Point-source dispersion of quasi-neutrally-buoyant inertial particles

We analyze the evolution of the distribution, both in the phase space and in the physical space, of inertial particles released by a spatially-localized (punctual) source and advected by an incompressible flow. The difference in mass density between fluid and particles is assumed as small, and represents the basic parameter for a regular perturbative expansion. By means of analytical techniques such as Hermitianization, we derive a chain of equations of the advection--diffusion--reaction type, easily solvable at least numerically. Our procedure provides results also for finite particle inertia, away from the over-damped limit of quasi-tracer dynamics.Comment: Submitted to EPJ

On the terminal velocity of sedimenting particles in a flowing fluid

The influence of an underlying carrier flow on the terminal velocity of sedimenting particles is investigated both analytically and numerically. Our theoretical framework works for a general class of (laminar or turbulent) velocity fields and, by means of an ordinary perturbation expansion at small Stokes number, leads to closed partial differential equations (PDE) whose solutions contain all relevant information on the sedimentation process. The set of PDE's are solved by means of direct numerical simulations for a class of 2D cellular flows (static and time dependent) and the resulting phenomenology is analysed and discussed.Comment: 13 pages, 2 figures, submitted to JP

Difficult patients or difficult encounters?

Universidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, BrazilWeb of Scienc

A Novel Protocol to Characterize Virtual Nickel–Titanium Endodontic Instruments

Publisher Copyright: © 2023 by the authors.The nickel–titanium (NiTi) instruments’ geometry plays an important role in their performance and behavior. The present assessment intends to validate and test the applicability of a 3D surface scanning method using a high-resolution laboratory-based optical scanner to create reliable virtual models of NiTi instruments. Sixteen instruments were scanned using a 12-megapixel optical 3D scanner, and methodological validation was performed by comparing quantitative and qualitative measurements of specific dimensions and identifying some geometric features of the 3D models with images obtained through scanning electron microscopy. Additionally, the reproducibility of the method was assessed by calculating 2D and 3D parameters of three different instruments twice. The quality of the 3D models created by two different optical scanners and a micro-CT device was compared. The 3D surface scanning method using the high-resolution laboratory-based optical scanner allowed for the creation of reliable and precise virtual models of different NiTi instruments with discrepancies varying from 0.0002 to 0.0182 mm. The reproducibility of measurements performed with this method was high, and the acquired virtual models were adequate for use in in silico experiments, as well as for commercial or educational purposes. The quality of the 3D model obtained using the high-resolution optical scanner was superior to that acquired by micro-CT technology. The ability to superimpose virtual models of scanned instruments and apply them in Finite Element Analysis and educational purposes was also demonstrated.publishersversionpublishe

Bisphosphonate-associated jaws osteonecrosis: an important complication of oncology treatment

Os bisfosfonatos são um grupo de medicamentos utilizados no tratamento de doenças malignas metastáticas e em outras doenças ósseas como osteoporose e doença de Paget. A despeito dos seus benefícios, uma importante complicação denominada de osteonecrose dos maxilares vem sendo observada nos pacientes usuários crônicos dos bisfosfonatos que se caracteriza clinicamente por exposições ósseas na região maxilofacial persistente, acompanhadas de osteomielite, geralmente sintomáticas e cujo tratamento é complexo. Este estudo tem por objetivo revisar a literatura sobre a osteonecrose associada ao uso dos bisfosfonatos, em especial, em oncologia, no período de 2003 a 2008. Serão apresentados e discutidos os fatores de risco, aspectos etiopatogênicos, clínicos, imagenológicos, terapêuticos e preventivos desta doença. Devido à dificuldade de tratamento da osteonecrose associada aos bisfosfonatos, o foco deve ser a prevenção, sendo o ideal a eliminação de quadros infecciosos orais antes da terapia com os bisfosfonatos ter sido iniciada e minimizar traumas em boca após o uso destes medicamentos.Bisphosphonates are drugs used in the treatment of malignant metastatic diseases and in other bone lesions such as osteoporosis and Paget´s disease. Besides their benefits, jaw osteonecrosis, an important side effect, has been observed in long-term users of these drugs. Jaw osteonecrosis is clinically characterized by prolonged maxillary and mandible bone exposure accompanied by osteomyelitis. These lesions are usually symptomatic and difficult to treat. This study has the objective of reviewing publications from 2003 to 2008 about bisphosphonate-associated jaw osteonecrosis, in particular in relation to oncology. Risk factors, and etiopathological, clinical, radiographic, therapeutic, and preventive aspects of this condition are presented and discussed. Due to the difficulty to treat this disease, the focus must be prevention, with the ideal therapy being the elimination of oral infections before treatment with bisphosphonates is initiated thereby attempting to minimize possible traumas to the mouth with the use of these medications

Highly feminised sex ratio estimations for the world’s third largest nesting aggregation of the loggerhead sea turtle

This is the author accepted manuscript. The final version is available from Inter Research via the DOI in this record.Despite being a fundamental life history character, there is a paucity of population-wide, data-driven studies of primary sex ratios for any marine turtle species. The Republic of Cape Verde hosts the third largest nesting population of loggerhead turtles in the world (hosting up to 15% of global nesting by the species). Weighting for the spatial distribution of nests, we estimate that 84% female hatchlings are currently likely produced across the population, with 85% of nests laid on Boa Vista, where incubation temperatures were coolest. In future climate change scenarios (by 2100), irrespective of beach, island or sand colour, sex ratios reach over 99% female, and three islands (Fogo, Sao Nicolau, Santiago) would cease to produce males, with >90% of nests incubating at lethally high temperatures. Given that most of the population cannot move to nest on cooler islands, we highlight that temporal refugia are amongst primary means available to this population to adapt. Under Low Emissions Scenario, without phenological adaptation, there would only be an estimated 0.14% males produced across the whole population but in Mid and High Emissions Scenarios, male production may cease on most islands

Stellar tracers of the Cygnus Arm. II: A young open cluster in Cam OB3

Cam OB3 is the only defined OB association believed to belong to the Outer Galactic Arm or Cygnus Arm. Very few members have been observed and the distance modulus to the association is not well known. We attempt a more complete description of the population of Cam OB3 and a better determination of its distance modulus. We present uvby photometry of the area surrounding the O-type stars BD +56 864 and LS I +57 138, finding a clear sequence of early-type stars that define an uncatalogued open cluster, which we call Alicante 1. We also present spectroscopy of stars in this cluster and the surrounding association. From the spectral types for 18 very likely members of the association and UBV photometry found in the literature, we derive individual reddenings, finding a extinction law close to standard and an average distance modulus DM=13.0+-0.4. This value is in excellent agreement with the distance modulus to the new cluster Alicante 1 found by fitting the photometric sequence to the ZAMS. In spite of the presence of several O-type stars, Alicante 1 is a very sparsely populated open cluster, with an almost total absence of early B-type stars. Our results definitely confirm Cam OB3 to be located on the Cygnus Arm and identify the first open cluster known to belong to the association.Comment: Accepted for publication in Astronomy & Astrophysics. Tables 7 & 8 to appear only in electronic forma

Easy Semantification of Bioassays

Biological data and knowledge bases increasingly rely on Semantic Web technologies and the use of knowledge graphs for data integration, retrieval and federated queries. We propose a solution for automatically semantifying biological assays. Our solution contrasts the problem of automated semantification as labeling versus clustering where the two methods are on opposite ends of the method complexity spectrum. Characteristically modeling our problem, we find the clustering solution significantly outperforms a deep neural network state-of-the-art labeling approach. This novel contribution is based on two factors: 1) a learning objective closely modeled after the data outperforms an alternative approach with sophisticated semantic modeling; 2) automatically semantifying biological assays achieves a high performance F1 of nearly 83%, which to our knowledge is the first reported standardized evaluation of the task offering a strong benchmark model

SciBERT-based Semantification of Bioassays in the Open Research Knowledge Graph

As a novel contribution to the problem of semantifying biological assays, in this paper, we propose a neural-network-based approach to automatically semantify, thereby structure, unstructured bioassay text descriptions. Experimental evaluations, to this end, show promise as the neural-based semantification significantly outperforms a naive frequency-based baseline approach. Specifically, the neural method attains 72% F1 versus 47% F1 from the frequency-based method.Comment: In proceedings of the '22nd International Conference on Knowledge Engineering and Knowledge Management' 'Demo and Poster section

Coarse-grained description of a passive scalar

The issue of the parameterization of small-scale dynamics is addressed in the context of passive-scalar turbulence. The basic idea of our strategy is to identify dynamical equations for the coarse-grained scalar dynamics starting from closed equations for two-point statistical indicators. With the aim of performing a fully-analytical study, the Kraichnan advection model is considered. The white-in-time character of the latter model indeed leads to closed equations for the equal-time scalar correlation functions. The classical closure problem however still arises if a standard filtering procedure is applied to those equations in the spirit of the large-eddy-simulation strategy. We show both how to perform exact closures and how to identify the corresponding coarse-grained scalar evolution.Comment: 22 pages; submitted to Journal of Turbulenc