Asymmetric Mobility and Emigration of Highly Skilled Workers in Europe: The Portuguese case

Emigration is a chronic structural process of the Portuguese society. Th e discussion and key arguments raised in this chapter are mainly focused on data from a research project on Portuguese skilled emigration. Based on the outcomes of the BRADRAMO on-line survey to 1011 highly skilled emigrants it can be suggested that recent phenomena in general, and the crisis that began around 2008 in particular, profoundly transformed the patterns of Portuguese emigration. Nowadays, the country faces a brain drain dynamic that is dramatically altering the profiles of national migrants, emigration destinations, self-identity, and the strategies of those who leave the country. Academic mobility, mainly that promoted by the European Union (through grants from the Erasmus Program), created and fostered mobility flows that reinforced a latent mobility phenomenon. Once engaged in academic mobility programs, Portuguese higher education students tend to stay in the country of destination or, upon returning temporarily to Portugal, to evince a very strong predisposition to move to a country of the European Union. Th e profile of Portuguese high-skilled emigrants reveals a trend towards a permanent and a long-term (as opposed to a temporary or transitory) mobility, an insertion in the primary segment of the labor market of the destination countries, a predominance of professionals connected to the academic/scientific system and to professions requiring high skills, and a latent mobility (aft er a period of study in the country of destination) rather than direct mobility flows (aft er having entered in the employment system of the sending country)

Step towards monitoring intelligent agents in healthcare information systems

A platform for establishing interoperability between heterogeneous information systems implemented in a hospital environment is more a requirement than an option. The Agency for the Integration, Diffusion and Archiving of Medical and Clinical Information (AIDA) is an interoperability platform designed specifically to address the problem of integrating information from multiple systems and addressing interoperability, confidentiality, integrity and data availability. This article focuses on the relevance and need for such vigilance, finding and designing effective new ways to establish them. This study culminated in the creation of AIDAMonit, a surveillance platform developed and tested by ALGORITMI Center researchers, which has shown promise and is extremely beneficial for the well-functioning of the health facilities currently using the AIDA platform.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019 and DSAIPA/DS/0084/2018

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac Anomalies.

BACKGROUND: Adams-Oliver syndrome (AOS) is a rare disorder characterized by congenital limb defects and scalp cutis aplasia. In a proportion of cases, notable cardiac involvement is also apparent. Despite recent advances in the understanding of the genetic basis of AOS, for the majority of affected subjects, the underlying molecular defect remains unresolved. This study aimed to identify novel genetic determinants of AOS. METHODS AND RESULTS: Whole-exome sequencing was performed for 12 probands, each with a clinical diagnosis of AOS. Analyses led to the identification of novel heterozygous truncating NOTCH1 mutations (c.1649dupA and c.6049_6050delTC) in 2 kindreds in which AOS was segregating as an autosomal dominant trait. Screening a cohort of 52 unrelated AOS subjects, we detected 8 additional unique NOTCH1 mutations, including 3 de novo amino acid substitutions, all within the ligand-binding domain. Congenital heart anomalies were noted in 47% (8/17) of NOTCH1-positive probands and affected family members. In leukocyte-derived RNA from subjects harboring NOTCH1 extracellular domain mutations, we observed significant reduction of NOTCH1 expression, suggesting instability and degradation of mutant mRNA transcripts by the cellular machinery. Transient transfection of mutagenized NOTCH1 missense constructs also revealed significant reduction in gene expression. Mutant NOTCH1 expression was associated with downregulation of the Notch target genes HEY1 and HES1, indicating that NOTCH1-related AOS arises through dysregulation of the Notch signaling pathway. CONCLUSIONS: These findings highlight a key role for NOTCH1 across a range of developmental anomalies that include cardiac defects and implicate NOTCH1 haploinsufficiency as a likely molecular mechanism for this group of disorders

A new species of Bryconops (Teleostei: Characidae) from the rio Madeira basin, Northern Brazil

Uma nova espécie de Bryconops é descrita para um tributário do rio Madeira na bacia do rio Amazonas, Brasil. Bryconops piracolina pertence ao subgênero Bryconops por não possuir dentes ou raramente apresentar apenas um dente na maxila, e por possuir uma área nua na face entre o segundo e terceiro infraorbitais. A espécie nova se distingue de todas as espécies do subgênero Bryconops pela presença de uma grande mancha negra na base da nadadeira dorsal. Além disto, difere de todas as espécies do gênero, exceto B. inpai, por possuir a nadadeira adiposa inteiramente preta. Difere de B. inpai pela ausência de manchas umerais. Difere de todas as espécies de Bryconops, exceto B. caudomaculatus, por possuir as últimas escamas da série longitudinal de escamas da linha lateral sem poros além da terminação da placa hipural e difere de B. caudomaculatus pelo menor número de escamas com poros da linha lateral (31-36, média 34,6 vs. 37-43 média, 40,6; respectivamente).A new species of Bryconops is described from a tributary to the rio Madeira in the Amazon basin, State of Rondônia, Brazil. Bryconops piracolina belongs to the subgenus Bryconops by having no teeth or rarely one tooth in the maxilla, and a naked area on cheek between the second and third infraorbitals. The new species is distinguished from all species of this subgenus by the presence of a large black blotch on dorsal-fin base. Furthermore, it is distinguished from all congeners, except B. inpai, by possessing the adipose fin entirely black. It differs from B. inpai by the lack of humeral spots. It further differs from all species of the subgenus Bryconops, except B. caudomaculatus, by having the last scales of the longitudinal series of scales that bears the lateral line series not pored beyond the end of the hypural plate, and differs from B. caudomaculatus by the smaller number of pored lateral line scales (31-36, mean 34.6, vs. 37-43, mean = 40.6, respectively)

Use of hyghly reactive rice husk ash in the production of cement matrix reinforced with Green coconut fiber

[EN] This study evaluated the influence of partial replacement of Portland cement by rice husk ash (RHA) to enable the use of green coconut husk fiber as reinforcement for cementitious matrix. The use of highly reactive pozzolanic ash contributes for decreasing the alkaline attack on the vegetable fiber, originated from waste materials. The slurry dewatering technique was used for dispersion of the raw materials in aqueous solution, followed by vacuum drainage of water and pressing for the production of pad composites, as a simplified simulation of the Hatschek process for industrial manufacture. Five formulations were evaluated, two of them without any mineral additions. One of the mixtures served as a reference (without green coconut fibers) and the remaining ones were reinforced with the green coconut fibers (5% by weight of binder) and with the content of Portland cement replacement by RHA equal to 0, 30, 40 and 50%. The composites were analyzed at 28 days of age and after aging by immersion in warm wáter (65 ◦C), which lasted for 28 additional days. Physical and mechanical tests were applied for assessment of the performance of composites. Thermogravimetric analysis was used to observe the consumption of portlandite and chemically combined water content in the hydrated products for pastes presenting the same levels of Portland cement replacement by RHA (i.e., 0 50%) and with the water/binder ratio kept constant and equal to 0.5. The mechanical performance evaluated by bending test after 28 days reached the MOR of 15.7 MPa after the accelerate aging, for the composites reinforced with the green coconut fiber and with high levels of Portland cement replacement by RHA demonstrating that the use of Green coconut fiber for reinforcement can be very promising for the production of binary cement based matrix. The thermogravimetry showed that the replacement of Portland cement by the RHA helped in maintaining the mechanical behavior of the green coconut fiber in the composite subjected to the accelerated aging tests, and resulted in improved mechanical performance, providing a lightweight composite.To the Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) for financial support and ICITECH Universitat Politecnica de Valencia for facilitating the research development. To the Federal Agency CNPq, Brazil for grants provided to the USP team. Project 3018/2009 financed by Generalitat Valenciana, COMBURES project financed by Centro de Cooperacion al Desarrollo de la Universitat Politecnica de Valencia (ADSIDEO COOPERACIO) and Maicerias Espanolas DACSA S.A. for supplying RHA samples.Pereira, C.; Savastano, HJ.; Paya Bernabeu, JJ.; Santos, SF.; Borrachero Rosado, MV.; Monzó Balbuena, JM.; Soriano Martínez, L. (2013). Use of hyghly reactive rice husk ash in the production of cement matrix reinforced with Green coconut fiber. Industrial Crops and Products. 49:88-96. https://doi.org/10.1016/j.indcrop.2013.04.038S88964

MobiGrants: New Agents of Brain Drain in Portuguese Higher Education

Emigration is a chronic structural process of Portuguese society. The discussion and key arguments raised in this chapter are mainly focused on data from a research project (Bradramo) on Portuguese skilled emigration; based on the outcomes of the Bradramo project it can be suggested that recent phenomena in general, and the crisis that began around 2008 in particular, profoundly transformed the patterns of Portuguese emigration. Nowadays, the country faces a brain drain dynamic that is dramatically altering the profiles of national emigrants, emigration destinations, self-identity, and the strategies of those who leave the country. The neologism “MobiGrants” is used here to characterise recent Portuguese emigration. Academic mobility, which was mainly promoted by the European Union (through grants from the Erasmus Programme), created and fostered mobility flows that reinforced a latent mobility phenomenon. Once engaged in academic mobility programmes, Portuguese higher education students tend to stay in the country of destination or, upon returning temporarily to Portugal, to evince a very strong predisposition to move to a country of the European Union. Further, this grant-fuelled latent mobility exhibits a clear tendency towards moving between various countries and a very weak predisposition vis-à-vis a possible return to Portugal. Alongside this weak propensity to return, there is a marked refusal to assume a self-identity as emigrants. The profile of Portuguese “MobriGrants” reveals a trend towards a permanent and a long-term (as opposed to a temporary or transitory) mobility, an insertion in the primary segment of the labour market of the destination countries, a predominance of professionals connected to the academic/scientific system and to professions requiring high skills, and a latent mobility (after a period of study in the country of destination) rather than direct mobility flows (after having entered in the employment system of the sending country)

Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation

A novel multiscale mathematical and computational model of the pulmonary circulation is presented and used to analyse both arterial and venous pressure and flow. This work is a major advance over previous studies by Olufsen et al. (Ann Biomed Eng 28:1281–1299, 2012) which only considered the arterial circulation. For the first three generations of vessels within the pulmonary circulation, geometry is specified from patient-specific measurements obtained using magnetic resonance imaging (MRI). Blood flow and pressure in the larger arteries and veins are predicted using a nonlinear, cross-sectional-area-averaged system of equations for a Newtonian fluid in an elastic tube. Inflow into the main pulmonary artery is obtained from MRI measurements, while pressure entering the left atrium from the main pulmonary vein is kept constant at the normal mean value of 2 mmHg. Each terminal vessel in the network of ‘large’ arteries is connected to its corresponding terminal vein via a network of vessels representing the vascular bed of smaller arteries and veins. We develop and implement an algorithm to calculate the admittance of each vascular bed, using bifurcating structured trees and recursion. The structured-tree models take into account the geometry and material properties of the ‘smaller’ arteries and veins of radii ≥ 50 μ m. We study the effects on flow and pressure associated with three classes of pulmonary hypertension expressed via stiffening of larger and smaller vessels, and vascular rarefaction. The results of simulating these pathological conditions are in agreement with clinical observations, showing that the model has potential for assisting with diagnosis and treatment for circulatory diseases within the lung