Evaluating the Impacts of Urban Regeneration Companies in Portugal: The Case of Porto

Cities have undergone many changes since the 1950s, not least the expansion of urban areas to the detriment of the historic central areas, some of which have been left to decay. In Portugal the most visible results of this phenomenon are found in the metropolitan areas of Lisbon and Porto. To address this problem, the Portuguese Government conceived the first legal instrument for urban regeneration in 2004 which allows the local administrations to form publicly owned companies—urban regeneration companies (SRUs) to actively endorse urban regeneration in historic city centres. This paper discusses the activities of the Porto Vivo SRU, one of these companies created in Porto, in the context of the Portuguese milieu of urban regeneration and evaluates Porto Vivo's operation.Peer Reviewe

An evaluation methodology for urban rehabilitation processes

Peer Reviewe

Structural and kinetic characterisation of Trypanosoma congolense pyruvate kinase

Trypanosoma are blood-borne parasites and are the causative agents of neglected tropical diseases (NTDs) affecting both humans and animals. These parasites mainly rely on glycolysis for their energy production within the mammalian host, which is why trypanosomal glycolytic enzymes have been pursued as interesting targets for the development of trypanocidal drugs. The structure-function relationships of pyruvate kinases (PYKs) from trypanosomatids (Trypanosoma and Leishmania) have been well-studied within this context. In this paper, we describe the structural and enzymatic characterization of PYK from T. congolense (TcoPYK), the main causative agent of Animal African Trypanosomosis (AAT), by employing a combination of enzymatic assays, thermal unfolding studies and X-ray crystallography

Emergence of studies

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SIT for African malaria vectors: Epilogue

As a result of increased support and the diligent application of new and conventional anti-malaria tools, significant reductions in malaria transmission are being accomplished. Historical and current evolutionary responses of vectors and parasites to malaria interventions demonstrate that it is unwise to assume that a limited suite of tools will remain effective indefinitely, thus efforts to develop new interventions should continue. This collection of manuscripts surveys the prospects and technical challenges for applying a novel tool, the sterile insect technique (SIT), against mosquitoes that transmit malaria. The method has been very successful against many agricultural pest insects in area-wide programs, but demonstrations against malaria vectors have not been sufficient to determine its potential relative to current alternatives, much of which will hinge ultimately upon cost. These manuscripts provide an overview of current efforts to develop SIT and identify key research issues that remain

places and non places

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Long COVID in Children and Youth After Infection or Reinfection with the Omicron Variant: A Prospective Observational Study

To describe the prevalence of long COVID in children infected for the first time (n=332) or reinfected (n=243) with Omicron variant SARS-CoV-2, compared with test-negative children (n=311). 12-16% infected with Omicron met the research definition of long COVID at 3 and 6 months after infection, with no evidence of difference between cases of first-positive and reinfection (pchi-square=0.17)

The CLoCk study: A retrospective exploration of loneliness in children and young people during the COVID-19 pandemic, in England

BACKGROUND: During the COVID-19 pandemic children and young people (CYP) were socially restricted during a stage of life crucial to development, potentially putting an already vulnerable population at higher risk of loneliness, social isolation, and poorer wellbeing. The objectives of this study are to conduct an exploratory analysis into loneliness before and during the pandemic, and determine which self-reported factors are associated with loneliness. METHODS AND FINDINGS: Participants from The Children with Long COVID (CLoCk) national study were invited to take part via an online survey, with a total of 31,017 participants taking part, 31,016 of which reported on their experience of loneliness. Participants retrospectively answered questions on demographics, lifestyle, physical health and mental health and loneliness before the pandemic and at the time of answering the survey. Before the pandemic 6.5% (2,006/31,016) of participants reported experiencing loneliness "Often/Always" and at the time of survey completion 17.4% (5,395/31,016) reported feeling lonelier. There was an association between meeting the research definition of long COVID and loneliness [3.49 OR, 95%CI 3.28-3.72]. CYP who reported feeling lonelier at the time of the survey than before the pandemic were assigned female at birth, older CYP, those from Black/African/Caribbean/Black British or other ethnicity groups, those that had 3-4 siblings and lived in more deprived areas. CONCLUSIONS: We demonstrate associations between multiple factors and experiences of loneliness during the pandemic. There is a need for a multi-faceted integrated approach when developing interventions targeted at loneliness. It is important to follow up the CYP involved at regular intervals to investigate the progression of their experience of loneliness over time

Near-Ultraviolet Properties of a Large Sample of Type Ia Supernovae as Observed with the Swift UVOT

We present ultraviolet (UV) and optical photometry of 26 Type Ia supernovae (SNe~Ia) observed from March 2005 to March 2008 with the NASA {\it Swift} Ultraviolet and Optical Telescope (UVOT). The dataset consists of 2133 individual observations, making it by far the most complete study of the UV emission from SNe~Ia to date. Grouping the SNe into three subclasses as derived from optical observations, we investigate the evolution of the colors of these SNe, finding a high degree of homogeneity within the normal subclass, but dramatic differences between that group and the subluminous and SN 2002cx-like groups. For the normal events, the redder UV filters on UVOT ($u$, $uvw1$) show more homogeneity than do the bluer UV filters ($uvm2$, $uvw2$). Searching for purely UV characteristics to determine existing optically based groupings, we find the peak width to be a poor discriminant, but we do see a variation in the time delay between peak emission and the late, flat phase of the light curves. The UV light curves peak a few days before the $B$ band for most subclasses (as was previously reported by Jha et al. 2006a), although the SN 2002cx-like objects peak at a very early epoch in the UV. That group also features the bluest emission observed among SNe~Ia. As the observational campaign is ongoing, we discuss the critical times to observe, as determined by this study, in order to maximize the scientific output of future observations.Comment: Accepted to Astrophysical Journa