69 research outputs found
La «keta» (ketamina): del fĂĄrmaco a la droga de abuso. ClĂnica biopsicosocial del consumidor y algunas propuestas terapĂ©uticas
El «éxtasis lĂquido» (GHB): Âżuna droga de uso recreativo? ClĂnica biopsicosocial del consumidor y algunas propuestas terapĂ©uticas
ZONACIĂN BRIOFĂTICA DE UN TALUD DE MARGAS CALCĂREAS EN EL RIO GES (GIRONA)
This communnication synthesizes the bryophytic vegetation observed on subvertical banks by streams near VidrA, Ripolles, (Girona, 31TDG46). Fig. 1.
The results reflect an apparent vertical distribution of species in response to variation of moisture and substratum.Esta comunicaciĂłn sintetiza la vegetaciĂłn briofĂtica observada en paredes que se levantan sobre torrentes y arroyos pertenecientes al valle de Vidra, la confluencia de los cuales forma el rĂo Ges, afluente del Ter en la comarca del Ripolles, (Girona, 31 TDG46). Fig. 1.
Los resultados del estudio, muestran una evidente distribuciĂłn vertical de las especies en respuesta principalmente a la variaciĂłn del grado de humedad y tipo de sustrato
PLIO: a generic tool for real-time operational predictive optimal control of water networks
This paper presents a generic tool, named PLIO, that allows to implement the real-time operational
control of water networks. Control strategies are generated using predictive optimal control
techniques. This tool allows the flow management in a large water supply and distribution system
including reservoirs, open-flow channels for water transport, water treatment plants, pressurized
water pipe networks, tanks, flow/pressure control elements and a telemetry/telecontrol system.
Predictive optimal control is used to generate flow control strategies from the sources to the
consumer areas to meet future demands with appropriate pressure levels, optimizing operational
goals such as network safety volumes and flow control stability. PLIO allows to build the network
model graphically and then to automatically generate the model equations used by the predictive
optimal controller. Additionally, PLIO can work off-line (in simulation) and on-line (in real-time mode).
The case study of Santiago-Chile is presented to exemplify the control results obtained using PLIO
off-line (in simulation)Peer ReviewedPostprint (authorâs final draft
Actividades en control y supervisiĂłn inteligente del Grupo de Sistemas Avanzados de Control (SAC) de la Universidad PolitĂšcnica de Catalunya (UPC)
En esta ponencia se presenta un resumen de las actividades de investigaciĂłn que se estĂĄn
desarrollando en el grupo de âSistemas Avanzados de Controlâ (SAC) de la Universidad PolitĂ©cnica de
Catalunya UPC en el Campus de Terrassa con especial Ă©nfasis en el campo del control y la supervisiĂłn
inteligente. Para ilustrar esta actividad se presentarĂĄn tres aplicaciones reales que pueden tener gran
interés social y económicoPostprint (published version
Methodological advances in imaging intravital axonal transport.
Axonal transport is the active process whereby neurons transport cargoes such as organelles and proteins anterogradely from the cell body to the axon terminal and retrogradely in the opposite direction. Bi-directional transport in axons is absolutely essential for the functioning and survival of neurons and appears to be negatively impacted by both aging and diseases of the nervous system, such as Alzheimer's disease and amyotrophic lateral sclerosis. The movement of individual cargoes along axons has been studied in vitro in live neurons and tissue explants for a number of years; however, it is currently unclear as to whether these systems faithfully and consistently replicate the in vivo situation. A number of intravital techniques originally developed for studying diverse biological events have recently been adapted to monitor axonal transport in real-time in a range of live organisms and are providing novel insight into this dynamic process. Here, we highlight these methodological advances in intravital imaging of axonal transport, outlining key strengths and limitations while discussing findings, possible improvements, and outstanding questions
Drosophila Lipophorin Receptors Mediate the Uptake of Neutral Lipids in Oocytes and Imaginal Disc Cells by an Endocytosis-Independent Mechanism
Lipids are constantly shuttled through the body to redistribute energy and metabolites between sites of absorption, storage, and catabolism in a complex homeostatic equilibrium. In Drosophila, lipids are transported through the hemolymph in the form of lipoprotein particles, known as lipophorins. The mechanisms by which cells interact with circulating lipophorins and acquire their lipidic cargo are poorly understood. We have found that lipophorin receptor 1 and 2 (lpr1 and lpr2), two partially redundant genes belonging to the Low Density Lipoprotein Receptor (LDLR) family, are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs. Females lacking the lpr2 gene lay eggs with low lipid content and have reduced fertility, revealing a central role for lpr2 in mediating Drosophila vitellogenesis. lpr1 and lpr2 are transcribed into multiple isoforms. Interestingly, only a subset of these isoforms containing a particular LDLR type A module mediate neutral lipid uptake. Expression of these isoforms induces the extracellular stabilization of lipophorins. Furthermore, our data indicate that endocytosis of the lipophorin receptors is not required to mediate the uptake of neutral lipids. These findings suggest a model where lipophorin receptors promote the extracellular lipolysis of lipophorins. This model is reminiscent of the lipolytic processing of triglyceride-rich lipoproteins that occurs at the mammalian capillary endothelium, suggesting an ancient role for LDLRâlike proteins in this process
PINK1 Defect Causes Mitochondrial Dysfunction, Proteasomal Deficit and α-Synuclein Aggregation in Cell Culture Models of Parkinson's Disease
Mutations in PTEN induced kinase 1 (PINK1), a mitochondrial Ser/Thr kinase, cause an autosomal recessive form of Parkinson's disease (PD), PARK6. Here, we report that PINK1 exists as a dimer in mitochondrial protein complexes that co-migrate with respiratory chain complexes in sucrose gradients. PARK6 related mutations do not affect this dimerization and its associated complexes. Using in vitro cell culture systems, we found that mutant PINK1 or PINK1 knock-down caused deficits in mitochondrial respiration and ATP synthesis. Furthermore, proteasome function is impaired with a loss of PINK1. Importantly, these deficits are accompanied by increased α-synclein aggregation. Our results indicate that it will be important to delineate the relationship between mitochondrial functional deficits, proteasome dysfunction and α-synclein aggregation
Adolescentes, mozos e drogas de sĂntese: unha intervenciĂłn preventiva desde un modelo biopsicosocial
El «éxtasis lĂquido» (GHB): Âżuna droga de uso recreativo? ClĂnica biopsicosocial del consumidor
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