AINE y riesgo digestivo

Los antiinflamatorios no esteroideos (AINE) constituyen uno de los grupos de fármacos más consumidos en el mundo, y su prescripción está aumentando con el paso de los años1 debido al aumento en la esperanza de vida y en la prevalencia de enfermedades reumáticas. Hoy en día, sus propiedades antiinflamatorias, antipiréticas y analgésicas están ampliamente aceptadas. Sin embargo, su uso no es inocuo y está asociado a un amplio espectro de efectos adversos, siendo las complicaciones gastrointestinales (GI) y cardiovasculares (CV) las más importantes

Functional differences found in the elderly living in the community

Introduction: Successful aging lies in cognitive and functional maintenance, and in the optimal performance of daily tasks that keep the elderly free of disability and dependence. However, there is little evidence for functional differences for gender and age, and how cognitive and physical demands in past working lives can affect them, to design more personalized occupational therapy interventions to prevent functional and cognitive impairment. Method: This observational descrip-tive study evaluated 367 older adults living in a community with subjective memory complaints and scored between 24 and 35 with the Spanish version of the “Mini-Mental State Examination (MEC-35)”. Basic activities of daily living (BADL) were studied with the Barthel Index, while instrumental ADL (IADL) were examined with the Lawton–Brody scale. Functional differences for gender, age, and physico-mental occupation were examined. Results: The significant differences found for gender indicated that men did better in BADL (p = 0.026) and women better performed IADL (p < 0.001). Differences between age groups suggest that the younger group (aged 64–75) obtained better results for BADL (p = 0.001) and IADL (p < 0.001). For physico-mental occupation, statistically significant differences were found only in IADL for mental (p = 0.034) and physical occupation (p = 0.005). Conclusions: Gender, age, and the cognitive and physical demands of occupational stages, can be important predictors of cognitive and functional impairment. These results can be generalized to other health centers in the province and to other Spanish Autonomous Communities because their socio-demographic variables are similar. It would be interesting to carry out multimodal personalized interventions that consider the factors that might affect functional impairment to preserve personal autonomy. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Kinematics of Structures and Basin Evolution in the Central High Atlas: constraints from AMS and Paleomagnetic Data

[EN] From the application of the magnetic techniques (Anisotropy of Magnetic Susceptibility and paleomagnetism) it can be seen that to determine the age (and origin) of structures in the Moroccan Central High Atlas is not straightforward from geometrical features only and that similar structures can have different origins, or that the two limbs of a particular structure can have developed at different times. A classification of structures is proposed showing all these possibilities. As a general rule, many structures were initiated before compression and, with local exceptions associated with salt structures, paleo-dips were shallow at the remagnetization stage. This has allowed the restoration of structures and the characterization of the overall geometry of the atlasic basin as a narrow, steer’s head strongly subsiding basin whose geometry strongly conditioned its tectonic inversion during the Cenozoic compressional stage. As a synthesis, the Central High Atlas constitutes a good example of intra-plate chain in which different models of basin formation (continental rifting, salt tectonics, transtension) and inversion (thrust tectonics, transpression, buttressing and internal deformation…) can be tested and visualized.This work is part of the I+D+i research projects CGL2009-10840, CGL2009-8969, CGL2012-38481, CGL2016-77560-C2 (C21 and C22) and PID2019-108753GB-C2 (C21 and C22), funded by mICIN/AEI/https://doi.org/10.13039/501100011033 and by “ERDF A way of making Europe”.Peer reviewe

Incidence of cardiovascular events after kidney transplantation and cardiovascular risk scores: study protocol

<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease (CVD) is the major cause of death after renal transplantation. Not only conventional CVD risk factors, but also transplant-specific risk factors can influence the development of CVD in kidney transplant recipients.</p> <p>The main objective of this study will be to determine the incidence of post-transplant CVD after renal transplantation and related factors. A secondary objective will be to examine the ability of standard cardiovascular risk scores (Framingham, Regicor, SCORE, and DORICA) to predict post-transplantation cardiovascular events in renal transplant recipients, and to develop a new score for predicting the risk of CVD after kidney transplantation.</p> <p>Methods/Design</p> <p>Observational prospective cohort study of all kidney transplant recipients in the A Coruña Hospital (Spain) in the period 1981-2008 (2059 transplants corresponding to 1794 patients).</p> <p>The variables included will be: donor and recipient characteristics, chronic kidney disease-related risk factors, pre-transplant and post-transplant cardiovascular risk factors, routine biochemistry, and immunosuppressive, antihypertensive and lipid-lowering treatment. The events studied in the follow-up will be: patient and graft survival, acute rejection episodes and cardiovascular events (myocardial infarction, invasive coronary artery therapy, cerebral vascular events, new-onset angina, congestive heart failure, rhythm disturbances and peripheral vascular disease).</p> <p>Four cardiovascular risk scores were calculated at the time of transplantation: the Framingham score, the European Systematic Coronary Risk Evaluation (SCORE) equation, and the REGICOR (Registre Gironí del COR (Gerona Heart Registry)), and DORICA (Dyslipidemia, Obesity, and Cardiovascular Risk) functions.</p> <p>The cumulative incidence of cardiovascular events will be analyzed by competing risk survival methods. The clinical relevance of different variables will be calculated using the ARR (Absolute Risk Reduction), RRR (Relative Risk Reduction) and NNT (Number Needed to Treat).</p> <p>The ability of different cardiovascular risk scores to predict cardiovascular events will be analyzed by using the c index and the area under ROC curves. Based on the competing risks analysis, a nomogram to predict the probability of cardiovascular events after kidney transplantation will be developed.</p> <p>Discussion</p> <p>This study will make it possible to determine the post-transplant incidence of cardiovascular events in a large cohort of renal transplant recipients in Spain, to confirm the relationship between traditional and transplant-specific cardiovascular risk factors and CVD, and to develop a score to predict the risk of CVD in these patients.</p

Survival in Southern European patients waitlisted for kidney transplant after graft failure: A competing risk analysis

Background Whether patients waitlisted for a second transplant after failure of a previous kidney graft have higher mortality than transplant-näive waitlisted patients is uncertain. Methods We assessed the relationship between a failed transplant and mortality in 3851 adult KT candidates, listed between 1984–2012, using a competing risk analysis in the total population and in a propensity score-matched cohort. Mortality was also modeled by inverse probability weighting (IPTW) competing risk regression. Results At waitlist entry 225 (5.8%) patients had experienced transplant failure. All-cause mortality was higher in the post-graft failure group (16% vs. 11%; P = 0.033). Most deaths occurred within three years after listing. Cardiovascular disease was the leading cause of death (25.3%), followed by infections (19.3%). Multivariate competing risk regression showed that prior transplant failure was associated with a 1.5-fold increased risk of mortality (95% confidence interval [CI], 1.01–2.2). After propensity score matching (1:5), the competing risk regression model revealed a subhazard ratio (SHR) of 1.6 (95% CI, 1.01–2.5). A similar mortality risk was observed after the IPTW analysis (SHR, 1.7; 95% CI, 1.1–2.6). Conclusions Previous transplant failure is associated with increased mortality among KT candidates after relisting. This information is important in daily clinical practice when assessing relisted patients for a retransplant.This study was supported in part by the Spanish Ministry of Economy and Competitiveness (MINECO) (grant ICI14/00016) from the Instituto de Salud Carlos III co-funded by the Fondo Europeo de Desarrollo Regional±FEDER, RETICS (REDINREN RD16/0009/0006, RD16/0009/0031

Cuerpos estereotipados, cuerpos enterrados, cuerpos representados, cuerpos cambiantes. Una aproximación panorámica desde la arqueología feminista

En este trabajo abordamos distintas vías de aproximación a las identidades corporales femeninas y a su agencia, desde una perspectiva transversal, tomando como referencia algunos casos de estudio procedentes de contextos seleccionados de la prehistoria y protohistoria de la península ibérica, así como del Mediterráneo Antiguo. Tres ejes principales ordenarán este acercamiento: en primer lugar, una reflexión sobre los estereotipos de las imágenes de la prehistoria, que han generado modelos comprensivos sobre el pasado que están profundamente distorsionados; en segundo lugar, el estudio de las identidades corporales, a través del análisis de los cuerpos depositados y representados en distintos casos seleccionados y, por último, una mirada desde la bioarqueología sobre el rol, los cuidados y las transformaciones de los cuerpos femeninos contextualizados en su propio ciclo vital. Esta reflexión colectiva nos permite ofrecer una puesta al día aproximativa a las líneas de investigación que, desde el grupo Pastwomen, desarrollamos en relación con el estudio de las corporalidades en el pasado, como base analítica fundamental para profundizar en los comportamientos sociales y en la construcción de las identidades colectivas. Pero, también, para la generación de nuevas narrativas y de un imaginario del pasado, colectivo e inclusivo, basado en la investigación rigurosa. In this paper we present a number of approaches to the issue of female corporeal identities and their agency. Employing a traverse perspective, we focus on a variety of prehistoric and protohistoric case studies from the Iberian Peninsula as well as from the ancient Mediterranean in general. Our proposal follows three principal lines of research: first, we reflect on the stereotypical images of prehistory which have produced profoundly distorted models of the past. Second, we examine the question of corporeal identities based on a group of selected burials. Finally, using bioarchaeological data, the third line is a comprehensive overview of social status, level of care, and visible changes in female bodies within the context of their specific life cycle. We offer a general reflection which allows us to present the current state of research that has been undertaken by the group Past Women. This covers the study of corporeal identities in the past as a fundamental analytical basis to analyze social behavior and the construction of collective identities. It also helps generate new narratives, collective and inclusive, based on rigorous research

Structure of the Central High Atlas (Morocco): constraints from Potential Field Data and 3D Models

[EN] From a 3-D reconstruction based on serial cross-sections, structural observations, and potential field geophysical data we characterize the major structural frame of the Moroccan Central High Atlas. Its overall structure shows two fold-and-thrust systems (each one showing particular features) at the northern and southern borders of the chain, resulting from the inversion of the Mesozoic basin. Five more zones can be distinguished in the inner part of the chain, according to their structural features, ranging from basement-involved structures in the westernmost sector to completely detached structures in the eastern part. Most compressional structures show an ENE-WSW (atlasic) trend, also pinpointed by the orientation of pressure-solution and slaty cleavage associated with the compressional stage. Large-scale faults of crustal or lithospheric reach can be inferred from the aeromagnetic maps, that show that the gabbro intrusions (some of them showing sigmoidal shape) are aligned in an E-W direction, oblique to the main trend. The overall compressional structure is controlled by a main, low-angle, South-verging thrust involving both the Mesozoic cover and the Paleozoic basement thrusting over the southern foreland of the chain. Branching on this surface there is a series of back-thrusts and faults, some of them resulting from re-activation of extensional structures.This research was financed by projects CGL2016-77560-C2 (C21 and C22) and PID2019-108753GB-C2 (C21 and C22), funded by MICIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”.Peer reviewe

Back to the Grindstone? The Archaeological Potential of Grinding-Stone Studies in Africa with Reference to Contemporary Grinding Practices in Marakwet, Northwest Kenya

This article presents observations on grinding-stone implements and their uses in Elgeyo-Marakwet County, northwest Kenya. Tool use in Marakwet is contextualized with a select overview of literature on grinding-stones in Africa. Grinding-stones in Marakwet are incorporated not only into quotidian but also into more performative and ritual aspects of life. These tools have distinct local traditions laden with social as well as functional importance. It is argued that regionally and temporally specific studies of grinding-stone tool assemblages can be informative on the processing of various substances. Despite being common occurrences, grinding-stone tools are an under-discussed component of many African archaeological assemblages. Yet the significance of grinding-stones must be reevaluated, as they hold the potential to inform on landscapes of past food and material processing