Un teorema di regolarità relativo ad un problema unilaterale

Si considera una disequazione variazionale connessa ad un problema di contatto tra membrane, e si dimostrano un teorema di regolarità ed un teorema di dipendenza continua.A variational inequality connected with a contact problem between membrane is considered. A regularity theorem and a continuous dependence theorem are prove

Stage-struck; or, She would be an opera-singer.

Mode of access: Internet

The home life of Henry W. Longfellow. Reminiscences of many visits at Cambridge and Nahant, during the years 1880, 1881, and 1882.

Mode of access: Internet

Western Alpine and Grana Valley Sky Sanctuary, Italy

IAU Extended Case Study forma

Gelatin Porous Scaffolds as Delivery Systems of Calcium Alendronate

The systemic administration of bisphosphonates (BPs) for the treatment of metabolic diseases characterized by abnormal bone loss suffers from several adverse side effects, which can be reduced by implementation of alternative modes of administration. In this work, glutaraldehyde cross-linked gelatin scaffolds are proposed as delivery systems of calcium alendronate monohydrate (CaAL\u2022H2O). The 3D highly porous scaffolds display a relevant interconnected porosity (>94%), independently from CaAL\u2022H2O content (0, 3, and 6 wt%). At variance, pore size varies with composition. The relative increase of the number of smaller pores on increasing BP content is in agreement with the parallel significant increase of the compressive modulus and collapse strength. The scaffolds exhibit a sustained CaAL\u2022H2O release profile, and a significant amount of the drug is retained in the scaffolds even after 14 d. In vitro tests are carried out using cocultures of osteoblast (OB) and osteoclast (OC). The evaluation of differentiation markers is performed both on the supernatants of cell culture and by means of quantitative polymerase chain reaction. The results indicate that BP containing scaffolds support osteoblast proliferation and differentiation, whereas they inhibit osteoclast viability and activity, displaying a promising beneficial role on bone repair processes. (Figure presented.)