843 research outputs found

    Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

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    On subgroups in division rings of type 22

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    Let DD be a division ring with center FF. We say that DD is a {\em division ring of type 22} if for every two elements x,yD,x, y\in D, the division subring F(x,y)F(x, y) is a finite dimensional vector space over FF. In this paper we investigate multiplicative subgroups in such a ring.Comment: 10 pages, 0 figure

    Determination of developmental stages of embryo in the sea urchin, Echinometra mathaei

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    Sea Urchin is one of the most useful tools in developmental biology studies because this organism has the simplest kind of developmental stages. We aimed to determine developmental stages and timetable of Echinometra mathaei embryo (the species of Persian Gulf). The spawning of E. mathaei was induced by 0.5M KCl injection (1ml) into the coelomic cavity. After fertilization, embryos were placed in beakers and were incubated at 29°C and a salinity of 39 ppt until embryos reached the pluteus stage. The developmental stages of embryos and the timing of each stage including cleavage, morulae, blastula, gastrula, prism and pluteus larvae were studied under the microscope. Our results showed that after 30 hours from fertilization time, the embryos developed to pluteus larvae. E. mathaei had the shorter development time in comparison to the other Sea Urchin species. Therefore, it may be appropriate as a model organism in biological researches

    Real-time Coupling of Multi-Domain Representational and Analytical Building Object Models via Homology-based Mapping

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    Ideally, multiple computational building evaluation routines (particularly simulation tools) should be coupled in real-time to the representational design model to provide timely performance feed-back to the system user. In this paper we demonstrate how this can be achieved effectively and conveniently via homology-based mapping. We consider two models as homologous if they entail isomorphic topological information. If the general design representation (i.e., a shared object model) is generated in a manner so as to include both the topological building information and pointers to the semantic information base, it can be used to directly derive the domain representations (>enriched< object models with detailed configurational information and filtered semantic data) needed for evaluation purposes. As a proof of concept, we demonstrate a computational design environment that dynamically links an object-oriented space-based design model, with structurally homologous object models of various simulation routines

    Structure of the Galaxies in the NGC 80 Group

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    BV-bands photometric data obtained at the 6-m telescope of the Special Astrophysical Observatory are used to analyze the structure of 13 large disk galaxies in the NGC 80 group. Nine of the 13 galaxies under consideration are classified by us as lenticular galaxies. The stellar populations in the galaxies are very different, from old ones with ages of T>10 Gyrs (IC 1541) to relatively young, with the ages of T<2-3 Gyr (IC 1548, NGC 85). In one case, current star formation is known (UCM 0018+2216). In most of the galaxies, more precisely in all of them more luminous than M(B) -18, two-tiered (`antitruncated') stellar disks are detected, whose radial surface brightness profiles can be fitted by two exponential segments with different scalelengths -- shorter near the center and longer at the periphery. All dwarf S0 galaxies with single-scalelength exponential disks are close companions to giant galaxies. Except for this fact, no dependence of the properties of S0 galaxies on distance from the center of the group is found. Morphological traces of minor merger are found in the lenticular galaxy NGC 85. Basing on the last two points, we conclude that the most probable mechanisms for the transformation of spirals into lenticular galaxies in groups are gravitational ones, namely, minor mergers and tidal interactions.Comment: 24 pages, 9 figures, slightly improved version of the paper published in the December, 2009, issue of the Astronomy Report

    Information technology for construction management and building performance evaluation support - a North-American perspective

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    We provide a critical overview of the current status of computational support for construction the management and building performance evaluation in North-America. This overview is based on the research conducted in relation to the design and construction of the Intelligent Workplace (IW), Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. With regard to the commercial software products in the field of construction management the following limitations can be identified: Although project planning, cost estimating and construction simulation are supported, tasks like bidding as well as site and material management have not received the same level of attention. Few project management software packages are integrated in a total design support software system. Little analysis or evaluation options are provided to support managerial decision making. Various research groups address the construction planning and scheduling, construction contracting, site layout generation as well as the integration of these three topics. Currently problems such as efficient material management and calculation of environmental and energy responsive site management are insufficiently addressed within the ongoing research projects. In the domain of building performance simulation and decision support one can notice that, the development and application of computational tools is industry driven. As a result the concerns addressed by the tools are mainly issues pertaining to the selection and sizing of systems and components rather than an integrated performance evaluation. Consequently, these programs are rarely used by building designers, especially in the early design stages, where the predictive capabilities of simulation tools could be of significant value. Although many research institutions address the necessity for the integration of performance simulation within the overall design support environments most of the practically available performance simulation tools still remain mono-dimensional and isolated

    Novel approaches for the serodiagnosis of louse-borne relapsing fever

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    Louse-borne relapsing fever (LBRF) caused by B. recurrentis is a poverty-related and neglected infectious disease with an endemic focus in the Horn of Africa. Re-emergence of the disease occurred in Europe during the refugee crisis in 2015 and sporadic outbreaks were frequently reported in Eastern Africa where poor settings lack affordable diagnostics. Currently, there are no validated in vitro assays available for the serodiagnosis of LBRF. The aim of this study was to develop novel and reliable immunoassays by investigating clinically suspected and culture-confirmed serum samples from LBRF patients and a broad panel of serum samples from patients with other spirochetal, bacterial, and parasitic diseases. We identified two immunoreactive antigens (complement-inhibiting protein CihC and the glycerophosphodiester phosphodiesterase GlpQ of B. recurrentis) as the most promising target candidates leading to the evaluation of two immunoassays (line immunoblot and ELISA) for IgM and IgG. To optimize the IgM immunoassay, we conducted a bioinformatic approach to localize the relevant immunogenic regions within CihC. By utilizing a N-terminal CihC fragment, the sensitivity and specificity of both immunoassays (CihC and GlpQ) were high (IgM: sensitivity 100%, specificity of 89.9%, IgG: sensitivity 100%, specificity 99.2%). In conclusion, our findings indicate the diagnostic potential of CihC and GlpQ as valuable markers for the serodiagnosis of LBRF even at early time points of infection. Here, we provide strong evidence for the utilization of these immunoassays as reliable tools in clinical practice

    A stochastic hybrid algorithm for multi-depot and multi-product routing problem with heterogeneous vehicles

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    Abstract. A mathematical model and heuristic method for solving multi-depot and multi-product vehicle routing problem (MD-MPVRP) with heterogeneous vehicles have been proposed in this article. Customers can order eclectic products and depots are supposed to deliver customers&apos; orders before the lead time, using vehicles with diverse capacities, costs and velocities. Hence, mathematical model of multi-depot vehicle routing problem has been developed to mirror these conditions. This model is aimed at minimizing the serving distances which culminates in a reduction in prices and also serving time. As the problem is so complex and also solving would be too time-taking, a heuristic method has been offered. The heuristic method, at first, generates an initial solution through a three-step procedure which encompasses grouping, routing and vehicle selection, scheduling and packaging. Then it improves the solution by means of simulated annealing. We have considered the efficiency of offered algorithm by comparing its solutions with the optimum solutions and also during a case study. [V. Mahdavi Asl, S.A. Sadeghi, MR. Ostadali Makhmalbaf. A stochastic hybrid algorithm for multi-depot and multi-product routing problem with heterogeneous vehicles

    A Review of Recent Developments in Atomic Processes for Divertors and Edge Plasmas

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    The most promising concepts for power and particle control in tokamaks and other fusion experiments rely upon atomic processes to transfer the power and momentum from the edge plasma to the plasma chamber walls. This places a new emphasis on processes at low temperatures (1-200 eV) and high densities (10^20-10^22 m^-3). The most important atomic processes are impurity and hydrogen radiation, ionization, excitation, recombination, charge exchange, radiation transport, molecular collisions, and elastic scattering of atoms, molecules and ions. Important new developments have occurred in each of these areas. The best available data for these processes and an assessment of their role in plasma wall interactions are summarized, and the major areas where improved data are needed are reviewed.Comment: Preprint for the 11th PSI meeting, postscript with 22 figures, 40 page

    Search based software engineering: Trends, techniques and applications

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    © ACM, 2012. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version is available from the link below.In the past five years there has been a dramatic increase in work on Search-Based Software Engineering (SBSE), an approach to Software Engineering (SE) in which Search-Based Optimization (SBO) algorithms are used to address problems in SE. SBSE has been applied to problems throughout the SE lifecycle, from requirements and project planning to maintenance and reengineering. The approach is attractive because it offers a suite of adaptive automated and semiautomated solutions in situations typified by large complex problem spaces with multiple competing and conflicting objectives. This article provides a review and classification of literature on SBSE. The work identifies research trends and relationships between the techniques applied and the applications to which they have been applied and highlights gaps in the literature and avenues for further research.EPSRC and E
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