1,861 research outputs found
Using a Delphi technique to seek consensus regarding definitions, descriptions and classification of terms related to implicit and explicit forms of motor learning.
Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: Motor learning is central to domains such as sports and rehabilitation; however, often terminologies are insufficiently uniform to allow effective sharing of experience or translation of knowledge. A study using a Delphi technique was conducted to ascertain level of agreement between experts from different motor learning domains (i.e., therapists, coaches, researchers) with respect to definitions and descriptions of a fundamental conceptual distinction within motor learning, namely implicit and explicit motor learning. METHODS: A Delphi technique was embedded in multiple rounds of a survey designed to collect and aggregate informed opinions of 49 international respondents with expertise related to motor learning. The survey was administered via an online survey program and accompanied by feedback after each round. Consensus was considered to be reached if ≥70% of the experts agreed on a topic. RESULTS: Consensus was reached with respect to definitions of implicit and explicit motor learning, and seven common primary intervention strategies were identified in the context of implicit and explicit motor learning. Consensus was not reached with respect to whether the strategies promote implicit or explicit forms of learning. DISCUSSION: The definitions and descriptions agreed upon may aid translation and transfer of knowledge between domains in the field of motor learning. Empirical and clinical research is required to confirm the accuracy of the definitions and to explore the feasibility of the strategies that were identified in research, everyday practice and education.Stichting Alliantie Innovatie (Innovation Alliance Foundation)RAAK-internationa
Molecular hydrogen beyond the optical edge of an isolated spiral galaxy
We know little about the outermost portions of galaxies because there is
little light coming from them. We do know that in many cases atomic hydrogen
(HI) extends well beyond the optical radius \cite{Casertano91}. In the centers
of galaxies, however, molecular hydrogen (H2) usually dominates by a large
factor, raising the question of whether H2 is abundant also in the outer
regions but hitherto unseen.Here we report the detection of emission from
carbon monoxide (CO), the most abundant tracer of H2, beyond the optical radius
of the nearby galaxy NGC 4414. The molecular clouds probably formed in the
regions of relatively high HI column density and in the absence of spiral
density waves. The relative strength of the lines from the two lowest
rotational levels indicates that both the temperature and density of the H2 are
quite low compared to conditions closer to the center. The inferred surface
density of the molecular material continues the monotonic decrease from the
inner regions. We conclude that while molecular clouds can form in the outer
region of this galaxy, there is little mass associated with them.Comment: 3 Nature page
Order reduction approaches for the algebraic Riccati equation and the LQR problem
We explore order reduction techniques for solving the algebraic Riccati
equation (ARE), and investigating the numerical solution of the
linear-quadratic regulator problem (LQR). A classical approach is to build a
surrogate low dimensional model of the dynamical system, for instance by means
of balanced truncation, and then solve the corresponding ARE. Alternatively,
iterative methods can be used to directly solve the ARE and use its approximate
solution to estimate quantities associated with the LQR. We propose a class of
Petrov-Galerkin strategies that simultaneously reduce the dynamical system
while approximately solving the ARE by projection. This methodology
significantly generalizes a recently developed Galerkin method by using a pair
of projection spaces, as it is often done in model order reduction of dynamical
systems. Numerical experiments illustrate the advantages of the new class of
methods over classical approaches when dealing with large matrices
Susceptibility of hamsters to clostridium difficile isolates of differing toxinotype
Clostridium difficile is the most commonly associated cause of antibiotic associated disease (AAD), which caused ~21,000 cases of AAD in 2011 in the U.K. alone. The golden Syrian hamster model of CDI is an acute model displaying many of the clinical features of C. difficile disease. Using this model we characterised three clinical strains of C. difficile, all differing in toxinotype; CD1342 (PaLoc negative), M68 (toxinotype VIII) and BI-7 (toxinotype III). The naturally occurring non-toxic strain colonised all hamsters within 1-day post challenge (d.p.c.) with high-levels of spores being shed in the faeces of animals that appeared well throughout the entire experiment. However, some changes including increased neutrophil influx and unclotted red blood cells were observed at early time points despite the fact that the known C. difficile toxins (TcdA, TcdB and CDT) are absent from the genome. In contrast, hamsters challenged with strain M68 resulted in a 45% mortality rate, with those that survived challenge remaining highly colonised. It is currently unclear why some hamsters survive infection, as bacterial and toxin levels and histology scores were similar to those culled at a similar time-point. Hamsters challenged with strain BI-7 resulted in a rapid fatal infection in 100% of the hamsters approximately 26 hr post challenge. Severe caecal pathology, including transmural neutrophil infiltrates and extensive submucosal damage correlated with high levels of toxin measured in gut filtrates ex vivo. These data describes the infection kinetics and disease outcomes of 3 clinical C. difficile isolates differing in toxin carriage and provides additional insights to the role of each toxin in disease progression
Impact of Age and Body Site on Adult Female Skin Surface pH
Background: pH is known as an important parameter in epidermal barrier function and homeostasis. Aim: The impact of age and body site on skin surface pH (pH(SS)) of women was evaluated in vivo. Methods: Time domain dual lifetime referencing with luminescent sensor foils was used for pH(SS) measurements. pH(SS) was measured on the forehead, the temple, and the volar forearm of adult females (n = 97, 52.87 +/- 18.58 years, 20-97 years). Every single measurement contained 2,500 pH values due to the luminescence imaging technique used. Results: pH(SS) slightly increases with age on all three investigated body sites. There are no significant differences in pH(SS) between the three investigated body sites. Conclusion: Adult pH(SS) on the forehead, the temple and the volar forearm increases slightly with age. This knowledge is crucial for adapting medical skin care products. Copyright (C) 2012 S. Karger AG, Base
Tracing scientist's research trends realtimely
In this research, we propose a method to trace scientists' research trends
realtimely. By monitoring the downloads of scientific articles in the journal
of Scientometrics for 744 hours, namely one month, we investigate the download
statistics. Then we aggregate the keywords in these downloaded research papers,
and analyze the trends of article downloading and keyword downloading.
Furthermore, taking both the download of keywords and articles into
consideration, we design a method to detect the emerging research trends. We
find that in scientometrics field, social media, new indices to quantify
scientific productivity (g-index), webometrics, semantic, text mining, open
access are emerging fields that scientometrics researchers are focusing on.Comment: 13 pages, 7 figure
Molecular structure of the largemouth bass (Micropterus salmoides) Myf5 gene and its effect on skeletal muscle growth
Myogenic Regulatory Factors (MRFs), a family of basic helix-loop-helix (bHLH) transcription factors, play important roles in regulating skeletal muscle development and growth. Myf5, the primary factor of MRFs, initiates myogenesis. Its expression pattern during somitomyogenesis in some fish has been revealed. To further study its effect on fish muscle during postembryonic growth, characterization and function analysis of myf5 cDNA were carried out in largemouth bass. The 1,093 bp cDNA sequence was identified by RT-PCR and 3′RACE, then the ORF of Myf5 cDNA was cloned into the expression vector pcDNA3.1(−)/mycHisB. The recombinant plasmid pcDNA3.1(−)/mycHisB-Myf5 was injected into the dorsal muscle of tilapias. RT-PCR and histochemical results showed that the exogenous gene was transcribed and translated in vivo. Its effect on muscle growth focused on myofiber hypertrophy in white muscle 60 days post injection. This indicated that overexpression of Myf5 can promote myogenesis during the fish muscle postembryonic growth period
Development of Trust in an Online Breast Cancer Forum: A Qualitative Study
Background: Online health forums provide peer support for a range of medical conditions, including
life-threatening and terminal illnesses. Trust is an important component of peer-to-peer support,
although relatively little is known about how trust forms within online health forums.
Objective: The aim of this paper is to examine how trust develops and influences sharing among
users of an online breast cancer forum.
Methods: An interpretive qualitative approach was adopted. Data were collected from forum posts
from 135 threads on nine boards on the UK charity, Breast Cancer Care (BCC). Semi-structured
interviews were conducted with 14 BCC forum users. Both datasets were analysed thematically using
Braun and Clarke’s [2006] approach and combined to triangulate analysis.
Results: Trust operates in three dimensions, structural, relational and temporal, which intersect with
each other and do not operate in isolation. The structural dimension relates to how the affordances
and formal rules of the site affected trust. The relational dimension refers to how trust was
necessarily experienced in interactions with other forum users: it emerged within relationships and
was a social phenomenon. The temporal dimension relates to how trust changed over time and was
influenced by the length of time users spent on the forum.
Conclusions: Trust is a process that changes over time, and which is influenced by structural features
of the forum and informal but collectively understood relational interactions among forum users.
The study provides a better understanding of how the intersecting structural, relational and
temporal aspects that support the development of trust facilitate sharing in online environments.
These findings will help organisations developing online health forums
The intellectual influence of economic journals: quality versus quantity
The evaluation of scientific output has a key role in the allocation of
research funds and academic positions. Decisions are often based on quality indicators
for academic journals, and over the years, a handful of scoring methods have
been proposed for this purpose. Discussing the most prominent methods (de facto
standards) we show that they do not distinguish quality from quantity at article level.
The systematic bias we find is analytically tractable and implies that the methods are
manipulable. We introduce modified methods that correct for this bias, and use them
to provide rankings of economic journals. Our methodology is transparent; our results
are replicable
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