Cognitive modeling of informatization influence on socio-economic indicators of the region

The article discusses topical issues of the influence of informatization on the development of the country’s regions in the conditions of the modern unstable world. The nature of the development of a region can be reflected and understood on the basis of qualitative and quantitative information about its socio-economic indicators, about their relationship and trends in their changes under the influence of internal and external factors. At the same time, information can most often be incomplete, difficult to access, untimely, contradictory, etc. Therefore, in this paper, it is proposed to use a cognitive approach and cognitive modeling of complex systems to overcome the problems of information deficiency by imitating cognitive modeling of the structure and behavior of a complex regional system. The simulation was carried out using the author’s CMCS (Cognitive Modeling Complex System) software system. The results of multi-stage cognitive modeling, consisting in the development of cognitive maps “Influence of ICT on the state of the region” and “Digitalization of the republic” (according to the socio-economic state of the Republic of Dagestan), analysis of structural properties and modeling scenarios for the development of situations on the model are presented. Scenarios make it possible to foresee the ways of possible development of the system under the influence of various factors, including the factor of informatization

Association of angiotensinogen and angiotensin II receptor type I polymorphisms with biomarkers of carbohydrate and lipid metabolism in Dagestan residents with type 2 diabetes and hypertension

Aim. To study the associations of angiotensinogen (AGT) (s4762(С521Т), rs699(Т704C)) and angiotensin II receptor type I (AGTR1) (rs5186(A1166C)) genetic polymorphisms with serum levels of insulin, glucagon, C-peptide, leptin, as well as with dyslipidemia and glycemic levels in Dagestan residents with combination of type 2 diabetes (T2D) and hypertension (HTN), as well as with isolated T2D/HTN.Material and methods. We examined 16 patients with isolated T2D, 59 patients with T2D+HTN and 51 patients with isolated HTN from Dagestan. Genetic polymorphisms of the AGT and AGTR1 genes were studied. The levels of insulin, glucagon, C-peptide, and leptin were studied by enzyme-linked immunosorbent assay (ELISA), while lipid and carbohydrate metabolism — by biochemical methods.Results. In patients with T2D, the association of CC genotype of AGT gene rs4762(С521Т) polymorphism with a leptin decrease was determined, while its CT genotype was associated with an increase in serum level of triglycerides. The TC genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in leptin, triglyceride and glucose levels. The AA genotype of AGTR1 gene rs5186(A1166C) polymorphism was associated with an increase in insulin and glucose levels, as well as a decrease in leptin level. In patients with a combination of T2D and HTN, CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism was associated with a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with an increase in insulin, triglyceride, glucose and body mass index (BMI) levels. In isolated HTN, the CC and CT genotypes of AGT gene rs4762(С521Т) polymorphism were associated ith a decrease in glucagon level. The TT genotype of AGT gene rs699(Т704C) polymorphism was associated with increased levels of insulin, low density lipoproteins, and BMI.Conclusion. Associations of AGT (s4762(С521Т), rs699(Т704C)) and AGTR1 (rs5186(A1166C)) genetic polymorphisms with carbohydrate and lipid metabolism changes are an important pathogenetic link of T2D and HTN, which allows developing an individual prognosis of these diseases in Dagestan residents

Accounting of motivators and demotivators under introduction of the brc system

Рассматривается необходимость учета демотиваторов при работе с балльно-рейтинговой системой оцениванияThe article considers the need to take into account demotivators when working with the BRS syste

Check of knowleadge using score-rating system and independent test control

Анализируется проблема дублирования балльно-рейтинговой системы оценивания и независимого тестового контроля в системе подготовки специалистов. Предложены мероприятия по устранению недостатковIn article it is told about duplication of score-rating system and independent test controlin training system of specialists. Actions for elimination of shortcomingsare offere

Corrigendum: Twenty-year clinical progression of dysferlinopathy in patients from Dagestan [Front Neurol, 8, (2017) (77)] doi: 10.3389/fneur.2017.00077

The "Funding" section should be: This work was funded by Human Stem Cells Institute PJSC and Roman V. Deev. Theoretical part of this work was supported by Russian Scientific Foundation grant (14-15-00916). Ivan A. Yakovlev and Mikhail O. Mavlikeev were supported by the Russian Government Program of Competitive Growth of Kazan Federal University. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way

Hybrid ( laser- spark) a method of applying a reinforcement coating

Hybrid spark -laser treatment shows a positive effect on the performance properties of coatings (roughness, thickness, continuity, adhesion).Гибридная электроискровая –лазерная обработка показывает положительное влияние на эксплуатационные свойства покрытий (шероховатость, толщину, сплошность, адгезию)

The clinical case of limb-girdle muscle dystrophy 2Q associated with myasthenic syndrome and lung damage

Limb-girdle muscle dystrophy 2Q is one of the rarest forms of plectinopathies and is represented by an isolated muscular dystrophic syndrome, according to two previously described literature reports. There are five forms of plectinopathies, including limb-girdle muscle dystrophy 2Q, are caused by mutations in the PLEC gene, the alternative splicing of which determines the synthesis of 9 isoforms of the plectin protein (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 3) performing cytolinker function in the neuronal, epithelial and muscle tissue.The article describes the family observation of three sick siblings with the limb-girdle muscle dystrophy 2Q phenotype due to the presence of a new homozygous mutation (NM_201378.3:c.58G>T, NP_958780.1:p.Glu20Ter) in the isoform 1f PLEC revealed by whole-exome sequencing. Clinical, electromyography, visualization and histopathological features of limb-girdle muscle dystrophy 2Q were analyzed in detail. The onset of clinical manifestations in all the described siblings was observed in early childhood with moderate weakness mainly in the pelvic girdle muscles and proximal lower limbs with minimal involvement of the muscles of the shoulder girdle. A distinctive aspect is the stagnation of the myodystrophic process until 20—21 years, followed by the progression and development of episodes of respiratory failure, as well as the formation of rigidity of the cervical, thoracic spine and moderate contracture of the Achilles tendons. Typical features are marked atrophy of paravertebral muscles with the formation of pterygoid scapula and the presence of hypertrophy m. gastrocnemius, m. quadriceps femoris, m. deltoideus and m. triceps brachii. Histopathological examination m. vastus lateralis revealed myodystrophic process without inflammatory infiltration, muscle fiber cytoskeleton disorganization resulted from the plectin loss.Electrocardiography signs of the early repolarization syndrome, focal cardiosclerosis and sinus tachycardia are described. For the first time, involvement in the pathological process of pulmonary tissue in the form of noninfectious bronchiolitis, atelectasis, and the development of the myasthenic syndrome causing episodes of respiratory failure resulted in the death of two described siblings aged 29 and 31 years. Discussed pathogenetic role of PLEC 1f isoform in the development of described syndromes, expands understanding of rare nosology limb-girdle muscle dystrophy 2Q

A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity

A multidisciplinary approach identifies novel biochemical activities involved in the synthesisof C. elegans bile acid-like steroids, which act as hormones that regulate sterol metabolism and longevity

Ацербин в комплексном лечении длительно незаживающих ран

Object. To study the clinical efficacy of the Acerbin solution in topical administration and its effects on the morphological changes in tissues in the complex treatment of chronic wounds by various etiologies.Materials and methods. The prospective clinical study consistently included 32 patients aged from 28 to 74 years (mean age 54.3 ± 3.6 years) with chronic wounds of various etiologies and localizations (did not heal against the background of local treatment within 30 days from the moment of formation). Patients were hospitalized in the Department of Wounds and Wound Infections of the A. V. Vishnevsky National Medical Research Center of Surgery in 2016–2018. 16 (50.0 %) patients were admitted with extensive nonhealing wounds on the background of chronic venous insufficiency (C6 according to the CEAP classification). In 7 (21.9 %) patients, chronic postoperative wounds of various localization were diagnosed and in 9 (28.1 %) – non-healing wounds after surgical treatment of the neuropathic form of diabetic foot syndrome (DFS) – Wagner II–IV. The protocol of local treatment in all patients was the same. After Acerbin solution applying, the wound surface was closed with a gauze cloth soaked in Levomekol ointment. Re-dressings were performed daily for the first 5–7 days, and then every other day. The average duration of treatment under dressings using a Acerbin solution did not exceed two weeks. All patients at the same time carried out qualitative and quantitative microbiological studies. For an objective assessment of the dynamics of the course of the wound process cytological and morphological studies were performed.Results. In all cases, the initial clinical picture corresponded to a sluggish chronic process. Microbiological studies have shown a variety of pathogens of the infectious process. As a rule, associations of gram-positive and gram-negative microorganisms were detected. All isolated strains (Ps. Aeruginosa, E. coli, Acinetobacter sp., Kl. Pneumonia) were resistant to most broad-spectrum drugs, indicating their hospital affiliation. At 3–5 days of treatment in the cytograms changes in the cellular composition was revealed by increasing the number of polymorphonuclear neutrophils and a significant decrease in the number of polyblasts with their transition to active macrophages, a positive shift was observed during the wound process and an increase in the processes of biological wound cleansing. On days 7–10 of treatment the cytological picture indicated the activation of the regeneration process in the wound against the background of ongoing intensive biological cleansing. By 8–14 days of treatment, the wounds were completely cleared, which allowed to proceed to its final stage – to performance the reconstructive and plastic surgeries.Conclusion. Using the Acerbin solution in the complex treatment of patients with non-healing wounds made it possible to avoid additional surgical debridment. Purification of wounds from necrotic tissues and fibrin occurred in a shorter time compared with traditional methods of treatment, which made it possible to perform the reconstructive stage of treatment of patients in a shorter time.Цель исследования: изучить клиническую эффективность местного применения раствора Ацербин и его воздействие на морфологические изменения в тканях при комплексном лечении длительно незаживающих ран различной этиологии.Материалы и методы исследования. В проспективное клиническое исследование последовательно включено 32 пациента в возрасте от 28 до 74 лет (средний возраст 54,3 ± 3,6 лет) с хроническими ранами различной этиологии и локализации (не зажили на фоне местного лечения в течение 30 суток от момента образования). Больные находились на стационарном лечении в отделе ран и раневых инфекций ФГБУ «НМИЦ хирургии им. А. В. Вишневского» МЗ РФ в 2016–2018 гг. 16 (50,0 %) пациентов поступили с обширными длительно незаживающими ранами на фоне хронической венозной недостаточности (С6 по классификации СЕАР). У 7 (21,9 %) больных были диагностированы хронические послеоперационные раны различной локализации и у 9 (28,1 %) – длительно незаживающие раны после хирургического лечения нейропатической формы синдрома диабетической стопы (СДС) – Wagner II–IV. Протокол местного лечения у всех больных был единым. После нанесения раствора Ацербин раневую поверхность закрывали марлевой салфеткой, пропитанной мазью Левомеколь. Повторные перевязки на протяжении первых 5–7 суток выполняли ежедневно, а затем – через день. Средняя продолжительность лечения под повязками с использованием раствора Ацербин не превышала двух недель. Всем больным в эти же сроки проводили качественные и количественные микробиологические исследования. Для объективной оценки динамики течения раневого процесса – цитологические и морфологические исследования.Результаты. Во всех случаях исходная клиническая картина соответствовала вялотекущему хроническому процессу. Микробиологические исследования показали разнообразие возбудителей инфекционного процесса. Как правило, выявлялись ассоциации грамположительных и грамотрицательных микроорганизмов. Все выделенные штаммы (Ps. aeruginosa, E. coli, Acinetobacter sp., Kl. рneumonia) были устойчивы к большинству препаратов широкого спектра действия, что указывало на их госпитальную принадлежность. На 3–5 сутки лечения в цитограммах выявляли изменение клеточного состава за счет увеличения числа полиморфноядерных нейтрофилов и достоверного уменьшения числа полибластов с переходом их в активные макрофаги, наблюдался положительный сдвиг в течении раневого процесса и усиление процессов биологического очищения раны. На 7–10 сутки лечения цитологическая картина указывала на активизацию процесса регенерации в ране на фоне продолжающегося интенсивного биологического очищения. К 8–14 суткам лечение приводило к полному очищению ран, что позволяло перейти к его заключительному этапу – выполнению реконструктивных и пластических операций.Заключение. Применение раствора Ацербин в комплексном лечении большинства больных с длительно незаживающими ранами позволило избежать выполнения дополнительных хирургических обработок. Очищение ран от некротических тканей и фибрина происходило в более короткие сроки по сравнению с традиционными методами лечения, что позволяло выполнять реконструктивный этап лечения больных также в более короткие сроки

Характеристика лямблиоза и энтеробиоза у детей Астраханской области

Purpose: assessment of the clinical and epidemiological situation of current invasions in children of the Astrakhan region. 315 outpatient cards of children were analyzed in 2016.The diagnosis of Giardiasis was made to 151 children, the diagnosis of Enterobiasis — 164. The age of all observed children ranged from 9 months to 17 years. The largest part was made up of children aged 3 to 14 years of age — 80.3%, among them enterobiasis was identified — in 46.7%, giardiasis — in 33.6% of cases. Most of the children  — 90.5% were from organized groups (they attended preschool institutions or school). The reasons for the examination of all children were varied. Some children — 63.5% went to the doctor with complaints  or clinical symptoms. Another part of the children — 33% of the diagnosis was made as a result of preventive examinations.In most cases — 78.7% various bad habits were identified. Thus, geophagy (the habit of eating the earth) was noted in 33.3% of children, and onigophagy (the habit of biting the nails) in 24.8%. In 21.3% of cases, bad habits were absent. Contact with pets was established in 22.9% of children. According to the ultrasound, most children with giardiasis (83.8%) had pathology (reactive changes of the pancreas, liver, gallbladder dyskinesia, etc.)In case of giardiasis niferator, albendazole was administered. In case of enterobiasis albendazole, pyrantel, and mebendazole were administered in age dosages. After antiparasitic treatment, in 91.4% of cases, the clinical symptoms of the disease completely disappeared, with giardiasis — in 85.4%, with enterobiasis — in 97% of cases.In 1.3% of children with giardiasis, after several courses of antiparasitic drugs, Giardia was found in feces in the absence of complaints and clinical symptoms, indicating a possible Giardia carrier parasite in children.С целью оценки клинико-эпидемиологической ситуации по актуальным инвазиям у детей Астраханской области было проанализировано 315 амбулаторных карт детей, обратившихся в 2016  г. Диагноз Лямблиоз был поставлен 151 ребенку, диагноз Энтеробиоз — 164.Возраст всех наблюдаемых детей составлял от 9 месяцев до 17 лет. Наибольшую часть составили дети в возрасте от 3 до 14 лет жизни — 80,3%, среди них энтеробиоз был выявлен в 46,7%, лямблиоз — в 33,6% случаев. Большинство детей — 90,5% были из организованных коллективов (посещали  детские дошкольные учреждения или школу). Причины обследования всех детей были разнообразными.  Часть  детей  — 63,5% обратились к специалисту в связи с наличием у них тех или иных клинических симптомов и жалоб. Другой части  детей  — 33% диагноз был выставлен в результате профилактических осмотров.В большинстве  случаев — 78,7% были выявлены различные вредные привычки. Так, геофагия (привычка есть землю) отмечалась у 33,3% детей, а онигофагия (привычка грызть ногти) — у 24,8%. В 21,3% случаев вредные привычки отсутствовали. Котакт с домашними животными был установлен  у 22,9% детей. По данным УЗИ, у большинства детей с лямблиозом (83,8%) отмечалась патология (реактивные изменения поджелудочной железы, печени, дискинезия желчного пузыря и др.).В качестве антипаразитарной  терапии при лямблиозе назначался нифуратель, альбендазол, при энтеробиозе — альбендазол, пирантел и мебендазол в возрастных дозировках. После лечения в 91,4% случаев клинические симптомы заболевания полностью исчезли, при лямблиозе — в 85,4%, при энтеробиозе — в 97% случаев.У 1,3% детей с лямблиозом после нескольких курсов антипаразитарными препаратами обнаруживались лямблии в фекалиях при отсутствии жалоб и клинических симптомов, что свидетельствует о возможном паразитоносительстве лямблий у детей