55 research outputs found
Variable-Speed-of-Light Cosmology from Brane World Scenario
We argue that the four-dimensional universe on the TeV brane of the
Randall-Sundrum scenario takes the bimetric structure of Clayton and Moffat,
with gravitons traveling faster than photons instead, while the radion varies
with time. We show that such brane world bimetric model can thereby solve the
flatness and the cosmological constant problems, provided the speed of a
graviton decreases to the present day value rapidly enough. The resolution of
other cosmological problems such as the horizon problem and the monopole
problem requires supplementation by inflation, which may be achieved by the
radion field provided the radion potential satisfies the slow-roll
approximation.Comment: 18 pages, LaTeX, revised version to appear in Phys. Rev.
Interacting Kasner-type cosmologies
It is well known that Kasner-type cosmologies provide a useful framework for
analyzing the three-dimensional anisotropic expansion because of the
simplification of the anisotropic dynamics. In this paper relativistic
multi-fluid Kasner-type scenarios are studied. We first consider the general
case of a superposition of two ideal cosmic fluids, as well as the particular
cases of non-interacting and interacting ones, by introducing a
phenomenological coupling function . For two-fluid cosmological scenarios
there exist only cosmological scaling solutions, while for three-fluid
configurations there exist not only cosmological scaling ones, but also more
general solutions. In the case of triply interacting cosmic fluids we can have
energy transfer from two fluids to a third one, or energy transfer from one
cosmic fluid to the other two. It is shown that by requiring the positivity of
energy densities there always is a matter component which violates the dominant
energy condition in this kind of anisotropic cosmological scenarios.Comment: Accepted for publication in Astrophysics &Space Science, 8 page
The Sudbury Neutrino Observatory
The Sudbury Neutrino Observatory is a second generation water Cherenkov
detector designed to determine whether the currently observed solar neutrino
deficit is a result of neutrino oscillations. The detector is unique in its use
of D2O as a detection medium, permitting it to make a solar model-independent
test of the neutrino oscillation hypothesis by comparison of the charged- and
neutral-current interaction rates. In this paper the physical properties,
construction, and preliminary operation of the Sudbury Neutrino Observatory are
described. Data and predicted operating parameters are provided whenever
possible.Comment: 58 pages, 12 figures, submitted to Nucl. Inst. Meth. Uses elsart and
epsf style files. For additional information about SNO see
http://www.sno.phy.queensu.ca . This version has some new reference
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network
Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene and initiate at unconventional regions, outside promoters or enhancers. Here, we probe these unassigned TSSs and show that, in all species studied, a significant fraction of CAGE peaks initiate at microsatellites, also called short tandem repeats (STRs). To confirm this transcription, we develop Cap Trap RNA-seq, a technology which combines cap trapping and long read MinION sequencing. We train sequence-based deep learning models able to predict CAGE signal at STRs with high accuracy. These models unveil the importance of STR surrounding sequences not only to distinguish STR classes, but also to predict the level of transcription initiation. Importantly, genetic variants linked to human diseases are preferentially found at STRs with high transcription initiation level, supporting the biological and clinical relevance of transcription initiation at STRs. Together, our results extend the repertoire of non-coding transcription associated with DNA tandem repeats and complexify STR polymorphism
Plasma lipids and apolipoproteins in a population of Orang Asli ('aborigines') from West Malaysia
10.1016/S0021-9150(96)06013-3Atherosclerosis129149-51ATHS
Effect of apolipoprotein E variants on plasma lipids and apolipoproteins in the Orang Asli ('Aborigines') of Malaysia
Human Heredity444209-213HUHE
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