Communication is Inherent to the New Urban Condition

In general terms, a city is seen as the work of humans insofar as it incarnates a human creation and results from the will to leave a trace testifying to man's existence in both time and the material nature of the world. In this respect, we may cite the trench Romulus dug to define the boundary of Rome, a symbolic gesture which differentiates between nature - a world which man has no power over - and culture - a world, and in this case a city on which man can leave a trace. From this standpoi..

Conditions sociales, registres de vulnérabilité et territoires de vie dans la France d'aujourd'hui

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Gentrification of peri-urban spaces in France: the surroundings of Nancy

The process of gentrification in the peri-urban districts of French cities has scarcely been touched upon in recent research, which has hitherto seen the phenomenon as typically associated with core urban areas. The tendency has been to view the periphery through the lens of the social crisis of the banlieues. In contrast, the present article focuses on gentrification in the metropolitan area of Nancy (Grand Est region) as a development that also plays a role in municipalities around major cities and especially around regional metropolitan centres. Starting with a survey of current research approaches, the article first pinpoints some gaps and methodological imbalances that need to be tackled, before embarking on the case study of peri-urban Nancy. Statistical data and empirical surveys in the form of qualitative interviews indicate how Nancy's peri-urban districts have developed a logic of separation, exclusion and social decoupling - typical features of gentrification - particularly in connection with the construction of new single-family houses as a supplement to existing residential stock. Key questions here concern individual motives for choosing a particular residential location, and the creeping "segregation from above" that accompanies this process. The image of France's peri-urban spaces that arises from this study stands in explicit contrast to the received, markedly negative connotations of the "urban periphery".Gentrifizierungsprozesse in periurbanen Räumen Frankreichs fanden in der Forschung bisher kaum Beachtung; sie wurden als naheliegende Prozesse in Kernstädten verstanden und untersucht. Zudem wurde eher die Krise der Vorstädte, der banlieues, beachtet, womit Stigmatisierung und Ausgrenzung analyseleitend wurden. Im vorliegenden Beitrag wird nun hingegen am Beispiel des Umlandes der Metropole Nancy (Region Grand Est) Gentrifizierung als Entwicklung herausgestellt, die sich ebenfalls als konstitutiv für periurbane Räume und damit kleinere Umlandgemeinden von Städten bzw. insbesondere Metropolen andeutet. Vor dem Hintergrund einer Beleuchtung bisheriger Forschungszugänge werden zunächst Forschungslücken herausgearbeitet. Anhand der Auswertung statistischer Daten und empirischer Erhebungen mittels qualitativer Interviews im Umland von Nancy wird im Anschluss fallstudienbezogen gezeigt, wie sich periurbane Gemeinden, insbesondere in Verbindung mit dem Bau neuer Einfamilienhäuser in Ergänzung zu bestehender Bausubstanz, in eine Gentrifizierungslogik der Ab- und Ausgrenzung einschreiben, welche individuellen Beweggründe Wohnstandortwahlen beeinflussen und wie sich eine "Segregation von oben" immer mehr ausbreitet. Es entsteht so ein verändertes Bild periurbaner Räume, das im expliziten Kontrast zu einer eher negativ konnotierten "urbanen Peripherie" steht

Ethical reflection in dentistry: first steps at the Faculty of Dental Surgery of Toulouse.

International audienceThe goal of this work is to contribute to ethical reflection in the dental profession through the example of a survey of ethical reflection and ethical issues in dentistry conducted at the dental school of Toulouse. A written survey was given to the heads of departments and to the sixth-year students and also to the dental faculty at the hospital dental clinic in order to estimate their level of understanding and concern about these topics

Targeting of T/Tn Antigens with a Plant Lectin to Kill Human Leukemia Cells by Photochemotherapy

Photochemotherapy is used both for solid tumors and in extracorporeal treatment of various hematologic disorders. Nevertheless, its development in oncology remains limited, because of the low selectivity of photosensitizers (PS) towards human tumor cells. To enhance PS efficiency, we recently covalently linked a porphyrin (TrMPyP) to a plant lectin (Morniga G), known to recognize with high affinity tumor-associated T and Tn antigens. The conjugation allowed a quick uptake of PS by Tn-positive Jurkat leukemia cells and efficient PS-induced phototoxicity. The present study was performed: (i) to evaluate the targeting potential of the conjugate towards tumor and normal cells and its phototoxicity on various leukemia cells, (ii) to investigate the mechanism of conjugate-mediated cell death. The conjugate: (i) strongly increased (×1000) the PS phototoxicity towards leukemic Jurkat T cells through an O-glycan-dependent process; (ii) specifically purged tumor cells from a 1∶1 mixture of Jurkat leukemia (Tn-positive) and healthy (Tn-negative) lymphocytes, preserving the activation potential of healthy lymphocytes; (iii) was effective against various leukemic cell lines with distinct phenotypes, as well as fresh human primary acute and chronic lymphoid leukemia cells; (iv) induced mostly a caspase-independent cell death, which might be an advantage as tumor cells often resist caspase-dependent cell death. Altogether, the present observations suggest that conjugation with plant lectins can allow targeting of photosensitizers towards aberrant glycosylation of tumor cells, e.g. to purge leukemia cells from blood and to preserve the normal leukocytes in extracorporeal photochemotherapy

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Les responsables de résidence très sociales : des professionnels tiraillés entre différents cadres d’appréhension de la réalité

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Objectiver un métier relationnel au plus près de la pauvreté : les Responsables de résidence très sociales

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L’entretien participant : une méthode pour saisir le vécu de l’individu au volant

International audienceThe individual in his car, during his daily movements, inhabit necessarily the circumscribed space in which he is then. From this point of view, it seems necessary to develop an ethno-sociology of the ways of inhabiting one's automobile. To achieve this heuristic ambition, we will specify here the terms of this method that we call "participant interview". Mixing the methods of interview and participant observation, the participant interview (or in situ) seems to be a privileged tool able to make visible the fact of inhabit the daily mobilities made by car. Moreover, it allows us to understand the full thickness of the relationship of the contemporary individual to his automobile alternating between reflexivity and routines, between withdrawal and availability to the world and to oneself.L’individu dans son automobile, durant ses déplacements quotidiens, habite d’une façon ou d’une autre l’espace circonscrit dans lequel il se trouve alors. De ce point de vue, il apparaît nécessaire de développer une ethno-sociologie des manières d’habiter son automobile. Pour atteindre cette ambition heuristique, nous préciserons ici les termes de cette méthode que nous nommons « entretien participant ». Hybridant les méthodes de l’entretien et de l’observation participante, l’entretien du rapport de l’individu contemporain à son automobile alternant sans cesse entre réflexivité et routines, entre repli sur soi et disponibilité au monde et à soi