VIRTUAL TOURS OF HISTORICAL AND ARTISTIC HERITAGE IN THE PROVINCE OF CACERES

[EN] The 3D visualization of historical-artistic heritage in the province of Caceres is an essential tool for touristic promotion. To this end, a methodology is offered based on the application of panoramic spherical photography and terrestrial laser scanner (TLS). The general aim is the creation of geometric representations of sites of cultural interest by the visualization of spherical scenarios and the application of 3D modelling techniques. Particular aims include the geometric cataloguing and acquisition of this artistic heritage and the development of an interactive tool for tourists. A hypermedia atlas is created in which 3D spherical scenarios is visualized displaying videos obtained from the point of clouds and ASCII format downloadable 3D models are made freely available. Other benefits of this project are gains in the knowledge and assessment of the cultural heritage in Caceres.[ES] La visualización 3D del patrimonio histórico-artístico en la provincia de Cáceres, es una herramienta esencial para su promoción turística. Con este fin, se ofrece una metodología basada en la fotografía panorámica esférica y el uso del láser escáner. Como objetivo general se realiza la caracterización geométrica de los Bienes de Interés Cultural, mediante técnicas de visualización de escenarios esféricos y generación de modelado 3D. Los objetivos particulares son catalogar y adquirir de forma geométrica este patrimonio y desarrollar una herramienta interactiva de consulta. Por ello, se crea un atlas hypermedia donde visualizar escenarios fotográficos tridimensionales, videos a partir de las nubes de puntos e incluso su descarga en formato ASCII, todo de forma gratuita. Otros beneficios del proyecto son el conocimiento y la puesta en valor del patrimonio de CáceresNaranjo, JM.; Parrilla, MÁ.; Sanchez, M. (2016). VIRTUAL TOURS OF HISTORICAL AND ARTISTIC HERITAGE IN THE PROVINCE OF CACERES. En 8th International congress on archaeology, computer graphics, cultural heritage and innovation. Editorial Universitat Politècnica de València. 281-283. https://doi.org/10.4995/arqueologica8.2015.3390OCS28128

Importancia de la tetanalgesia en la realización de técnicas dolorosas en el recién nacido

Cartel presentado en la Segunda Conferencia Internacional de Comunicación en Salud, celebrada el 23 de octubre de 2015 en la Universidad Carlos III de MadridIntroducción: Hoy en día, es conocido que las estructuras que transmiten el dolor están totalmente desarrolladas antes del nacimiento, al contrario de lo que se pensaba hasta hace no mas de una década. Así pues, hay numerosos estudios que demuestran que los recién nacidos son capaces de sentir dolor e incluso tener una respuesta mas exagerado con respecto a niños de más edad. Con el término tetanalgesia se entiende el efecto analgésico producido en los neonatos cuando están siendo amamantados. Objetivos: Conocer los beneficios del uso de la tetanalgesia en los recién nacidos cuando son sometidos a técnicas dolorosas. Metodología: Estudio observacional sobre datos publicados. Se realiza un revisión bibliográfica con las bases de datos Pubmed, CINAHL, Cochrane y google académico usando las palabras claves: newborn, analgesia, breast feeding, pain. Resultados: Aunque el mecanismo analgésico de la lactancia materna no es bien conocido se cree que se debe a la relación de varios factores tales como el contacto piel con piel, el componente hormonal, el tacto y el gusto azucarado entre otros. La leche materna contiene mayor cantidad de triptófano que la artificial, siendo este un precursor de la melatonina que aumenta la concentración de las endorfinas beta. Según estudios llevados a cabo se ha observado que el amamantamiento es el procedimento mas efectivo frente a otras técnicas analgésicas, mostrando una reducción del tiempo de llanto del 98% en la realizacion de la prueba del talon. Una revisión de la Cochrane concluye que el amamantamiento en la realización de técnicas dolorosas se asocia a menor cambios en la frecuencia cardíaca y en la duración del llanto. Conclusiones: El uso de la lactancia materna en procedimientos dolorosos es el método no farmacológico más eficaz

THERMOGRAVIMETRIC ANALYSIS OF THERMAL AND KINETIC BEHAVIOR OF ACACIA MANGIUM WOOD

Thermogravimetric analysis was used to study the thermal behavior of Acacia mangium wood under inert atmosphere at heating rates ranging from 5 to 15C min -1, from room temperature to 800C. Weight losses of A. mangium wood in inert atmosphere were found to occur in three stages. These three states are generally associated with the decomposition of the three main components of the lignocellulosic materials. Most decomposition occurred in the range of 300-400C (80% weight approximately). The kinetic parameters of the process were evaluated using the independent parallel reaction model, attributed to the three main components of lignocellulosic materials: hemicelluloses, cellulose, and lignin. The values of activation energy, preexponential factor, and contribution factor were similar to those reported in other studies for this type of biomass. The model proposed predicted an acceptable correlation between the experimental and the calculated curve to the decomposition of A. mangium, with an error of less than 3% of deviation in the temperature range studied

Bovine Tuberculosis in Doñana Biosphere Reserve: The Role of Wild Ungulates as Disease Reservoirs in the Last Iberian Lynx Strongholds

Doñana National Park (DNP) in southern Spain is a UNESCO Biosphere Reserve where commercial hunting and wildlife artificial feeding do not take place and traditional cattle husbandry still exists. Herein, we hypothesized that Mycobacterium bovis infection prevalence in wild ungulates will depend on host ecology and that variation in prevalence will reflect variation in the interaction between hosts and environmental risk factors. Cattle bTB reactor rates increased in DNP despite compulsory testing and culling of infected animals. In this study, 124 European wild boar, 95 red deer, and 97 fallow deer were sampled from April 2006 to April 2007 and analyzed for M. bovis infection. Modelling and GIS were used to identify risk factors and intra and inter-species relationships. Infection with M. bovis was confirmed in 65 (52.4%) wild boar, 26 (27.4%) red deer and 18 (18.5%) fallow deer. In the absence of cattle, wild boar M. bovis prevalence reached 92.3% in the northern third of DNP. Wild boar showed more than twice prevalence than that in deer (p<0.001). Modelling revealed that M. bovis prevalence decreased from North to South in wild boar (p<0.001) and red deer (p<0.01), whereas no spatial pattern was evidenced for fallow deer. Infection risk in wild boar was dependent on wild boar M. bovis prevalence in the buffer area containing interacting individuals (p<0.01). The prevalence recorded in this study is among the highest reported in wildlife. Remarkably, this high prevalence occurs in the absence of wildlife artificial feeding, suggesting that a feeding ban alone would have a limited effect on wildlife M. bovis prevalence. In DNP, M. bovis transmission may occur predominantly at the intra-species level due to ecological, behavioural and epidemiological factors. The results of this study allow inferring conclusions on epidemiological bTB risk factors in Mediterranean habitats that are not managed for hunting purposes. Our results support the need to consider wildlife species for the control of bTB in cattle and strongly suggest that bTB may affect animal welfare and conservation

How to increase technology transfers to developing countries: a synthesis of the evidence

The existing United Nations Framework Convention on Climate Change (UNFCCC) has failed to deliver the rate of low-carbon technology transfer (TT) required to curb GHG emissions in developing countries. This failure has exposed the limitations of universalism and renewed interest in bilateral approaches to TT. Gaps are identified in the UNFCCC approach to climate change TT: missing links between international institutions and the national enabling environments that encourage private investment; a non-differentiated approach for (developing) country and technology characteristics; and a lack of clear measurements of the volume and effectiveness of TTs. Evidence from econometric literature and business experience on climate change TT is reviewed, so as to address the identified pitfalls of the UNFCCC process. Strengths and weaknesses of different methodological approaches are highlighted. International policy recommendations are offered aimed at improving the level of emission reductions achieved through TT

The interplay between functioning problems and symptoms in first episode of psychosis: an approach from network analysis

The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this populationThis work was supported by the Madrid Regional Government (R&D activities in Biomedicine (grant number S2017/BMD-3740 - AGES-CM 2-CM)) and Structural Funds of the European Union. Ana Izquierdo’s work is supported by the PFIS predoctoral program (FI17/00138) from the Instituto de Salud Carlos III (Spain) and co-funded by the European Union (ERDF/ESF, "A way to make Europe”/ “Investing in your future”) and The Biomedical Research Foundation of La Princesa University Hospital. Angela Ib´a˜nez thanks the support of CIBERSAM and of the Spanish Ministry of Science, Innovation and Universities. Instituto de Salud Carlos III (PI16/00834 and PI19/01295) co-financed by ERDF Funds from the European Commission. Covadonga M. Díaz-Caneja holds a Juan Rod´es Grant from Instituto de Salud Carlos III (JR19/00024). Celso Arango was supported by the Spanish Ministry of Science and Innovation. Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/ 024), co-financed by ERDF Funds from the European Commission, “A way of making Europe”, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds. European Union Seventh Framework Program under grant agreements FP7-4-HEALTH-2009-2.2.1-2-241909 (Project EU-GEI), FP7- HEALTH- 2013-2.2.1-2-603196 (Project PSYSCAN) and FP7- HEALTH-2013- 2.2.1-2-602478 (Project METSY); and European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking (grant agreement No 115916, Project PRISM, and grant agreement No 777394, Project AIMS-2-TRIALS), Fundaci´on Familia Alonso, Fundaci´on Alicia Koplowitz and Fundaci´on Mutua Madrile˜n

¡El pueblo no se rinde en la pandemia!

El 2020 estuvo marcado por el número de medidas restrictivas emitidas para enfrentar la pandemia del Covid-19[1], fortalecer y preparar el sistema de salud nacional y proteger la salud de los colombianos. Además de la evidente crisis en el sistema de salud, dada su incapacidad para atender un número significativo de ciudadanos, las medidas de confinamiento adoptadas por las autoridades nacionales, regionales y municipales produjeron una crisis social y económica nunca antes vista. Amplios sectores de la sociedad colombiana se quedaron sin empleo o fuente de ingresos. En este sentido, la privación de recursos para el sostenimiento de las familias fue extendida a varios estratos del país. Las carencias económicas para cubrir las necesidades básicas de los hogares colombianos se sintieron tanto en los sectores populares, como en las clases medias y profesionales del país

Retos y perspectivas del derecho administrativo : segunda parte

Bajo la denominación de , la presente obra colectiva presenta las ponencias expuestas por los participantes en el Seminario que con el mismo nombre organizó la Facultad de Jurisprudencia de la Universidad del Rosario para conmemorar el décimo aniversario de la Maestría de Derecho Administrativo. El seminario tuvo como objetivos ofrecer una retrospectiva de la evolución histórica del derecho administrativo nacional y comparado con los ejes de internacionalización. Protección de los derechos y actuación administrativa y jurisdiccional: presentar una visión reflexiva acerca de los cambios ocurridos en los contenidos del derecho administrativo determinado por las transformaciones del Estado social y democrático de derecho; y mostrar las tendencias contemporáneas de construcción del derecho administrativo como respuesta a la globalización y la internacionalización

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development