Medical Student Feedback Initiative

Medical Schoolhttps://deepblue.lib.umich.edu/bitstream/2027.42/148178/1/marchettik.pd

Emotion Regulation in Consumption: Antecedents and Consequences

While people often feel “ruled by their passions,” individuals can and do exert substantial control over their emotional experiences. A growing body of literature in psychology suggests that the various ways emotions are regulated can have considerable impact on both the emotional experience and other psychological processes. Over three essays, this work examines how individuals regulate their emotions, when they are motivated to do so, and why these concepts are important for consumer behavior. In the first essay, I investigate how emotions are managed by looking at one specific emotion regulation strategy: attention deployment. Using experimental methods, I determine that individuals naturally use attention deployment to regulate their emotions, but the effectiveness varies with the emotion being regulated. After establishing attention deployment as a viable emotion regulation strategy, the second essay asks when individuals are motivated to change their emotions. I propose that identities are associated with discrete emotions, and that these associations give rise to emotion profiles that describe appropriate emotional experiences for individuals with that active identity. The studies reported in the second essay establish that social identities have associations to specific emotions, these associations differ between identities, and the emotion-identity relationships lead to outcomes in cognition, affect, motivation, and regulation. Additional experiments demonstrate that individuals engage in emotion regulation to reduce (enhance) their experience of emotions which are inconsistent (consistent) with the identity’s emotion profile. In the third and final essay, I connect emotion regulation and emotion profiles to marketing and consumer outcomes. Four studies show that experiencing emotions consistent with the identity’s emotion profile enhances persuasion, product choice, and consumption—even for identity-unrelated products and advertisements. Ultimately, consequences for the framing and positioning of identity-relevant products are drawn. Across the three essays, I investigate how, when and why emotion regulation processes influence consumer outcomes. From identifying a specific emotion regulation strategy, to introducing the concept of emotion profiles, new insights into the emotion regulation process are provided. These findings suggest that emotion regulation has widespread impact on consumer outcomes, and represents a new viewpoint on how the emotion experience varies by individual

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

Although the interaction of matrix proteins with integrins is known to initiate signaling pathways that are essential for cell survival, a role for tumor suppressors in the regulation of these pathways has not been established. We demonstrate here that p53 can inhibit the survival function of integrins by inducing the caspase-dependent cleavage and inactivation of the serine/threonine kinase AKT/PKB. Specifically, we show that the alpha6beta4 integrin promotes the survival of p53-deficient carcinoma cells by activating AKT/PKB. In contrast, this integrin does not activate AKT/PKB in carcinoma cells that express wild-type p53 and it actually stimulates their apoptosis, in agreement with our previous findings (Bachelder, R.E., A. Marchetti, R. Falcioni, S. Soddu, and A.M. Mercurio. 1999. J. Biol. Chem. 274:20733-20737). Interestingly, we observed reduced levels of AKT/PKB protein after antibody clustering of alpha6beta4 in carcinoma cells that express wild-type p53. In contrast, alpha6beta4 clustering did not reduce the level of AKT/PKB in carcinoma cells that lack functional p53. The involvement of caspase 3 in AKT/PKB regulation was indicated by the ability of Z-DEVD-FMK, a caspase 3 inhibitor, to block the alpha6beta4-associated reduction in AKT/PKB levels in vivo, and by the ability of recombinant caspase 3 to promote the cleavage of AKT/PKB in vitro. In addition, the ability of alpha6beta4 to activate AKT/PKB could be restored in p53 wild-type carcinoma cells by inhibiting caspase 3 activity. These studies demonstrate that the p53 tumor suppressor can inhibit integrin-associated survival signaling pathways

Hubungan antara kepuasan hubungan romantis dengan intensi berselingkuh pada mahasiswa

<p>[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref007" target="_blank">7</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref010" target="_blank">10</a>]DrmMS did not retain many of the DrmMS contact sites with DrmMS-R2, consistent with SAR data that indicate the analog is inactive in heart and gut. Thus, taken together, these data indicated [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref007" target="_blank">7</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref010" target="_blank">10</a>]DrmMS, one less N-terminal residue than [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref006" target="_blank">6</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120492#pone.0120492.ref010" target="_blank">10</a>]DrmMS, the active core in heart, did not activate DrmMS-R2, in line with this receptor transducing the DrmMS-R2 signal.</p

RR Lyrae Stars Belonging to the Candidate Globular Cluster Patchick 99

Patchick 99 is a candidate globular cluster located in the direction of the Galactic bulge, with a proper motion almost identical to the field and extreme field star contamination. A recent analysis suggests it is a low-luminosity globular cluster with a population of RR Lyrae stars. We present new spectra of stars in and around Patchick 99, targeting specifically the 3 RR Lyrae stars associated with the cluster as well as the other RR Lyrae stars in the field. A sample of 53 giant stars selected from proper motions and a position on CMD are also observed. The three RR Lyrae stars associated with the cluster have similar radial velocities and distances, and two of the targeted giants also have radial velocities in this velocity regime and [Fe/H] metallicities that are slightly more metal-poor than the field. Therefore, if Patchick 99 is a bonafide globular cluster, it would have a radial velocity of -92+/-10 km s-1, a distance of 6.7+/-0.4 kpc (as determined from the RR Lyrae stars), and an orbit that confines it to the inner bulge.Comment: Accepted to The Astrophysical Journal Letters. Replaced due to a typo in the titl

The Milky Way Bulge extra-tidal star survey: BH 261 (AL 3)

The Milky Way Bulge extra-tidal star survey (MWBest) is a spectroscopic survey with the goal of identifying stripped globular cluster stars from inner Galaxy clusters. In this way, an indication of the fraction of metal-poor bulge stars that originated from globular clusters can be determined. We observed and analyzed stars in and around BH 261, an understudied globular cluster in the bulge. From seven giants within the tidal radius of the cluster, we measured an average heliocentric radial velocity of = -61 +- 2.6 km/s with a radial velocity dispersion of \sigma = 6.1 +- 1.9 km/s. The large velocity dispersion may have arisen from tidal heating in the cluster's orbit about the Galactic center, or because BH 261 has a high dynamical mass as well as a high mass-to-light ratio. From spectra of five giants, we measure an average metallicity of = -1.1 +- 0.2 dex. We also spectroscopically confirm an RR Lyrae star in BH 261, which yields a distance to the cluster of 7.1 +- 0.4~kpc. Stars with 3D velocities and metallicities consistent with BH 261 reaching to ~0.5 degrees from the cluster are identified. A handful of these stars are also consistent with the spatial distribution of that potential debris from models focussing on the most recent disruption of the cluster.Comment: accepted for publication in The Astronomical Journa

The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): illuminating the functional diversity of eukaryotic life in the oceans through transcriptome sequencing

International audienceCurrent sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans

Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction

Myocardial infarction (MI) is the leading cause of death worldwide. MicroRNAs regulate the expression of their target genes, thus mediating a plethora of pathophysiological functions. Recently, miRNA-24 emerged as an important but controversial miRNA involved in post-MI responses. Here, we aimed at clarifying the effect of adenovirus-mediate intra-myocardial delivery of a decoy for miRNA-24 in a mouse MI model and to investigate the impact of miRNA-24 inhibition on angiogenesis and cardiovascular apoptosis. After MI induction, miRNA-24 expression was lower in the peri-infarct tissue and its resident cardiomyocytes and fibroblasts; while it increased in endothelial cells (ECs). Local adenovirus-mediated miRNA-24 decoy delivery increased angiogenesis and blood perfusion in the peri-infarct myocardium, reduced infarct size, induced fibroblast apopotosis and overall improved cardiac function. Notwithstanding these beneficial effects, miRNA-24 decoy increased cardiomyocytes apoptosis. In vitro, miRNA-24 inhibition enhanced ECs survival, proliferation and networking in capillary-like tubes and induced cardiomyocyte and fibroblast apoptosis. Finally, we identified eNOS as a novel direct target of miR-24 in human cultured ECs and in vivo. Our findings suggest that miRNA-24 inhibition exerts distinct biological effects on ECs, cardiomyocytes and fibroblasts. The overall result of post-infarction local miRNA-24 inhibition appears to be therapeutic

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p