MIOCENE QUANTITATIVE CALCAREOUS NANNOFOSSIL BIOSTRATIGRAPHY FROM SOUTHERN APENNINES FOREDEEP DEPOSITS AND MEDITERRANEAN DSDP SITE 372

A quantitative biostratigraphic study based on calcareous nannofossil assemblages was carried out in nine Miocene calcareous and siliciclastic foredeep sections, cropping out in the outer part of the Southern Apennines and generally ascribed to the external Irpinian units. Several biozonal events were recognised by means of quantitative analyses, according to the biostratigraphic schemes of Fornaciari & Rio (1996) and Fornaciari et al. (1996) for the lower and middle Miocene and of Theodoridis (1984) for the upper Miocene. In the lower and middle Miocene interval some biohorizons such as the first common occurrence of Helicosphaera walbersdorfensis and last common occurrence of Calcidiscus premacintyrei are not always detectable in the studied sections and the first common occurrence of Calcidiscus macintyrei appears to be a better biohorizon in the MNN6b/7 than the last common occurrence of C. premacintyrei. New data on abundance patterns of selected calcareous nannofossils have been collected, thus improving the biostratigraphic resolution of the zonal schemes: a paracme interval of small Reticulofenestra pseudoumbilicus was noted within Zone MNN4b and MNN5a; the beginning and the end of the paracme are useful events in the studied sections for stratigraphic correlations. Moreover the occurrence of R. pseudoumbilicus has been recorded from Zone MNN2b on upwards, fairly below the FCO of the species that defines the base of Zone MNN6b. The distributions observed in the on-land sections are consistent with those recognised in DSDP Site 372 located in the western Mediterranean Sea, confirming their potential biostratigraphic utility within the Mediterranean region.&nbsp

MIOCENE QUANTITATIVE CALCAREOUS NANNOFOSSIL BIOSTRATIGRAPHY FROM SOUTHERN APENNINES FOREDEEP DEPOSITS AND MEDITERRANEAN DSDP SITE 372

A quantitative biostratigraphic study based on calcareous nannofossil assemblages was carried out in nine Miocene calcareous and siliciclastic foredeep sections, cropping out in the outer part of the Southern Apennines and generally ascribed to the external Irpinian units. Several biozonal events were recognised by means of quantitative analyses, according to the biostratigraphic schemes of Fornaciari & Rio (1996) and Fornaciari et al. (1996) for the lower and middle Miocene and of Theodoridis (1984) for the upper Miocene. In the lower and middle Miocene interval some biohorizons such as the first common occurrence of Helicosphaera walbersdorfensis and last common occurrence of Calcidiscus premacintyrei are not always detectable in the studied sections and the first common occurrence of Calcidiscus macintyrei appears to be a better biohorizon in the MNN6b/7 than the last common occurrence of C. premacintyrei. New data on abundance patterns of selected calcareous nannofossils have been collected, thus improving the biostratigraphic resolution of the zonal schemes: a paracme interval of small Reticulofenestra pseudoumbilicus was noted within Zone MNN4b and MNN5a; the beginning and the end of the paracme are useful events in the studied sections for stratigraphic correlations. Moreover the occurrence of R. pseudoumbilicus has been recorded from Zone MNN2b on upwards, fairly below the FCO of the species that defines the base of Zone MNN6b. The distributions observed in the on-land sections are consistent with those recognised in DSDP Site 372 located in the western Mediterranean Sea, confirming their potential biostratigraphic utility within the Mediterranean region.&nbsp

Junior Students’ with Hearing Impairment Psychological Correction of Learning Motivation Development

У статті розглянуто основні методологічні принципи, методи, етапи корекційного процесу. Обґрунтовано використання гуманістичного підходу до корекції мотиваційної сфери учіння та підібрано комплекс корекційних завдань для розвитку цієї сфери в молодших школярів із порушеннями слуху. The article presents basic methodological principles, methods, main stages of correctional process. A humanitarian approach to learning motivation development correction has been grounded and a complex of correctional tasks for junior students with hearing impairment has been selected

Holocene climate variability of the Western Mediterranean: surface water dynamics inferred from calcareous plankton assemblages

A high-resolution study (centennial scale) has been performed on the calcareous plankton assemblage of the Holocene portion of the Ocean Drilling Program Site 976 (Alboran Sea) with the aim to identify the main changes in the surface water dynamic. The dataset also provided a seasonal foraminiferal sea surface water temperatures (SSTs), estimated using the modern analog technique SIMMAX 28, and it was compared with available geochemical and pollen data at the site. Three main climate shifts were identified as (1) the increase in abundance of Syracosphaera spp. and Turborotalita quinqueloba marks the early Holocene humid phase, during maximum summer insolation and enhanced river runoff. It is concomitant with the expansion of Quercus, supporting high humidity on land. It ends at 8.2 ka, registering a sudden temperature and humidity reduction; (2) the rise in the abundances of Florisphaera profunda and Globorotalia inflata, at ca. 8 ka, indicates the development of the modern geostrophic front, gyre circulation, and of a deep nutricline following the sea-level rise; and (3) the increase of small Gephyrocapsa and Globigerina bulloides at 5.3 ka suggests enhanced nutrient availability in surface waters, related to more persistent wind-induced upwelling conditions. Relatively higher winter SST in the last 3.5 ka favored the increase of Trilobatus sacculifer, likely connected to more stable surface water conditions. Over the main trends, a short-term cyclicity is registered in coccolithophore productivity during the last 8 ka. Short periods of increased productivity are in phase with Atlantic waters inflow, and more arid intervals on land. This cyclicity has been related with periods of positive North Atlantic Oscillation (NAO) circulations. Spectral analysis on coccolithophore productivity confirms the occurrence of millennial-scale cyclicity, suggesting an external (i.e. solar) and an internal (i.e. atmospheric/oceanic) forcing.Geoscience PhD scholarship, Universita degli Studi di BariPotenziamento Strutturale dell'Universita degli Studi di Bari, Laboratorio per lo Sviluppo Integrato delle Scienze e delle Tecnologie dei Materiali Avanzati e per dispositivi innovativi (SISTEMA) [PONa3_00369]Fundacao para a Ciencia e a Tecnologia (FCT)Portuguese Foundation for Science and TechnologyEuropean Commission [SFRH/BPD/111433/2015]info:eu-repo/semantics/submittedVersio

Coccolithophores as proxy of seawater changes at orbital-to-millennial scale during middle Pleistocene Marine Isotope Stages 14-9 in North Atlantic core MD01-2446

midlatitude North Atlantic, to reconstruct climatically induced sea surface water conditions throughout Marine Isotope Stages (MIS) 14–9. The data are compared to new and available paleoenvironmental proxies from the same site as well as other nearby North Atlantic records that support the coccolithophore signature at glacial‐interglacial to millennial climate scale. Total coccolithophore absolute abundance increases during interglacials but abruptly drops during the colder glacial phases and deglaciations. Coccolithophore warm water taxa (wwt) indicate that MIS11c and MIS9e experienced warmer and more stable conditions throughout the whole photic zone compared to MIS13. MIS11 was a long‐lasting warmer and stable interglacial characterized by a climate optimum during MIS11c when a more prominent influence of the subtropical front at the site is inferred. The wwt pattern also suggests distinct interstadial and stadial events lasting about 4–10 kyr. The glacial increases of Gephyrocapsa margereli‐G. muellerae 3–4 µm along with higher values of Corg, additionally supported by the total alkenone abundance at Site U1313, indicate more productive surface waters, likely reflecting the migration of the polar front into the midlatitude North Atlantic. Distinctive peaks of G. margereli‐muellerae (>4 µm), C. pelagicus pelagicus , Neogloboquadrina pachyderma left coiling, and reworked nannofossils, combined with minima in total nannofossil accumulation rate, are tracers of Heinrich‐type events during MIS12 and MIS10. Additional Heinrich‐type events are suggested during MIS12 and MIS14 based on biotic proxies, and we discuss possible iceberg sources at these times. Our results improve the understanding of mid‐Brunhes paleoclimate and the impact on phytoplankton diversity in the midlatitude North Atlantic region.Provided by PTCRIS: 58282, C2007-FCT/319/2006info:eu-repo/semantics/publishedVersio

Coccolithophore relative abundances at the Ideale Section - Montalbano Jonico, Southern Italy

In the present dataset we provide relative abundance (%) of the main taxa of the coccolithophore. Slides for coccolithophore analysis were prepared following Flores and Sierro (1997). Quantitative analyses were performed at University of Bari, Italy, using a polarized light microscope at 1000× magnification. Abundances were determined by counting at least 500 coccoliths of all sizes. We also provide estimate of reworked calcareous nannofossils, i.e. taxa belonging to older (Mesozoic and Paleogene-Neogene) stratigraphic intervals, estimated separately during this counting. Warm-water coccoliths include the following taxa: Umbilicosphaera sibogae s.l., Calciosolenia spp., Discosphaera tubifera, Rhabdospaera clavigera, Umbellosphaera spp., Oolithotus spp. The coccolith dissolution index (DI) was estimated according to the following ratio: DI = small Gephyrocapsa/(small Gephyrocapsa + Calcidiscus leptoporus). High values of DI indicate good preservation. Species dominance of the coccolithophore assemblage has been obtained using PAleontological STatistics Software 4.02 (Hammer et al., 2001) and is equivalent to 1-Simpson index

Coccolithophore absolute abundances at the Ideale Section - Montalbano Jonico, Southern Italy

In the present dataset we provide absolute abundance of total coccolithophore assemblage (Total N) and of the main taxa as # coccoliths/g *107. Slides for coccolithophore analysis were prepared following Flores and Sierro (1997). Quantitative analyses were performed at University of Bari, Italy, using a polarized light microscope at 1000× magnification. Abundances were determined by counting at least 500 coccoliths of all sizes

Adenosine Pathway as a prognostic biomarker and an actionable target to overcome “immune escape” of human tumors: the Mesothelioma model.

Malignant pleural mesothelioma is an aggressive cancer and, for this disease, chemotherapy, surgery and radiotherapy are not curative. During the last years, numerous of studies have focused on immune therapies exploiting the use of immune checkpoint inhibitors. So far, these treatments are based on the use of molecules that inhibit proteins and receptors such as PD-1, PD-L1 and CTLA-4 [1]. Thus, there is the urgent need to find other immune targets. The purinergic pathway is a field of great interest as in fact there is evidence that the hypoxic environment of tumors induces increased expression of CD73 and CD39 (enzymes that produce adenosine starting from ATP) which promote the increase in extracellular adenosine [2]. High levels of adenosine are characteristic of the tumor microenvironment and induce immunosuppressive signals promoting growth and progression of tumors. For this reason [3], inhibitors of the purinergic pathway drawing attention to restore immune response to cancer cells. Our study is aimed at the identification of adenosine pathway members in MPM tissue and if this same pathway is active in this tumor. We have detected high expression of the Adenosine receptors and CD73 in MPM cells. Accordingly, treatment with the A2Br antagonist (MRS1754) provided the evidence that adenosine signaling is active in MPM cells and is a potential novel druggable target against MPM