XMM-Newton study of 30 Dor C and a newly identified MCSNR J0536-6913 in the Large Magellanic Cloud

Aims: We present a study of the superbubble (SB) 30 Dor C and the newly identified MCSNR J0536-6913 in the LMC. Methods: All available XMM-Newton data (exposure times of 420 ks EPIC-pn, 556 ks EPIC-MOS1, 614 ks EPIC-MOS2) were used to characterise the thermal X-ray emission in the region. An analysis of the non-thermal X-rays is also presented and discussed in the context of emission mechanisms previously suggested in the literature. These data are supplemented by X-ray data from Chandra, optical data from the MCELS, and radio data from ATCA and MOST. Results: The brightest thermal emission was found to be associated with a new supernova remnant, MCSNR J0536-6913. X-ray spectral analysis of MCSNR J0536-6913 suggested an ejecta-dominated remnant with lines of O, Ne, Mg, and Si, and a total 0.3-10 keV luminosity of ~8E+34 erg/s. Based on derived ejecta abundance ratios, we determined the mass of the stellar progenitor to be either ~18 M_sun or as high as >40 M_sun, though the spectral fits were subject to assumptions (e.g., uniform temperature and well-mixed ejecta). The thermal emission from the SB exhibited enrichment by alpha-process elements, evidence for a recent core-collapse SNR interaction with the SB shell. We detected non-thermal X-ray emission throughout 30 Dor C, with the brightest regions being highly correlated with the H-alpha and radio shells. We created a non-thermal spectral energy distribution for the north-eastern shell of 30 Dor C which was best-fit with an exponentially cut-off synchrotron model. Conclusions: Thermal X-ray emission from 30 Dor C is very complex, consisting of a large scale SB emission at the eastern shell wall with the brightest emission due to MCSNR J0536-6913. The fact that the non-thermal spectral energy distribution of the SB shell was observed to roll-off is further evidence that the non-thermal X-rays from 30 Dor C are synchrotron in origin.Comment: 22 pages, 21 figures, accepted for publication in Astronomy and Astrophysic

Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?

During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody\u2013antigen reactions detectable by the old-fashioned hemagglutination test. In this commentary, we review evidence supporting the utility of SARS-CoV-2 Spike kodecytes for clinical diagnostic purposes and serosurveys in resource-poor settings

Interestingness of traces in declarative process mining: The janus LTLPf Approach

Declarative process mining is the set of techniques aimed at extracting behavioural constraints from event logs. These constraints are inherently of a reactive nature, in that their activation restricts the occurrence of other activities. In this way, they are prone to the principle of ex falso quod libet: they can be satisfied even when not activated. As a consequence, constraints can be mined that are hardly interesting to users or even potentially misleading. In this paper, we build on the observation that users typically read and write temporal constraints as if-statements with an explicit indication of the activation condition. Our approach is called Janus, because it permits the specification and verification of reactive constraints that, upon activation, look forward into the future and backwards into the past of a trace. Reactive constraints are expressed using Linear-time Temporal Logic with Past on Finite Traces (LTLp f). To mine them out of event logs, we devise a time bi-directional valuation technique based on triplets of automata operating in an on-line fashion. Our solution proves efficient, being at most quadratic w.r.t. trace length, and effective in recognising interestingness of discovered constraints

XMM-Newton observation of SNR J0533-7202 in the Large Magellanic Cloud

Aims. We present an X-ray study of the supernova remnant SNR J0533-7202 in the Large Magellanic Cloud (LMC) and determine its physical characteristics based on its X-ray emission. Methods. We observed SNR J0533-7202 with XMM-Newton (flare-filtered exposure times of 18 ks EPIC-pn and 31 ks EPIC-MOS1/MOS2). We produced X-ray images of the SNR, performed an X-ray spectral analysis, and compared the results to multi-wavelength studies. Results. The distribution of X-ray emission is highly non-uniform, with the south-west region brighter than the north-east. The X-ray emission is correlated with the radio emission from the remnant. We determine that this morphology is likely due to the SNR expanding into a non-uniform ambient medium and not an absorption effect. We estimate the size to be 53.9 (\pm 3.4) x 43.6 (\pm 3.4) pc, with the major axis rotated ~64 degrees east of north. We find no spectral signatures of ejecta and infer that the X-ray plasma is dominated by swept-up interstellar medium. Using the spectral fit results and the Sedov self-similar solution, we estimate an age of ~17-27 kyr, with an initial explosion energy of (0.09-0.83) x 10^51 erg. We detected an X-ray source located near the centre of the remnant, namely XMMU J053348.2-720233. The source type could not be conclusively determined due to the lack of a multi-wavelength counterpart and low X-ray counts. We find that it is likely either a background active galactic nucleus or a low-mass X-ray binary in the LMC. Conclusions. We detected bright thermal X-ray emission from SNR J0533-7202 and determined that the remnant is in the Sedov phase of its evolution. The lack of ejecta emission prohibits us from typing the remnant with the X-ray data. Therefore, the likely Type Ia classification based on the local stellar population and star formation history reported in the literature cannot be improved upon.Comment: 7 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

The population of X-ray supernova remnants in the Large Magellanic Cloud

We present a comprehensive X-ray study of the population of supernova remnants (SNRs) in the LMC. Using primarily XMM-Newton, we conduct a systematic spectral analysis of LMC SNRs to gain new insights on their evolution and the interplay with their host galaxy. We combined all the archival XMM observations of the LMC with those of our Very Large Programme survey. We produced X-ray images and spectra of 51 SNRs, out of a list of 59. Using a careful modelling of the background, we consistently analysed all the X-ray spectra and measure temperatures, luminosities, and chemical compositions. We investigated the spatial distribution of SNRs in the LMC and the connection with their environment, characterised by various SFHs. We tentatively typed all LMC SNRs to constrain the ratio of core-collapse to type Ia SN rates in the LMC. We compared the X-ray-derived column densities to HI maps to probe the three-dimensional structure of the LMC. This work provides the first homogeneous catalogue of X-ray spectral properties of LMC SNRs. It offers a complete census of LMC SNRs exhibiting Fe K lines (13% of the sample), or revealing contribution from hot SN ejecta (39%). Abundances in the LMC ISM are found to be 0.2-0.5 solar, with a lower [$\alpha$/Fe] than in the Milky Way. The ratio of CC/type Ia SN in the LMC is $N_{\mathrm{CC}}/N_{\mathrm{Ia}} = 1.35(_{-0.24}^{+0.11})$, lower than in local SN surveys and galaxy clusters. Comparison of X-ray luminosity functions of SNRs in Local Group galaxies reveals an intriguing excess of bright objects in the LMC. We confirm that 30 Doradus and the LMC Bar are offset from the main disc of the LMC, to the far and near sides, respectively. (abridged)Comment: Accepted for publication in Astronomy and Astrophysics. 54 pages, 18 figures, 12 tables. The resolution of the figures has been reduced compared to the journal version; v2: New title, minor text edits; v3: Correct version

Additional diagnostic value of implantable loop recorder for differentiating syncope from non-syncopal forms of transient loss of consciousness

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Dexamethasone blocks the migration of the human neuroblastoma cell line SK-N-SH

Glucocorticoids (Gc) influence the differentiation of neural crestderived cells such as those composing sympathoadrenal tumors like pheochromocytomas, as well as neuroblastomas and gangliomas. In order to obtain further information on the effects of Gc on cells evolving from the neural crest, we have used the human neuroblastoma cell line SK-N-SH to analyze: 1) the presence and the binding characteristics of Gc receptors in these cells, 2) the effect of dexamethasone (Dex) on the migration of SK-N-SH cells, and 3) the effect of Dex on the organization of the cytoskeleton of SK-N-SH cells. We show that: 1) receptors that bind [ 3 H]-Dex with high affinity and high capacity (Kd of 9.6 nM, Bmax of 47 fmol/mg cytosolic protein, corresponding to 28,303 sites/cell) are present in cytosolic preparations of SK-N-SH cells, and 2) treatment with Dex (in the range of 10 nM to 1 µM) has an inhibitory effect (from 100% to 74 and 43%, respectively) on the chemotaxis of SK-N-SH cells elicited by fetal bovine serum. This inhibition is completely reversed by the Gc receptor antagonist RU486 (1 µM), and 3) as demonstrated by fluorescent phalloidin-actin detection, the effect of Dex (100 nM) on SK-NSH cell migration is accompanied by modifications of the cytoskeleton organization that appear with stress fibers. These modifications did not take place in the presence of 1 µM RU486. The present data demonstrate for the first time that Dex affects the migration of neuroblastoma cells as well as their cytoskeleton organization by interacting with specific receptors. These findings provide new insights on the mechanism(s) of action of Gc on cells originating in the neural crest

Multi-frequency observations of a superbubble in the LMC: The case of LHA 120-N 70

We present a detailed study of new Australia Telescope Compact Array (ATCA) and XMM-Newton observations of LHA 120-N 70 (hereafter N 70), a spherically shaped object in the Large Magellanic Cloud (LMC) classified as a superbubble (SB). Both archival and new observations were used to produce high quality radio-continuum, X-ray and optical images. The radio spectral index of N 70 is estimated to be $\alpha=-0.12\pm 0.06$ indicating that while a supernova or supernovae have occurred in the region at some time in the distant past, N70 is not the remnant of a single specific supernova. N70 exhibits limited polarisation with a maximum fractional polarisation of 9% in a small area of the north west limb. We estimate the size of N 70 to have a diameter of 104 pc ($\pm 1$ pc). The morphology of N 70 in X-rays closely follows that in radio and optical, with most X-ray emission confined within the bright shell seen at longer wavelengths. Purely thermal models adequately fit the soft X-ray spectrum which lacks harder emission (above 1 keV). We also examine the pressure output of N 70 where the values for the hot (PX) and warm (PHii) phase are consistent with other studied Hii regions. However, the dust-processed radiation pressure (PIR) is significantly smaller than in any other object studied in Lopez et al. (2013). N70 is a very complex region that is likely to have had multiple factors contributing to both the origin and evolution of the entire region.Comment: 21 pages 8 figures accepted for publication in A