Higgs ultraviolet softening

We analyze the leading effective operators which induce a quartic momentum dependence in the Higgs propagator, for a linear and for a non-linear realization of electroweak symmetry breaking. Their specific study is relevant for the understanding of the ultraviolet sensitivity to new physics. Two methods of analysis are applied, trading the Lagrangian coupling by: i) a "ghost" scalar, after the Lee-Wick procedure; ii) other effective operators via the equations of motion. The two paths are shown to lead to the same effective Lagrangian at first order in the operator coefficients. It follows a modification of the Higgs potential and of the fermionic couplings in the linear realization, while in the non-linear one anomalous quartic gauge couplings, Higgs-gauge couplings and gauge-fermion interactions are induced in addition. Finally, all LHC Higgs and other data presently available are used to constrain the operator coefficients; the future impact of $pp\to\text{4 leptons}$ data via off-shell Higgs exchange and of vector boson fusion data is considered as well. For completeness, a summary of pure-gauge and gauge-Higgs signals exclusive to non-linear dynamics at leading-order is included.Comment: 31 pages, 3 figures, 7 table

Same-sign WW scattering in the HEFT: discoverability vs. EFT validity

Vector boson scatterings are fundamental processes to shed light on the nature of the electroweak symmetry breaking mechanism. Deviations from the Standard Model predictions on the corresponding observables can be interpreted in terms of effective field theories, that however undergo consistency conditions. In this paper, the same-sign W W scattering is considered within the HEFT context and the correct usage of the effective field theory approach is discussed. Regions of the parameters space are identified where a signal of new physics could be measured at HL-LHC with a significance of more than 5σ and the effective field theory description is consistently adopted. These results are then translated into bounds on the ξ parameter in the composite Higgs scenario. The discussion on the agreement with previous literature and the comparison with the equivalent analysis in the SMEFT case are also included.The work of P.K. is supported by the Spanish MINECO project FPA2016-78220-C3-1-P (Fondos FEDER) and by National Science Centre, Poland, the PRELUDIUM project under contract 2018/29/N/ST2/01153. L.M. acknowledges partial nancial support by the Spanish MINECO through the \Ramón y Cajal" programme (RYC-2015-17173), by the Spanish \Agencia Estatal de Investigación" (AEI) and the EU \Fondo Europeo de Desarrollo Regional" (FEDER) through the project FPA2016-78645-P, and through the Centro de excelencia Severo Ochoa Program under grant SEV-2016-0597, and by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreements No 690575 and No 674896. The work of S.P. is partially supported by the National Science Centre, Poland, under research grants DEC-2015/18/M/ST2/00054 and DEC-2016/23/G/ST2/04301. M.S. is partially supported by the generous COST grant, COST Action No. CA16108 (VBSCan). L.M. thanks the Institute of Theoretical Physics of the University of Warsaw for hospitality during the development of this project. S.P. thanks the Instituto de Física Teórica (IFT UAM-CSIC) in Madrid for its support via the Centro de Excelencia Severo Ochoa Program under Grant SEV-2016-0597

Disentangling a dynamical Higgs

The pattern of deviations from Standard Model predictions and couplings is different for theories of new physics based on a non-linear realization of the $SU(2)_L\times U(1)_Y$ gauge symmetry breaking and those assuming a linear realization. We clarify this issue in a model-independent way via its effective Lagrangian formulation in the presence of a light Higgs particle, up to first order in the expansions: dimension-six operators for the linear expansion and four derivatives for the non-linear one. Complete sets of pure gauge and gauge-Higgs operators are considered, implementing the renormalization procedure and deriving the Feynman rules for the non-linear expansion. We establish the theoretical relation and the differences in physics impact between the two expansions. Promising discriminating signals include the decorrelation in the non-linear case of signals correlated in the linear one: some pure gauge versus gauge-Higgs couplings and also between couplings with the same number of Higgs legs. Furthermore, anomalous signals expected at first order in the non-linear realization may appear only at higher orders of the linear one, and vice versa. We analyze in detail the impact of both type of discriminating signals on LHC physics.Comment: Version published in JHE

PSMA-Specific CAR-Engineered T Cells Eradicate Disseminated Prostate Cancer in Preclinical Models.

Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. We developed a chimeric antigen receptor (CAR) construct targeting the human prostate-specific membrane antigen (hPSMA), based on a novel and high affinity specific mAb. As a transfer method, we employed last-generation lentiviral vectors (LV) carrying a synthetic bidirectional promoter capable of robust and coordinated expression of the CAR molecule, and a bioluminescent reporter gene to allow the tracking of transgenic T cells after in vivo adoptive transfer. Overall, we demonstrated that CAR-expressing LV efficiently transduced short-term activated PBMC, which in turn were readily stimulated to produce cytokines and to exert a relevant cytotoxic activity by engagement with PSMA+ prostate tumor cells. Upon in vivo transfer in tumor-bearing mice, CAR-transduced T cells were capable to completely eradicate a disseminated neoplasia in the majority of treated animals, thus supporting the translation of such approach in the clinical setting

A Simplest A4 Model for Tri-Bimaximal Neutrino Mixing

We present a see-saw $A_4$ model for Tri-Bimaximal mixing which is based on a very economical flavour symmetry and field content and still possesses all the good features of $A_4$ models. In particular the charged lepton mass hierarchies are determined by the $A_4\times Z_4$ flavour symmetry itself without invoking a Froggatt-Nielsen U(1) symmetry. Tri-Bimaximal mixing is exact in leading order while all the mixing angles receive corrections of the same order in next-to-the-leading approximation. As a consequence the predicted value of $\theta_{13}$ is within the sensitivity of the experiments which will take data in the near future. The light neutrino spectrum, typical of $A_4$ see-saw models, with its phenomenological implications, also including leptoproduction, is studied in detail.Comment: 20 pages, 2 figure

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter.

Background: Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. Methods: We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. Results: We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. Limitations: The modest sample size and the absence of women in our series could limit the impact of our results. Conclusion: Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis

Hipertemia não pirogênica. Relato de casos

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