys. J.