Mixed-Integer Linear Programming for Vehicle Routing Problem with Simultaneous Delivery and Pick-Up with Maximum Route-Length

The vehicle routing problem with simultaneous delivery and pick-up (VRPSDP) is the problem of optimally assimilating goods collection and distribution, when no priority constraints are imposed on the order in which the vehicle must perform the operations. This paper considers an additional constraint of maximum route length in VRPSDP. We develop a mixed-integer linear programming model for VRPSDP with an additional constraint of maximum route length. The results are encouraging for a sample benchmark data set

Two-parameter uniformly elliptic Sturm–Liouville problems with eigenparameter-dependent boundary conditions

We consider the two-parameter Sturm–Liouville system –y "1+q1y1=(λr11+μr12)y1 [0,1], with the boundary conditions y'1(0)/y1(0)=cotΑ1 and y'1(1)/y1(1)=a1λ+b1/c1λ+d1 and –y" 2+q2y2=(λr21+μr22)y2 on [0,1] with the boundary conditions y'2(0)/y2(0)=cotΑ2 and y'2(1)/y2(1)=a2μ+b2/c2μ+d2 subject to the uniform-left-definite and uniform-ellipticity conditions; where and qi and rij are continuous real valued functions on [0,1], the angle Αi is in [0, π) and ai, bi, ci, di, and are real numbers with δ i = aidi - bici > 0 and ci ≠0 for i,j = 1,2. Results are given on asymptotics, oscillation of eigenfunctions and location of eigenvalues

Oral contrast radiography evaluation in adhesive intestinal obstruction

Background: Adhesive small bowel obstruction (ASBO) is a common cause for admission in the surgery casualty. Non-operative management is initially recommended unless there is suspicion of complication, but its optimal duration is controversial. The aims of this study were to evaluate the usefulness of radiographic small bowel examination with contrast medium to predict the need for surgery in ASBO and to decrease late-surgery morbidity.Methods: This prospective observational study was carried out in a tertiary apex institute in Kerala, India enrolling 50 patients with clinical and radiological features of adhesive SBO. The past surgical history, as well as clinical picture, blood tests and radiological findings in these patients were studied. Fifty millilitres of 5% barium suspension were given via naso-gastric tube, and plain abdominal radiographs were taken at 6 and 24 hours afterwards. The primary variable assessed was the presence/absence of contrast in right colon. Surgical intervention was decided upon, based on the treating surgeon's discretion.Results: In 36 patients, barium contrast appeared in the right colon. In the remaining 14 patients, no evidence of barium contrast in the right colon was seen, and 8 of them underwent surgery, while the other 6 were treated conservatively. There was a statistical significant relationship (p<0.01) between the presence of contrast medium in the right colon and being treated conservatively. There was also a statistically significant (p<0.05) relationship between index case being one for malignancy and undergoing laparotomy for ASBO in the study.Conclusions: Early oral administration of a radiological contrast medium in patients with adhesive small bowel obstruction can effectively predict the need for a surgical procedure. It can shorten not only hospital stay, but also the potential morbidity of late surgery, secondary to a prolonged and unsuccessful non-operative treatment

A Feasibility Study on Using Gfrp Composites Bar in Rc Flexural Member

Steel reinforcements are commonly used for Reinforced Concrete (RC) beams all around the world to take flexural tension. But, the durability of the structure is reduced due to reinforcement steel corrosion. Avoiding reinforcement corrosion and finding alternative material to take flexural tension is the contemporary research work in the field of structural engineering. In the present study, RC beams are reinforced with Glass Fibre Reinforced polymer (GFRP) composites bar at tension zone and flexural test was carried out to determine the bending moment resistance of the beam. GFRP bars were prepared in the industry with the help of pultruded U-section box formwork. GFRP bars were coated with sand using epoxy resin to increase the bond between bars and the RC beam. Three GFRP reinforced concrete beam specimens of size 700 mm × 200 mm × 200 mm were prepared. Also, same size of normal steel reinforced cement concrete beam member was prepared. After 28 days curing, three point bending test was carried out for all the four beams. Flexural capacity of beams with GFRP bars were compared with RC beam with steel bars. The results revealed that the flexural capacity of RC beams with GFRP bars is more than that of RC beam with steel bars. Also, theoretical analysis was carried out to determine the flexural strength of RC beam with steel and GFRP bars and compared with experimental results

Isolation, identification and culture of the marine rotifer Colurella adriatica Ehrenberg, 1831 (Family: Lepadellidae) from Andaman & Nicobar Islands: A promising live feed for larval rearing of high value shellfishes and finfishes

An extremely small rotifer was isolated from the micro zooplankton samples collected during February, 2014 from Havelock islands of Andaman and Nicobar Islands. The species was identified as Colurella adriatica Ehrenberg, 1831 (Family: Lapadellidae). Its lorica length under culture period ranged from 47.530 to 98.868 μm and width from 34.308 to 56.277 μm. The size of the eggs, neonates and adults are also documented. Comparison of size of C. adriatica with Brachionus plicatilis (L type) and B. rotundiformis (S and SS type) revealed that C. adriatica is smaller in length and width than the SS-type rotifer which is currently used as a first feed in marine tropical fish larval rearing. However, the larvae of many marine food fishes including groupers and high value marine ornamental fishes are unable to consume the SS-type rotifers as a first feed due to their extremely small mouth gape. The culture of C. adriatica was carried out using Nannochloropsis oculata Diet-I), N. oculata and yeast (0.01g/litre) (Diet-II), Yeast (0.01g/litre) alone (Diet-III). Average population density of C. adriatica with these diets reached a maximum of 1000 nos. of individuals /ml on 10th day of culture on feeding with Diet-I; 950 nos. /ml on 14th day (Diet-II) and 650 nos. /ml on 15th day of culture (Diet-III). Diet I &II and Diet II &III did not show any significant difference (P>0.05) whereas, Diet I and III showed significant difference (P<0.01). Preliminary studies of C. adriatica as a feed to the larvae of Stenopus hispidus, Lysmata amboinensis and Pomacentrus caeruleus showed better survival than larvae fed with B. routundiformis during first phase of larval rearing

Stepwise Formation Constants of La(III), Ce(III), Pr(III) & Nd(III) with 4-H'ydroxy- 3-formyl-(2'/4')-methylazobenzenes

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Evaluation of hypolipidemic effect of Tinospora cordifolia in cholesterol diet induced hyperlipidemia in rats

Background: There is always a need for developing novel drugs with higher efficacy and fewer side effects. Though statins are generally well-tolerated drugs for hyperlipidemia with high efficacy they are not free from adverse effects. Herbal drugs are well known for their cost-effectiveness and minimal side effects. Tinospora cordifolia (T. cordifolia) is one such plant with known hypolipidemic activity and wide availability in India. Hence this study is an attempt to verify and evaluate the extent of efficacy of T. cordifolia as a hypolipidemic agent. The objective of the study is to compare the hypolipidemic activity of aqueous root extract of T. cordifolia with that of Rosuvastatin in cholesterol diet-induced hyperlipidemia in rats.Methods: Hyperlipidemia was induced in male albino rats of wistar strain in the first 30 days of feeding period and continued in the next 30 days of treatment period. Aqueous root extract of T. cordifolia (2.5 and 5g/kg, per oral) was administered as test drug in the treatment period. Rosuvastatin (10 mg/kg,      per oral) was used as the standard drug. Serum lipid profile, atherogenic index and body weights were estimated for all rats on the day before the start of the feeding period and on day 0, 15 and 30 of the treatment period. The results were analyzed statistically using student’s unpaired and paired t-test wherever applicable.Results: Serum lipid levels showed significant reduction (p <0.001) in TC,TG, LDL-C and VLDL-C with significant elevation (p <0.001) of HDL-C in both the rosuvastatin and test groups, but the percentage reduction in lipid levels, percentage elevation of HDL-C and percentage protection from atherosclerosis was higher in rosuvastatin group than in test groups.Conclusions: T.cordifolia has a definite hypolipidemic potential. Although its effectiveness is lesser than rosuvastatin its beneficial role as hypolipidemic agent may be tested in clinical studies

Evaluation of hypolipidemic effect of Tinospora cordifolia in cholesterol diet induced hyperlipidemia in rats

Background: There is always a need for developing novel drugs with higher efficacy and fewer side effects. Though statins are generally well-tolerated drugs for hyperlipidemia with high efficacy they are not free from adverse effects. Herbal drugs are well known for their cost-effectiveness and minimal side effects. Tinospora cordifolia (T. cordifolia) is one such plant with known hypolipidemic activity and wide availability in India. Hence this study is an attempt to verify and evaluate the extent of efficacy of T. cordifolia as a hypolipidemic agent. The objective of the study is to compare the hypolipidemic activity of aqueous root extract of T. cordifolia with that of Rosuvastatin in cholesterol diet-induced hyperlipidemia in rats.Methods: Hyperlipidemia was induced in male albino rats of wistar strain in the first 30 days of feeding period and continued in the next 30 days of treatment period. Aqueous root extract of T. cordifolia (2.5 and 5g/kg, per oral) was administered as test drug in the treatment period. Rosuvastatin (10 mg/kg,      per oral) was used as the standard drug. Serum lipid profile, atherogenic index and body weights were estimated for all rats on the day before the start of the feeding period and on day 0, 15 and 30 of the treatment period. The results were analyzed statistically using student’s unpaired and paired t-test wherever applicable.Results: Serum lipid levels showed significant reduction (p <0.001) in TC,TG, LDL-C and VLDL-C with significant elevation (p <0.001) of HDL-C in both the rosuvastatin and test groups, but the percentage reduction in lipid levels, percentage elevation of HDL-C and percentage protection from atherosclerosis was higher in rosuvastatin group than in test groups.Conclusions: T.cordifolia has a definite hypolipidemic potential. Although its effectiveness is lesser than rosuvastatin its beneficial role as hypolipidemic agent may be tested in clinical studies

Quality of life of alcohol dependent patients attending a deaddiction centre in Kannur district

Background: Quality of life (QOL) is individuals' perceptions of their position in life. QOL of alcohol dependent patients is an area that has received relatively less attention compared to other alcohol related problems.Methods: A deaddiction centre based cross sectional study was done on 370 individuals using a predesigned questionnaire during the period of 2012-2013. The data was analyzed using SPSS version 17. Spearman’s rank correlation test was used to find association between the study variables.Results: The mean age of the study subjects was 38.08±8.46 years. The mean duration of drinking was 12.62±7.47 years. The overall score of the QOL and the perceived health in alcohol dependent patients was 3.19±0.89 and 3.01±0.98 respectively. The mean of the transformed scores of physical, psychological, social and environmental domains are 69.12±12.82, 57.84±12.81, 58.52±17.05, 68.62±10.23 respectively. Statistical analysis of age with physical, environmental and social domains showed a significant negative correlation; literacy status with QOL, perceived health, physical, psychological, social and environmental domains showed a significant positive correlation; socio economic status with QOL and psychological domain showed a significant positive correlation; duration of drinking with QOL, perceived health, physical and psychological domain showed a significant negative correlation.Conclusions: Harm from alcohol use is a major public health problem. Reducing the level of social and health harms from alcohol requires preparation and planning

Presence of Multiple Tendinous Insertions of Palmaris Longus: A Unique Variation of a Retrogressive Muscle

Background: Palmaris longus, being the most variable muscle of the upper extremity is generally considered important morphologically rather than functionally. The palmar aponeurosis represents the distal part of the tendon of Palmaris longus.Case Details: We report here a unique case of palmaris longus presenting variation distally as its tendon divides to gain multiple attachments with the fascia covering the abductor pollicis brevis, flexor retinaculum and the tendon of flexor carpi ulnaris. In addition, it also continues as palmar aponeurosis as its normal course.Conclusion: Presence of this kind of variation might result in compression of the median and ulnar nerves and may aggravate the complications in case of inflammation of palmar aponeurosis thus mimicking the manifestations of Dupuytren’s contracture.Keywords: Palmaris longus, palmar aponeurosis, Dupuytren’s contractur