90 research outputs found
Inadvertent injection of sodium hypochlorite into the periradicular tissues during root canal treatment.
- Publication venue
- 'Mark Allen Group'
- Publication date
- 01/01/2009
- Field of study
This paper describes a sodium hypochlorite (NaOCl) incident occurring during routine endodontic treatment of a patient who presented with chronic periapical periodontitis of a maxillary canine tooth and discusses the immediate and late treatment of this case
Turing Patterns Inside Cells
- Author
- A Boiteux
- A Goldbeter
- A Goldbeter
- AM Turing
- B Hasslacher
- B Hess
- Damián E. Strier
- DE Clapham
- DE Strier
- DE Strier
- DE Strier
- DJ Sharp
- EE Selkov
- EE Selkov
- EK Pye
- H Meinhardt
- H-T Xu
- I Lengyel
- I Prigogine
- JD Murray
- JE Pearson
- Nick Monk
- PA Lawrence
- PH Richter
- PK Hepler
- Q Ouyang
- S Bagyan
- S Dano
- S Kondo
- Silvina Ponce Dawson
- SM Bezrukov
- T Mair
- V Castets
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2007
- Field of study
Concentration gradients inside cells are involved in key processes such as cell division and morphogenesis. Here we show that a model of the enzymatic step catalized by phosphofructokinase (PFK), a step which is responsible for the appearance of homogeneous oscillations in the glycolytic pathway, displays Turing patterns with an intrinsic length-scale that is smaller than a typical cell size. All the parameter values are fully consistent with classic experiments on glycolytic oscillations and equal diffusion coefficients are assumed for ATP and ADP. We identify the enzyme concentration and the glycolytic flux as the possible regulators of the pattern. To the best of our knowledge, this is the first closed example of Turing pattern formation in a model of a vital step of the cell metabolism, with a built-in mechanism for changing the diffusion length of the reactants, and with parameter values that are compatible with experiments. Turing patterns inside cells could provide a check-point that combines mechanical and biochemical information to trigger events during the cell division process
Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
- Author
- Aberer Werner
- Adachi Mitsuru
- Agusti Alvar
- Akdis Cezmi
- Akdis Mubeccel
- Alonso A.
- Ankri J.
- Annesi Maesano Isabella
- Ansotegui Ignacio J.
- Anto Josep M.
- Arnavielhe Sylvie
- Arshad S. Hasan
- Bachert Claus
- Bai Chunxue
- Baiardini Ilaria
- Baigenzhin Abay K.
- Barbara Cristina
- Bateman Eric D.
- Bedbrook Anna
- Beghé Bianca
- Bel Elisabeth H.
- Bennoor Kazi S.
- Benson Michael
- Bergmann Karl Christian
- Bewick M.
- Bieber T.
- Bindslev Jensen Carsten
- Bjermer Leif
- Blain Hubert
- Blasi F.
- Boner A. L.
- Bonini Matteo
- Bonini Sergio
- Bosnic Anticevitch Sinthia
- Boulet Louis Philippe
- Bourret Rodolphe A.
- Bousquet Jean
- Bousquet Philippe J.
- Braido Fulvio
- Briggs Andrew H.
- Brightling Christopher E.
- Brozek Jan L.
- Buhl Roland
- Burney Peter G.
- Bush Andrew
- Caballero Fonseca Fernando
- Caimmi Davide P.
- Calderon M. A.
- Calverley P. M.
- Camargos P. A. M.
- Camuzat Thierry
- Canonica G. Walter
- Carlsen Kai Hakon
- Carr Warner
- Carriazo A.
- Casale Thomas B.
- Cepeda Sarabia A. M.
- Chatzi Leda
- Chavannes Niels H.
- Chen Yuzhi Z.
- Chiron Raphaël
- Chkhartishvili Ekaterine
- Chuchalin Alexander G.
- Chung K. F.
- Ciprandi Georgio
- Cirule Ieva
- Correia de Sousa J.
- Costa D. J.
- Cox Linda
- Crooks George
- Cruz A. A.
- Custovic Adnan
- Dahl Ronald
- Dahlen Sven Erik
- Darsow Ulf
- De Blay Frédéric
- De Carlo Giuseppe
- De Manuel Keenoy Esteban
- Dedeu Tony
- Deleanu Diana
- Demoly Pascal
- Denburg J. A.
- Devillier Phillipe
- Didier Alain
- Dinh Xuan Anh Tuan
- Djukanovic R.
- Dokic D.
- Douagui Habib B.
- Dray Gérard
- Dubakiene Ruta
- Durham S. R.
- Dykewicz Mark S.
- El Gamal Yehia
- Emuzyte R.
- Fabbri L. Muller
- Farrell J.
- Fink Wagner Antje H.
- Fiocchi Alessandro
- Fletcher Monica
- Fokkens Wytske J.
- Fonseca Joao A.
- Forastiere Francesco
- Frith P.
- Gaga M.
- Gamkrelidze Amiran
- Garcés J.
- García Aymerich J.
- Gemicioğlu Bilun
- Gereda José E.
- González Díaz Sandra Nora
- Gotua Maia
- Grisle Ineta
- Grouse Lawrence
- Gutter Z.
- Guzmán M. Antonieta
- Haahtela Tari
- Heaney L. G.
- Heinrich Joachim
- Hellings Peter W.
- Hellquist Dahl Birthe
- Henderson D.
- Hendry A.
- Heve D.
- Horak F.
- Hourihane J. O’. B.
- Howarth P.
- Humbert Marc
- Hyland M. E.
- Illario M.
- Ivancevich Juan Carlos
- Jardim José R.
- Jares Edgardo José
- Jeandel C.
- Jenkins C.
- Johnston Sebastian L.
- Jonquet Olivier
- Joos Guy
- Julge K.
- Jung Ki Suck
- Just Jocelyne
- Kaidashev Igor P.
- Kalayci Omer
- Kalyoncu A. F.
- Keil Thomas
- Keith Paul K.
- Khaitov Musa R.
- Khaltaev Nikolai
- Kheder A. Ben
- Klimek Ludger
- Koffi N'Goran B.
- Kolek Vítězslav
- Koppelman Gerard H.
- Kowalski M. L.
- Kull Inger
- Kuna Piotr
- Kvedariene Violeta
- Lambrecht Bart
- Larenas Linnemann Désirée
- Lau Susanne
- Laune Daniel
- Le L. T. T.
- Li Jingmei
- Lieberman Phillipe
- Lipworth Brian J.
- Lodrup Carlsen Karin C.
- Louis R.
- MacNee W.
- Magard Yves
- Magnan Antoine
- Mahboub Bassam
- Mair A.
- Majer Ivan
- Makela M. J.
- Malva J.
- Manning Peter J.
- Mara S.
- Marshall G. D.
- Masjedi Mohamad R.
- Matignon P.
- Maurer Marcus
- Mavale Manuel Sandra
- Melo Gomes Elisabete
- Meltzer E. O.
- Melén Erik
- Menzies Gow A.
- Mercier Jacques
- Merk Hans
- Michel J. P.
- Miculinic N.
- Mihaltan Florin
- Milenkovic Branislava
- Mohammad G. M. Y.
- Molimard Mathieu
- Momas Isabelle
- Montilla Santana Anna
- Morais Almeida Mario
- Morgan M.
- Mullol Jaoquim
- Muraro Antonella
- Mösges Ralph
- Naclerio Robert N.
- Nafti S.
- Namazova Baranova Leyla
- Neffen Hugo
- Nekam Kristof
- Neou Angelos
- Niggemann Bodo
- Ninot G.
- Nogues M.
- Nyembue T. Dieudonné
- O'Hehir Robyn E.
- Ohta Ken
- Okamoto Yoshitaka
- Okubo Kim
- Ouedraogo Solange
- Paggiaro Pier Luigi
- Pali Schöll Isabella
- Palkonen Susanna
- Panzner Petr
- Papadopoulos Nikolaos G.
- Papi Alberto
- Park Hae-Sim
- Passalacqua Giovanni
- Pavord Ian
- Pawankar Ruby
- Pedersen S.
- Pengelly R.
- Pfaar Oliver
- Picard Robert
- Pigearias Bernard
- Pin Isabelle
- Plavec Davor
- Poethig D.
- Pohl Wolfgang
- Popov Todor A.
- Portejoie F.
- Postma Dirkje S.
- Potter Paul
- Price David
- Rabe Klaus F.
- Raciborski Filip
- Radier Pontal F.
- Reitamo Sakari
- Rennard S.
- Repka Ramirez S.
- Robalo Cordeiro Carlos
- Roberts J.
- Roca J.
- Rodenas Francisco
- Rodriguez Mañas L.
- Rolland Christine
- Roman Rodriguez M.
- Romano A.
- Rosado Pinto José
- Rosario Nelson A.
- Rosenwasser Lanny
- Rottem Menachem
- Ryan Dermot
- Samolinski Boleslaw
- Scadding Glenis K.
- Schmid Grendelmeier Peter
- Schulz H.
- Schünemann Holger J.
- Serrano Eli
- Sheikh Aziz
- Shields M.
- Siafakas N.
- Sibille Y.
- Similowski T.
- Simons F. Estelle R.
- Sisul Alvariza Juan Carlos
- Skrindo Ingebjorg
- Smit Henriette A.
- Solé Dirceu
- Sooronbaev Talant
- Spranger Otto
- Stelmach Raphael
- Sterk P. J.
- Strandberg Timo
- Sunyer Jordi
- Sánchez Borges Mario
- Thijs C.
- To Teresa
- Todo Bom Ana Maria
- Triggiani Massimo
- Valenta Rudolf
- Valero Antonio L.
- Valia E.
- Valiulis Arunas
- Valovirta Erkka
- Van Ganse E.
- Van Hage Marianne
- Vandenplas Olivier
- Vasankari T.
- Vellas B.
- Vestbo J.
- Vezzani G.
- Vichyanond Pakit
- Viegi Giovanni
- Vogelmeier C.
- Vontetsianos T.
- Wagenmann Martin
- Wahn Ulrich
- Walker Samantha
- Wallaert B.
- Wang D. Y.
- Wickman Magnus
- Williams D. M.
- Williams S.
- Wright John
- Yawn Barbara P.
- Yiallouros P. K.
- Yorgancioglu Arzu
- Yusuf Osman M.
- Zaidi A.
- Zar Heather J.
- Zernotti Mario
- Zhang Luo
- Zhong Nanshan
- Zidarn Mihaela
- Zuberbier Torsten
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
Inside the Hybrid Organization: An Organizational Level View of Responses to Conflicting Institutional Demands
- Author
- A Binder
- A C Pache
- A D Chandler
- A J Hoffman
- A Nigam
- A Swidler
- Anne-Claire Pache
- B E Ashforth
- C A Heimer
- C Greenwood
- C Greenwood
- E Boxenbaum
- E George
- E J Zajac
- E S Clemens
- Filipe M. Santos
- H A Haveman
- H A Haveman
- H A Haveman
- H Hwang
- H Leblebici
- H Rao
- J Aurini
- J Battilana
- J D Westphal
- J D Westphal
- J D Westphal
- J D Westphal
- J M Hugues
- J M Purdy
- J M Stevens
- J Mair
- J Meyer
- J Pfeffer
- J W Meyer
- K K Chen
- M A Glynn
- M A Glynn
- M C Suchman
- M Lounsbury
- M Lounsbury
- M S Kraatz
- M Seo
- N Brunsson
- N Fligstein
- O N Basu
- P C Fiss
- P C Fiss
- P D Sherer
- P Frumkin
- P H Thornton
- P H Thornton
- P H Thornton
- P H Thornton
- P M Hirsch
- P S Ring
- P Tracey
- R Friedland
- R Greenwood
- R Greenwood
- R Greenwood
- R K Yin
- R R Nelson
- S Pauly-Aboubadra
- T B Lawrence
- T B Zilber
- T B Zilber
- T Baker
- T Kostova
- T Reay
- W R Scott
- W R Scott
- W R Scott
- W R Scott
- W R Scott
- W W Powell
- W W Powell
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2010
- Field of study
Recommended from our members
Interstitial Spaces: Microinteraction Settings and the Genesis of New Practices Between Institutional Fields
- Author
- Anderson C.
- Ansari S. M.
- Arkes H. R.
- Armstrong E.
- Barley S. R.
- Battilana J.
- Battilana J.
- Bechky B. A.
- Becker H. S.
- Berger P. L.
- Binder A.
- Bourdieu P.
- Boxenbaum E.
- Buenstorf G.
- Carlile P.
- Clemens E. S.
- Coleman G.
- Collins R.
- Collins R.
- Colyvas J. A.
- Corrigall-Brown C.
- Cowan B. W.
- Czarniawska B.
- Czarniawska B.
- Delmestri G.
- Dezalay Y.
- DiMaggio P. J.
- DiMaggio P. J.
- Douglas M.
- Eccles R. G.
- Edmondson A. C.
- Ellis M.
- Emirbayer M.
- Feld S.
- Feldman M. S.
- Fiss P. C.
- Fligstein N.
- Frijda N. H.
- Garud R.
- George E.
- Gitlin T.
- Goffman E.
- Greenwood R.
- Habermas J.
- Hallett T.
- Hallett T.
- Hargadon A.
- Heimer C. A.
- Himanen P.
- Howard-Grenville J.
- Jarzabkowski P.
- Jonsen A. R.
- Kellogg K.
- Kennedy M. K.
- Kraatz M. S.
- Lampel J.
- Lawrence T.
- Lawrence T. B.
- Lawrence T. B.
- Leifer E.
- Leifer E.
- Leonardi P. M.
- Levitt B.
- Levy S.
- Lok J.
- Lounsbury M.
- Magaudda P.
- Maguire S.
- Mair J.
- Mann M.
- Markoff J.
- McAdam D.
- McCall G.
- McPherson C.
- Mead G. H.
- Metiu A.
- Miller D.
- Morgan D.
- Murray F.
- Nigam A.
- Obstfeld D.
- Ocasio W.
- Ocasio W.
- Oldenburg R.
- Oldenburg R.
- Padgett J. F.
- Padgett J. F.
- Penning C.
- Powell W. W.
- Powell W. W.
- Powell W. W.
- Putnam R.
- Quinn R. W.
- Rao H.
- Reay T.
- Reay T.
- Ruef M.
- Sahlin K.
- Santi Furnari
- Sautet M.
- Scott W. R.
- Scott W. R.
- Smets M.
- Sorenson O.
- Souitaris V.
- Star S. L.
- Stinchcombe A. L.
- Stowe P.
- Strang D.
- Stringham E. P.
- Stryker S.
- Summers-Effler E.
- Swidler A.
- Thornton P.
- Thornton P.
- Thornton P.
- Thornton P. H.
- Tolbert P. S.
- Tracey P.
- Turner F.
- Turner V.
- Turner V.
- von Hippel E.
- Walter-Herrmann J.
- Watson D.
- Weber K.
- Weick K.
- Wooten M.
- Wright C.
- Zietsma C.
- Zilber T. B.
- Zilber T. B.
- Zilber T. B.
- Publication venue
- 'Academy of Management'
- Publication date
- 01/10/2014
- Field of study
I develop a model linking specific microinteraction dynamics between members of different institutional fields and the genesis of new practices. The model centers on the concept of interstitial spaces—that is, small-scale settings where individuals from different fields interact occasionally and informally around common activities to which they devote limited time (e.g., hobbyist clubs, hangouts, workshops, meet-ups). I argue that the features of interstitial spaces (e.g., their institutional diversity and their occasional and informal nature) facilitate the individuals interacting in these settings to temporarily break free from existing institutions and experiment collectively with new activities and ideas. However, these very same features hinder the constitution of such new activities and ideas into new practices. I identify two microlevel conditions that enable the new activities and ideas developed in interstitial spaces to be constituted into new practices: the emergence of successful interaction rituals, and the presence of catalysts sustaining others' interactions and assisting the construction of shared meanings
For social reflexivity in Organization and Management Theory
- Author
- Alvesson M.
- Alvesson M.
- Alvesson M.
- Amis J. M.
- Amis J. M.
- Becher T.
- Benner M. J.
- Berg M.
- Bolton S.
- Buchanan S.
- Carter C.
- Clegg S.
- Cloutier C.
- Collini S.
- Cooper D.
- Danišková Z.
- Davis G. F.
- Dillard D.
- DiMaggio P.
- Etzioni A.
- Friedland R.
- Friedland R.
- Gist-Mackey A. N.
- Gitterman A.
- Goffman E.
- Gouldner A.
- Gray B.
- Gruchy A.
- Hall P
- Hamann R.
- Hardy C.
- Haveman H.
- Held D.
- Hirsch P.
- Howard-Grenville J.
- Katz
- Keeling J.
- Khan F.R.
- Laski H.
- Lawrence T.
- Lefsrud L.
- Loh R. K.
- Lortie D.
- Lounsbury M.
- Maguire S.
- Mair J.
- McCarthy J.
- Meyer J.
- Morris P.
- Moten F.
- Munir K.
- Parker M.
- Reed M.
- Reinecke J.
- Rowlinson M.
- Said E.
- Schinkel W.
- Schüssler E.
- Scott W. R.
- Selznick P
- Selznick P.
- Simpson R.
- Skinner D. J.
- Spence C.
- Stinchcombe A.
- Streeck W.
- Suddaby R.
- Sweeney J.
- Thelen K.
- Willmott H.
- Witschge T.
- Wittneben B.
- Publication venue
- 'Emerald'
- Publication date
- 11/04/2019
- Field of study
Institutional Strategies in Emerging Markets
- Author
- A B Hargadon
- A J Hillman
- A J Hillman
- A J Hillman
- A J Hillman
- A Kriauciunas
- A Musacchio
- A O Laplume
- A Shleifer
- A Spicer
- Andrew King
- Andr�s Tilcsik
- B G King
- B Shaffer
- C D Ram�rez
- C Marquis
- C Marquis
- C Marquis
- C Marquis
- C N Chung
- C Oliver
- C Oliver
- C Oliver
- C Seelos
- Christopher Marquis
- D A Palmer
- D A Ralston
- D A Ready
- D A Schuler
- D B Yoffie
- D C North
- D C North
- D Etzion
- D J Arnold
- D Mcadam
- D O&apos
- D P Baron
- D Stark
- D Wang
- D Xu
- E Boxenbaum
- E T Walker
- G Cuadra
- G D Bruton
- G D Keim
- G F Davis
- G F Davis
- G F Davis
- G F Davis
- G F Davis
- G Keim
- G Keim
- G L Holburn
- G Pop-Eleches
- G R Carroll
- G Roland
- Gautam Ahuja
- H Ibarra
- H Li
- H Li
- H Rao
- H Zhu
- H.-M Chung
- I Guler
- I Okhmatovskiy
- J B Wade
- J Battilana
- J Battilana
- J Child
- J Child
- J D Mccarthy
- J F Mahon
- J Galaskiewicz
- J Galaskiewicz
- J K Ault
- J L Campbell
- J L Campbell
- J M De Figueiredo
- J M Podolny
- J Mair
- J Mair
- J P Bonardi
- J P H Fan
- J P Walsh
- J Pfeffer
- J S Harrison
- J S Harrison
- J Siegel
- J W Meyer
- J W Meyer
- J W Webb
- J Zhang
- K Lamertz
- K M Eisenhardt
- K S James
- L Nachum
- L W Busenitz
- L Zu
- La Porta
- M A Hitt
- M A Hitt
- M A Hitt
- M A Zimmerman
- M B E Clarkson
- M D Lord
- M F Guill�n
- M Kraatz
- M L Weidenbaum
- M Lounsbury
- M Raynard
- M W Peng
- M W Peng
- M W Peng
- M W Peng
- M W Peng
- M Wright
- M Zhao
- M.-G Seo
- Mia Raynard
- Michael Spence
- N Fligstein
- N Jia
- Neil Gunningham
- O E Williamson
- P A Hall
- P A Hall
- P Evans
- P H Thornton
- P Ingram
- P J Dimaggio
- P Kowalski
- P L Ingram
- P M Hirsch
- P Murrell
- P P M A R Heugens
- P Rodriguez
- P Sun
- R C Bird
- R E Freeman
- R E Freeman
- R E Hoskisson
- R Friedland
- R G Cook
- R Greenwood
- R Greenwood
- R K Kozhikode
- R K Mitchell
- R O Greenwood
- R R Miller
- R Whitley
- S A Soule
- S A Waddock
- S D Julian
- S Douma
- S L Berman
- S Luthra
- S Lux
- S M Puffer
- S M Puffer
- S R Hiatt
- S R Hiatt
- S R Hiatt
- S-J Choi
- S.-J Chang
- See
- T B Lawrence
- T Bartley
- T Bartley
- T C Melewar
- T Casciaro
- T Donaldson
- T J Dean
- T Khanna
- T Khanna
- T Khanna
- T Khanna
- T Khanna
- T Khanna
- T Kostova
- T Kostova
- T Kostova
- T Lawrence
- T London
- T R Harting
- U Uzo
- V F S Sit
- V Nee
- V Nee
- V V Tarnovskaya
- W J Henisz
- W J Henisz
- W R Scott
- W R Scott
- W R Scott
- W R Scott
- W R Scott
- X Luo
- X Luo
- Y Gao
- Y Han
- Y Luo
- Y Luo
- Y Luo
- Y Luo
- Y Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
- Amin A.
- Amit B.
- Anand A.
- Anantapatnaikuni S.
- Anderson L.
- Anderson M.
- Anderson M.
- Anderson N.
- Anderson R.
- Andrews A.
- Ang A.
- Anguvaa L.
- Aniruddhan K.
- Antonina Z.
- Araujo M.
- Archer A.
- Archer S.
- Arimoto R.
- Arkley C.
- Armah C.
- Armistead J.
- Armstrong C.
- Arnison-Newgass C.
- Arora D.
- Arya A.
- Arya R.
- Asghar A.
- Ashbrook-Raby C.
- Asher G.
- Ashley D.
- Ashraf S.
- Ashton D.
- Ashworth R.
- Aslam A.
- Atomode A.
- Attubato E.
- Aubrey P.
- Aujayeb A.
- Aung N.
- Avery M.
- Avram C.
- Aya A.
- Ayaz E.
- Aziz G.
- Babatunde F.
- Babington G.
- Bachour M.
- Badhan G.
- Bae J.
- Bagley G.
- Bagshaw L.
- Bailey A.
- Baillie J.
- Baillie J.K.
- Baird D.
- Bajandouh A.
- Baker D.
- Baker K.
- Bakere H.
- Bakhai A.
- Balasingam P.
- Balaskas T.
- Balasubramaniam M.
- Balcombe A.
- Baldwin A.
- Baldwin-Jones R.
- Balfour J.
- Balmforth C.
- Baluwala A.
- Bamford A.
- Bancroft H.
- Banda J.
- Banks H.
- Banks P.
- Bannister O.
- Baptist M.
- Barclay C.
- Barker D.
- Barker J.
- Barker-Williams K.
- Barnacle J.
- Barnard A.
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- Barr A.
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- Barrett A.
- Barrow E.
- Bartholomew J.
- Bartlett G.
- Bartley S.
- Barton J.
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- Baruah R.
- Bashir H.
- Bashyal A.
- Basoglu A.
- Bassett J.
- Bateman K.
- Bates M.
- Batra D.
- Baxter M.
- Bazaz R.
- Beacham L.
- Beadon K.
- Beard K.
- Beaumont-Jewell D.
- Beazley C.
- Beddall H.
- Beddows S.
- Beer S.
- Beety J.
- Bega G.
- Begg S.
- Behrouzi R.
- Belcher J.
- Belfield K.
- Bell J.
- Bell N.
- Bellamy M.
- Bellamy T.
- Bendall L.
- Benetti N.
- Bennett A.
- Bennett M.
- Benson V.
- Bentley A.
- Beranova E.
- Beresford M.
- Bergin C.
- Bernatoniene J.
- Best K.
- Bhadi A.
- Bhagani S.
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- Bhandari A.
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- Biggs S.
- Biju A.
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- Birch C.
- Birchall K.
- Biswas N.
- Black P.
- Blackgrove H.
- Blackledge B.
- Blackley S.
- Blackman H.
- Blackstock C.
- Blair C.
- Blamey H.
- Blane S.
- Blazeby J.
- Blencowe N.
- Bloss A.
- Blunt T.
- Bobie B.
- Bobruk K.
- Boehmer G.
- Bohnacker N.
- Bokhari S.
- Bond H.
- Boothroyd M.
- Bostock K.
- Boumrah T.
- Bourke S.
- Bowes A.
- Bowker P.
- Bowler H.
- Bowman L.
- Bowman S.
- Bowring A.
- Boyd J.
- Boyle P.
- Bracken A.
- Bradley P.
- Bradley P.
- Bradley P.
- Bradley-Potts J.
- Brady S.
- Braithwaite M.
- Brankin-Frisby T.
- Bray F.
- Brear T.
- Brend M.
- Bretland G.
- Bridgwood G.
- Bright J.
- Broadhurst R.
- Brockelsby C.
- Brockley T.
- Brodsky M.
- Brokke F.
- Brookes M.
- Brooks S.
- Brown J.
- Brown J.
- Brown N.
- Brown R.
- Brown R.
- Brraka A.
- Bruce J.
- Bruce M.
- Brudlo W.
- Buch M.H.
- Buchan R.
- Buck A.
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- Bugg G.
- Bujazia R.
- Bullock E.
- Burda D.
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- Burgess S.
- Burman A.
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- Butler E.
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- Buttress D.
- Byrne J.
- Byrne W.
- Byrne-Watts V.
- Cale E.
- Calisti G.
- Callens C.
- Cameron E.
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- Camm C.
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- Cann A.
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- Caplin B.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Abdul Rasheed A.
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- Data Monitoring Committee of the RECOVERY Collaborative Group
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- Farzana S.
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- Fatemi M.
- Faust S. N.
- Faust Saul N.
- Fearby S.
- Felton T.
- Fenlon K.
- Fenn A.
- Fenner I.
- Fenton C.
- Ferenando G.
- Ferguson C.
- Ferguson S.
- Ferguson V.
- Fernandez Lopez S.
- Ferriman E.
- Ferron S.
- Fethers N.
- Fielding J.
- Finch S.
- Fineman N.
- Finn A.
- Fiouni S.
- Fisher J.
- Fitzgerald F.
- Flaherty J.
- Fleming L.
- Fletcher L.
- Fogarty G.
- Foot H.
- Fordham I.
- Forrest A.
- Forster E.
- Foster E.
- Foster R.
- Fowler Robert
- Fowler S.
- Fox A.
- Fox C.
- Fox S.
- Frake R.
- Francis S.
- Frankland H.
- Franklin J.
- Franklin S.
- Freeman H.
- Freeman N.
- Frise M.
- Froud O.
- Fullerton D.
- G N.
- Gabbitas E.
- Gabriel C.
- Gabriel Z.
- Gale C.
- Gale H.
- Gallagher B.
- Gamble L.
- Gan C.
- Garden E.
- Gardiner P.
- Gardiner S.
- Garg I.
- Garty F.
- Gaughan E.
- Geele F.
- George B.
- George S.
- George V.
- Georgiou D.
- Gerdes L.
- Gettings S.
- Giannopoulou S.
- Gibani M.
- Gibb C.
- Gibbison B.
- Gibbons K.
- Gibson A.
- Gill L.
- Gillesen A.
- Gillian A.
- Gilliland D.
- Gillott R.
- Gilmour K.
- Gipson A.
- Glasgow S.
- Glover Bengtsson J.
- Glynn S.
- Gnanalingam C.
- Godden E.
- Godson E.
- Goldacre R.
- Goodall J.
- Goodenough B.
- Goodwin E.
- Goodwin J.
- Goonasekara M.
- Gorsuch T.
- Gosai J.
- Gotham D.
- Gould N.
- Gould S.
- Gourbault L.
- Gowans S.
- Gower H.
- Graham J.
- Grahamslaw J.
- Grana G.
- Grant A.
- Grant D.
- Gray A.
- Gray G.
- Gray J.
- Gray K.
- Grayson A.
- Green A.
- Green C.
- Green Christopher A.
- Green N.
- Greene D.
- Greenhalgh A.
- Gregory K.
- Greig J.
- Gresty J.
- Grey G.
- Griffin B.
- Griffin M.
- Grobovaite E.
- Groome R.
- Grover H.
- Grubb N.
- Grundy J.
- Guerin J.
- Gureviciute A.
- Gurung Rai S.
- Gurung L.
- Hackney P.
- Hadfield D.
- Hadfield S.
- Haider N.
- Haigh K.
- Haile V.
- Hainey S.
- Hall A.
- Hall C.
- Hall E.
- Hall J.
- Hallas J.
- Halls H.
- Hamdollah-Zadeh M.
- Hameed B.
- Hamid I.
- Hamilton G.
- Hamilton M.
- Hamilton S.
- Hammans B.
- Hammersley S.
- Hammond S.
- Hamoodi I.
- Hampshire K.
- Hampson L.
- Hanci O.
- Handrean S.
- Handzewniak N.
- Haney S.
- Hanison E.
- Hannington A.
- Hanrath A.
- Hanson A.
- Hanson H.
- Hanson J.
- Hanson S.
- Harden L.
- Harding Z.
- Hardman S.
- Hargreaves C.
- Harin A.
- Harman T.
- Harper C.
- Harper H.
- Harris J.
- Harris M.
- Harrison D.
- Harrison M.
- Harrison R.
- Harrison S.
- Harrod E.
- Hartrey W.
- Harvey A.
- Harvey M.
- Haslam J.
- Hastings B.
- Havinden-Williams M.
- Hawker L.
- Hayat A.
- Haynes Richard
- Hays C.
- Haysom S.
- Hazelton T.
- Hazenberg P.
- Headon E.
- Health records (for the RECOVERY Collaborative Group)
- Hector G.
- Heddon S.
- Henry J.
- Henshall D.
- Hernandez F.
- Herrington W.
- Heslop P.
- Hester S.
- Hey S.
- Heywood J.
- Hicks J.
- Hicks S.
- Higgins L.
- Hill P.
- Hilton J.
- Hindle A.
- Hindmarsh A.
- Hine P.
- Hird C.
- Hobson S.
- Hodgen L.
- Hodgkinson S.
- Hodgson H.
- Hodgson S.
- Hogg L.
- Hoggett L.
- Holden C.
- Holdhof N.
- Holland L.
- Hollands M.
- Holling N.
- Holmes R.
- Holt L.
- Hope S.
- Hopkins B.
- Horby Peter W.
- Horrobin C.
- Horsley A.
- Hough M.
- Houghton C.
- Houghton K.
- Houlihan R.
- Housely K.
- How L.
- Howard L.
- Howard M.
- Howard S.
- Howard-Sandy L.
- Howell A.
- Howie L.
- Hrycaiczuk J.
- Htwe S.
- Hudak A.
- Hudson H.
- Hughes G.
- Hughes H.
- Hughes S.
- Hulbert R.
- Hull D.
- Hull R.
- Hulme A.
- Hulme P.
- Hum R.
- Hunt L.
- Hunter E.
- Hunter K.
- Hunter N.
- Hunter S.
- Hurditch E.
- Hurley K.
- Hussain A.
- Hussain S.
- Hussain Y.
- Hutchinson C.
- Hutton P.
- Hyslop M.
- Ibrahim A.
- Ibrahim M.
- Ijaz M.
- Ilyas F.
- Ingham J.
- Ingram T.
- Ionita A.
- Iqbal J.
- Iqbal M.
- Irons R.
- Irving R.
- Islam S.
- Islim A.
- Ismail O.
- Iwanikiw S.
- Jack C.
- Jackman S.
- Jackson B.
- Jackson S.
- Jacob J.
- Jacob P.
- Jacques N.
- Jafar A.
- Jagannathan V.
- Jaime F.
- Jaki Thomas
- Jaly Y.
- Jama R.
- Jamal A.
- Jamal S.
- James L.
- Jameson J.
- Janes K.
- Japp D.
- Jarman C.
- Jarvis C.
- Jarvis R.
- Jastrzebska P.
- Jeebun V.
- Jeffery Katie
- Jeffreys N.
- Jeffs B.
- Jenkins P.
- Jennings F.
- Jennings V.
- Jerry D.
- Jimenez Gil A.
- Johal S.
- John A.
- John M.
- Johnson G.
- Johnston B.
- Johnston S.
- Johnstone D.
- Johnstone E.
- Jones A.
- Jones B.
- Jones E.
- Jones G.
- Jones J.
- Jones P.
- Jones R.
- Jones S.
- Jones T.
- Jordache R.
- Jose S.
- Joseph G.
- Joseph R.
- Josiah B.
- Ju Wen Kwek A.
- Judge P.
- Juszczak Edmund
- Kailey A.
- Kalayi R.
- Kamath P.
- Kamfose M.
- Kanabar D.
- Kapoor R.
- Karunaratne N.
- Kaur J.
- Kausar Z.
- Kavanagh S.
- Kay S.
- Kayappurathu J.
- Ke M.
- Keating L.
- Keddie-Gray E.
- Kelly E.
- Kelly R.
- Kelly S.
- Kendall E.
- Kennedy A.
- Kennedy M.
- Keogan L.
- Khan A.
- Khan M.
- Khan W.
- Khatun T.
- Khin H.
- Khurana C.
- Kibutu F.
- Kidd M.
- Kidney S.
- Kim M.
- Kimber A.
- King A.
- King J.
- King S.
- King-Oakley E.
- Kirk J.
- Kirkham E.
- Kirkpatrick L.
- Kitching T.
- Kitto L.
- Knight A.
- Knight F.
- Knight Marian
- Knight S.
- Knowles C.
- Knowles L.
- Koch O.
- Koe Y.
- Koirata A.
- Kolakaluri E.
- Kononen M.
- Koo H.
- Kosmidis C.
- Kothandaraman E.
- Koukou K.
- Kountourgioti A.
- Krasauskas K.
- Krishnamurthy V.
- Krizak S.
- Krupej S.
- Kudsk-Iversen S.
- Kudzinskas A.
- Kumar R.
- Kurani A.
- Kurdy M.
- Kuriakose K.
- Kyere-Diabour T.
- Kyi N.
- Labao J.
- Lacson M.
- Ladan Z.
- Lagnado A.
- Lalloo David
- Lalloo F.
- Lamb L.
- Lamb T.
- Landray Martin J.
- Lane N.
- Lang A.
- Lang S.
- Langley M.
- Langoya C.
- Lassa S.
- Latham S.
- Latham V.
- Laurenson M.
- Law H.
- Lawless L.
- Lawrence G.
- Lawrence H.
- Lawrie R.
- Lay M.
- Lazo M.
- Le V.
- Leach L.
- Leandro L.
- Lee S.
- Lees D.
- Legge H.
- Leitch D.
- Lemoine N.
- Lennon K.
- Levett C.
- Levynska A.
- Lewis H.
- Lewis J.
- Lewis K.
- Lewis L.
- Lewis N.
- Liao A.
- Lim Wei Shen
- Linares C.
- Lindergard G.
- Lindsay M.
- Lipscomb G.
- Lipscomb K.
- Little J.
- Liu P.
- Liu S.
- Lloyd A.
- Lloyd O.
- Lo S.
- Loader D.
- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
- Locke T.
- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
- Lomme K.
- Looby L.
- Lopez P.
- Lord R.
- Loro F.
- Lovell M.
- Low A.
- Low S.
- Lowe C.
- Lowsby R.
- Luintel A.
- Luke H.
- Luke J.
- Lunn M.
- Luo J.
- Lye A.
- Lyell B.
- Lynch D.
- Mabb H.
- Macfarlane J.
- Macfarlane L.
- MacInnes L.
- MacIntyre I.
- Mackay L.
- MacKenzie J.
- Mackey A.
- Mackintosh C.
- Macmahon M.
- MacRaild A.
- Madden A.
- Madeja N.
- Mafham Marion
- Magnaye L.
- Maharajh A.
- Mahaveer A.
- Mahdi H.
- Maheswaran A.
- Mahmood W.
- Mahmood Z.
- Mahony E.
- Mahungu T.
- Mair L.
- Majekdunmi T.
- Majumdar Jaydip
- Malein Flora
- Mancinelli R.
- Mandal S.
- Manderson L.
- Mandeville J.
- Mane T.
- Manso K.
- Mansour M.
- Marecka M.
- Maren D.
- Margabanthu G.
- Margaritopoulos G.
- Maria del Rocio F.
- Mariano V.
- Marks B.
- Marks P.
- Marriott C.
- Marriott N.
- Marsden P.
- Marshall A.
- Martin H.
- Martin K.
- Martin M.
- Martinez Garrido J.
- Maseda D.
- Mashate S.
- Masih S.
- Masoli M.
- Mathen S.
- Mather N.
- Mathew B.
- Mathews J.
- Mathioudakis A.
- Matila D.
- Matisa E.
- Matkins E.
- Matovu E.
- Matthews C.
- May P.
- Mayanagao I.
- Mayer J.
- Mayo T.
- Mazhani T.
- McAlinden P.
- McAndrew J.
- McBrearty C.
- McBride E.
- McCafferty G.
- McCann C.
- McCarthy E.
- McCorkindale A.
- McCrae J.
- McCullagh I.
- McCullagh L.
- McCullough K.
- McCullough S.
- McCurrach F.
- McDermott J.
- McDonald S.
- McDonnell N.
- McEleavy I.
- McEvoy E.
- McGhee C.
- McGrath B.
- McIntyre K.
- Mckie H.
- Mckie L.
- McLachlan H.
- McLarty N.
- McLeish M.
- McLure S.
- McMahon G.
- McMaster P.
- McMillan N.
- McMullen H.
- McNeill C.
- McNeill J.
- McNelis U.
- McNulty M.
- McSorland D.
- Mead J.
- Meakin O.
- Mears K.
- Mediana A.
- Medine R.
- Meghani N.
- Megson S.
- Mehar A.
- Mehra R.
- Meiring J.
- Melander S.
- Mellor F.
- Mellor Z.
- Melville A.
- Melville J.
- Membrey H.
- Mendonca C.
- Mentzer A.
- Meredith M.
- Merron P.
- Metcalfe B.
- Metryka A.
- Mew L.
- Mguni N.
- Miah N.
- Micallef D.
- Michalak N.
- Michalec O.
- Middle J.
- Middleton J.
- Middleton M.
- Millard J.
- Miller J.
- Millett L.
- Milligan H.
- Millington K.
- Millington S.
- Millward H.
- Minton J.
- Mishra A.
- Mishra B.
- Mistry H.
- Mital D.
- Mitchell B.
- Mitchelmore P.
- Mitra S.
- Moatt E.
- Mohamed O.
- Mohammed O.
- Mok J.
- Molina M.
- Molloy A.
- Monaghan H.
- Monsell K.
- Montasser M.
- Montgomery Alan
- Moon A.
- Moon J.
- Moonan M.
- Moore F.
- Moores R.
- Morales J.
- Moran L.
- Moray G.
- Morgan A.
- Morgan L.
- Morgan-Smith E.
- Morilla J.
- Morley W.
- Morris L.
- Morris P.
- Morris S.
- Morrison S.
- Morrissey M.
- Morrow A.
- Moss S.
- Moth G.
- Motherwell N.
- Moulton H.
- Mounce G.
- Mtuwa S.
- Muazzam A.
- Mudawi D.
- Mulcahy M.
- Mulligan S.
- Mumford Andrew
- Munavvar Mohammed
- Munt S.
- Murphy S.
- Murray C.
- Murray D.
- Murray I.
- Murray K.
- Murray L.
- Murthy M.
- Mutch C.
- Muzengi N.
- Mwaura E.
- Nafei M.
- Nagarajan T.
- Naglik L.
- Naguib M.
- Naicker K.
- Naisbitt J.
- Nandani A.
- Nandwani T.
- Nasa S.
- Natarajan N.
- Nathvani M.
- Navarra H.
- Naveed S.
- Naz M.
- Neal A.
- Nelson B.
- Nelson S.
- Nethercott D.
- Newby D.
- Newman T.
- Newport R.
- Ng S.
- Ngumo A.
- Nicholas N.
- Nicholas P.
- Nickson I.
- Nicol R.
- Nightingale T.
- Nilsson A.
- Ninan P.
- Nirmalan M.
- Nixon J.
- Nizam Ud Din K.
- Noe H.
- Norton R.
- Nourein K.
- Nunn K.
- Nunn M.
- Nunnick J.
- Nurgat Z.
- Nuttall A.
- Nwajiugo P.
- Oboh C.
- Obukofe R.
- Odam M.
- Odedra K.
- Odell N.
- Offord P.
- Ohia U.
- Okeke T.
- OKell E.
- Oliver A.
- Oliver J.
- Oliver Z.
- Oomatia A.
- Oram R.
- Oreilly C.
- Osadcow A.
- Osanlou R.
- Osborne N.
- Osborne R.
- Osborne W.
- Osei-Bobie J.
- Oxlade R.
- O’Brien R.
- O’Callaghan C.
- O’Connor G.
- O’Donovan C.
- O’Farrell S.
- O’Riordan D.
- O’Sullivan E.
- Padden G.
- Page I.
- Page S.
- Pagett K.
- Pajak S.
- Pakou G.
- Palacios A.
- Palfrey H.
- Pandya T.
- Panes A.
- Pantin C.
- Parambil V.
- Parashar S.
- Parekh A.
- Parekh D.
- Parker B.
- Parker J.
- Parker S.
- Parkinson A.
- Passby L.
- Passey S.
- Patachako J.
- Patel M.
- Patel P.
- Patel S.
- Patience A.
- Patten S.
- Patterson C.
- Patterson L.
- Pauls L.
- Paulus S.
- Payne B.
- Payne E.
- Payne R.
- Peacock L.
- Pearce J.
- Pearson K.
- Peasley A.
- Peggie H.
- Pelham C.
- Penman C.
- Penman J.
- Penman R.
- Percival R.
- Perez E.
- Periyasamy L.
- Perry A.
- Perry M.
- Pessoa-Amorim Guilherme
- Peters C.
- Peterson A.
- Peto Leon
- Petrova B.
- Pezard-Snell M.
- Phelan P.
- Philbin J.
- Phillips N.
- PI M.
- Pick S.
- Pickard J.
- Pickering G.
- Piercy C.
- Pinches H.
- Pine K.
- Pinjala M.
- Pitchford M.
- Pleass R.
- Plowright M.
- Plumptre C.
- Pomery F.
- Poole L.
- Porter D.
- Porter L.
- Potter A.
- Potts J.
- Poustie V.
- Power N.
- Poyner E.
- Pradhan V.
- Prady H.
- Prasath S.
- Pratt A.
- Pratt S.
- Preiss D.
- Prest C.
- Price A.
- Price C.
- Price D.
- Price K.
- Price L.
- Price V.
- Price-Eland R.
- Priest A.
- Prince C.
- Pringle S.
- Pristopan V.
- Priyash V.
- Prudon Benjamin
- Pugh L.
- Purdue C.
- Purdy R.
- Pursell M.
- Purvis S.
- Putensen D.
- Pyart E.
- Quek E.
- Quigley J.
- Quindoyos J.
- Quinn T.
- Rabinowicz S.
- Rafique J.
- Rahman M.
- Rai S.
- Raithatha A.
- Rajasri A.
- Ramanan A.
- Ramasamy M.
- Ramchandani A.
- Ramirez J.
- Rampling T.
- Ramsay J.
- Ramshaw A.
- Rana G.
- Rand J.
- Rank H.
- Rankhelawon R.
- Rasheed A.
- Ratcliffe S.
- Raw J.
- Razvi Z.
- RECOVERY Collaborative Group
- Redknap I.
- Redman N.
- Rees A.
- Rees M.
- Rees S.
- Rehman Z.
- Reilly M.
- Reith C.
- Renshaw S.
- Rey S.
- Reynard C.
- Reynolds H.
- Rhodes J.
- Rice E.
- Rice M.
- Rice N.
- Richardson E.
- Richardson N.
- Rigby L.
- Riley M.
- Riley P.
- Ripley D.
- Rishton C.
- Riste M.
- Ritchings A.
- Rivera Ortega P.
- Robbins E.
- Roberts V.
- Robertson C.
- Robertson J.
- Robertson N.
- Robinson J.
- Robinson L.
- Robinson S.
- Robson S.
- Roderick M.
- Rodger A.
- Rodgers A.
- Rodgers N.
- Rodgers P.
- Roehr C.
- Rogers J.
- Rogers S.
- Rogers T.
- Rook C.
- Rooney L.
- Rosby E.
- Rose A.
- Rose Z.
- Ross I.
- Rothman A.
- Rothwell J.
- Roughley L.
- Rowan Kathryn
- Rowan N.
- Rowe A.
- Rowe N.
- Rowley M.
- Rudenko A.
- Rule R.
- Rushmer J.
- Ryan A.
- Ryan L.
- Ryan P.
- Rybka E.
- Ryder S.
- Salberg A.
- Saleh M.
- Salih H.
- Salman R.
- Salmon R.
- Sam M.
- Sam S.
- Saminathan S.
- Sammons E.
- Sammut D.
- Sampson J.
- Samuel M.
- Samuel Y.
- Sanchez Gonzalez A.
- Sanchez V.
- Sandercock Peter
- Sangombe M.
- Sanju M.
- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
- Scarratt L.
- Scattergood S.
- Schadenberg A.
- Schafers J.
- Schneblen W.
- Schofield E.
- Schumacher N.
- Schunke N.
- Scobie A.
- Scoones T.
- Scott A.
- Scott C.
- Scullion A.
- Seaton I.
- Sedano J.
- Segovia M.
- Selby F.
- Sellers K.
- Sen N.
- Sengupta A.
- Sewdin T.
- Seymour J.
- Shah H.
- Shah R.
- Shah S.
- Shaibu A.
- Shanahan T.
- Sharaf H.
- Sharma B.
- Sharma O.
- Sharma S.
- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
- Shioi C.
- Shirley K.
- Shurlock J.
- Shurmer Jack
- Siamia L.
- Siddle E.
- Sime R.
- Simpson A.
- Simpson D.
- Simpson J.
- Simpson M.
- Simpson P.
- Sinclair S.
- Singh C.
- Singh S.
- Singhal P.
- Sithiravel S.
- Sivanadarajah S.
- Skaria A.
- Skehan N.
- Skinner T.
- Skinner V.
- Skorko A.
- Slack A.
- Slade H.
- Small E.
- Smallridge A.
- Smart B.
- Smith C.
- Smith E.
- Smith H.
- Smith J.
- Smith L.
- Smith M.
- Smith N.
- Smith P.
- Smith R.
- Smith S.
- Smith T.
- Smith V.
- Snell D.
- Sobande T.
- Sobrino Diaz A.
- Solly R.
- Soni G.
- Soor P.
- Soothill G.
- Soren J.
- Spiller W.
- Spring O.
- Squires G.
- Squires J.
- Squires R.
- Srinivasan R.
- Stagg W.
- Stanton A.
- Staplin Natalie
- Starnes D.
- Steer J.
- Stefania V.
- Stefanowska P.
- Stephens A.
- Stephensen D.
- Stephenson E.
- Sterrenburg M.
- Stevens W.
- Stevenson A.
- Stevenson S.
- Steward M.
- Stewart C.
- Stewart K.
- Stewart Richard
- Stickley J.
- Stirrup S.
- Stock S.
- Stockdale A.
- Stone B.
- Stone S.
- Storey I.
- Stratton E.
- Stratton J.
- Stubbs A.
- Stuttard M.
- Subudhi C.
- Sugden P.
- Sukumaran A.
- Sundar S.
- Surtees M.
- Sutherland R.
- Sutherland S.
- Sutu M.
- Swanson-Low C.
- Swart T.
- Swift E.
- Swist-Szulik K.
- Sykes D.
- Sykes E.
- Symon D.
- Syndercombe A.
- T-Michael H.
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- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
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