The mechano-chemistry of cytoskeletal force generation

In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as well as the chemistry of dynamic cell contractility. In this setting we are able to develop a framework that relates (a) the dynamics of force generation within the cell and (b) the cell response to external stimuli to the chemical processes occurring within the cell, as well as to the mechanics of linkage between the stress fibers, focal adhesions and extra-cellular matrix.Comment: 22 pages, 6 figures, 1 table, accepted in Biomechanics and Modeling in Mechanobiolog

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014

Epidemiological studies suggest that high dietary intake of phytochemicals and in particular of polyphenols is associated with decreased risk of a multitude of diseases states including cardiovascular disease, cancer, and neurodegenerative diseases. As oxidative stress is involved in all these pathological conditions, the antioxidant properties of polyphenols and other natural compounds have attracted the interest of many authors

Natural compounds as modulators of NADPH oxidases.

Reactive oxygen species (ROS) are cellular signals generated ubiquitously by all mammalian cells, but their relative unbalance triggers also diseases through intracellular damage to DNA, RNA, proteins, and lipids. NADPH oxidases (NOX) are the only known enzyme family with the sole function to produce ROS. The NOX physiological functions concern host defence, cellular signaling, regulation of gene expression, and cell differentiation. On the other hand, increased NOX activity contributes to a wide range of pathological processes, including cardiovascular diseases, neurodegeneration, organ failure, and cancer. Therefore targeting these enzymatic ROS sources by natural compounds, without affecting the physiological redox state, may be an important tool. This review summarizes the current state of knowledge of the role of NOX enzymes in physiology and pathology and provides an overview of the currently available NADPH oxidase inhibitors derived from natural extracts such as polyphenols

The Varieties of Afterlife Experience: Epistemological and Cultural Implications

When parapsychologists talk about survival, they are usually implying personal survival, that is, a process in which memories, motivations, and personality characteristics of a given person somehow persist after bodily death. Are there other conceptions of survival (and of personal identity) that deserve further scientific examination? My purpose with this brief commentary is to expand on Rock et al’s approach by urging survivalists to discuss and investigate further the many different conceptions of (and explanations for) survival. I propose we critically reflect on our theoretical assumptions and their epistemological and cultural consequences

Amniotic Fluid and Placental Membranes as Sources of Stem Cells: Progress and Challenges

: The intention of this special edition is to collect review and original research articles that illustrate and stimulate growing efforts to understand the implication of perinatal stem cells in pathological conditions such as cardiovascular and metabolic diseases and inflammatory, autoimmune, musculoskeletal, and degenerative diseases [...]

The Varieties of Afterlife Experience: Epistemological and Cultural Implications

When parapsychologists talk about survival, they are usually implying personal survival, that is, a process in which memories, motivations, and personality characteristics of a given person somehow persist after bodily death. Are there other conceptions of survival (and of personal identity) that deserve further scientific examination? My purpose with this brief commentary is to expand on Rock et al’s approach by urging survivalists to discuss and investigate further the many different conceptions of (and explanations for) survival. I propose we critically reflect on our theoretical assumptions and their epistemological and cultural consequences

New frontiers of inositide-specific phospholipase C in nuclear signalling

Strong evidence has been obtained during the last 16 years suggesting that phosphoinositides, which are involved in the regulation of a large variety of cellular processes in the cytoplasm and in the plasma membrane, are present within the nucleus. A number of advances has resulted in the discovery that nuclear phosphoinositides and their metabolizing enzymes are deeply involved in cell growth and differentiation. Remarkably, the nuclear inositide metabolism is regulated independently from that present elsewhere in the cell. Even though nuclear inositol lipids generate second messengers such as diacyglycerol and inositol 1,4,5-trisphosphate, it is becoming increasingly clear that in the nucleus polyphosphoinositides may act by themselves to influence functions such as pre-mRNA splicing and chromatin structure. This review aims at highlighting the most significant and up-dated findings about inositol lipid metabolism in the nucleus