BAT AGN Spectroscopic Survey - XIX. Type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows

We present a detailed study of ionized outflows in a large sample of ∼650 hard X-ray-detected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [O iii] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z ∼0.05). We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass, gas column density, Eddington ratio, [O iii], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [O iii] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature

BAT AGN Spectroscopic Survey – XIX. Type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows

We present a detailed study of ionized outflows in a large sample of ∼650 hard X-ray-detected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [O III] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z ∼0.05). We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass (⁠M_(BH)⁠), gas column density (⁠N_H⁠), Eddington ratio (⁠λ_(Edd)⁠), [O III], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [O III] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios [log(⁠λ_(Edd)⁠) ≳ −1.7]. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature

BAT AGN spectroscopic survey, XIX : type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows

We present a detailed study of ionized outflows in a large sample of similar to 650 hard X-ray-detected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [OIII] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z similar to 0.05). We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass (M-BH), gas column density (N-H), Eddington ratio (lambda(Edd)), [OIII], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [OIII] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios [log(lambda(Edd)) greater than or similar to -1.7]. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature

DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos

DNA damage independent of caspase activation accompanies programmed cell death in different vertebrate embryonic organs. We analyzed the significance of DNA damage during the regression of the interdigital tissue, which sculpts the digits in the embryonic limb. Interdigit remodeling involves oxidative stress, massive apoptosis and cell senescence. Phosphorylation of H2AX mediated by ATM precedes caspase dependent apoptosis and cell senescence during interdigit regression. The association of ?H2AX with other downstream DNA repair factors, including MDC1, Rad50 and 53BP1 suggests a defensive response of cells against DNA damage. The relative distribution of cells ?H2AX-only positive, TUNEL-only positive, and cells double positive for both markers is consistent with a sequence of degenerative events starting by damage of the DNA. In support of this interpretation, the relative number of ?H2AX-only cells increases after caspase inhibition while the relative number of TUNELonly cells increases after inhibition of ATM. Furthermore, cultured interdigits survived and maintained intense chondrogenic potential, even at advanced stages of degeneration, discarding a previous commitment to die. Our findings support a new biological paradigm considering embryonic cell death secondary to genotoxic stimuli, challenging the idea that considers physiological cell death a cell suicide regulated by an internal death clock that pre-programmes degeneration

Placement and orientation of individual DNA shapes on lithographically patterned surfaces

Artificial DNA nanostructures show promise for the organization of functional materials to create nanoelectronic or nano-optical devices. DNA origami, in which a long single strand of DNA is folded into a shape using shorter 'staple strands', can display 6-nm-resolution patterns of binding sites, in principle allowing complex arrangements of carbon nanotubes, silicon nanowires, or quantum dots. However, DNA origami are synthesized in solution and uncontrolled deposition results in random arrangements; this makes it difficult to measure the properties of attached nanodevices or to integrate them with conventionally fabricated microcircuitry. Here we describe the use of electron-beam lithography and dry oxidative etching to create DNA origami-shaped binding sites on technologically useful materials, such as SiO_2 and diamond-like carbon. In buffer with ~ 100 mM MgCl_2, DNA origami bind with high selectivity and good orientation: 70–95% of sites have individual origami aligned with an angular dispersion (±1 s.d.) as low as ±10° (on diamond-like carbon) or ±20° (on SiO_2)

A small satellite version of a soft x-ray polarimeter

We describe a new implementation of a broad-band soft X-ray polarimeter, substantially based on a previous design. This implementation, the Pioneer Soft X-ray Polarimeter (PiSoX) is a SmallSat, designed for NASA’s call for Astrophysics Pioneers, small missions that could be CubeSats, balloon experiments, or SmallSats. As in REDSoX, the grating arrangement is designed optimally for the purpose of polarimetry with broad-band focussing optics by matching the dispersion of the spectrometer channels to laterally graded multilayers (LGMLs). The system can achieve polarization modulation factors over 90%. For PiSoX, the optics are lightweight Si mirrors in a one-bounce parabolic configuration. High efficiency, blazed gratings from opposite sectors are oriented to disperse to a LGML forming a channel covering the wavelength range from 35 Å to 75 Å (165 - 350 eV). Upon satellite rotation, the intensities of the dispersed spectra, after reflection and polarizing by the LGMLs, give the three Stokes parameters needed to determine a source’s linear polarization fraction and orientation. The design can be extended to higher energies as LGMLs are developed further. We describe examples of the potential scientific return from instruments based on this design.Accepted manuscrip

Induction and transmission of oncogene-induced senescence

Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level

BAT AGN Spectroscopic Survey – XIX. Type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows

We present a detailed study of ionized outflows in a large sample of ∼650 hard X-raydetected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [OIII] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z ∼0.05).We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass (MBH), gas column density (NH), Eddington ratio (λEdd), [O III], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [OIII] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios [log(λEdd) −1.7]. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature.Idexación:Scopu