Replacement of dichloromethane within chromatographic purification : a guide to alternative solvents

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes

United Kingdom, the United States and nuclear proliferation in South Asia: the case of Pakistan, 1974-1980

This thesis is a history of American and British efforts to halt or retard the Pakistani nuclear weapons programme. It assesses US and UK non-proliferation policy towards Pakistan from the Indian nuclear test of May 1974 to the decline of anti-proliferation activity in 1979 and 1980. A broadly chronological analysis of key government and media sources from American and British archives highlights the development of non-proliferation policy and the factors that influenced anti-proliferation activity. Scrutiny of British—and not just American—involvement in Pakistan’s nuclear programme permits an assessment of the existence of a ‘non-proliferation special relationship’ between Washington and London. This study demonstrates that successive British governments played a significant role in creating, shaping, and at times adversely affecting, non-proliferation activity on the sub-continent. Additionally, this thesis demonstrates that the UK frequently deprioritised non-proliferation concerns in favour of economic considerations, creating tension between London and Washington. Thus, it is shown that there was a close working relationship between the US and UK governments, but the relationship was riven with fissures. Alongside this examination of British policy, this study also examines American policy and attitudes, demonstrating that infighting and conflicts between strategic priorities impaired the effectiveness of American non-proliferation policy. Furthermore, this study offers a detailed examination of the cultural underpinnings of UK-US non-proliferation policy directed against Pakistan. It demonstrates that—contrary to popular and long-lasting media representations—the paradigm of an ‘Islamic bomb’ played no part in the creation and application of non-proliferation policy. This thesis makes it clear that in UK-US efforts to halt or retard Pakistani nuclear attainment, issues of credibility and global standing were far more significant than religious factors. Overall, this study examines a key moment in non-proliferation history and offers new findings on the Anglo-American relationship and the role of cultural factors in shaping foreign policy

The Truman Administration and Non-use of the Atomic Bomb During the Korean War, June 1950 to January 1953

This thesis examines the Truman administration's non-use of nuclear weapons during the Korean War, June 1950 to January 1953. It investigates the entirety of the Truman administration's experience of the Korean War, rather than focusing on certain key periods. By examining official documentation, memoirs, newspaper reports, and information about public opinion, this thesis explains why the Truman administration chose not to utilise the atomic arsenal. It examines the opinions and influence of significant decision makers such as President Harry S. Truman, Secretary of State Dean Acheson, and Director of the Policy Planning Staff Paul H. Nitze. Truman, as president and ultimate decision maker, will be paid special attention, not least on account of his unique experience of having ordered the atomic attacks on Japan in 1945. This thesis also looks into the position of high-ranking military officers, such as General Omar N. Bradley, General Hoyt S. Vandenberg, and General Matthew B. Ridgway. In order to explain non-use, this thesis also investigates the influence of foreign allies and foreign opinion, particularly that expressed by the United Kingdom, the United States' most important ally. The role of public opinion within the United States is also considered. By examining in detail all of these factors and building a composite picture of the forces acting upon the administration, this thesis provides a more rounded and nuanced view of non-use by the Truman administration during the Korean War than that offered by the existing scholarship. It demonstrates that non-use was always a complex and problematic matter

The effect of knowledge, species aesthetic appeal, familiarity and conservation need on willingness to donate

Environmental non-governmental organizations (ENGOs) largely select flagship species for conservation marketing based on their aesthetic appeal. However, little is known about the fundraising effectiveness of this approach or how it compares to ecosystem conservation campaigns that use habitat types as flagships. By performing a willingness to donate (WTD) survey of potential online donors from Finland, we identified which motivations and donor characteristics influence their preferences for a range of different flagship species and ecosystems. Using the contingent valuation method and the payment card approach, we found the combined funding for eight mammal flagship species was 29% higher funding than for eight bird flagship species. Furthermore, the aesthetically more appealing species, as well as the species and ecosystems that are native to Finland, attracted the most funding. We then used ordinal logistic regression to identify the factors influencing a donor's WTD, finding that knowledge of biodiversity conservation and familiarity with the flagship was associated with an increased WTD to birds and ecosystems, and people with higher education levels had an increased WTD to ecosystems. Surprisingly, species aesthetic appeal was not related to an increased WTD, although "need of conservation" was, suggesting that highlighting the plight of these less appealing threatened species or ecosystems could raise money. Our results suggest that the factors driving donating to mammals, birds or ecosystems differ, and so underline the importance of considering the diverse motivations behind donation behaviour in fundraising campaigns. They also provide new evidence of the motivations of online donors, an under-studied group who are likely to become an increasingly important source of conservation funding.Peer reviewe

Evaluation of alternative solvents in common amide coupling reactions : replacement of dichloromethane and N,N-dimethylformamide

A range of alternative solvents have been evaluated within amidation reactions employing common coupling reagents with a view to identifying suitable replacements for dichloromethane and N,N-dimethylformamid

Elevating the impact of conservation physiology by building a community devoted to excellence, transparency, ethics, integrity and mutual respect

[Extract] Ten years ago, the journal Conservation Physiology was launched jointly by the Society for Experimental Biology and Oxford University Press. Much has been accomplished since 2012 including publishing over 600 papers in the journal and helping to build a sense of place for aspiring and practicing conservation physiologists (Cooke et al., 2020). Yet, more work is needed to further elevate the impact of conservation physiology as a discipline and community. Here, we summarize what is needed to build and strengthen a community devoted to not only excellence, transparency, ethics, integrity and mutual respect, but also courage to tackle some of the overarching challenges humanity faces. As active voices in the conservation physiology community we hope that this paper will help shape the future of our discipline while also guiding the activities and priorities of the journal and editorial team. Since the term ‘conservation physiology’ was coined by Wikelski and Cooke (2006) it has emerged as an essential component of conservation science and practice. Conservation physiology is about the use of physiological tools, knowledge and concepts to understand and solve conservation problems across diverse taxa (Cooke et al., 2013). It is regarded as being particularly effective at understanding mechanisms, generating cause–effect relationships (e.g. threat X does Y to organism Z), creating predictive tools and testing conservation interventions (Cooke and O’Connor, 2010). Issues relevant to conservation physiology range from very local, focused on recovery of an imperilled population (Birnie-Gauvin et al., 2017), to global-scale issues such as tackling the UN Sustainable Development Goals (Cooke et al., 2020) and the climate crisis (Madliger et al., 2021c). The discipline is now supported by a conceptual framework (Coristine et al., 2014), a journal (https://academic.oup.com/conphys) and a reference book (Madliger et al. 2021a). There is also a growing community of researchers who engage in conservation physiology and even define themselves as conservation physiologists (Madliger et al., 2021b). Moreover, in conservation physiology there are success stories that demonstrate the potential of conservation physiology (Madliger et al., 2016)

Alphabetic Letter Identification: Effects of perceivability, similarity, and bias

The legibility of the letters in the Latin alphabet has been measured numerous times since the beginning of\ud experimental psychology. To identify the theoretical mechanisms attributed to letter identification, we report\ud a comprehensive review of literature, spanning more than a century. This review revealed that identification\ud accuracy has frequently been attributed to a subset of three common sources: perceivability, bias, and simi-\ud larity. However, simultaneous estimates of these values have rarely (if ever) been performed. We present the\ud results of two new experiments which allow for the simultaneous estimation of these factors, and examine\ud how the shape of a visual mask impacts each of them, as inferred through a new statistical model. Results showed that the shape and identity of the mask impacted the inferred perceivability, bias, and similarity space of a letter set, but that there were aspects of similarity that were robust to the choice of mask. The results illustrate how the psychological concepts of perceivability, bias, and similarity can be estimated simultaneously, and how each make powerful contributions to visual letter identification

Reframing conservation physiology to be more inclusive, integrative, relevant and forward-looking: Reflections and a horizon scan

Applying physiological tools, knowledge and concepts to understand conservation problems (i.e. conservation physiology) has becomecommonplace and confers an ability to understand mechanistic processes,develop predictive models and identify cause-and-effect relationships. Conservation physiology is making contributions to conservation solutions; the number of \u27success stories\u27 is growing, but there remain unexplored opportunities for which conservation physiology shows immense promise and has the potential to contribute to major advances in protecting and restoring biodiversity. Here, we consider howconservation physiology has evolved with a focus on reframing the discipline to be more inclusive and integrative.Using a \u27horizon scan\u27,we further exploreways in which conservation physiology can be more relevant to pressing conservation issues of today (e.g. addressing the Sustainable Development Goals; delivering science to support the UN Decade on Ecosystem Restoration), aswell as more forward-looking to inform emerging issues and policies for tomorrow. Our horizon scan provides evidence that, as the discipline of conservation physiology continues to mature, it provides a wealth of opportunities to promote integration, inclusivity and forward-thinking goals that contribute to achieving conservation gains. To advance environmentalmanagementand ecosystemrestoration,we need to ensure that the underlying science (such as that generated by conservation physiology) is relevant with accompanying messaging that is straightforward and accessible to end users

One hundred research questions in conservation physiology for generating actionable evidence to inform conservation policy and practice

Environmental change and biodiversity loss are but two of the complex challenges facing conservation practitioners and policy makers. Relevant and robust scientific knowledge is critical for providing decision-makers with the actionable evidence needed to inform conservation decisions. In the Anthropocene, science that leads to meaningful improvements in biodiversity conservation, restoration and management is desperately needed. Conservation Physiology has emerged as a discipline that is well-positioned to identify the mechanisms underpinning population declines, predict responses to environmental change and test different in situ and ex situ conservation interventions for diverse taxa and ecosystems. Here we present a consensus list of 10 priority research themes. Within each theme we identify specific research questions (100 in total), answers to which will address conservation problems and should improve the management of biological resources. The themes frame a set of research questions related to the following: (i) adaptation and phenotypic plasticity; (ii) human-induced environmental change; (iii) human-wildlife interactions; (iv) invasive species; (v) methods, biomarkers and monitoring; (vi) policy, engagement and communication; (vii) pollution; (viii) restoration actions; (ix) threatened species; and (x) urban systems. The themes and questions will hopefully guide and inspire researchers while also helping to demonstrate to practitioners and policy makers the many ways in which physiology can help to support their decisions