Primer registro de la cojolita (Penelope purpurascens) en el estado de Guanajuato, México

-Aquí se informa sobre el registro de la cojolita en la Reserva de Biosfera Sierra Gorda de Guanajuato, el cual es el registro más central para esa latitud y el primero para el estado. Esta especie fue registrada fotográfícamente en un bosque de encino. La presencia de esta especie enfatiza la necesidad de continuar realizando inventarios biológicos en esta Reserva de la Biosfer

Descripción de los nidos del Cocodrilo de pantano Crocodylus moreletii en un paisaje urbanizado en el sureste de México

Laguna de las Ilusiones is an isolated urban lake in the city of Villahermosa, Tabasco in México that retains a population of Morelet´s crocodile (Crocodylus moreletii ). During the years 2007 and 2008 we studied 22 natural nests of this species. Most of the nests (53%) were built with vegetal material (leaf-litter, stems and thin branches). Also, we recorded human waste as part of the materialsfor nest construction. Mean clutch size was 30.4 ± 10. 8 eggs by nest (nests n = 19, eggs n = 578). Mean egg volume is significantly different among nests, an indication of size differences between the nesting females. Physical characteristics of the nests in 2007-2008 were compared with nests found at the same area during 1991-1994. We found that nest diameter, shore distance and clutch size were significantly higher in 2007-2008. Hatching in Laguna de las Ilusiones was low during 2007-2008 (33.9% ± 31.21) compared with other crocodilians. All new born crocodiles in 2007 and 2008 were males. We discuss how the city may affect the nesting of Morelet´s crocodiles, influencing different aspects such as, theuse of new materials for nest construction, increasing the size of the basal area of the nests, or promoting the search for a nesting site away from the shore. We recommend a management of the crocodiles with female reintroduction and artificial incubation in the Laguna de las Ilusiones to facilitate conservation of this population.La Laguna de las Ilusiones es un lago urbano aislado en la ciudad de Villahermosa, Tabasco que mantiene una población de cocodrilo de pantano (Crocodylus moreletii). Durante los años 2007 y 2008 se estudiaron 22 nidos silvestres de esta especie. En la mayoría de los nidos (53%) además de estar construidos con material vegetal (hojas, tallos y ramas delgadas) se registran productos de desechohumano como parte de los materiales para construcción de los nidos, el resto de los nidos está construido como lo descrito en otros trabajos. El tamaño promedio de la nidada es de 30.4 ± 10.8 huevos por nido (nidos n = 19, huevos n = 578). El tamaño y volumen promedio de los huevos es significativamente diferente entre nidos, lo que indica que existen diferencias en los tamaños de las hembras nidificantes. Las características físicas de los nidos en 2007-2008 fueron comparadas con las de otros nidos encontrados en la misma área de estudio en el periodo 1991-1994, encontrando que el diámetro de los nidos, la distancia a la orilla y el tamaño de la nidada son significativamente mayores en 2007-2008. El porcentajede eclosión en 2007-2008 en la Laguna de las Ilusiones es bajo (33.9 ± 31.21) comparado con otras especies de cocodrilianos. El 100% de los neonatos en 2007 y 2008 fueron machos. El efecto de la ciudad posiblemente puede afectar la ecología de la anidación en el cocodrilo de pantano, influyendo en nuevos materiales para la construcción de los nidos, aumentando el tamaño del área basal de los nidos y promoviendo la búsqueda de lugares más alejados de la orilla para la anidación. Debido al fuerte sesgo que existe hacia los machos en los nacimientos, se recomienda un manejo de la de la población de cocodrilos que incluya la reintroducción de hembras e incubación artificial en la Laguna de las Ilusiones que coadyuve a la conservación de esta población en esa área

Dos nuevos registros de alimentación de Quiscalus Mexicanus Y Cyanocorax Sanblasianus en la costa de chamela, Jalisco, México

Information over the feeding habits of neotropical birds have been relatively few documented, this is the first report in México over the depredation of the mole crabs (Emerita spp.) by the Great-tailed Grackle (Quiscalus mexicanus) and for Ruddy-ground Dove (Columbina talpacoti) by San Blas Jay (Cyanocorax sanblasianus), in the coast of Chamela, Jalisco, México.

Acuerdo Asociación UE-CAN: ¿quiénes ganan y quiénes pierden? : un estudio exploratorio sobre el sector agrícola

El presente estudio, elaborado por encargo de la Red UE-CAN, cuenta con tres partes. En la primera parte se analizan los efectos sobre la CAN de un Acuerdo de Asociación con la UE, integrando el análisis de Bolivia, Colombia, Ecuador y Perú. Basta con leer esto pero, si uno quiere un análisis más detallado o buscar las fuentes de información, deberá recurrir a las siguientes partes dado que han sido insumos más detallados para la elaboración de ésta

Alocação de recursos médicos em tempo de COVID-19: uma abordagem bioética

Introduction: The COVID-19 pandemic has claimed more than two million lives, leading to the collapse of health systems around the world, especially in low-income countries. As the pandemic progressed, the imbalance between the supply of and demand for medical resources created ethical dilemmas regarding how best to allocate available resources. Discussion: Peru did not have the necessary resources to deal with a pandemic like that of COVID-19, which is why its health system collapsed, showing the highest mortality rate worldwide during the first wave. Faced with the saturation of hospital services, the dilemma presented was: when, how and to whom should the few available medical resources be allocated? From a bioethical point of view, health professionals should seek to save as many lives as possible, giving priority to patients with better prognosis and those who could contribute to this aim, such as health workers. Conclusion: Identifying the ethical dilemmas that arise from the pandemic will help doctors make decisions that are close to what is considered appropriate for the group, not only of health workers, but also of patients and family members. The recommendations described here could help in making these decisions.Introducción: La pandemia de la COVID-19 ha cobrado más de dos millones de muertes, generando el colapso de los sistemas de salud en todo el mundo, especialmente en países de bajos recursos. A medida que la pandemia fue avanzando, el desequilibrio entre la oferta y la demanda de recursos médicos creó dilemas éticos relacionados con la mejor manera de asignar los recursos disponibles. Discusión: El Perú no contaba con los recursos necesarios para enfrentar una pandemia como la del COVID-19, es por ello que su sistema sanitario colapsó, mostrando la tasa de mortalidad más alta a nivel mundial durante la primera ola. Ante la saturación de los servicios hospitalarios, el dilema que se presentó fue: ¿cuándo, cómo y a quién se le debe asignar los pocos recursos médicos disponibles? Desde un punto de vista bioético, los profesionales de la salud deben buscar salvar la mayor cantidad de vidas, dando prioridad a los pacientes con mejor pronóstico y a quienes podrían contribuir a este fin, como el personal sanitario. Conclusión: La identificación de los dilemas éticos que surgen por la pandemia ayudará a los médicos a tomar decisiones cercanas a lo que se considere adecuado para el grupo, no solo de trabajadores de salud, sino también de pacientes y familiares. Las recomendaciones aquí descritas podrían ayudar a la toma de estas decisiones.Introdução: A pandemia da COVID-19 causou mais de dois milhões de mortes, causando o colapso dos sistemas de saúde em todo o mundo, especialmente em países de baixos recursos. À medida que a pandemia foi avançando, o desequilíbrio entre a oferta e a procura de recursos médicos criou dilemas éticos relacionados com a melhor maneira de alocar os recursos disponíveis. Discussão: O Peru não tinha os recursos necessários para enfrentar uma pandemia como a do COVID-19, por isso seu sistema de saúde entrou em colapso, mostrando a maior taxa de mortalidade mundial durante a primeira onda. Perante a saturação dos serviços hospitalares, o dilema que se apresentou foi: como, quando e a quem devem ser atribuídos os poucos recursos médicos disponíveis? Do ponto de vista bioético, os profissionais de saúde devem procurar salvar o maior número possível de vidas, dando prioridade aos pacientes com melhor prognóstico e aos que poderiam contribuir para este fim, como o pessoal de saúde. Conclusão: A identificação dos dilemas éticos que surgem por causa da pandemia ajudará os médicos a tomar decisões próximas ao que se considere adequado para o grupo, não só de trabalhadores da saúde, mas também de pacientes e familiares. As recomendações aqui descritas podem ajudar a tomar estas decisões

The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback

Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease

Age at menopause in Latin America

OBJECTIVE: To assess the age at menopause (AM) in Latin America urban areas. DESIGN: A total of 17,150 healthy women, aged 40 to 59 years, accompanying patients to healthcare centers in 47 cities of 15 Latin American countries, were surveyed regarding their age, educational level, healthcare coverage, history of gynecological surgery, smoking habit, presence of menses, and the use of contraception or hormone therapy at menopause. The AM was calculated using logit analysis. RESULTS: The mean age of the entire sample was 49.4 ± 5.5 years. Mean educational level was 9.9 ± 4.5 years, and the use of hormone therapy and oral contraception was 22.1% and 7.9%, respectively. The median AM of women in all centers was 48.6 years, ranging from 43.8 years in Asuncion (Paraguay) to 53 years in Cartagena de Indias (Colombia). Logistic regression analysis determined that women aged 49 living in cities at 2,000 meters or more above sea level (OR = 2.0, 95% CI: 1.4-2.9, P less than 0.001) and those with lower educational level (OR = 1.9, 95% CI: 1.3-2.8, P less than 0.001) or living in countries with low gross national product (OR = 2.1, 95% CI: 1.5-2.9, P less than 0.001) were more prone to an earlier onset of menopause. CONCLUSIONS: The AM varies widely in Latin America. Lower income and related poverty conditions influence the onset of menopause. © 2006 by The North American Menopause Society

Co-option of Neutrophil Fates by Tissue Environments.

Classically considered short-lived and purely defensive leukocytes, neutrophils are unique in their fast and moldable response to stimulation. This plastic behavior may underlie variable and even antagonistic functions during inflammation or cancer, yet the full spectrum of neutrophil properties as they enter healthy tissues remains unexplored. Using a new model to track neutrophil fates, we found short but variable lifetimes across multiple tissues. Through analysis of the receptor, transcriptional, and chromatin accessibility landscapes, we identify varying neutrophil states and assign non-canonical functions, including vascular repair and hematopoietic homeostasis. Accordingly, depletion of neutrophils compromised angiogenesis during early age, genotoxic injury, and viral infection, and impaired hematopoietic recovery after irradiation. Neutrophils acquired these properties in target tissues, a process that, in the lungs, occurred in CXCL12-rich areas and relied on CXCR4. Our results reveal that tissues co-opt neutrophils en route for elimination to induce programs that support their physiological demands.This study was supported byIntramural grants from the Severo Ochoa program (IGP-SO), a grant from Fundacio la Marato de TV3 (120/C/2015-20153032), grant SAF2015-65607-R fromMinisterio de Ciencia e Innovacion (MICINN) with co-funding by Fondo Eu-ropeo de Desarrollo Regional (FEDER), RTI2018-095497-B-I00 from MICINN,HR17_00527 from Fundacion La Caixa, and Transatlantic Network of Excel-lence (TNE-18CVD04) from the Leducq Foundation to A.H. I.B. is supportedby fellowship MSCA-IF-EF-748381 and EMBO short-term fellowship 8261.A.R.-P. is supported by a fellowship (BES-2016-076635) and J.A.N.-A. byfellowship SVP-2014-068595 from MICINN. R.O. is supported by ERC startinggrant 759532, Italian Telethon Foundation SR-Tiget grant award F04, ItalianMoH grant GR-201602362156, AIRC MFAG 20247, Cariplo Foundation grant2015-0990, and the EU Infect-ERA 126. C.S. is supported by the SFB 1123,project A07, as well as by the DZHK (German Centre for Cardiovascular Research) and the BMBF (German Ministry of Education and Research) grant81Z0600204. L.G.N. is supported by SIgN core funding from A*STAR. The CNIC is supported by the MICINN and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MICINN award SEV-2015-0505). G.F.-C. issupported by the Spanish Ministerio de Ciencia e Innovacio ́n (grantPID2019-110895RB-100) and Junta de Comunidades de Castilla-La Mancha(grant SBPLY/19/180501/000211). C.R. received funding from the BoehingerIngelheim Foundation (consortium grant ‘‘Novel and Neglected CardiovascularRisk Factors’’) and German Federal Ministry of Education and Research(BMBF 01EO1503) and is a Fellow of the Gutenberg Research College (GFK)at the Johannes Gutenberg-University MainzS

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus